Click here to switch to the map view.

The map label for this gene is yfbQ [C]

Identifier: 16272241

GI number: 16272241

Start: 319804

End: 321018

Strand: Direct

Name: yfbQ [C]

Synonym: HI0286

Alternate gene names: 16272241

Gene position: 319804-321018 (Clockwise)

Preceding gene: 30995365

Following gene: 16272242

Centisome position: 17.47

GC content: 40.74

Gene sequence:

>1215_bases
ATGCGATTATTCCCAAAATCCGACAAATTAGAACACGTATGTTATGACATTCGCGGACCTGTGCATAAAGAAGCACTACG
CTTAGAAGAAGAAGGCAATAAAATTTTAAAACTTAATATCGGCAATCCCGCACCTTTCGGCTTTGAAGCACCAGATGAAA
TTTTGGTGGACGTATTGCGTAATTTGCCGTCAGCTCAAGGCTACTGCGATTCAAAAGGATTATATTCTGCTCGTAAAGCC
ATTGTTCAATATTACCAATCAAAAGGGATTCTCGGCGCGACCGTCAATGATGTGTATATTGGTAACGGCGTATCTGAGCT
TATCACAATGGCAATGCAAGCATTGCTCAATGATGGCGATGAAGTGCTTGTGCCGATGCCTGATTATCCGCTTTGGACTG
CTGCGGTAACCCTTTCTGGCGGTAAAGCAGTGCATTATCTCTGTGATGAAGACGCAAATTGGTTTCCCACTATTGATGAT
ATTAAAGCAAAGGTGAATGCGAAAACTAAAGCGATTGTCATCATCAACCCGAACAACCCAACGGGTGCTGTGTATAGCAA
AGAATTATTACAAGAAATTGTGGAAATCGCGCGTCAAAATAATTTAATTATCTTCGCTGACGAAATCTACGACAAAATTT
TATATGATGGCGCGGTGCATCATCACATTGCCGCACTTGCTCCTGATTTATTAACCGTTACATTGAATGGGTTATCAAAA
GCTTATCGAGTTGCAGGCTTCCGCCAAGGCTGGATGATTTTGAACGGCCCAAAACATAATGCGAAAGGTTATATTGAAGG
CTTGGATATGCTGGCATCAATGCGTTTATGTGCCAACGTACCAATGCAACATGCAATTCAAACCGCACTTGGTGGCTATC
AAAGTATTAATGAATTTATTTTACCAGGCGGTCGATTACTTGAGCAACGAAACAAAGCCTATGATCTCATCACTCAAATT
CCAGGCATTACTTGCGTGAAACCAATGGGGGCGATGTATATGTTCCCGAAAATTGATGTGAAAAAATTCAATATTCACAG
TGATGAAAAAATGGTGCTGGATTTACTCCGCCAAGAAAAAGTACTACTTGTGCACGGTAAAGGATTTAATTGGCATTCAC
CAGATCACTTCCGTATTGTTACTCTTCCTTATGTGAATCAGCTTGAAGAAGCCATTACAAAATTAGCAAGATTTTTGTCG
GATTACCGTCAATAA

Upstream 100 bases:

>100_bases
GACAAAAAATTTTTTTACAAAATCTTTTCAATATTGAAAATTCAGCGTAAATTAACCGCACTTTTCTCGAAAAATTTATT
AGAAACAAAAGGATTTCACT

Downstream 100 bases:

>100_bases
TGAATGCTTTGACAACATTACAAAGGGGACTAAATGTCCCCTTTTTATCGATATAAATATATTGCACTTTCCTTGTGTAC
TACTATAATAGTGCAAATTT

Product: aminotransferase AlaT

Products: oxaloacetate; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MRLFPKSDKLEHVCYDIRGPVHKEALRLEEEGNKILKLNIGNPAPFGFEAPDEILVDVLRNLPSAQGYCDSKGLYSARKA
IVQYYQSKGILGATVNDVYIGNGVSELITMAMQALLNDGDEVLVPMPDYPLWTAAVTLSGGKAVHYLCDEDANWFPTIDD
IKAKVNAKTKAIVIINPNNPTGAVYSKELLQEIVEIARQNNLIIFADEIYDKILYDGAVHHHIAALAPDLLTVTLNGLSK
AYRVAGFRQGWMILNGPKHNAKGYIEGLDMLASMRLCANVPMQHAIQTALGGYQSINEFILPGGRLLEQRNKAYDLITQI
PGITCVKPMGAMYMFPKIDVKKFNIHSDEKMVLDLLRQEKVLLVHGKGFNWHSPDHFRIVTLPYVNQLEEAITKLARFLS
DYRQ

Sequences:

>Translated_404_residues
MRLFPKSDKLEHVCYDIRGPVHKEALRLEEEGNKILKLNIGNPAPFGFEAPDEILVDVLRNLPSAQGYCDSKGLYSARKA
IVQYYQSKGILGATVNDVYIGNGVSELITMAMQALLNDGDEVLVPMPDYPLWTAAVTLSGGKAVHYLCDEDANWFPTIDD
IKAKVNAKTKAIVIINPNNPTGAVYSKELLQEIVEIARQNNLIIFADEIYDKILYDGAVHHHIAALAPDLLTVTLNGLSK
AYRVAGFRQGWMILNGPKHNAKGYIEGLDMLASMRLCANVPMQHAIQTALGGYQSINEFILPGGRLLEQRNKAYDLITQI
PGITCVKPMGAMYMFPKIDVKKFNIHSDEKMVLDLLRQEKVLLVHGKGFNWHSPDHFRIVTLPYVNQLEEAITKLARFLS
DYRQ
>Mature_404_residues
MRLFPKSDKLEHVCYDIRGPVHKEALRLEEEGNKILKLNIGNPAPFGFEAPDEILVDVLRNLPSAQGYCDSKGLYSARKA
IVQYYQSKGILGATVNDVYIGNGVSELITMAMQALLNDGDEVLVPMPDYPLWTAAVTLSGGKAVHYLCDEDANWFPTIDD
IKAKVNAKTKAIVIINPNNPTGAVYSKELLQEIVEIARQNNLIIFADEIYDKILYDGAVHHHIAALAPDLLTVTLNGLSK
AYRVAGFRQGWMILNGPKHNAKGYIEGLDMLASMRLCANVPMQHAIQTALGGYQSINEFILPGGRLLEQRNKAYDLITQI
PGITCVKPMGAMYMFPKIDVKKFNIHSDEKMVLDLLRQEKVLLVHGKGFNWHSPDHFRIVTLPYVNQLEEAITKLARFLS
DYRQ

Specific function: Unknown

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family

Homologues:

Organism=Homo sapiens, GI4507369, Length=386, Percent_Identity=27.4611398963731, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI215599424, Length=372, Percent_Identity=27.1505376344086, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI19263340, Length=372, Percent_Identity=27.1505376344086, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI4885351, Length=470, Percent_Identity=24.6808510638298, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI56713254, Length=191, Percent_Identity=30.3664921465969, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI56713256, Length=191, Percent_Identity=30.3664921465969, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI95147551, Length=172, Percent_Identity=30.8139534883721, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI169881279, Length=172, Percent_Identity=30.8139534883721, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI169881281, Length=129, Percent_Identity=31.7829457364341, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI187936925, Length=377, Percent_Identity=23.8726790450928, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI14211921, Length=377, Percent_Identity=23.8726790450928, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI149944424, Length=366, Percent_Identity=22.1311475409836, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1788627, Length=404, Percent_Identity=77.970297029703, Blast_Score=669, Evalue=0.0,
Organism=Escherichia coli, GI1788722, Length=409, Percent_Identity=25.9168704156479, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1786816, Length=196, Percent_Identity=23.469387755102, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17567663, Length=380, Percent_Identity=31.0526315789474, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI71981209, Length=473, Percent_Identity=24.3128964059197, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI71994472, Length=206, Percent_Identity=33.0097087378641, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71994476, Length=206, Percent_Identity=33.0097087378641, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17567369, Length=244, Percent_Identity=30.327868852459, Blast_Score=91, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI71981215, Length=293, Percent_Identity=25.5972696245734, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6323118, Length=349, Percent_Identity=27.7936962750716, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6320317, Length=478, Percent_Identity=25.5230125523013, Blast_Score=127, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6322401, Length=362, Percent_Identity=23.7569060773481, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI18859735, Length=389, Percent_Identity=28.5347043701799, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI45551451, Length=469, Percent_Identity=25.5863539445629, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24641770, Length=469, Percent_Identity=25.5863539445629, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24641760, Length=469, Percent_Identity=25.5863539445629, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24641768, Length=469, Percent_Identity=25.5863539445629, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24641766, Length=469, Percent_Identity=25.5863539445629, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24641764, Length=469, Percent_Identity=25.5863539445629, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI28573069, Length=322, Percent_Identity=25.1552795031056, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24646114, Length=322, Percent_Identity=25.1552795031056, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI28573067, Length=322, Percent_Identity=25.1552795031056, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI28573065, Length=322, Percent_Identity=25.1552795031056, Blast_Score=89, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y286_HAEIN (P71348)

Other databases:

- EMBL:   L42023
- RefSeq:   NP_438453.1
- ProteinModelPortal:   P71348
- SMR:   P71348
- GeneID:   949411
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0286
- NMPDR:   fig|71421.1.peg.268
- TIGR:   HI_0286
- HOGENOM:   HBG645860
- OMA:   MFPKIDT
- ProtClustDB:   PRK09265
- BioCyc:   HINF71421:HI_0286-MONOMER
- GO:   GO:0005737
- InterPro:   IPR001176
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PRINTS:   PR00753

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: 2.6.1.1

Molecular weight: Translated: 45161; Mature: 45161

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: BINDING 41-41 BINDING 179-179 BINDING 378-378

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLFPKSDKLEHVCYDIRGPVHKEALRLEEEGNKILKLNIGNPAPFGFEAPDEILVDVLR
CCCCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHH
NLPSAQGYCDSKGLYSARKAIVQYYQSKGILGATVNDVYIGNGVSELITMAMQALLNDGD
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCEEECCCHHHHHHHHHHHHHCCCC
EVLVPMPDYPLWTAAVTLSGGKAVHYLCDEDANWFPTIDDIKAKVNAKTKAIVIINPNNP
EEEEECCCCCCEEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHCCCCEEEEEEEECCCC
TGAVYSKELLQEIVEIARQNNLIIFADEIYDKILYDGAVHHHIAALAPDLLTVTLNGLSK
CCHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHCCHHHHHHHHHCCHHHEEEHHHHHH
AYRVAGFRQGWMILNGPKHNAKGYIEGLDMLASMRLCANVPMQHAIQTALGGYQSINEFI
HHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHH
LPGGRLLEQRNKAYDLITQIPGITCVKPMGAMYMFPKIDVKKFNIHSDEKMVLDLLRQEK
CCCHHHHHHHHHHHHHHHHCCCCEEECCCCCEEECCCCCEEEECCCCCHHHHHHHHCCCC
VLLVHGKGFNWHSPDHFRIVTLPYVNQLEEAITKLARFLSDYRQ
EEEEECCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRLFPKSDKLEHVCYDIRGPVHKEALRLEEEGNKILKLNIGNPAPFGFEAPDEILVDVLR
CCCCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHH
NLPSAQGYCDSKGLYSARKAIVQYYQSKGILGATVNDVYIGNGVSELITMAMQALLNDGD
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCEEECCCHHHHHHHHHHHHHCCCC
EVLVPMPDYPLWTAAVTLSGGKAVHYLCDEDANWFPTIDDIKAKVNAKTKAIVIINPNNP
EEEEECCCCCCEEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHCCCCEEEEEEEECCCC
TGAVYSKELLQEIVEIARQNNLIIFADEIYDKILYDGAVHHHIAALAPDLLTVTLNGLSK
CCHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHCCHHHHHHHHHCCHHHEEEHHHHHH
AYRVAGFRQGWMILNGPKHNAKGYIEGLDMLASMRLCANVPMQHAIQTALGGYQSINEFI
HHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHH
LPGGRLLEQRNKAYDLITQIPGITCVKPMGAMYMFPKIDVKKFNIHSDEKMVLDLLRQEK
CCCHHHHHHHHHHHHHHHHCCCCEEECCCCCEEECCCCCEEEECCCCCHHHHHHHHCCCC
VLLVHGKGFNWHSPDHFRIVTLPYVNQLEEAITKLARFLSDYRQ
EEEEECCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate; 2-oxoglutarate

Specific reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800