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The map label for this gene is sdaC

Identifier: 16272244

GI number: 16272244

Start: 323902

End: 325140

Strand: Reverse

Name: sdaC

Synonym: HI0289

Alternate gene names: 16272244

Gene position: 325140-323902 (Counterclockwise)

Preceding gene: 16272245

Following gene: 16272243

Centisome position: 17.77

GC content: 36.88

Gene sequence:

>1239_bases
ATGAAATCAACAGAAAAACTCAAATGGAACAAATTTGATGCAACGTGGATGTTAAACCTTTTCGGTACGGCGGTTGGCGC
GGGCGTATTGTTCTTGCCGATTAACGCAGGGATGGGTGGATTTTGGCCGTTAGTTTTAATGGCAATTATCGTCGGGCCAA
TGACTTATTTTGCTCACCGTGGCTTAGCCTACTTTGTACTTTCATCAAAAAATCCTGGCAGCGATATTACTGAAGTAGTG
GAAGAACACTTTGGTAAAACAGCGGGTAAACTTATTACCTTACTTTATTTTTTCGCGATTTTCCCTATTCTGTTGATTTA
CGGTAACGGTATCACGAACACCGTAGATTCTTTTATTGTGAATCAACTTGGTATGGCATCACCAAATCGAGTCATTCTCT
CTTTTGTATTAATTGCGGTATTGATTTCCGTGATGTTATTTAATGAAAAAGTGATGTTAAAAATCACAGAATGGCTTGTT
TATCCGTTAGTCTTAATTTTATTTGTTCTTTCTATTTACTTAATTCCTGAATGGAATAGTGCCGTATTATATGAATTTCC
AACAGTAGGCGGTTTCTTAACAACTTTATGGCTAACCATTCCCGTATTAGTATTTTCATTTAACCATTCGCCAGCAATTT
CATCTTTCACTTGCTCACAATTCCGTGAATATAAAACTTTCGATGGTGCAGAACGCCATATCAGCCATACAGAAAAAGGC
GCCTCAACGATTTTGTTATTCTTCGTAATGTTCTTCGTATTTAGCTGTGTATTAACATTAACACCTGAAGAATTAGTGGC
AGCAAAAGAACAGAATATTAGTATCTTGTCTTTCTTAGCGAATAAATTTGATAATCCATATATCTCTTATTTTGGCCCGC
TTGTTGCATTCTTAGCGATTACTAGTTCATTCTTCGGTCACTATATGGGGGCACGTGAAGGCTTAGAAGGTTTATATTTA
AAAATGAAAGGTGAAGCAGTAAATCGTAAAAAACTCAATTATGCGACCGCACTTTTCTTCTTATTAACGTTATGGGGCGT
TGCGATTATTAATCCAAGTATCTTAGGCTTAATCGAATCTCTTGGCGGCCCAATCATTGCGATGATTTTGTTTATCATGC
CAATGTACGCGATTCGAAAAATCCCAGCAATGAAACGCTACAGCGGACGTTTCAGTAATGTATTTGTAACAATTATGGGG
CTAATTGCTATTTCTGCAGTTGTTTATGGATTATTATAA

Upstream 100 bases:

>100_bases
ATTCTCTATTTATTGGCATAACATAATACTCAAATTTAGTTGGAGCGGATTTTGCTCTACAAATTGACAAATTTAAGTAA
TTTATGCTTTGGAGCAAACT

Downstream 100 bases:

>100_bases
TCGCCTTTAATTTTTAACGAATTTTGAGAAATTTATGATTAGCGTATTTGATATGTTTAAAGTGGGAATTGGGCCATCCA
GTTCCCACACGGTCGGTCCG

Product: serine transporter

Products: Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MKSTEKLKWNKFDATWMLNLFGTAVGAGVLFLPINAGMGGFWPLVLMAIIVGPMTYFAHRGLAYFVLSSKNPGSDITEVV
EEHFGKTAGKLITLLYFFAIFPILLIYGNGITNTVDSFIVNQLGMASPNRVILSFVLIAVLISVMLFNEKVMLKITEWLV
YPLVLILFVLSIYLIPEWNSAVLYEFPTVGGFLTTLWLTIPVLVFSFNHSPAISSFTCSQFREYKTFDGAERHISHTEKG
ASTILLFFVMFFVFSCVLTLTPEELVAAKEQNISILSFLANKFDNPYISYFGPLVAFLAITSSFFGHYMGAREGLEGLYL
KMKGEAVNRKKLNYATALFFLLTLWGVAIINPSILGLIESLGGPIIAMILFIMPMYAIRKIPAMKRYSGRFSNVFVTIMG
LIAISAVVYGLL

Sequences:

>Translated_412_residues
MKSTEKLKWNKFDATWMLNLFGTAVGAGVLFLPINAGMGGFWPLVLMAIIVGPMTYFAHRGLAYFVLSSKNPGSDITEVV
EEHFGKTAGKLITLLYFFAIFPILLIYGNGITNTVDSFIVNQLGMASPNRVILSFVLIAVLISVMLFNEKVMLKITEWLV
YPLVLILFVLSIYLIPEWNSAVLYEFPTVGGFLTTLWLTIPVLVFSFNHSPAISSFTCSQFREYKTFDGAERHISHTEKG
ASTILLFFVMFFVFSCVLTLTPEELVAAKEQNISILSFLANKFDNPYISYFGPLVAFLAITSSFFGHYMGAREGLEGLYL
KMKGEAVNRKKLNYATALFFLLTLWGVAIINPSILGLIESLGGPIIAMILFIMPMYAIRKIPAMKRYSGRFSNVFVTIMG
LIAISAVVYGLL
>Mature_412_residues
MKSTEKLKWNKFDATWMLNLFGTAVGAGVLFLPINAGMGGFWPLVLMAIIVGPMTYFAHRGLAYFVLSSKNPGSDITEVV
EEHFGKTAGKLITLLYFFAIFPILLIYGNGITNTVDSFIVNQLGMASPNRVILSFVLIAVLISVMLFNEKVMLKITEWLV
YPLVLILFVLSIYLIPEWNSAVLYEFPTVGGFLTTLWLTIPVLVFSFNHSPAISSFTCSQFREYKTFDGAERHISHTEKG
ASTILLFFVMFFVFSCVLTLTPEELVAAKEQNISILSFLANKFDNPYISYFGPLVAFLAITSSFFGHYMGAREGLEGLYL
KMKGEAVNRKKLNYATALFFLLTLWGVAIINPSILGLIESLGGPIIAMILFIMPMYAIRKIPAMKRYSGRFSNVFVTIMG
LIAISAVVYGLL

Specific function: Involved in the import of serine into the cell

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily

Homologues:

Organism=Escherichia coli, GI1789160, Length=416, Percent_Identity=59.375, Blast_Score=471, Evalue=1e-134,
Organism=Escherichia coli, GI1789504, Length=433, Percent_Identity=46.6512702078522, Blast_Score=360, Evalue=1e-100,
Organism=Escherichia coli, GI1789211, Length=406, Percent_Identity=36.2068965517241, Blast_Score=228, Evalue=5e-61,
Organism=Escherichia coli, GI145693183, Length=396, Percent_Identity=26.010101010101, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1789961, Length=396, Percent_Identity=26.010101010101, Blast_Score=139, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SDAC_HAEIN (P44615)

Other databases:

- EMBL:   L42023
- PIR:   G64059
- RefSeq:   NP_438456.1
- GeneID:   950177
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0289
- NMPDR:   fig|71421.1.peg.271
- TIGR:   HI_0289
- HOGENOM:   HBG296888
- OMA:   GVGITNV
- ProtClustDB:   CLSK869944
- BioCyc:   HINF71421:HI_0289-MONOMER
- InterPro:   IPR004694
- InterPro:   IPR018227
- TIGRFAMs:   TIGR00814

Pfam domain/function: PF03222 Trp_Tyr_perm

EC number: NA

Molecular weight: Translated: 45895; Mature: 45895

Theoretical pI: Translated: 9.25; Mature: 9.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xc9d00dc)-; HASH(0xc5bf2c8)-; HASH(0xc856998)-; HASH(0xc826770)-; HASH(0xba5b260)-; HASH(0xbcef188)-; HASH(0xb94fc44)-; HASH(0xb679b10)-; HASH(0xb91cc5c)-; HASH(0xb9c747c)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSTEKLKWNKFDATWMLNLFGTAVGAGVLFLPINAGMGGFWPLVLMAIIVGPMTYFAHR
CCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHC
GLAYFVLSSKNPGSDITEVVEEHFGKTAGKLITLLYFFAIFPILLIYGNGITNTVDSFIV
CEEEEEEECCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
NQLGMASPNRVILSFVLIAVLISVMLFNEKVMLKITEWLVYPLVLILFVLSIYLIPEWNS
HHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
AVLYEFPTVGGFLTTLWLTIPVLVFSFNHSPAISSFTCSQFREYKTFDGAERHISHTEKG
EEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHH
ASTILLFFVMFFVFSCVLTLTPEELVAAKEQNISILSFLANKFDNPYISYFGPLVAFLAI
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
TSSFFGHYMGAREGLEGLYLKMKGEAVNRKKLNYATALFFLLTLWGVAIINPSILGLIES
HHHHHHHHHHHHHCCCCEEEEEECCHHCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
LGGPIIAMILFIMPMYAIRKIPAMKRYSGRFSNVFVTIMGLIAISAVVYGLL
HCCHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure
MKSTEKLKWNKFDATWMLNLFGTAVGAGVLFLPINAGMGGFWPLVLMAIIVGPMTYFAHR
CCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHC
GLAYFVLSSKNPGSDITEVVEEHFGKTAGKLITLLYFFAIFPILLIYGNGITNTVDSFIV
CEEEEEEECCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
NQLGMASPNRVILSFVLIAVLISVMLFNEKVMLKITEWLVYPLVLILFVLSIYLIPEWNS
HHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
AVLYEFPTVGGFLTTLWLTIPVLVFSFNHSPAISSFTCSQFREYKTFDGAERHISHTEKG
EEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHH
ASTILLFFVMFFVFSCVLTLTPEELVAAKEQNISILSFLANKFDNPYISYFGPLVAFLAI
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
TSSFFGHYMGAREGLEGLYLKMKGEAVNRKKLNYATALFFLLTLWGVAIINPSILGLIES
HHHHHHHHHHHHHCCCCEEEEEECCHHCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
LGGPIIAMILFIMPMYAIRKIPAMKRYSGRFSNVFVTIMGLIAISAVVYGLL
HCCHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800