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The map label for this gene is mutL [H]

Identifier: 16272041

GI number: 16272041

Start: 70214

End: 72103

Strand: Direct

Name: mutL [H]

Synonym: HI0067

Alternate gene names: 16272041

Gene position: 70214-72103 (Clockwise)

Preceding gene: 16272040

Following gene: 16272042

Centisome position: 3.84

GC content: 39.52

Gene sequence:

>1890_bases
ATGCCTATTAAAATTCTTTCCCCACAACTTGCTAACCAAATTGCTGCTGGAGAAGTGGTAGAACGCCCTGCATCAGTGGT
AAAAGAATTAGTGGAAAATAGCCTTGATGCAGGTGCAAATAAAATCCAAATTGATATCGAAAATGGTGGGGCAAATTTAA
TCCGCATTCGTGACAATGGCTGTGGTATTCCAAAAGAAGAATTAAGCCTCGCTTTGGCACGACATGCCACGAGTAAAATA
GCCGATCTTGATGATCTCGAAGCGATTTTAAGTTTAGGTTTTCGTGGCGAGGCATTAGCTAGTATCAGTTCCGTATCACG
CCTAACCCTTACTTCTCGTACCGAAGAACAAACTGAAGCGTGGCAAGTTTATGCGCAAGGTCGTGATATGGAAACCACAA
TCAAACCCGCATCACATCCTGTCGGCACAACAGTTGAAGTCGCCAATCTTTTTTTCAACACACCAGCCCGCCGAAAATTT
TTGCGCACAGATAAAACAGAATTTTCCCATATTGATGAAGTCATTCGTCGTATTGCTTTAACGAAATTCAACACAGCATT
TACATTAACGCATAATGGAAAAATTATCCGTCAATACCGTCCTGCCGAAGCAATCAATCAACAACTAAAACGTGTCGCCG
CTATTTGTGGGGATGATTTTGTCAAAAATGCCTTACGAATTGAGTGGAAACACGATGATTTACATTTATCAGGTTGGGTG
GCGACACCAAATTTTAGCCGAACTCAAAATGATTTAAGTTATTGCTATATTAATGGCCGAATGGTTCGAGATAAGGTAAT
CAGCCATGCTATTCGACAAGCCTATGCACAATATTTACCAACCGATGCTTATCCTGCGTTTGTGTTGTTTATTGATTTAA
ACCCGCACGATGTAGATGTCAATGTTCATCCAACCAAACATGAAGTACGCTTTCATCAACAACGCCTCATTCATGATTTT
ATTTACGAAGGCATAAGTCATGCGCTAAACAATCAAGAACAGATTAATTGGCATACAGACCAAAGTGCGGTAGAAAATCA
CGAAGAAAATACGGTGCGTGAGCCCCAACCGAATTACAGCATTCGTCCTAATCGTGCAACTGCGGGGCAAAATAGCTTTG
CGCCACAATATCATGAAAAACCACAGCAAAATCAACCGCACTTTTCTAACACACCAATGTTTCCAAATCATGTAAGTACT
GGTTATCGAGATTACCGTTCTGATGCACCGAGTAAAACTGAGCAACGTTTATATGCTGAATTGTTACGCACGTTACCGCC
TACAGCGCAAAAGGATATATCGGATACAGCACAACAAAATATTTCAGATACAGCTAAAATCATCTCAACTGAAATAATTG
AGTGTTCATCACATCTACGAGCCCTTTCACTTATTGAAAATCGTGCGTTGTTATTACAACAGAACCAAGATTTCTTTTTG
CTTTCATTGGAAAAATTACAACGCTTGCAATGGCAACTAGCGTTAAAACAAATACAGATTGAACAACAGGCTTTATTGAT
TCCAATCGTGTTCCGATTAACCGAATCACAATTTCAAGCATGGCAACAATATTCAGATGACTTCAAAAAAATTGGCTTTG
AATTTATCGAAAATCAAGCACAATTACGCTTAACCTTAAATAAAGTGCCAAGTGCATTACGCACACAAAATCTACAAAAA
TGCGTGATGGCAATGCTGACTAGAGATGAAAATTCATCATCATTTTTAACCGCACTTTGCGCACAATTAGAATGCAAAAC
CTTTAACGCTTTAGCGGATGCACTCAATTTATTGAGCGAGACGGAACGTTTACTCACGCAAACAAATCGCACAGCATTCA
CCCAATTACTCAAACCTGTTAATTGGCAGCCTTTATTAGACGAAATTTAA

Upstream 100 bases:

>100_bases
GGAATATAACATTCCAGTAAATATACTATTGAGCCTAAATCCACATTTAAAAAATGGCAAAGTTATTACAGGACAAAAAA
TAAAATTAAGAGAAAAATAA

Downstream 100 bases:

>100_bases
ATTCTTCATGAAACCAACCGCAATTTTTTTAATGGGCCCAACAGCCTCAGGTAAAACAGATTTAGCCATTCAACTACGAA
GCCAACTTCCAGTCGAAGTG

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 629; Mature: 628

Protein sequence:

>629_residues
MPIKILSPQLANQIAAGEVVERPASVVKELVENSLDAGANKIQIDIENGGANLIRIRDNGCGIPKEELSLALARHATSKI
ADLDDLEAILSLGFRGEALASISSVSRLTLTSRTEEQTEAWQVYAQGRDMETTIKPASHPVGTTVEVANLFFNTPARRKF
LRTDKTEFSHIDEVIRRIALTKFNTAFTLTHNGKIIRQYRPAEAINQQLKRVAAICGDDFVKNALRIEWKHDDLHLSGWV
ATPNFSRTQNDLSYCYINGRMVRDKVISHAIRQAYAQYLPTDAYPAFVLFIDLNPHDVDVNVHPTKHEVRFHQQRLIHDF
IYEGISHALNNQEQINWHTDQSAVENHEENTVREPQPNYSIRPNRATAGQNSFAPQYHEKPQQNQPHFSNTPMFPNHVST
GYRDYRSDAPSKTEQRLYAELLRTLPPTAQKDISDTAQQNISDTAKIISTEIIECSSHLRALSLIENRALLLQQNQDFFL
LSLEKLQRLQWQLALKQIQIEQQALLIPIVFRLTESQFQAWQQYSDDFKKIGFEFIENQAQLRLTLNKVPSALRTQNLQK
CVMAMLTRDENSSSFLTALCAQLECKTFNALADALNLLSETERLLTQTNRTAFTQLLKPVNWQPLLDEI

Sequences:

>Translated_629_residues
MPIKILSPQLANQIAAGEVVERPASVVKELVENSLDAGANKIQIDIENGGANLIRIRDNGCGIPKEELSLALARHATSKI
ADLDDLEAILSLGFRGEALASISSVSRLTLTSRTEEQTEAWQVYAQGRDMETTIKPASHPVGTTVEVANLFFNTPARRKF
LRTDKTEFSHIDEVIRRIALTKFNTAFTLTHNGKIIRQYRPAEAINQQLKRVAAICGDDFVKNALRIEWKHDDLHLSGWV
ATPNFSRTQNDLSYCYINGRMVRDKVISHAIRQAYAQYLPTDAYPAFVLFIDLNPHDVDVNVHPTKHEVRFHQQRLIHDF
IYEGISHALNNQEQINWHTDQSAVENHEENTVREPQPNYSIRPNRATAGQNSFAPQYHEKPQQNQPHFSNTPMFPNHVST
GYRDYRSDAPSKTEQRLYAELLRTLPPTAQKDISDTAQQNISDTAKIISTEIIECSSHLRALSLIENRALLLQQNQDFFL
LSLEKLQRLQWQLALKQIQIEQQALLIPIVFRLTESQFQAWQQYSDDFKKIGFEFIENQAQLRLTLNKVPSALRTQNLQK
CVMAMLTRDENSSSFLTALCAQLECKTFNALADALNLLSETERLLTQTNRTAFTQLLKPVNWQPLLDEI
>Mature_628_residues
PIKILSPQLANQIAAGEVVERPASVVKELVENSLDAGANKIQIDIENGGANLIRIRDNGCGIPKEELSLALARHATSKIA
DLDDLEAILSLGFRGEALASISSVSRLTLTSRTEEQTEAWQVYAQGRDMETTIKPASHPVGTTVEVANLFFNTPARRKFL
RTDKTEFSHIDEVIRRIALTKFNTAFTLTHNGKIIRQYRPAEAINQQLKRVAAICGDDFVKNALRIEWKHDDLHLSGWVA
TPNFSRTQNDLSYCYINGRMVRDKVISHAIRQAYAQYLPTDAYPAFVLFIDLNPHDVDVNVHPTKHEVRFHQQRLIHDFI
YEGISHALNNQEQINWHTDQSAVENHEENTVREPQPNYSIRPNRATAGQNSFAPQYHEKPQQNQPHFSNTPMFPNHVSTG
YRDYRSDAPSKTEQRLYAELLRTLPPTAQKDISDTAQQNISDTAKIISTEIIECSSHLRALSLIENRALLLQQNQDFFLL
SLEKLQRLQWQLALKQIQIEQQALLIPIVFRLTESQFQAWQQYSDDFKKIGFEFIENQAQLRLTLNKVPSALRTQNLQKC
VMAMLTRDENSSSFLTALCAQLECKTFNALADALNLLSETERLLTQTNRTAFTQLLKPVNWQPLLDEI

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=319, Percent_Identity=35.7366771159875, Blast_Score=212, Evalue=9e-55,
Organism=Homo sapiens, GI4505911, Length=309, Percent_Identity=31.3915857605178, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI189458898, Length=309, Percent_Identity=31.3915857605178, Blast_Score=146, Evalue=6e-35,
Organism=Homo sapiens, GI189458896, Length=305, Percent_Identity=30.8196721311475, Blast_Score=137, Evalue=4e-32,
Organism=Homo sapiens, GI4505913, Length=340, Percent_Identity=28.8235294117647, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI310128478, Length=344, Percent_Identity=28.7790697674419, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI263191589, Length=225, Percent_Identity=30.6666666666667, Blast_Score=118, Evalue=2e-26,
Organism=Homo sapiens, GI310128480, Length=297, Percent_Identity=25.9259259259259, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI91992160, Length=360, Percent_Identity=23.8888888888889, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI91992162, Length=360, Percent_Identity=23.8888888888889, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI263191733, Length=83, Percent_Identity=37.3493975903614, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI263191713, Length=83, Percent_Identity=37.3493975903614, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI1790612, Length=647, Percent_Identity=48.0680061823802, Blast_Score=562, Evalue=1e-161,
Organism=Caenorhabditis elegans, GI71991825, Length=326, Percent_Identity=33.4355828220859, Blast_Score=170, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17562796, Length=344, Percent_Identity=27.6162790697674, Blast_Score=127, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6323819, Length=352, Percent_Identity=36.3636363636364, Blast_Score=204, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6324247, Length=352, Percent_Identity=28.4090909090909, Blast_Score=123, Evalue=8e-29,
Organism=Saccharomyces cerevisiae, GI6323063, Length=355, Percent_Identity=27.0422535211268, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6325093, Length=439, Percent_Identity=23.9179954441913, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI17136968, Length=332, Percent_Identity=35.8433734939759, Blast_Score=201, Evalue=1e-51,
Organism=Drosophila melanogaster, GI17136970, Length=363, Percent_Identity=27.5482093663912, Blast_Score=120, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 71624; Mature: 71493

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIKILSPQLANQIAAGEVVERPASVVKELVENSLDAGANKIQIDIENGGANLIRIRDNG
CCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCC
CGIPKEELSLALARHATSKIADLDDLEAILSLGFRGEALASISSVSRLTLTSRTEEQTEA
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHH
WQVYAQGRDMETTIKPASHPVGTTVEVANLFFNTPARRKFLRTDKTEFSHIDEVIRRIAL
HHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHH
TKFNTAFTLTHNGKIIRQYRPAEAINQQLKRVAAICGDDFVKNALRIEWKHDDLHLSGWV
HHCCCEEEEEECCEEEEECCCHHHHHHHHHHHHHHHCCHHHCCCEEEEEECCCEEEEEEE
ATPNFSRTQNDLSYCYINGRMVRDKVISHAIRQAYAQYLPTDAYPAFVLFIDLNPHDVDV
ECCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEE
NVHPTKHEVRFHQQRLIHDFIYEGISHALNNQEQINWHTDQSAVENHEENTVREPQPNYS
EECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHCCCCCCCCCCCCCCC
IRPNRATAGQNSFAPQYHEKPQQNQPHFSNTPMFPNHVSTGYRDYRSDAPSKTEQRLYAE
CCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHH
LLRTLPPTAQKDISDTAQQNISDTAKIISTEIIECSSHLRALSLIENRALLLQQNQDFFL
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCCEEE
LSLEKLQRLQWQLALKQIQIEQQALLIPIVFRLTESQFQAWQQYSDDFKKIGFEFIENQA
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
QLRLTLNKVPSALRTQNLQKCVMAMLTRDENSSSFLTALCAQLECKTFNALADALNLLSE
HEEEEHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TERLLTQTNRTAFTQLLKPVNWQPLLDEI
HHHHHHHCCHHHHHHHHCCCCCCCHHHCC
>Mature Secondary Structure 
PIKILSPQLANQIAAGEVVERPASVVKELVENSLDAGANKIQIDIENGGANLIRIRDNG
CCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCC
CGIPKEELSLALARHATSKIADLDDLEAILSLGFRGEALASISSVSRLTLTSRTEEQTEA
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHH
WQVYAQGRDMETTIKPASHPVGTTVEVANLFFNTPARRKFLRTDKTEFSHIDEVIRRIAL
HHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHH
TKFNTAFTLTHNGKIIRQYRPAEAINQQLKRVAAICGDDFVKNALRIEWKHDDLHLSGWV
HHCCCEEEEEECCEEEEECCCHHHHHHHHHHHHHHHCCHHHCCCEEEEEECCCEEEEEEE
ATPNFSRTQNDLSYCYINGRMVRDKVISHAIRQAYAQYLPTDAYPAFVLFIDLNPHDVDV
ECCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEE
NVHPTKHEVRFHQQRLIHDFIYEGISHALNNQEQINWHTDQSAVENHEENTVREPQPNYS
EECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHCCCCCCCCCCCCCCC
IRPNRATAGQNSFAPQYHEKPQQNQPHFSNTPMFPNHVSTGYRDYRSDAPSKTEQRLYAE
CCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHH
LLRTLPPTAQKDISDTAQQNISDTAKIISTEIIECSSHLRALSLIENRALLLQQNQDFFL
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCCEEE
LSLEKLQRLQWQLALKQIQIEQQALLIPIVFRLTESQFQAWQQYSDDFKKIGFEFIENQA
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
QLRLTLNKVPSALRTQNLQKCVMAMLTRDENSSSFLTALCAQLECKTFNALADALNLLSE
HEEEEHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TERLLTQTNRTAFTQLLKPVNWQPLLDEI
HHHHHHHCCHHHHHHHHCCCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA