Click here to switch to the map view.

The map label for this gene is sdaA

Identifier: 16272243

GI number: 16272243

Start: 322500

End: 323867

Strand: Reverse

Name: sdaA

Synonym: HI0288

Alternate gene names: 16272243

Gene position: 323867-322500 (Counterclockwise)

Preceding gene: 16272244

Following gene: 16272240

Centisome position: 17.7

GC content: 40.94

Gene sequence:

>1368_bases
ATGATTAGCGTATTTGATATGTTTAAAGTGGGAATTGGGCCATCCAGTTCCCACACGGTCGGTCCGATGAAAGCGGGTAA
ACAATTTATAGACGACTTAATTAAACGAAATCAATTTGAACAAACTACTGAAATTCACGTAGATGTGTACGGTTCTCTTT
CAATGACAGGACGAGGACACAGTACAGATATTGCCATTATTATGGGGTTAGCGGGTTATTTACCACATAATGTGGATATT
GATATGATTTCAGGTTTCATTGAGAAAGTTAAACAAACTGCGCTTTTACCCATTAATGTCGGTCAAAAGATAGTAAAATT
TGATTTTGAAAATAATCTCATTTTCCACCGCACTTTTTTAAAATTGCACGAAAATGGCATGACAATTACCGCTCTTGATG
AAAATCGCACAGAGCTTTATCGCCAAACCTATTATTCGATTGGGGGTGGTTTTATTGTCGATGAAGCCCATTTTGGCAAA
GAAGAAAAAAACACAGTCCAAGTGCCTTATCCTTACAAAAATGCCGAAGATATTTTGAAACATTGTAGTGATAACGGCTT
AATGCTTTCCACTGTGATGTTGGAAAATGAAATCGCATTGAATGGCAAAGAGGCTGTTAGTGCTCATCTAGAGAATGTCT
GGAAAACGATGCAGGCTTGTATTGAACACGGCATTCACACAGAGGGTATTTTACCCGGCCCATTAAGAGTACCACGTCGT
GCAGCTTCACTTTATCGTGCGTTGCAAGCAAATACGAATTTATCTAACGATCCAATGCGCGTAATCGACTGGGTCAATAT
GTTTGCGCTTGCTGTCAATGAAGAAAATGCAGCAGGTGGACGCGTGGTTACGGCACCAACTAATGGTGCGTGCGGGATTA
TTCCAGCGGTATTAGCTTACTATGAAAAATTCATCTCGCCATTAACACCTGAAATCATTGAACGCTATTTATTAGCCGCA
GGGATGATTGGTTCACTTTATAAGATGAACGCTTCTATTTCTGGTGCAGAAGTGGGTTGCCAAGGTGAAGTGGGTGTAGC
CTGTTCCATGGCGGCTGCAGGACTAGCTGAAATTTTGGGTGGTAATCCACTACAAGTATGCATCGCAGCTGAAATTGCAA
TGGAGCATAATTTAGGATTAACTTGCGACCCTGTCGGCGGTCAAGTTCAAGTACCTTGTATCGAACGCAATGCGATTGCT
TCAGTTAAAGCAATCAATGCATCGCGTATGGCTTTACGCCGTACCACTAATCCAAGAGTAACTTTAGATAAAGTGATTGA
AACAATGTACGAAACAGGTAAAGATATGAACGCCAAGTATCGCGAAACATCTCAAGGCGGACTTGCAGTTAAGATTGTTT
GTAACTAA

Upstream 100 bases:

>100_bases
AGTAATGTATTTGTAACAATTATGGGGCTAATTGCTATTTCTGCAGTTGTTTATGGATTATTATAATCGCCTTTAATTTT
TAACGAATTTTGAGAAATTT

Downstream 100 bases:

>100_bases
TAAAAAGTAAAATAATTAAGGGGCTGATCTACACGAATTAGTTGGACTACATAACCCACTGTTAAAGTGCAGATCGCTAT
TTAATAATTTAAATTTATTT

Product: L-serine deaminase

Products: NA

Alternate protein names: SDH; L-serine deaminase; L-SD

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MISVFDMFKVGIGPSSSHTVGPMKAGKQFIDDLIKRNQFEQTTEIHVDVYGSLSMTGRGHSTDIAIIMGLAGYLPHNVDI
DMISGFIEKVKQTALLPINVGQKIVKFDFENNLIFHRTFLKLHENGMTITALDENRTELYRQTYYSIGGGFIVDEAHFGK
EEKNTVQVPYPYKNAEDILKHCSDNGLMLSTVMLENEIALNGKEAVSAHLENVWKTMQACIEHGIHTEGILPGPLRVPRR
AASLYRALQANTNLSNDPMRVIDWVNMFALAVNEENAAGGRVVTAPTNGACGIIPAVLAYYEKFISPLTPEIIERYLLAA
GMIGSLYKMNASISGAEVGCQGEVGVACSMAAAGLAEILGGNPLQVCIAAEIAMEHNLGLTCDPVGGQVQVPCIERNAIA
SVKAINASRMALRRTTNPRVTLDKVIETMYETGKDMNAKYRETSQGGLAVKIVCN

Sequences:

>Translated_455_residues
MISVFDMFKVGIGPSSSHTVGPMKAGKQFIDDLIKRNQFEQTTEIHVDVYGSLSMTGRGHSTDIAIIMGLAGYLPHNVDI
DMISGFIEKVKQTALLPINVGQKIVKFDFENNLIFHRTFLKLHENGMTITALDENRTELYRQTYYSIGGGFIVDEAHFGK
EEKNTVQVPYPYKNAEDILKHCSDNGLMLSTVMLENEIALNGKEAVSAHLENVWKTMQACIEHGIHTEGILPGPLRVPRR
AASLYRALQANTNLSNDPMRVIDWVNMFALAVNEENAAGGRVVTAPTNGACGIIPAVLAYYEKFISPLTPEIIERYLLAA
GMIGSLYKMNASISGAEVGCQGEVGVACSMAAAGLAEILGGNPLQVCIAAEIAMEHNLGLTCDPVGGQVQVPCIERNAIA
SVKAINASRMALRRTTNPRVTLDKVIETMYETGKDMNAKYRETSQGGLAVKIVCN
>Mature_455_residues
MISVFDMFKVGIGPSSSHTVGPMKAGKQFIDDLIKRNQFEQTTEIHVDVYGSLSMTGRGHSTDIAIIMGLAGYLPHNVDI
DMISGFIEKVKQTALLPINVGQKIVKFDFENNLIFHRTFLKLHENGMTITALDENRTELYRQTYYSIGGGFIVDEAHFGK
EEKNTVQVPYPYKNAEDILKHCSDNGLMLSTVMLENEIALNGKEAVSAHLENVWKTMQACIEHGIHTEGILPGPLRVPRR
AASLYRALQANTNLSNDPMRVIDWVNMFALAVNEENAAGGRVVTAPTNGACGIIPAVLAYYEKFISPLTPEIIERYLLAA
GMIGSLYKMNASISGAEVGCQGEVGVACSMAAAGLAEILGGNPLQVCIAAEIAMEHNLGLTCDPVGGQVQVPCIERNAIA
SVKAINASRMALRRTTNPRVTLDKVIETMYETGKDMNAKYRETSQGGLAVKIVCN

Specific function: Deaminates Also Threonine, Particularly When It Is Present In High Concentration. [C]

COG id: COG1760

COG function: function code E; L-serine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-sulfur dependent L-serine dehydratase family

Homologues:

Organism=Escherichia coli, GI1788116, Length=455, Percent_Identity=69.010989010989, Blast_Score=664, Evalue=0.0,
Organism=Escherichia coli, GI1789161, Length=453, Percent_Identity=70.6401766004415, Blast_Score=660, Evalue=0.0,
Organism=Escherichia coli, GI48994925, Length=454, Percent_Identity=65.6387665198238, Blast_Score=619, Evalue=1e-178,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SDHL_HAEIN (P71349)

Other databases:

- EMBL:   L42023
- RefSeq:   NP_438455.1
- ProteinModelPortal:   P71349
- SMR:   P71349
- GeneID:   949415
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0288
- NMPDR:   fig|71421.1.peg.270
- TIGR:   HI_0288
- HOGENOM:   HBG304565
- OMA:   KNEIAMH
- ProtClustDB:   CLSK789299
- BioCyc:   HINF71421:HI_0288-MONOMER
- BRENDA:   4.3.1.17
- GO:   GO:0006094
- InterPro:   IPR004644
- InterPro:   IPR005130
- InterPro:   IPR005131
- TIGRFAMs:   TIGR00720

Pfam domain/function: PF03313 SDH_alpha; PF03315 SDH_beta

EC number: =4.3.1.17

Molecular weight: Translated: 49539; Mature: 49539

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISVFDMFKVGIGPSSSHTVGPMKAGKQFIDDLIKRNQFEQTTEIHVDVYGSLSMTGRGH
CCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEEEECCCCC
STDIAIIMGLAGYLPHNVDIDMISGFIEKVKQTALLPINVGQKIVKFDFENNLIFHRTFL
CCCHHHEEHHHHHCCCCCCHHHHHHHHHHHHHHEEEEECCCCEEEEEECCCCEEEEEHEE
KLHENGMTITALDENRTELYRQTYYSIGGGFIVDEAHFGKEEKNTVQVPYPYKNAEDILK
HHHCCCCEEEEECCCHHHHHHHHHHHCCCCEEEEHHHCCCCCCCEEECCCCCCCHHHHHH
HCSDNGLMLSTVMLENEIALNGKEAVSAHLENVWKTMQACIEHGIHTEGILPGPLRVPRR
HCCCCCEEEEEEEECCCEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHH
AASLYRALQANTNLSNDPMRVIDWVNMFALAVNEENAAGGRVVTAPTNGACGIIPAVLAY
HHHHHHHHHCCCCCCCCHHHHHHHHHHHEEEECCCCCCCCEEEECCCCCCCHHHHHHHHH
YEKFISPLTPEIIERYLLAAGMIGSLYKMNASISGAEVGCQGEVGVACSMAAAGLAEILG
HHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
GNPLQVCIAAEIAMEHNLGLTCDPVGGQVQVPCIERNAIASVKAINASRMALRRTTNPRV
CCCEEEEEEEHHHHHCCCCEEECCCCCEEEEEEECCCHHHHHHHCCHHHHHHHCCCCCCE
TLDKVIETMYETGKDMNAKYRETSQGGLAVKIVCN
EHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEC
>Mature Secondary Structure
MISVFDMFKVGIGPSSSHTVGPMKAGKQFIDDLIKRNQFEQTTEIHVDVYGSLSMTGRGH
CCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEEEECCCCC
STDIAIIMGLAGYLPHNVDIDMISGFIEKVKQTALLPINVGQKIVKFDFENNLIFHRTFL
CCCHHHEEHHHHHCCCCCCHHHHHHHHHHHHHHEEEEECCCCEEEEEECCCCEEEEEHEE
KLHENGMTITALDENRTELYRQTYYSIGGGFIVDEAHFGKEEKNTVQVPYPYKNAEDILK
HHHCCCCEEEEECCCHHHHHHHHHHHCCCCEEEEHHHCCCCCCCEEECCCCCCCHHHHHH
HCSDNGLMLSTVMLENEIALNGKEAVSAHLENVWKTMQACIEHGIHTEGILPGPLRVPRR
HCCCCCEEEEEEEECCCEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHH
AASLYRALQANTNLSNDPMRVIDWVNMFALAVNEENAAGGRVVTAPTNGACGIIPAVLAY
HHHHHHHHHCCCCCCCCHHHHHHHHHHHEEEECCCCCCCCEEEECCCCCCCHHHHHHHHH
YEKFISPLTPEIIERYLLAAGMIGSLYKMNASISGAEVGCQGEVGVACSMAAAGLAEILG
HHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
GNPLQVCIAAEIAMEHNLGLTCDPVGGQVQVPCIERNAIASVKAINASRMALRRTTNPRV
CCCEEEEEEEHHHHHCCCCEEECCCCCEEEEEEECCCHHHHHHHCCHHHHHHHCCCCCCE
TLDKVIETMYETGKDMNAKYRETSQGGLAVKIVCN
EHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800