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The map label for this gene is ponA [H]

Identifier: 16272388

GI number: 16272388

Start: 460645

End: 463239

Strand: Direct

Name: ponA [H]

Synonym: HI0440

Alternate gene names: 16272388

Gene position: 460645-463239 (Clockwise)

Preceding gene: 16272376

Following gene: 16272389

Centisome position: 25.17

GC content: 41.27

Gene sequence:

>2595_bases
ATGCGGATCGCAAAATTAATATTAAACACCCTATTAACTTTATGTATTTTAGGTTTAGTAGCAGGCGGAATGTTGTATTT
CCACTTAAAATCTGAATTGCCCTCAGTAGAAACATTAAAAACCGTTGAATTACAGCAACCAATGCAGATTTATACGGCTG
ACGGTAAATTAATTGGCGAAGTGGGTGAGCAACGCCGTATTCCAGTGAAATTAGCCGATGTGCCACAACGCTTAATTGAC
GCATTTTTAGCGACGGAAGACAGTCGTTTTTACGATCATCACGGATTAGACCCTATCGGCATTGCCCGTGCATTGTTTGT
CGCAGTGAGTAATGGCGGTGCATCACAAGGCGCAAGTACGATTACTCAACAATTAGCGCGTAACTTTTTCTTAACCTCAG
AAAAAACCATTATTCGTAAAGCTCGTGAAGCCGTGCTTGCGGTAGAAATCGAAAATACTCTCAACAAACAAGAAATATTA
GAGCTTTATTTAAACAAAATCTTTTTAGGCTATCGTTCTTATGGTGTTGCAGCGGCAGCACAAACCTATTTCGGTAAATC
ATTGAATGAATTGACCTTATCGGAAATGGCGATTATTGCTGGTTTACCTAAAGCACCTTCAACAATGAACCCGCTTTATT
CTTTAAAACGTTCAGAAGAACGCCGCAATGTGGTGCTAAGCCGTATGTTAGATGAAAAATACATCAGCAAAGAAGAATAT
GATGCTGCATTGAAAGAGCCGATTGTGGCGAGCTATCACGGCGCAAAATTTGAATTTCGAGCCGATTATGTCACTGAAAT
GGTGCGTCAAGAAATGGTGCGTCGTTTTGGCGAAGAAAATGCTTACACCAGTGGTTATAAAGTATTTACCACTGTACTTT
CAAAAGACCAAGCTGAAGCCCAAAAAGCTGTGCGTAATAACTTGATTGATTACGATATGCGTCACGGTTATCGCGGTGGC
GCGCCATTATGGCAAAAAAATGAAGCCGCTTGGGACAATGATCGCATTGTCGGTTTTCTACGCAAACTACCTGATTCAGA
GCCATTTATTCCTGCGGCAGTGATTGGAATTGTAAAAGGCGGTGCTGATATATTGCTCGCTTCTGGGGAAAAAATGACCT
TATCAACCAATGCAATGCGTTGGACAGGCAGAAGCAATCCTGTGAAAGTCGGCGAGCAAATTTGGATTCATCAGCGTGCT
AATGGGGAATGGCAATTAGGACAAATTCCCGCAGCAAATTCAGCATTAGTTTCTCTTAATTCAGATAATGGTGCGATTGA
AGCAGTGGTCGGTGGCTTTAGCTATGAACAAAGTAAATTCAATCGAGCCACACAGTCTTTAGTTCAAGTGGGTTCTTCTA
TCAAACCATTTATTTACGCGGCAGCATTAGAAAAAGGCTTAACACTTTCAAGCGTATTACAAGACAGCCCGATTTCTATT
CAAAAACCGGGACAAAAAATGTGGCAACCGAAAAACTCGCCTGATCGTTATGATGGCCCGATGCGTTTACGCGTAGGATT
AGGTCAATCCAAAAATATAATTGCTATTCGTGCTATCCAAACGGCAGGTATTGATTTCACAGCAGAATTTTTACAACGTT
TTGGTTTTAAACGTGATCAATATTTTGCCAGTGAAGCCTTAGCACTTGGCGCAGCCTCTTTCACACCATTAGAAATGGCG
CGAGCTTATGCGGTGTTTGATAATGGTGGCTTCCTCATTGAACCTTATATCATTGAAAAAATTCAAGATAACACGGGTAA
AGACTTATTTATTGCAAACCCTAAAATTGCTTGCATTGAATGTAATGATATACCTGTAATTTATGGCGAAACCAAAGACA
AAATCAACGGCTTTGCCAATATTCCTTTAGGCGAGAATGCCTTAAAACCAACAGATGACAGCACCAATGGCGAAGAATTA
GATCAACAACCTGAAACTGTGCCTGAACTGCCAGAATTACAATCAAATATGACCGCACTTAAAGAAGATGCGATTGATTT
AATGGCTGCTGCAAAAAATGCTTCGTCGAAAATAGAATATGCGCCACGTGTCATTAGTGGCGAACTTGCTTTTCTCATTC
GTAGTGCCTTAAATACGGCAATTTATGGCGAACAAGGTTTAGACTGGAAAGGCACCAGCTGGCGTATTGCACAAAGCATT
AAACGTAGCGATATAGGCGGTAAAACAGGTACTACCAACAGTTCAAAAGTGGCTTGGTATGCGGGATTTGGTGCAAACTT
AGTAACCACAACTTATGTCGGGTTTGATGATAACAAACGAGTACTTGGGCGTGGAGAAGCAGGAGCAAAAACAGCAATGC
CTGCTTGGATCACTTATATGAAAACGGCTTTGAGTGATAAGCCAGAACGTAAATTGTCGCTACCGCCAAAAATTGTGGAA
AAAAACATTGATACTTTGACAGGTTTGCTTTCTCCAAACGGTGGGCGCAAAGAATATTTTATTGCGGGAACAGAACCGAC
ACGTACCTATCTTTCGGAAATGCAAGAGCGTGGTTATTATGTTCCTACTGAGTTACAGCAACGCTTAAATAATGAAGGCA
ATACGCCAGCGACGCAACCACAAGAACTCTTCTAA

Upstream 100 bases:

>100_bases
ATATTCTTTCCTATTCTTTAAAGGCTGAATCTTTTATACTTAACAGCCAAATCATAGGTCTCTTGACAAGAATATTCATT
AACGAAGCGAGAATTTTACG

Downstream 100 bases:

>100_bases
AAATGACCGCACTTTAGTGTGTAATCGGGCGAGTCAATTGGCTCGCCTTCGTTATTAAACAAATAAGGAATATATAAGGA
ATATATTATGCTGAGTTATC

Product: penicillin-binding protein 1A

Products: NA

Alternate protein names: PBP-1a; PBP1a; Penicillin-binding protein A; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Penicillin-sensitive transpeptidase; DD-transpeptidase [H]

Number of amino acids: Translated: 864; Mature: 864

Protein sequence:

>864_residues
MRIAKLILNTLLTLCILGLVAGGMLYFHLKSELPSVETLKTVELQQPMQIYTADGKLIGEVGEQRRIPVKLADVPQRLID
AFLATEDSRFYDHHGLDPIGIARALFVAVSNGGASQGASTITQQLARNFFLTSEKTIIRKAREAVLAVEIENTLNKQEIL
ELYLNKIFLGYRSYGVAAAAQTYFGKSLNELTLSEMAIIAGLPKAPSTMNPLYSLKRSEERRNVVLSRMLDEKYISKEEY
DAALKEPIVASYHGAKFEFRADYVTEMVRQEMVRRFGEENAYTSGYKVFTTVLSKDQAEAQKAVRNNLIDYDMRHGYRGG
APLWQKNEAAWDNDRIVGFLRKLPDSEPFIPAAVIGIVKGGADILLASGEKMTLSTNAMRWTGRSNPVKVGEQIWIHQRA
NGEWQLGQIPAANSALVSLNSDNGAIEAVVGGFSYEQSKFNRATQSLVQVGSSIKPFIYAAALEKGLTLSSVLQDSPISI
QKPGQKMWQPKNSPDRYDGPMRLRVGLGQSKNIIAIRAIQTAGIDFTAEFLQRFGFKRDQYFASEALALGAASFTPLEMA
RAYAVFDNGGFLIEPYIIEKIQDNTGKDLFIANPKIACIECNDIPVIYGETKDKINGFANIPLGENALKPTDDSTNGEEL
DQQPETVPELPELQSNMTALKEDAIDLMAAAKNASSKIEYAPRVISGELAFLIRSALNTAIYGEQGLDWKGTSWRIAQSI
KRSDIGGKTGTTNSSKVAWYAGFGANLVTTTYVGFDDNKRVLGRGEAGAKTAMPAWITYMKTALSDKPERKLSLPPKIVE
KNIDTLTGLLSPNGGRKEYFIAGTEPTRTYLSEMQERGYYVPTELQQRLNNEGNTPATQPQELF

Sequences:

>Translated_864_residues
MRIAKLILNTLLTLCILGLVAGGMLYFHLKSELPSVETLKTVELQQPMQIYTADGKLIGEVGEQRRIPVKLADVPQRLID
AFLATEDSRFYDHHGLDPIGIARALFVAVSNGGASQGASTITQQLARNFFLTSEKTIIRKAREAVLAVEIENTLNKQEIL
ELYLNKIFLGYRSYGVAAAAQTYFGKSLNELTLSEMAIIAGLPKAPSTMNPLYSLKRSEERRNVVLSRMLDEKYISKEEY
DAALKEPIVASYHGAKFEFRADYVTEMVRQEMVRRFGEENAYTSGYKVFTTVLSKDQAEAQKAVRNNLIDYDMRHGYRGG
APLWQKNEAAWDNDRIVGFLRKLPDSEPFIPAAVIGIVKGGADILLASGEKMTLSTNAMRWTGRSNPVKVGEQIWIHQRA
NGEWQLGQIPAANSALVSLNSDNGAIEAVVGGFSYEQSKFNRATQSLVQVGSSIKPFIYAAALEKGLTLSSVLQDSPISI
QKPGQKMWQPKNSPDRYDGPMRLRVGLGQSKNIIAIRAIQTAGIDFTAEFLQRFGFKRDQYFASEALALGAASFTPLEMA
RAYAVFDNGGFLIEPYIIEKIQDNTGKDLFIANPKIACIECNDIPVIYGETKDKINGFANIPLGENALKPTDDSTNGEEL
DQQPETVPELPELQSNMTALKEDAIDLMAAAKNASSKIEYAPRVISGELAFLIRSALNTAIYGEQGLDWKGTSWRIAQSI
KRSDIGGKTGTTNSSKVAWYAGFGANLVTTTYVGFDDNKRVLGRGEAGAKTAMPAWITYMKTALSDKPERKLSLPPKIVE
KNIDTLTGLLSPNGGRKEYFIAGTEPTRTYLSEMQERGYYVPTELQQRLNNEGNTPATQPQELF
>Mature_864_residues
MRIAKLILNTLLTLCILGLVAGGMLYFHLKSELPSVETLKTVELQQPMQIYTADGKLIGEVGEQRRIPVKLADVPQRLID
AFLATEDSRFYDHHGLDPIGIARALFVAVSNGGASQGASTITQQLARNFFLTSEKTIIRKAREAVLAVEIENTLNKQEIL
ELYLNKIFLGYRSYGVAAAAQTYFGKSLNELTLSEMAIIAGLPKAPSTMNPLYSLKRSEERRNVVLSRMLDEKYISKEEY
DAALKEPIVASYHGAKFEFRADYVTEMVRQEMVRRFGEENAYTSGYKVFTTVLSKDQAEAQKAVRNNLIDYDMRHGYRGG
APLWQKNEAAWDNDRIVGFLRKLPDSEPFIPAAVIGIVKGGADILLASGEKMTLSTNAMRWTGRSNPVKVGEQIWIHQRA
NGEWQLGQIPAANSALVSLNSDNGAIEAVVGGFSYEQSKFNRATQSLVQVGSSIKPFIYAAALEKGLTLSSVLQDSPISI
QKPGQKMWQPKNSPDRYDGPMRLRVGLGQSKNIIAIRAIQTAGIDFTAEFLQRFGFKRDQYFASEALALGAASFTPLEMA
RAYAVFDNGGFLIEPYIIEKIQDNTGKDLFIANPKIACIECNDIPVIYGETKDKINGFANIPLGENALKPTDDSTNGEEL
DQQPETVPELPELQSNMTALKEDAIDLMAAAKNASSKIEYAPRVISGELAFLIRSALNTAIYGEQGLDWKGTSWRIAQSI
KRSDIGGKTGTTNSSKVAWYAGFGANLVTTTYVGFDDNKRVLGRGEAGAKTAMPAWITYMKTALSDKPERKLSLPPKIVE
KNIDTLTGLLSPNGGRKEYFIAGTEPTRTYLSEMQERGYYVPTELQQRLNNEGNTPATQPQELF

Specific function: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal

COG id: COG5009

COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI87082258, Length=867, Percent_Identity=52.5951557093426, Blast_Score=869, Evalue=0.0,
Organism=Escherichia coli, GI1786343, Length=276, Percent_Identity=35.5072463768116, Blast_Score=151, Evalue=2e-37,
Organism=Escherichia coli, GI1788867, Length=237, Percent_Identity=33.7552742616034, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1789601, Length=126, Percent_Identity=42.0634920634921, Blast_Score=90, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011816
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.2.-; 3.4.-.-

Molecular weight: Translated: 95420; Mature: 95420

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIAKLILNTLLTLCILGLVAGGMLYFHLKSELPSVETLKTVELQQPMQIYTADGKLIGE
CHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHCCCCCHHHHHHHHCCCCEEEECCCHHHHH
VGEQRRIPVKLADVPQRLIDAFLATEDSRFYDHHGLDPIGIARALFVAVSNGGASQGAST
CCCCCCCCEEHHHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHEECCCCCCCHHHH
ITQQLARNFFLTSEKTIIRKAREAVLAVEIENTLNKQEILELYLNKIFLGYRSYGVAAAA
HHHHHHHHHCCCCHHHHHHHHHHHEEEEEHHHHCCHHHHHHHHHHHHHHHHHHHCHHHHH
QTYFGKSLNELTLSEMAIIAGLPKAPSTMNPLYSLKRSEERRNVVLSRMLDEKYISKEEY
HHHHCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
DAALKEPIVASYHGAKFEFRADYVTEMVRQEMVRRFGEENAYTSGYKVFTTVLSKDQAEA
HHHHHCCCEECCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCHHHHH
QKAVRNNLIDYDMRHGYRGGAPLWQKNEAAWDNDRIVGFLRKLPDSEPFIPAAVIGIVKG
HHHHHHCCCCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCC
GADILLASGEKMTLSTNAMRWTGRSNPVKVGEQIWIHQRANGEWQLGQIPAANSALVSLN
CCEEEEECCCEEEEECCCEEECCCCCCCCCCCEEEEEECCCCCEEECCCCCCCCEEEEEC
SDNGAIEAVVGGFSYEQSKFNRATQSLVQVGSSIKPFIYAAALEKGLTLSSVLQDSPISI
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHCCCCCCC
QKPGQKMWQPKNSPDRYDGPMRLRVGLGQSKNIIAIRAIQTAGIDFTAEFLQRFGFKRDQ
CCCCHHHCCCCCCCCCCCCCEEEEEECCCCCCEEEEEEEEECCCCHHHHHHHHHCCCHHH
YFASEALALGAASFTPLEMARAYAVFDNGGFLIEPYIIEKIQDNTGKDLFIANPKIACIE
HHHHHHHHHCCCCCCHHHHHHEEEEEECCCEEECHHHHHHHCCCCCCEEEEECCCEEEEE
CNDIPVIYGETKDKINGFANIPLGENALKPTDDSTNGEELDQQPETVPELPELQSNMTAL
ECCEEEEECCCHHHCCCEECCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHH
KEDAIDLMAAAKNASSKIEYAPRVISGELAFLIRSALNTAIYGEQGLDWKGTSWRIAQSI
HHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
KRSDIGGKTGTTNSSKVAWYAGFGANLVTTTYVGFDDNKRVLGRGEAGAKTAMPAWITYM
HHHCCCCCCCCCCCCCEEEEECCCCCEEEEEEECCCCCCEEEECCCCCCCHHHHHHHHHH
KTALSDKPERKLSLPPKIVEKNIDTLTGLLSPNGGRKEYFIAGTEPTRTYLSEMQERGYY
HHHHCCCCCCCCCCCHHHHHCCHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHCCCC
VPTELQQRLNNEGNTPATQPQELF
CCHHHHHHHCCCCCCCCCCCHHCC
>Mature Secondary Structure
MRIAKLILNTLLTLCILGLVAGGMLYFHLKSELPSVETLKTVELQQPMQIYTADGKLIGE
CHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHCCCCCHHHHHHHHCCCCEEEECCCHHHHH
VGEQRRIPVKLADVPQRLIDAFLATEDSRFYDHHGLDPIGIARALFVAVSNGGASQGAST
CCCCCCCCEEHHHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHEECCCCCCCHHHH
ITQQLARNFFLTSEKTIIRKAREAVLAVEIENTLNKQEILELYLNKIFLGYRSYGVAAAA
HHHHHHHHHCCCCHHHHHHHHHHHEEEEEHHHHCCHHHHHHHHHHHHHHHHHHHCHHHHH
QTYFGKSLNELTLSEMAIIAGLPKAPSTMNPLYSLKRSEERRNVVLSRMLDEKYISKEEY
HHHHCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
DAALKEPIVASYHGAKFEFRADYVTEMVRQEMVRRFGEENAYTSGYKVFTTVLSKDQAEA
HHHHHCCCEECCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCHHHHH
QKAVRNNLIDYDMRHGYRGGAPLWQKNEAAWDNDRIVGFLRKLPDSEPFIPAAVIGIVKG
HHHHHHCCCCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCC
GADILLASGEKMTLSTNAMRWTGRSNPVKVGEQIWIHQRANGEWQLGQIPAANSALVSLN
CCEEEEECCCEEEEECCCEEECCCCCCCCCCCEEEEEECCCCCEEECCCCCCCCEEEEEC
SDNGAIEAVVGGFSYEQSKFNRATQSLVQVGSSIKPFIYAAALEKGLTLSSVLQDSPISI
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHCCCCCCC
QKPGQKMWQPKNSPDRYDGPMRLRVGLGQSKNIIAIRAIQTAGIDFTAEFLQRFGFKRDQ
CCCCHHHCCCCCCCCCCCCCEEEEEECCCCCCEEEEEEEEECCCCHHHHHHHHHCCCHHH
YFASEALALGAASFTPLEMARAYAVFDNGGFLIEPYIIEKIQDNTGKDLFIANPKIACIE
HHHHHHHHHCCCCCCHHHHHHEEEEEECCCEEECHHHHHHHCCCCCCEEEEECCCEEEEE
CNDIPVIYGETKDKINGFANIPLGENALKPTDDSTNGEELDQQPETVPELPELQSNMTAL
ECCEEEEECCCHHHCCCEECCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHH
KEDAIDLMAAAKNASSKIEYAPRVISGELAFLIRSALNTAIYGEQGLDWKGTSWRIAQSI
HHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
KRSDIGGKTGTTNSSKVAWYAGFGANLVTTTYVGFDDNKRVLGRGEAGAKTAMPAWITYM
HHHCCCCCCCCCCCCCEEEEECCCCCEEEEEEECCCCCCEEEECCCCCCCHHHHHHHHHH
KTALSDKPERKLSLPPKIVEKNIDTLTGLLSPNGGRKEYFIAGTEPTRTYLSEMQERGYY
HHHHCCCCCCCCCCCHHHHHCCHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHCCCC
VPTELQQRLNNEGNTPATQPQELF
CCHHHHHHHCCCCCCCCCCCHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferases; Acyltransferases; Aminoacyltransferases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1916268; 7542800; 7592463; 10675023 [H]