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The map label for this gene is hisS [H]

Identifier: 16272317

GI number: 16272317

Start: 392674

End: 393945

Strand: Direct

Name: hisS [H]

Synonym: HI0369

Alternate gene names: 16272317

Gene position: 392674-393945 (Clockwise)

Preceding gene: 16272316

Following gene: 16272318

Centisome position: 21.46

GC content: 39.47

Gene sequence:

>1272_bases
GTGGCAAAAACAATTCAAGCAATTCGTGGTATGAACGATTGTGCCCCAACAGAATCTCCATTATGGCAATGGATTGAAGC
ACAAGTACGCAATGTATTAAATAGTTATGGCTATTCGGAAGTGCGTATGCCAATTGTAGAAAGTACGCCATTGTTTGCGC
GTGCAATCGGCGAAGTAACTGATGTTGTCTCAAAAGAAATGTACACATTTTGGGATAACGATGAACAATTAACCTTACGC
CCTGAAGGCACAGCAGGTTGTGTGCGAGCAGCCATTGAACACGGTTGGATCTATAATAATGAACAACGCTTATGGTATAT
CGGGCCAATGTTCCGTCATGAACGTCCACAAAAAGGGCGTTACCGTCAATTCCATCAAGTAGGTGTTGAGGTATTCGGTA
TTGCAAATCCAGAAATCGATGCCGAATTAATCATGCTTACCTATCGTTTATGGAAAGCATTAGGTATCGATCAACATGTT
ACACTTCAACTTAACTCAATTGGTTCTTTAGAAGCTCGAGCAAATTATCGTTCAGCTTTAGTTGGATTCTTAGAAAACCA
TCAAGATTTAATGAGCGATGAAGAAAAAGAGCGTTTAGTAAGAAATCCGCTTCGTATTTTGGATACAAAAAATCCAGAAT
TACAAAAAGTATTAGATAACGCGCCTAAATTGCTTGATTATTTAGATGATGAAAGCCGTACGCATTTTGAACAATTATGT
TCATTATTAGATGCAGTGGGTATTCAATATGAAATTAATCCTAAACTCGTTCGTGGCTTAGATTATTACAACAAAACTGT
ATTTGAATGGGTAACCTCTGCTCTTGGCGCACAAGGTACCGTGTGTGGCGGCGGTCGTTATGACGGTTTAGTGGAACAAC
TTGGCGGACACGCAACGCCAAGTATCGGATTTGCGATGGGATTAGAGCGTTTAGTCTTGTTGGTGCAAGAAGTTAATCCA
AATGTTCCTGCGAAAAGTGCGGTGGATATTTATGTTGTTTATCAAGGCGAAGGCGCAACATTAGCCGCTTTTGAATTAGC
GGAAAAAGTACGCTCGGAATTACCGCACTTAAATACCATGTTGCACTGCTCTAGCGGTAATTTTAAAAAACAATTTAAAC
GTGCAGATAAATCTGGTGCAACATTGGCATTAGTTATCGGCGAAAGCGAAGTACAAAATAAACAAGTCGTTGTTAAACAC
TTACAAGGTGGCACAGATCAGCAAACCTTAGATTTAGTGAATATAATCGACTATCTTCAAACTCAATTTTAA

Upstream 100 bases:

>100_bases
GCGTTTTGATAACGAAGATATAGTGAACCAATTAGAAGCAAAAATTCGTGCGAAAGTCGCACGACAAGATCCAAAAAACA
GAATTATTTAAGGAAAGCTC

Downstream 100 bases:

>100_bases
TTTAAAAGGGGAAAACATGGCTTATTCCATTGAAGAAGAACAAGAGATTAACCAGTTAAAAGACTGGTGGAAAGAGAATG
GCAAAACAATTATTGTCGCT

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS [H]

Number of amino acids: Translated: 423; Mature: 422

Protein sequence:

>423_residues
MAKTIQAIRGMNDCAPTESPLWQWIEAQVRNVLNSYGYSEVRMPIVESTPLFARAIGEVTDVVSKEMYTFWDNDEQLTLR
PEGTAGCVRAAIEHGWIYNNEQRLWYIGPMFRHERPQKGRYRQFHQVGVEVFGIANPEIDAELIMLTYRLWKALGIDQHV
TLQLNSIGSLEARANYRSALVGFLENHQDLMSDEEKERLVRNPLRILDTKNPELQKVLDNAPKLLDYLDDESRTHFEQLC
SLLDAVGIQYEINPKLVRGLDYYNKTVFEWVTSALGAQGTVCGGGRYDGLVEQLGGHATPSIGFAMGLERLVLLVQEVNP
NVPAKSAVDIYVVYQGEGATLAAFELAEKVRSELPHLNTMLHCSSGNFKKQFKRADKSGATLALVIGESEVQNKQVVVKH
LQGGTDQQTLDLVNIIDYLQTQF

Sequences:

>Translated_423_residues
MAKTIQAIRGMNDCAPTESPLWQWIEAQVRNVLNSYGYSEVRMPIVESTPLFARAIGEVTDVVSKEMYTFWDNDEQLTLR
PEGTAGCVRAAIEHGWIYNNEQRLWYIGPMFRHERPQKGRYRQFHQVGVEVFGIANPEIDAELIMLTYRLWKALGIDQHV
TLQLNSIGSLEARANYRSALVGFLENHQDLMSDEEKERLVRNPLRILDTKNPELQKVLDNAPKLLDYLDDESRTHFEQLC
SLLDAVGIQYEINPKLVRGLDYYNKTVFEWVTSALGAQGTVCGGGRYDGLVEQLGGHATPSIGFAMGLERLVLLVQEVNP
NVPAKSAVDIYVVYQGEGATLAAFELAEKVRSELPHLNTMLHCSSGNFKKQFKRADKSGATLALVIGESEVQNKQVVVKH
LQGGTDQQTLDLVNIIDYLQTQF
>Mature_422_residues
AKTIQAIRGMNDCAPTESPLWQWIEAQVRNVLNSYGYSEVRMPIVESTPLFARAIGEVTDVVSKEMYTFWDNDEQLTLRP
EGTAGCVRAAIEHGWIYNNEQRLWYIGPMFRHERPQKGRYRQFHQVGVEVFGIANPEIDAELIMLTYRLWKALGIDQHVT
LQLNSIGSLEARANYRSALVGFLENHQDLMSDEEKERLVRNPLRILDTKNPELQKVLDNAPKLLDYLDDESRTHFEQLCS
LLDAVGIQYEINPKLVRGLDYYNKTVFEWVTSALGAQGTVCGGGRYDGLVEQLGGHATPSIGFAMGLERLVLLVQEVNPN
VPAKSAVDIYVVYQGEGATLAAFELAEKVRSELPHLNTMLHCSSGNFKKQFKRADKSGATLALVIGESEVQNKQVVVKHL
QGGTDQQTLDLVNIIDYLQTQF

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Escherichia coli, GI1788861, Length=422, Percent_Identity=66.824644549763, Blast_Score=584, Evalue=1e-168,
Organism=Caenorhabditis elegans, GI71993693, Length=471, Percent_Identity=24.6284501061571, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71993686, Length=471, Percent_Identity=24.8407643312102, Blast_Score=82, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6325290, Length=475, Percent_Identity=23.1578947368421, Blast_Score=78, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.21 [H]

Molecular weight: Translated: 47673; Mature: 47542

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKTIQAIRGMNDCAPTESPLWQWIEAQVRNVLNSYGYSEVRMPIVESTPLFARAIGEVT
CCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCHHHHHHHHHH
DVVSKEMYTFWDNDEQLTLRPEGTAGCVRAAIEHGWIYNNEQRLWYIGPMFRHERPQKGR
HHHHHHHHEEECCCCEEEECCCCCHHHHHHHHHHCCEEECCCEEEEECCHHHCCCCCCCH
YRQFHQVGVEVFGIANPEIDAELIMLTYRLWKALGIDQHVTLQLNSIGSLEARANYRSAL
HHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHH
VGFLENHQDLMSDEEKERLVRNPLRILDTKNPELQKVLDNAPKLLDYLDDESRTHFEQLC
HHHHHHHHHHHCCHHHHHHHHCCHHHHCCCCHHHHHHHHCHHHHHHHHCCCHHHHHHHHH
SLLDAVGIQYEINPKLVRGLDYYNKTVFEWVTSALGAQGTVCGGGRYDGLVEQLGGHATP
HHHHHHCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCC
SIGFAMGLERLVLLVQEVNPNVPAKSAVDIYVVYQGEGATLAAFELAEKVRSELPHLNTM
CHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCCCEE
LHCSSGNFKKQFKRADKSGATLALVIGESEVQNKQVVVKHLQGGTDQQTLDLVNIIDYLQ
EEECCCCHHHHHHHHCCCCCEEEEEECCCHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHH
TQF
HCC
>Mature Secondary Structure 
AKTIQAIRGMNDCAPTESPLWQWIEAQVRNVLNSYGYSEVRMPIVESTPLFARAIGEVT
CCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCHHHHHHHHHH
DVVSKEMYTFWDNDEQLTLRPEGTAGCVRAAIEHGWIYNNEQRLWYIGPMFRHERPQKGR
HHHHHHHHEEECCCCEEEECCCCCHHHHHHHHHHCCEEECCCEEEEECCHHHCCCCCCCH
YRQFHQVGVEVFGIANPEIDAELIMLTYRLWKALGIDQHVTLQLNSIGSLEARANYRSAL
HHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHH
VGFLENHQDLMSDEEKERLVRNPLRILDTKNPELQKVLDNAPKLLDYLDDESRTHFEQLC
HHHHHHHHHHHCCHHHHHHHHCCHHHHCCCCHHHHHHHHCHHHHHHHHCCCHHHHHHHHH
SLLDAVGIQYEINPKLVRGLDYYNKTVFEWVTSALGAQGTVCGGGRYDGLVEQLGGHATP
HHHHHHCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCC
SIGFAMGLERLVLLVQEVNPNVPAKSAVDIYVVYQGEGATLAAFELAEKVRSELPHLNTM
CHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCCCEE
LHCSSGNFKKQFKRADKSGATLALVIGESEVQNKQVVVKHLQGGTDQQTLDLVNIIDYLQ
EEECCCCHHHHHHHHCCCCCEEEEEECCCHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHH
TQF
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA