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The map label for this gene is ffh

Identifier: 16272080

GI number: 16272080

Start: 113277

End: 114665

Strand: Reverse

Name: ffh

Synonym: HI0106

Alternate gene names: 16272080

Gene position: 114665-113277 (Counterclockwise)

Preceding gene: 16272083

Following gene: 16272078

Centisome position: 6.27

GC content: 43.56

Gene sequence:

>1389_bases
ATGTTTGAGAATTTATCGGATCGCCTTTCCAAAACCTTACGTAATATCACAGGAAAAGGCCGTTTAACGGAAGATAATAT
TAAAGAAACCTTACGCGAAGTGCGTATGGCATTACTTGAAGCCGATGTTGCCTTGCCTGTGGTGCGTGAATTTATCGCAA
AAGTAAAAGAAAGCGCGCTTGGGGAAGAAGTCAATAAAAGTTTAACGCCAGGGCAAGAATTCTTAAAAATCGTTCAGCGT
GAGCTTGAAAAAGCCATGGGCGAAGCGAATGAGAGTTTAAATCTCGCAACCCAACCACCAGCAGTTATCTTAATGGCGGG
TTTACAAGGGGCGGGTAAAACCACCAGTGTGGGTAAATTGGCAAAATTCTTGCGTGAACGCCATAAAAAGAAAGTGTTAG
TGGTGTCTGCTGACGTATATCGCCCTGCTGCGATTAAGCAACTTGAAACCTTGGCTCAATCCGTTGGCGTGGATTTTTTT
CCATCGGATGTTAAACAAAACCCCGTTGATATTGCTAAATCGGCGCTTGCTGATGCAAAACTGAAATTCTACGATGTGTT
GATTGTGGATACGGCAGGTCGCCTACACGTTGATACAGAAATGATGGACGAAATCAAGCAAGTCCATGCTGCATTAAATC
CAATCGAAACTCTTTTCACTGTTGATGCGATGACTGGTCAAGATGCGGCAAATACAGCAAAAGCCTTTAATGAAGCATTG
CCTCTTACAGGGGTTATTTTGACGAAAGTGGACGGTGATGCGCGCGGTGGTGCGGCGTTATCGATTCGTCAAATCACAGG
TAAACCAATCAAATTCTTGGGTGTGGGCGAGAAAACAGAGGCGCTTGAGCCATTCCATCCTGATCGTGTCGCTTCCCGTA
TTTTGGGCATGGGCGATGTGCTTTCCCTTATCGAAGATCTTGAACGTTCTGTTGATCGTGAAAAAGCGGAAAAAATGGCG
CAGAAATTCAAGAAAGGCGATGATTTTACTTTAGATGATTTCCGCGAACAGCTGATCGAAATGAAAAAAATGGGCGGCAT
GATGTCTATGCTTGAGAAATTACCAGGTGCAAAAAATTTGTCTGAGCACGTTAAAAATCAAGTAGATGACAAAATGTTTG
TCAAAATGGAAGCGATCATTAACTCCATGACCCTAAAAGAACGTGCCAACCCAGATATTATCAAAGGATCTCGCCGTCGT
CGTATTGCATTAGGCTCTGGCACTCAAGTGCAAGATGTCAATAAATTACTTAAACAATTCGATGAAATGCAACGTATGAT
GAAGAAAATGCGTAAAGGCGGCATGGCTAAAATGATGCGTGGAATGCAAGGCTTAATGGGCGGAGGCTTAGGCGGTCTTG
GCGGTTTAGGCGGAATGTTTAAACGATAA

Upstream 100 bases:

>100_bases
AATCGCCTACTCAAAAAGTCATTTTCATTTGAAATGATGAAAAACGCCTAAATTTCGGTATAATCAGCACAATTTTTTAA
GAAAAACAGGATTGTTAGCC

Downstream 100 bases:

>100_bases
TTTCAGAAGATAAAAGTGCGGTTAAAAAAGAAATATTTTTACCGCACTTTTGTATTTTATGCTGGATTATCTATATCTTT
AAATTCTACGTCAAAGCCAT

Product: Signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MFENLSDRLSKTLRNITGKGRLTEDNIKETLREVRMALLEADVALPVVREFIAKVKESALGEEVNKSLTPGQEFLKIVQR
ELEKAMGEANESLNLATQPPAVILMAGLQGAGKTTSVGKLAKFLRERHKKKVLVVSADVYRPAAIKQLETLAQSVGVDFF
PSDVKQNPVDIAKSALADAKLKFYDVLIVDTAGRLHVDTEMMDEIKQVHAALNPIETLFTVDAMTGQDAANTAKAFNEAL
PLTGVILTKVDGDARGGAALSIRQITGKPIKFLGVGEKTEALEPFHPDRVASRILGMGDVLSLIEDLERSVDREKAEKMA
QKFKKGDDFTLDDFREQLIEMKKMGGMMSMLEKLPGAKNLSEHVKNQVDDKMFVKMEAIINSMTLKERANPDIIKGSRRR
RIALGSGTQVQDVNKLLKQFDEMQRMMKKMRKGGMAKMMRGMQGLMGGGLGGLGGLGGMFKR

Sequences:

>Translated_462_residues
MFENLSDRLSKTLRNITGKGRLTEDNIKETLREVRMALLEADVALPVVREFIAKVKESALGEEVNKSLTPGQEFLKIVQR
ELEKAMGEANESLNLATQPPAVILMAGLQGAGKTTSVGKLAKFLRERHKKKVLVVSADVYRPAAIKQLETLAQSVGVDFF
PSDVKQNPVDIAKSALADAKLKFYDVLIVDTAGRLHVDTEMMDEIKQVHAALNPIETLFTVDAMTGQDAANTAKAFNEAL
PLTGVILTKVDGDARGGAALSIRQITGKPIKFLGVGEKTEALEPFHPDRVASRILGMGDVLSLIEDLERSVDREKAEKMA
QKFKKGDDFTLDDFREQLIEMKKMGGMMSMLEKLPGAKNLSEHVKNQVDDKMFVKMEAIINSMTLKERANPDIIKGSRRR
RIALGSGTQVQDVNKLLKQFDEMQRMMKKMRKGGMAKMMRGMQGLMGGGLGGLGGLGGMFKR
>Mature_462_residues
MFENLSDRLSKTLRNITGKGRLTEDNIKETLREVRMALLEADVALPVVREFIAKVKESALGEEVNKSLTPGQEFLKIVQR
ELEKAMGEANESLNLATQPPAVILMAGLQGAGKTTSVGKLAKFLRERHKKKVLVVSADVYRPAAIKQLETLAQSVGVDFF
PSDVKQNPVDIAKSALADAKLKFYDVLIVDTAGRLHVDTEMMDEIKQVHAALNPIETLFTVDAMTGQDAANTAKAFNEAL
PLTGVILTKVDGDARGGAALSIRQITGKPIKFLGVGEKTEALEPFHPDRVASRILGMGDVLSLIEDLERSVDREKAEKMA
QKFKKGDDFTLDDFREQLIEMKKMGGMMSMLEKLPGAKNLSEHVKNQVDDKMFVKMEAIINSMTLKERANPDIIKGSRRR
RIALGSGTQVQDVNKLLKQFDEMQRMMKKMRKGGMAKMMRGMQGLMGGGLGGLGGLGGMFKR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family

Homologues:

Organism=Homo sapiens, GI4507215, Length=444, Percent_Identity=32.4324324324324, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI226371618, Length=346, Percent_Identity=34.6820809248555, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI89061728, Length=165, Percent_Identity=35.7575757575758, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI23308697, Length=222, Percent_Identity=29.2792792792793, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI295424842, Length=222, Percent_Identity=29.2792792792793, Blast_Score=96, Evalue=5e-20,
Organism=Escherichia coli, GI1788963, Length=452, Percent_Identity=79.8672566371681, Blast_Score=709, Evalue=0.0,
Organism=Escherichia coli, GI1789874, Length=254, Percent_Identity=36.2204724409449, Blast_Score=159, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17539958, Length=446, Percent_Identity=30.0448430493274, Blast_Score=191, Evalue=9e-49,
Organism=Caenorhabditis elegans, GI193206261, Length=216, Percent_Identity=31.9444444444444, Blast_Score=99, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6325345, Length=438, Percent_Identity=32.4200913242009, Blast_Score=214, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6320498, Length=314, Percent_Identity=26.1146496815287, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17647949, Length=433, Percent_Identity=29.3302540415704, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24641198, Length=220, Percent_Identity=28.1818181818182, Blast_Score=94, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SRP54_HAEIN (P44518)

Other databases:

- EMBL:   L42023
- PIR:   H64048
- RefSeq:   NP_438280.1
- ProteinModelPortal:   P44518
- SMR:   P44518
- GeneID:   951009
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0106
- NMPDR:   fig|71421.1.peg.103
- TIGR:   HI_0106
- HOGENOM:   HBG562580
- OMA:   IINGSRR
- ProtClustDB:   PRK10867
- BioCyc:   HINF71421:HI_0106-MONOMER
- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125
- Gene3D:   G3DSA:1.20.120.140
- Gene3D:   G3DSA:1.10.260.30
- PANTHER:   PTHR11564:SF7
- SMART:   SM00382
- SMART:   SM00962
- SMART:   SM00963
- TIGRFAMs:   TIGR00959

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB; SSF47446 Signal_recog_particle_SRP54_M; SSF47364 SRP54

EC number: NA

Molecular weight: Translated: 50844; Mature: 50844

Theoretical pI: Translated: 10.12; Mature: 10.12

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.8 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFENLSDRLSKTLRNITGKGRLTEDNIKETLREVRMALLEADVALPVVREFIAKVKESAL
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GEEVNKSLTPGQEFLKIVQRELEKAMGEANESLNLATQPPAVILMAGLQGAGKTTSVGKL
HHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHH
AKFLRERHKKKVLVVSADVYRPAAIKQLETLAQSVGVDFFPSDVKQNPVDIAKSALADAK
HHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHCCCHHHHHHHHHHHHH
LKFYDVLIVDTAGRLHVDTEMMDEIKQVHAALNPIETLFTVDAMTGQDAANTAKAFNEAL
HHHEEEEEEECCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHC
PLTGVILTKVDGDARGGAALSIRQITGKPIKFLGVGEKTEALEPFHPDRVASRILGMGDV
CCCEEEEEECCCCCCCCCEEEEEHHCCCCEEEEECCCHHCCCCCCCHHHHHHHHHCHHHH
LSLIEDLERSVDREKAEKMAQKFKKGDDFTLDDFREQLIEMKKMGGMMSMLEKLPGAKNL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCHHHHHHHHCCCCCCH
SEHVKNQVDDKMFVKMEAIINSMTLKERANPDIIKGSRRRRIALGSGTQVQDVNKLLKQF
HHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHH
DEMQRMMKKMRKGGMAKMMRGMQGLMGGGLGGLGGLGGMFKR
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHCCHHCCC
>Mature Secondary Structure
MFENLSDRLSKTLRNITGKGRLTEDNIKETLREVRMALLEADVALPVVREFIAKVKESAL
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GEEVNKSLTPGQEFLKIVQRELEKAMGEANESLNLATQPPAVILMAGLQGAGKTTSVGKL
HHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHH
AKFLRERHKKKVLVVSADVYRPAAIKQLETLAQSVGVDFFPSDVKQNPVDIAKSALADAK
HHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHCCCHHHHHHHHHHHHH
LKFYDVLIVDTAGRLHVDTEMMDEIKQVHAALNPIETLFTVDAMTGQDAANTAKAFNEAL
HHHEEEEEEECCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHC
PLTGVILTKVDGDARGGAALSIRQITGKPIKFLGVGEKTEALEPFHPDRVASRILGMGDV
CCCEEEEEECCCCCCCCCEEEEEHHCCCCEEEEECCCHHCCCCCCCHHHHHHHHHCHHHH
LSLIEDLERSVDREKAEKMAQKFKKGDDFTLDDFREQLIEMKKMGGMMSMLEKLPGAKNL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCHHHHHHHHCCCCCCH
SEHVKNQVDDKMFVKMEAIINSMTLKERANPDIIKGSRRRRIALGSGTQVQDVNKLLKQF
HHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHH
DEMQRMMKKMRKGGMAKMMRGMQGLMGGGLGGLGGLGGMFKR
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800