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The map label for this gene is guaB

Identifier: 16272183

GI number: 16272183

Start: 248948

End: 250414

Strand: Direct

Name: guaB

Synonym: HI0221

Alternate gene names: 16272183

Gene position: 248948-250414 (Clockwise)

Preceding gene: 16272179

Following gene: 16272184

Centisome position: 13.6

GC content: 42.4

Gene sequence:

>1467_bases
ATGTCATTACGCATTAAACAAGAAGCCCTTACTTTTGACGATGTTCTACTCGTCCCAGCTCACTCAACTGTGCTTCCAAA
TACTGCCAACCTTTCAACTCAACTTACTAAAGAAATTCGTTTAAATATCCCAATGCTTTCAGCAGCAATGGATACCGTAA
CTGAAACCAAACTTGCGATCTCTTTAGCACAAGAAGGCGGTATTGGCTTTATTCATAAAAATATGACGATCGAACGCCAA
GCAGATCGCGTGCGTAAAGTAAAAAAATTCGAAAGTGGTATCGTTTCTGAACCAGTAACTGTTTTACCAAATTTAACGCT
TGCCGAACTTGCTGAAATGGTGAAGAAAAACGGATTTGCGGGCTACCCTGTTGTAGATGGGGAAAATAATTTAATCGGTA
TCATTACTGGCCGTGATACACGTTTCGTAAAAGATTTAAGCAAAACAGTTTCACAAGTAATGACGAAAAAAGAAGACTTG
GTGACCGTAAAAGAAGGGGCGAGTCGCGAAGAAATTTTGGAATTAATGCATCAACACCGTGTTGAAAAAGTATTAGTGGT
TAATGATAGTTTCAAACTTAAAGGTATGATTACCGTTAAAGACTTCCAAAAAGCAGAACAAAAACCAAATGCATGTAAAG
ATGAATTCGGTCGTTTACGTGTCGGTGCGGCTGTAGGTGCAGGTGCTGGCAACGAAGAACGTATTGATGCCTTAGTGAAA
GCAGGCGTAGATGTACTATTAATTGATTCTTCTCACGGTCACTCAGAAGGCGTATTACAACGCGTTCGTGAAACTCGTGC
AAAATATCCAAATTTGCCTATCGTTGCAGGTAACGTAGCAACGGCTGAAGGCGCAATTGCATTAGCAGACGCAGGTGCAA
GTGCTGTAAAAGTAGGTATTGGTCCTGGTTCAATTTGTACAACTCGTATTGTAACTGGCGTAGGTGTTCCACAAATTACC
GCTATCGCAGATGCAGCTGCTGCATTAAAAGATCGTGGTATTCCTGTAATTGCTGACGGTGGTATCCGTTTCTCTGGCGA
TATTGCAAAAGCTATCGCTGCTGGTGCAAGCTGTGTAATGGTTGGCTCGATGTTTGCGGGTACAGAAGAGGCTCCAGGTG
AAATCGAACTTTATCAAGGTCGTGCATTTAAATCTTACCGTGGTATGGGCTCATTAGGTGCCATGGCGAAAGGCTCATCA
GACCGTTATTTCCAATCGGATAACGCGGCAGATAAACTCGTACCGGAAGGTATTGAAGGCCGTATTCCATATAAAGGTTA
CTTAAAAGAAATCATCCACCAACAAATGGGTGGCTTACGTTCTTGTATGGGCTTAACGGGCTGTGCAACTATTGATGAAC
TACGCACCAAAGCGGAATTTGTTCGCATTAGCGGTGCAGGCATTAAAGAAAGCCACGTTCACGATGTTGCTATTACTAAA
GAAGCACCTAACTATCGTATGGGCTAA

Upstream 100 bases:

>100_bases
CATAGCATAAATCCTAAAATTTCGTTTTCAAAATAAAGTGAAATCTGTATAATCTCGTCGCAATATTTTTTAACTTCAAC
TTATTAGCGAGAATATTGCA

Downstream 100 bases:

>100_bases
TCTTTAAGGTGGGCTTTAGCCTGCCTTTTGCTGTTTAAAGTGCGGTTGGTTTTTGCAAAGTTTTAAATAATATGAACCGC
TTACACTATCAATAATAAGA

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH

Number of amino acids: Translated: 488; Mature: 487

Protein sequence:

>488_residues
MSLRIKQEALTFDDVLLVPAHSTVLPNTANLSTQLTKEIRLNIPMLSAAMDTVTETKLAISLAQEGGIGFIHKNMTIERQ
ADRVRKVKKFESGIVSEPVTVLPNLTLAELAEMVKKNGFAGYPVVDGENNLIGIITGRDTRFVKDLSKTVSQVMTKKEDL
VTVKEGASREEILELMHQHRVEKVLVVNDSFKLKGMITVKDFQKAEQKPNACKDEFGRLRVGAAVGAGAGNEERIDALVK
AGVDVLLIDSSHGHSEGVLQRVRETRAKYPNLPIVAGNVATAEGAIALADAGASAVKVGIGPGSICTTRIVTGVGVPQIT
AIADAAAALKDRGIPVIADGGIRFSGDIAKAIAAGASCVMVGSMFAGTEEAPGEIELYQGRAFKSYRGMGSLGAMAKGSS
DRYFQSDNAADKLVPEGIEGRIPYKGYLKEIIHQQMGGLRSCMGLTGCATIDELRTKAEFVRISGAGIKESHVHDVAITK
EAPNYRMG

Sequences:

>Translated_488_residues
MSLRIKQEALTFDDVLLVPAHSTVLPNTANLSTQLTKEIRLNIPMLSAAMDTVTETKLAISLAQEGGIGFIHKNMTIERQ
ADRVRKVKKFESGIVSEPVTVLPNLTLAELAEMVKKNGFAGYPVVDGENNLIGIITGRDTRFVKDLSKTVSQVMTKKEDL
VTVKEGASREEILELMHQHRVEKVLVVNDSFKLKGMITVKDFQKAEQKPNACKDEFGRLRVGAAVGAGAGNEERIDALVK
AGVDVLLIDSSHGHSEGVLQRVRETRAKYPNLPIVAGNVATAEGAIALADAGASAVKVGIGPGSICTTRIVTGVGVPQIT
AIADAAAALKDRGIPVIADGGIRFSGDIAKAIAAGASCVMVGSMFAGTEEAPGEIELYQGRAFKSYRGMGSLGAMAKGSS
DRYFQSDNAADKLVPEGIEGRIPYKGYLKEIIHQQMGGLRSCMGLTGCATIDELRTKAEFVRISGAGIKESHVHDVAITK
EAPNYRMG
>Mature_487_residues
SLRIKQEALTFDDVLLVPAHSTVLPNTANLSTQLTKEIRLNIPMLSAAMDTVTETKLAISLAQEGGIGFIHKNMTIERQA
DRVRKVKKFESGIVSEPVTVLPNLTLAELAEMVKKNGFAGYPVVDGENNLIGIITGRDTRFVKDLSKTVSQVMTKKEDLV
TVKEGASREEILELMHQHRVEKVLVVNDSFKLKGMITVKDFQKAEQKPNACKDEFGRLRVGAAVGAGAGNEERIDALVKA
GVDVLLIDSSHGHSEGVLQRVRETRAKYPNLPIVAGNVATAEGAIALADAGASAVKVGIGPGSICTTRIVTGVGVPQITA
IADAAAALKDRGIPVIADGGIRFSGDIAKAIAAGASCVMVGSMFAGTEEAPGEIELYQGRAFKSYRGMGSLGAMAKGSSD
RYFQSDNAADKLVPEGIEGRIPYKGYLKEIIHQQMGGLRSCMGLTGCATIDELRTKAEFVRISGAGIKESHVHDVAITKE
APNYRMG

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains

Homologues:

Organism=Homo sapiens, GI66933016, Length=456, Percent_Identity=40.3508771929825, Blast_Score=328, Evalue=5e-90,
Organism=Homo sapiens, GI217035146, Length=457, Percent_Identity=40.2625820568928, Blast_Score=326, Evalue=3e-89,
Organism=Homo sapiens, GI156616279, Length=457, Percent_Identity=40.2625820568928, Blast_Score=325, Evalue=5e-89,
Organism=Homo sapiens, GI34328928, Length=457, Percent_Identity=40.2625820568928, Blast_Score=325, Evalue=5e-89,
Organism=Homo sapiens, GI34328930, Length=457, Percent_Identity=40.2625820568928, Blast_Score=325, Evalue=6e-89,
Organism=Homo sapiens, GI217035152, Length=451, Percent_Identity=40.3547671840355, Blast_Score=318, Evalue=5e-87,
Organism=Homo sapiens, GI217035148, Length=457, Percent_Identity=39.1684901531729, Blast_Score=311, Evalue=1e-84,
Organism=Homo sapiens, GI217035150, Length=457, Percent_Identity=36.5426695842451, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI156104880, Length=249, Percent_Identity=39.3574297188755, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI50541954, Length=250, Percent_Identity=37.6, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI50541952, Length=250, Percent_Identity=37.6, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI50541948, Length=250, Percent_Identity=37.6, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI50541956, Length=250, Percent_Identity=37.6, Blast_Score=158, Evalue=1e-38,
Organism=Escherichia coli, GI1788855, Length=486, Percent_Identity=82.5102880658436, Blast_Score=762, Evalue=0.0,
Organism=Escherichia coli, GI1786293, Length=221, Percent_Identity=38.0090497737557, Blast_Score=145, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI71994385, Length=474, Percent_Identity=36.4978902953587, Blast_Score=268, Evalue=6e-72,
Organism=Caenorhabditis elegans, GI71994389, Length=419, Percent_Identity=38.9021479713604, Blast_Score=260, Evalue=1e-69,
Organism=Caenorhabditis elegans, GI17560440, Length=276, Percent_Identity=33.695652173913, Blast_Score=154, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6323585, Length=460, Percent_Identity=40.2173913043478, Blast_Score=327, Evalue=4e-90,
Organism=Saccharomyces cerevisiae, GI6322012, Length=482, Percent_Identity=39.4190871369295, Blast_Score=325, Evalue=1e-89,
Organism=Saccharomyces cerevisiae, GI6323464, Length=444, Percent_Identity=41.6666666666667, Blast_Score=314, Evalue=2e-86,
Organism=Saccharomyces cerevisiae, GI6319352, Length=338, Percent_Identity=40.5325443786982, Blast_Score=247, Evalue=4e-66,
Organism=Saccharomyces cerevisiae, GI6319353, Length=118, Percent_Identity=38.135593220339, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24641071, Length=483, Percent_Identity=38.7163561076605, Blast_Score=311, Evalue=9e-85,
Organism=Drosophila melanogaster, GI24641073, Length=483, Percent_Identity=38.7163561076605, Blast_Score=311, Evalue=9e-85,
Organism=Drosophila melanogaster, GI28571163, Length=441, Percent_Identity=39.2290249433107, Blast_Score=280, Evalue=1e-75,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): IMDH_HAEIN (P44334)

Other databases:

- EMBL:   L42023
- PIR:   H64055
- RefSeq:   NP_438392.1
- ProteinModelPortal:   P44334
- SMR:   P44334
- GeneID:   951137
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0221
- NMPDR:   fig|71421.1.peg.210
- TIGR:   HI_0221
- HOGENOM:   HBG298985
- OMA:   CVGLITV
- ProtClustDB:   PRK05567
- BioCyc:   HINF71421:HI_0221-MONOMER
- BRENDA:   1.1.1.205
- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000130
- SMART:   SM00116
- TIGRFAMs:   TIGR01302

Pfam domain/function: PF00571 CBS; PF00478 IMPDH

EC number: =1.1.1.205

Molecular weight: Translated: 51982; Mature: 51850

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: PS51371 CBS; PS00487 IMP_DH_GMP_RED

Important sites: ACT_SITE 306-306 BINDING 339-339 BINDING 386-386

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLRIKQEALTFDDVLLVPAHSTVLPNTANLSTQLTKEIRLNIPMLSAAMDTVTETKLAI
CCCEECHHHCCCCCEEEEECCCEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHEE
SLAQEGGIGFIHKNMTIERQADRVRKVKKFESGIVSEPVTVLPNLTLAELAEMVKKNGFA
EECCCCCEEEEECCCEEHHHHHHHHHHHHHHCCCCCCCHHHCCCCHHHHHHHHHHHCCCC
GYPVVDGENNLIGIITGRDTRFVKDLSKTVSQVMTKKEDLVTVKEGASREEILELMHQHR
CCCEECCCCCEEEEEECCCHHHHHHHHHHHHHHHHCHHHEEEECCCCCHHHHHHHHHHHC
VEKVLVVNDSFKLKGMITVKDFQKAEQKPNACKDEFGRLRVGAAVGAGAGNEERIDALVK
CCEEEEECCCEEEEEEEEHHHHHHHHCCCCHHHHHHCCEEEEEEECCCCCCHHHHHHHHH
AGVDVLLIDSSHGHSEGVLQRVRETRAKYPNLPIVAGNVATAEGAIALADAGASAVKVGI
CCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCEEEECCCCCEEEEEC
GPGSICTTRIVTGVGVPQITAIADAAAALKDRGIPVIADGGIRFSGDIAKAIAAGASCVM
CCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEECCCEEECCHHHHHHHCCCHHEE
VGSMFAGTEEAPGEIELYQGRAFKSYRGMGSLGAMAKGSSDRYFQSDNAADKLVPEGIEG
EHHHHCCCCCCCCCEEEECCCCHHHHCCCCCCCCCCCCCCCCEECCCCCHHHCCCCCCCC
RIPYKGYLKEIIHQQMGGLRSCMGLTGCATIDELRTKAEFVRISGAGIKESHVHDVAITK
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHEEEEECCCCCCCCCEEEEEEC
EAPNYRMG
CCCCCCCC
>Mature Secondary Structure 
SLRIKQEALTFDDVLLVPAHSTVLPNTANLSTQLTKEIRLNIPMLSAAMDTVTETKLAI
CCEECHHHCCCCCEEEEECCCEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHEE
SLAQEGGIGFIHKNMTIERQADRVRKVKKFESGIVSEPVTVLPNLTLAELAEMVKKNGFA
EECCCCCEEEEECCCEEHHHHHHHHHHHHHHCCCCCCCHHHCCCCHHHHHHHHHHHCCCC
GYPVVDGENNLIGIITGRDTRFVKDLSKTVSQVMTKKEDLVTVKEGASREEILELMHQHR
CCCEECCCCCEEEEEECCCHHHHHHHHHHHHHHHHCHHHEEEECCCCCHHHHHHHHHHHC
VEKVLVVNDSFKLKGMITVKDFQKAEQKPNACKDEFGRLRVGAAVGAGAGNEERIDALVK
CCEEEEECCCEEEEEEEEHHHHHHHHCCCCHHHHHHCCEEEEEEECCCCCCHHHHHHHHH
AGVDVLLIDSSHGHSEGVLQRVRETRAKYPNLPIVAGNVATAEGAIALADAGASAVKVGI
CCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCEEEECCCCCEEEEEC
GPGSICTTRIVTGVGVPQITAIADAAAALKDRGIPVIADGGIRFSGDIAKAIAAGASCVM
CCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEECCCEEECCHHHHHHHCCCHHEE
VGSMFAGTEEAPGEIELYQGRAFKSYRGMGSLGAMAKGSSDRYFQSDNAADKLVPEGIEG
EHHHHCCCCCCCCCEEEECCCCHHHHCCCCCCCCCCCCCCCCEECCCCCHHHCCCCCCCC
RIPYKGYLKEIIHQQMGGLRSCMGLTGCATIDELRTKAEFVRISGAGIKESHVHDVAITK
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHEEEEECCCCCCCCCEEEEEEC
EAPNYRMG
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800