Click here to switch to the map view.

The map label for this gene is gor

Identifier: 16272128

GI number: 16272128

Start: 176718

End: 178088

Strand: Reverse

Name: gor

Synonym: HI0161

Alternate gene names: 16272128

Gene position: 178088-176718 (Counterclockwise)

Preceding gene: 16272129

Following gene: 16272126

Centisome position: 9.73

GC content: 38.44

Gene sequence:

>1371_bases
ATGACTAAACATTATGATTATATTGCTATTGGCGGTGGCAGTGGCGGTATTGCGTCTCTAAATCGAGCAGCAAGCTATGG
AAAAAAATGTGCAATCATTGAAGCAAAACATCTTGGCGGAACTTGTGTAAATGTCGGTTGTGTACCTAAAAAAGTGATGT
TTTATGGTGCGCATATTGCAGAAGCAATCAACAATTATGCGCCAGATTATGGTTTTGATGTTGAAGTGAAAAAATTTGAT
TTTTCAAAACTGATTGAAAGTCGCCAAGCCTATATTAGTCGTATCCATACATCTTATAATAATGTATTAGCGAAAAATAA
TATTGATGTAATTAATGGTTTCGGAAAATTTGTCGATGCCCATACCATTGAAGTAACACTTGCTGATGGTACAAAAGAAC
AAGTAACCGCAGATCATATTTTAATCGCAACTGGTGGTCGTCCATATCGTCCAAATATTAAAGGACAAGAATACGGCATT
GATTCAGATGGTTTCTTTGCATTAACCGAATTACCAAAACGTGCTGCTGTTATTGGTGCAGGCTATATTGCTGTTGAACT
TTCTGGCGTATTAAATAGCTTAGGCGTGGAAACACATTTATTAGTGCGTCGCCATGCGCCAATGCGTAATCAGGATCCAT
TAATCGTAGAAACATTAGTGGAAGTGCTTGCGCAAGATGGAATTCAATTACATACCAATTCTACCCCATCTGAAATTGTA
AAAAATGCAGATGGTTCACTTACTGTAAGATGTGATGGTCAATCTGATGTTACCGTAGATTGCGTTATTTGGGCTGCGGG
TCGTGTTCCAACGACAGATAAAATTGGCTTAGAAAATGCTGGCGTAGAAACGAACGAACATGGCTATGTCAAAGTAGATA
AATATCAAAATACTAATGTGAAAGGCATTTATGCGGTAGGCGATATTATCGAAAACGGCATTGAATTAACACCAGTTGCA
GTTGCAGCAGGTCGTCGCCTTTCTGAGCGTTTATTTAATAATAAACCGACTGAATATTTAGATTACAGTTTAGTTCCAAC
CGTTGTATTTAGCCATCCGCCTATCGGCACTGTAGGTTTAACTGAACCGCAAGCGATTGAGCAGTACGGCGCAGAAAATG
TTAAGGTATATAAATCTTCTTTCACAGCGATGTACACTGCGGTAACTCAACATCGCCAACCGTGCAAAATGAAATTAGTT
TGTGTGGGTAAAGATGAAAAAGTTGTGGGTTTACATGGTATTGGTTTTGGTGTAGATGAAATGATTCAAGGATTTGCTGT
AGCAATCAAAATGGGTGCAACAAAAGCTGATTTTGACAATACGGTGGCAATTCATCCAACAGGTTCAGAGGAATTTGTAA
CAATGCGTTAA

Upstream 100 bases:

>100_bases
AGTAAAAAATATTCATAAAACCAATTACATCAATTTATAGCATTCTTTATAAAAATTAGGCAGAATACAAAAAAATTTTA
GTTTAAAAAAGGTTCAAACT

Downstream 100 bases:

>100_bases
TTGTTCAAATGAAAGAAGAAAAAGGCAGTAAGGTTATACTGCCTTTAAAGAAGTGAGAAATATCTACTTTCAGGATTTGT
TTCTGTCATTTATGGAAATA

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MTKHYDYIAIGGGSGGIASLNRAASYGKKCAIIEAKHLGGTCVNVGCVPKKVMFYGAHIAEAINNYAPDYGFDVEVKKFD
FSKLIESRQAYISRIHTSYNNVLAKNNIDVINGFGKFVDAHTIEVTLADGTKEQVTADHILIATGGRPYRPNIKGQEYGI
DSDGFFALTELPKRAAVIGAGYIAVELSGVLNSLGVETHLLVRRHAPMRNQDPLIVETLVEVLAQDGIQLHTNSTPSEIV
KNADGSLTVRCDGQSDVTVDCVIWAAGRVPTTDKIGLENAGVETNEHGYVKVDKYQNTNVKGIYAVGDIIENGIELTPVA
VAAGRRLSERLFNNKPTEYLDYSLVPTVVFSHPPIGTVGLTEPQAIEQYGAENVKVYKSSFTAMYTAVTQHRQPCKMKLV
CVGKDEKVVGLHGIGFGVDEMIQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR

Sequences:

>Translated_456_residues
MTKHYDYIAIGGGSGGIASLNRAASYGKKCAIIEAKHLGGTCVNVGCVPKKVMFYGAHIAEAINNYAPDYGFDVEVKKFD
FSKLIESRQAYISRIHTSYNNVLAKNNIDVINGFGKFVDAHTIEVTLADGTKEQVTADHILIATGGRPYRPNIKGQEYGI
DSDGFFALTELPKRAAVIGAGYIAVELSGVLNSLGVETHLLVRRHAPMRNQDPLIVETLVEVLAQDGIQLHTNSTPSEIV
KNADGSLTVRCDGQSDVTVDCVIWAAGRVPTTDKIGLENAGVETNEHGYVKVDKYQNTNVKGIYAVGDIIENGIELTPVA
VAAGRRLSERLFNNKPTEYLDYSLVPTVVFSHPPIGTVGLTEPQAIEQYGAENVKVYKSSFTAMYTAVTQHRQPCKMKLV
CVGKDEKVVGLHGIGFGVDEMIQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR
>Mature_455_residues
TKHYDYIAIGGGSGGIASLNRAASYGKKCAIIEAKHLGGTCVNVGCVPKKVMFYGAHIAEAINNYAPDYGFDVEVKKFDF
SKLIESRQAYISRIHTSYNNVLAKNNIDVINGFGKFVDAHTIEVTLADGTKEQVTADHILIATGGRPYRPNIKGQEYGID
SDGFFALTELPKRAAVIGAGYIAVELSGVLNSLGVETHLLVRRHAPMRNQDPLIVETLVEVLAQDGIQLHTNSTPSEIVK
NADGSLTVRCDGQSDVTVDCVIWAAGRVPTTDKIGLENAGVETNEHGYVKVDKYQNTNVKGIYAVGDIIENGIELTPVAV
AAGRRLSERLFNNKPTEYLDYSLVPTVVFSHPPIGTVGLTEPQAIEQYGAENVKVYKSSFTAMYTAVTQHRQPCKMKLVC
VGKDEKVVGLHGIGFGVDEMIQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR

Specific function: Maintains high levels of reduced glutathione in the cytosol

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family

Homologues:

Organism=Homo sapiens, GI50301238, Length=465, Percent_Identity=52.0430107526882, Blast_Score=449, Evalue=1e-126,
Organism=Homo sapiens, GI22035672, Length=475, Percent_Identity=39.1578947368421, Blast_Score=292, Evalue=4e-79,
Organism=Homo sapiens, GI148277065, Length=455, Percent_Identity=37.1428571428571, Blast_Score=273, Evalue=3e-73,
Organism=Homo sapiens, GI148277071, Length=455, Percent_Identity=37.1428571428571, Blast_Score=273, Evalue=3e-73,
Organism=Homo sapiens, GI33519430, Length=455, Percent_Identity=37.1428571428571, Blast_Score=273, Evalue=3e-73,
Organism=Homo sapiens, GI33519428, Length=455, Percent_Identity=37.1428571428571, Blast_Score=273, Evalue=3e-73,
Organism=Homo sapiens, GI33519426, Length=455, Percent_Identity=37.1428571428571, Blast_Score=273, Evalue=3e-73,
Organism=Homo sapiens, GI291045266, Length=455, Percent_Identity=35.1648351648352, Blast_Score=252, Evalue=6e-67,
Organism=Homo sapiens, GI291045268, Length=455, Percent_Identity=31.8681318681319, Blast_Score=212, Evalue=6e-55,
Organism=Homo sapiens, GI91199540, Length=459, Percent_Identity=29.4117647058824, Blast_Score=184, Evalue=1e-46,
Organism=Escherichia coli, GI1789915, Length=457, Percent_Identity=73.5229759299781, Blast_Score=666, Evalue=0.0,
Organism=Escherichia coli, GI1786307, Length=448, Percent_Identity=28.5714285714286, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI87082354, Length=457, Percent_Identity=26.6958424507659, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI87081717, Length=454, Percent_Identity=26.6519823788546, Blast_Score=145, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI71983419, Length=456, Percent_Identity=51.5350877192982, Blast_Score=412, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI71983429, Length=456, Percent_Identity=51.3157894736842, Blast_Score=412, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI17557007, Length=473, Percent_Identity=36.1522198731501, Blast_Score=284, Evalue=5e-77,
Organism=Caenorhabditis elegans, GI71982272, Length=481, Percent_Identity=33.2640332640333, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI32565766, Length=461, Percent_Identity=30.3687635574837, Blast_Score=184, Evalue=9e-47,
Organism=Saccharomyces cerevisiae, GI6325166, Length=466, Percent_Identity=49.3562231759657, Blast_Score=423, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6321091, Length=469, Percent_Identity=28.1449893390192, Blast_Score=158, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6325240, Length=469, Percent_Identity=23.6673773987207, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24640553, Length=470, Percent_Identity=38.936170212766, Blast_Score=286, Evalue=1e-77,
Organism=Drosophila melanogaster, GI24640549, Length=470, Percent_Identity=38.936170212766, Blast_Score=286, Evalue=2e-77,
Organism=Drosophila melanogaster, GI24640551, Length=470, Percent_Identity=38.936170212766, Blast_Score=286, Evalue=2e-77,
Organism=Drosophila melanogaster, GI17737741, Length=473, Percent_Identity=37.6321353065539, Blast_Score=274, Evalue=7e-74,
Organism=Drosophila melanogaster, GI21358499, Length=468, Percent_Identity=30.3418803418803, Blast_Score=176, Evalue=4e-44,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): GSHR_HAEIN (P43783)

Other databases:

- EMBL:   U20229
- EMBL:   L42023
- PIR:   A64052
- RefSeq:   NP_438331.1
- ProteinModelPortal:   P43783
- SMR:   P43783
- GeneID:   951071
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0161
- NMPDR:   fig|71421.1.peg.152
- TIGR:   HI_0161
- HOGENOM:   HBG515043
- OMA:   VTSHRQP
- ProtClustDB:   PRK06116
- BioCyc:   HINF71421:HI_0161-MONOMER
- BRENDA:   1.8.1.7
- GO:   GO:0005737
- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006322
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327
- Gene3D:   G3DSA:3.30.390.30
- PRINTS:   PR00368
- TIGRFAMs:   TIGR01421

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim; SSF55424 FAD/NAD-linked_reductase_dimer

EC number: =1.8.1.7

Molecular weight: Translated: 49330; Mature: 49199

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: ACT_SITE 445-445

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKHYDYIAIGGGSGGIASLNRAASYGKKCAIIEAKHLGGTCVNVGCVPKKVMFYGAHIA
CCCCEEEEEEECCCCCHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCCHHHHHHHHHHH
EAINNYAPDYGFDVEVKKFDFSKLIESRQAYISRIHTSYNNVLAKNNIDVINGFGKFVDA
HHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCEEECCCCEEEECCHHHCCC
HTIEVTLADGTKEQVTADHILIATGGRPYRPNIKGQEYGIDSDGFFALTELPKRAAVIGA
EEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCHHEEEEC
GYIAVELSGVLNSLGVETHLLVRRHAPMRNQDPLIVETLVEVLAQDGIQLHTNSTPSEIV
CEEEEEHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCEEEECCCCHHHHH
KNADGSLTVRCDGQSDVTVDCVIWAAGRVPTTDKIGLENAGVETNEHGYVKVDKYQNTNV
HCCCCCEEEEECCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCC
KGIYAVGDIIENGIELTPVAVAAGRRLSERLFNNKPTEYLDYSLVPTVVFSHPPIGTVGL
CEEEEEHHHHHCCCEEEEEHHHHHHHHHHHHHCCCCHHHCCCEEECEEEECCCCCCCCCC
TEPQAIEQYGAENVKVYKSSFTAMYTAVTQHRQPCKMKLVCVGKDEKVVGLHGIGFGVDE
CCCHHHHHCCCCCEEEEHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEECCCCHHH
MIQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR
HHHHEEEEEEECCCCCCCCCEEEEECCCCCCEEEEC
>Mature Secondary Structure 
TKHYDYIAIGGGSGGIASLNRAASYGKKCAIIEAKHLGGTCVNVGCVPKKVMFYGAHIA
CCCEEEEEEECCCCCHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCCHHHHHHHHHHH
EAINNYAPDYGFDVEVKKFDFSKLIESRQAYISRIHTSYNNVLAKNNIDVINGFGKFVDA
HHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCEEECCCCEEEECCHHHCCC
HTIEVTLADGTKEQVTADHILIATGGRPYRPNIKGQEYGIDSDGFFALTELPKRAAVIGA
EEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCHHEEEEC
GYIAVELSGVLNSLGVETHLLVRRHAPMRNQDPLIVETLVEVLAQDGIQLHTNSTPSEIV
CEEEEEHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCEEEECCCCHHHHH
KNADGSLTVRCDGQSDVTVDCVIWAAGRVPTTDKIGLENAGVETNEHGYVKVDKYQNTNV
HCCCCCEEEEECCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCC
KGIYAVGDIIENGIELTPVAVAAGRRLSERLFNNKPTEYLDYSLVPTVVFSHPPIGTVGL
CEEEEEHHHHHCCCEEEEEHHHHHHHHHHHHHCCCCHHHCCCEEECEEEECCCCCCCCCC
TEPQAIEQYGAENVKVYKSSFTAMYTAVTQHRQPCKMKLVCVGKDEKVVGLHGIGFGVDE
CCCHHHHHCCCCCEEEEHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEEECCCCHHH
MIQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR
HHHHEEEEEEECCCCCCCCCEEEEECCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800