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The map label for this gene is nanM [H]

Identifier: 16272115

GI number: 16272115

Start: 164623

End: 165762

Strand: Direct

Name: nanM [H]

Synonym: HI0148

Alternate gene names: 16272115

Gene position: 164623-165762 (Clockwise)

Preceding gene: 16272114

Following gene: 16272116

Centisome position: 9.0

GC content: 40.18

Gene sequence:

>1140_bases
ATGGGGTTTATTATGAAACTAACTAAAACAGCATTATGTACTGCACTTTTTGCCACCTTTACTTTTTCAGCGAACGCACA
AACTTATCCTGATTTGCCAGTGGGGATCAAAGGAGGAACAGGCGCATTAATTGGCGACACAGTTTATGTGGGATTAGGTT
CTGGTGGCGATAAATTCTATACCTTAGACCTAAAAGATCCTTCAGCACAATGGAAAGAAATTGCTACATTTCCGGGTGGC
GAACGCAATCAACCTGTTGCAGCCGCAGTGGATGGAAAACTTTATGTATTCGGTGGTTTACAAAAAAATGAAAAAGGCGA
ACTTCAACTCGTTAATGACGCTTATCGCTATAACCCAAGCGATAATACTTGGATGAAACTTCCTACTCGTTCTCCCCGTG
GTTTAGTAGGATCAAGTGGTGCATCTCACGGAGATAAAGTTTATATTTTAGGCGGCTCTAATCTCTCTATATTTAATGGC
TTCTTCCAAGACACTGTGGCAGCAGGTGAAGATAAAGCGAAAAAAGATGAAATCGCAGCAGCTTATTTCGATCAACGTCC
AGAAGATTATTTCTTTACAACAGAATTATTGAGCTATGAACCATCAACCAATAAATGGCGCAATGAAGGTCGTATTCCAT
TCTCTGGTCGTGCTGGTGCAGCCTTTACAATTCAAGGTAATGAGCTAGTGGTTGTCAATGGCGAAATTAAACCTGGACTT
CGCACCGCTGAAACCCATCAAGGTAAATTCACTGCTAAAGGTGTGCAATGGAAAAACTTACCTGACTTACCTGCTCCAAA
AGGCAAATCACAAGATGGTTTAGCTGGTGCGCTTTCAGGCTATAGTAACGGTCATTATTTAGTCACTGGCGGCGCAAATT
TTCCAGGTTCAATCAAACAATTCAAAGAAGGAAAACTTCACGCACATAAAGGTTTAAGCAAAGCTTGGCATAACGAAGTT
TATACGTTGAATAATGGTAAATGGCGCATTGTTGGGGAATTACCAATGAATATTGGTTATGGTTTTTCTGTATCTTACAA
CAATAAAGTTTTACTGATTGGCGGTGAAACTGATGGAGGTAAGGCTTTAACTAGCGTCAAAGCAATAAGCTATGACGGTA
AAAAATTAACCATCGAATAA

Upstream 100 bases:

>100_bases
ATCTGCCGTATCTTACAATACAAAAGGGTGCAATAACTGCACTTTATCAACGCCTATTCAATGCCGTTTAATGAATAGAA
AACTGTAAACACAACTCAAA

Downstream 100 bases:

>100_bases
TTTATCACAGAATAGTGCATAAAATTTATAATAATCAAAAGCGGCGAAATTTATCGCCGCTTTATGCAAAATAAAAGTAA
TTAAAGCAAAATTAAGACAA

Product: N-acetylneuraminic acid mutarotase

Products: NA

Alternate protein names: N-acetylneuraminate mutarotase; Neu5Ac mutarotase; Sialic acid epimerase [H]

Number of amino acids: Translated: 379; Mature: 378

Protein sequence:

>379_residues
MGFIMKLTKTALCTALFATFTFSANAQTYPDLPVGIKGGTGALIGDTVYVGLGSGGDKFYTLDLKDPSAQWKEIATFPGG
ERNQPVAAAVDGKLYVFGGLQKNEKGELQLVNDAYRYNPSDNTWMKLPTRSPRGLVGSSGASHGDKVYILGGSNLSIFNG
FFQDTVAAGEDKAKKDEIAAAYFDQRPEDYFFTTELLSYEPSTNKWRNEGRIPFSGRAGAAFTIQGNELVVVNGEIKPGL
RTAETHQGKFTAKGVQWKNLPDLPAPKGKSQDGLAGALSGYSNGHYLVTGGANFPGSIKQFKEGKLHAHKGLSKAWHNEV
YTLNNGKWRIVGELPMNIGYGFSVSYNNKVLLIGGETDGGKALTSVKAISYDGKKLTIE

Sequences:

>Translated_379_residues
MGFIMKLTKTALCTALFATFTFSANAQTYPDLPVGIKGGTGALIGDTVYVGLGSGGDKFYTLDLKDPSAQWKEIATFPGG
ERNQPVAAAVDGKLYVFGGLQKNEKGELQLVNDAYRYNPSDNTWMKLPTRSPRGLVGSSGASHGDKVYILGGSNLSIFNG
FFQDTVAAGEDKAKKDEIAAAYFDQRPEDYFFTTELLSYEPSTNKWRNEGRIPFSGRAGAAFTIQGNELVVVNGEIKPGL
RTAETHQGKFTAKGVQWKNLPDLPAPKGKSQDGLAGALSGYSNGHYLVTGGANFPGSIKQFKEGKLHAHKGLSKAWHNEV
YTLNNGKWRIVGELPMNIGYGFSVSYNNKVLLIGGETDGGKALTSVKAISYDGKKLTIE
>Mature_378_residues
GFIMKLTKTALCTALFATFTFSANAQTYPDLPVGIKGGTGALIGDTVYVGLGSGGDKFYTLDLKDPSAQWKEIATFPGGE
RNQPVAAAVDGKLYVFGGLQKNEKGELQLVNDAYRYNPSDNTWMKLPTRSPRGLVGSSGASHGDKVYILGGSNLSIFNGF
FQDTVAAGEDKAKKDEIAAAYFDQRPEDYFFTTELLSYEPSTNKWRNEGRIPFSGRAGAAFTIQGNELVVVNGEIKPGLR
TAETHQGKFTAKGVQWKNLPDLPAPKGKSQDGLAGALSGYSNGHYLVTGGANFPGSIKQFKEGKLHAHKGLSKAWHNEVY
TLNNGKWRIVGELPMNIGYGFSVSYNNKVLLIGGETDGGKALTSVKAISYDGKKLTIE

Specific function: Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, whic

COG id: COG3055

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 7 Kelch repeats [H]

Homologues:

Organism=Escherichia coli, GI87082419, Length=375, Percent_Identity=43.4666666666667, Blast_Score=320, Evalue=7e-89,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013089
- InterPro:   IPR015915
- InterPro:   IPR006652
- InterPro:   IPR019936 [H]

Pfam domain/function: PF01344 Kelch_1 [H]

EC number: NA

Molecular weight: Translated: 40792; Mature: 40661

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGFIMKLTKTALCTALFATFTFSANAQTYPDLPVGIKGGTGALIGDTVYVGLGSGGDKFY
CCHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCEEECCCCCEEEECEEEEEECCCCCEEE
TLDLKDPSAQWKEIATFPGGERNQPVAAAVDGKLYVFGGLQKNEKGELQLVNDAYRYNPS
EEEECCCCCHHHHHCCCCCCCCCCCEEEEECCEEEEEECCCCCCCCCEEEEEEEEEECCC
DNTWMKLPTRSPRGLVGSSGASHGDKVYILGGSNLSIFNGFFQDTVAAGEDKAKKDEIAA
CCCEEEECCCCCCCCCCCCCCCCCCEEEEEECCCEEEEHHHHHHHHHCCCCCCCHHHHHH
AYFDQRPEDYFFTTELLSYEPSTNKWRNEGRIPFSGRAGAAFTIQGNELVVVNGEIKPGL
HHHCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCEEEEECCCCCCCC
RTAETHQGKFTAKGVQWKNLPDLPAPKGKSQDGLAGALSGYSNGHYLVTGGANFPGSIKQ
CCCCCCCCEEEECCEEECCCCCCCCCCCCCCCCCEEHHCCCCCCCEEEECCCCCCHHHHH
FKEGKLHAHKGLSKAWHNEVYTLNNGKWRIVGELPMNIGYGFSVSYNNKVLLIGGETDGG
HHCCCCHHHHCHHHHHCCCEEEEECCCEEEEEECCCCCCCEEEEECCCEEEEEECCCCCC
KALTSVKAISYDGKKLTIE
CEEEEEEEEEECCCEEEEC
>Mature Secondary Structure 
GFIMKLTKTALCTALFATFTFSANAQTYPDLPVGIKGGTGALIGDTVYVGLGSGGDKFY
CHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCEEECCCCCEEEECEEEEEECCCCCEEE
TLDLKDPSAQWKEIATFPGGERNQPVAAAVDGKLYVFGGLQKNEKGELQLVNDAYRYNPS
EEEECCCCCHHHHHCCCCCCCCCCCEEEEECCEEEEEECCCCCCCCCEEEEEEEEEECCC
DNTWMKLPTRSPRGLVGSSGASHGDKVYILGGSNLSIFNGFFQDTVAAGEDKAKKDEIAA
CCCEEEECCCCCCCCCCCCCCCCCCEEEEEECCCEEEEHHHHHHHHHCCCCCCCHHHHHH
AYFDQRPEDYFFTTELLSYEPSTNKWRNEGRIPFSGRAGAAFTIQGNELVVVNGEIKPGL
HHHCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCEEEEECCCCCCCC
RTAETHQGKFTAKGVQWKNLPDLPAPKGKSQDGLAGALSGYSNGHYLVTGGANFPGSIKQ
CCCCCCCCEEEECCEEECCCCCCCCCCCCCCCCCEEHHCCCCCCCEEEECCCCCCHHHHH
FKEGKLHAHKGLSKAWHNEVYTLNNGKWRIVGELPMNIGYGFSVSYNNKVLLIGGETDGG
HHCCCCHHHHCHHHHHCCCEEEEECCCEEEEEECCCCCCCEEEEECCCEEEEEECCCCCC
KALTSVKAISYDGKKLTIE
CEEEEEEEEEECCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA