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The map label for this gene is tme [H]

Identifier: 99082717

GI number: 99082717

Start: 3046844

End: 3049099

Strand: Direct

Name: tme [H]

Synonym: TM1040_2877

Alternate gene names: 99082717

Gene position: 3046844-3049099 (Clockwise)

Preceding gene: 99082714

Following gene: 99082718

Centisome position: 95.19

GC content: 57.62

Gene sequence:

>2256_bases
ATGCCCAAAGCCAAGATTACCGATGAAGAGGCACTGGCCTTTCACTTGGAACCCAGCCCCGGTAAATGGGAGGTCACCGC
GACGGTTCCGATGACCACGCAGCGGGATCTGTCCTTGGCCTATAGCCCCGGTGTTGCGGTGCCTTGCGAAGCCATCGCTG
AAAACCCCGAAACCGCCTATGACTACACAAACAAGGGCAATCTTGTTGCGGTGATCTCCAATGGGACCGCCGTTCTGGGT
CTTGGCAACCTCGGCGCGCTGGGTTCAAAGCCCGTGATGGAAGGGAAATCGGTCCTCTTCAAACGCTTTGCAGATGTGAA
CTCGATCGACATCGAACTCGACACCGAGGACCCGGACGAATTCATCAAGGCGGTTAGACTGATGGGGCCGACCTTTGGCG
GCATCAACCTTGAGGACATCAAGGCGCCCGAGTGTTTCATCATCGAACAGAAGCTCAAGGAAGAGATGGACATTCCGGTC
TTCCATGACGACCAGCATGGCACCGCCGTGATCTGCGCCGCCGGTCTGATCAACGCGCTGCATTTATCGGGCAAGAAGAT
CGAAGATGTGCGGATTGTCCTCAATGGGGCAGGGGCGGCGGGCATTGCTTGTATTGAGCTCTTGAAATCCATGGGCGCGC
GGCACGAAAACTGCATCGTCTGCGACACCAAGGGCGTGATCTATCAGGGCCGTACCGAGGGGATGAACCAGTGGAAGTCA
GCGCATGCGGTGAAGACAGAACTGCGCTCGCTCGAAGAAGCCATGAATGGCGCGGATGTATTCCTTGGCGTTTCGGTCAA
AGGTGCGGTGACGCAGGACATGGTAAAATCCATGGCCGACAACCCGGTTATCTTTGCGATGGCAAACCCCGATCCGGAAA
TTACGCCCGAAGAGGCGCATGAGGTTCGCGTGGATGCGATCGTGGCGACGGGACGTTCGGACTATCCGAACCAGGTAAAC
AACGTTCTCGGCTTTCCTTATCTCTTCCGCGGAGCGCTCGATATTCATGCCCGGGCCATCAATGATGAGATGAAGATCGC
CTGCGCGCATGCTTTGGCGCGCCTTGCGCGCGAGGATGTGCCGGATGAGGTCGCGCTGGCCTATGGTAAATCCCTGTCCT
TTGGTCGCGACTACATCATCCCGACGCCCTTTGATCCACGCCTGATCCACCGCATTCCGCCAGCGGTTGCCAAGGCCGGC
ATGGATACTGGTGTAGCCCGTCGTCCGATCATCGATATGGACGCCTACGAACACGGTCTGCGCGGACGTATGGACCCGAC
GCAATCGATCTTGCGCGGTCTCAATGCACGCGCGCGTGCAGCGCAGTCGCGGATGATCTTCGCCGAAGGTGATGATCCAC
GCGTTCTGCGTGCAGCCGTCACCTATCAGCGCTCAGGATTTGGCAAGGCTCTGGTCGTGGGACGTCAGGACGACGTCAAA
GCCAAACTTGAAGAAGCGGGTCTGGGCGATGCCGTGCGTGAGCTGGAGGTCGTGAACGCCGCCAATACGCATCACTTTGA
AACCTATAAGGATTTCCTTTACGAGAGACTGAACCGCAAAGGGTTTGATCGCAAGGATATTCACCGTCTGGTGGGGCGTG
ATAGACATGTGTTCTCTGCGCTGATGCTTGCACATGGACATGGCGACGGTCTGGTTTCGGGCGCGACTCGCAAGTCTGCG
CATGTGCTCGACCGGATCAACCATGTGTTCGACGCAGATGCGGAACATGGTGCCGCTGGGGTCACGGCATTGCTTCACAA
GGGTCGCATTGTCTTGATCGGAGACACGCTCGTTCATGAATGGCCTGACGAGAATGACCTAGCCACCATTGCAGAGCGTG
CAGCTGGTGTGGCGCGCCACATGGGTCTTGATCCGCGTGTGGCCTTCGTCAGTTTTTCGACCTTCGGCTATCCGGTCTCG
GAGCGGGCGGAGAAGATGCATATTGCGCCAACCGTGCTTGATAAACGCGGTGTAGATTTTGAATACGAAGGCGAAATGAC
CGTAGATGTCGCCCTCAACGCCAAGGCGCAGGAGCATTATCCGTTCCAGCGCCTGTCTGGTCCGGCCAATATCCTGGTGG
TTCCGGCGCGTCACTCGGCATCGATCTCGGTGAAGCTGATGCAGGAGATGGGTGGTGCCACGGTTGTGGGTCCGATCCTT
TCGGGTGTCGACAAACCGATCCAGATCTGCTCCACCACCTCGACCGCAAATGACGTGCTGAACATGGCCGTTCTTGCGGC
CTGCAACATCGGTTGA

Upstream 100 bases:

>100_bases
TTGAAAGAAATGCAAAATAGTGAATTGTGAAAGCCGTGCATTGAGAGGTTTGGCTGGCTGAGATATGACAGTTTTCGACT
AGGAGAGGACGAAGACCGAC

Downstream 100 bases:

>100_bases
ACCAGAAGGGAGGCTGCTCATGGCGATCTGGAACCTTGGGTCGATCAACATCGACATGGTCTATTCGCTGCCGCATATGC
CGCAGCCGGGCGAGACGCTG

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 751; Mature: 750

Protein sequence:

>751_residues
MPKAKITDEEALAFHLEPSPGKWEVTATVPMTTQRDLSLAYSPGVAVPCEAIAENPETAYDYTNKGNLVAVISNGTAVLG
LGNLGALGSKPVMEGKSVLFKRFADVNSIDIELDTEDPDEFIKAVRLMGPTFGGINLEDIKAPECFIIEQKLKEEMDIPV
FHDDQHGTAVICAAGLINALHLSGKKIEDVRIVLNGAGAAGIACIELLKSMGARHENCIVCDTKGVIYQGRTEGMNQWKS
AHAVKTELRSLEEAMNGADVFLGVSVKGAVTQDMVKSMADNPVIFAMANPDPEITPEEAHEVRVDAIVATGRSDYPNQVN
NVLGFPYLFRGALDIHARAINDEMKIACAHALARLAREDVPDEVALAYGKSLSFGRDYIIPTPFDPRLIHRIPPAVAKAG
MDTGVARRPIIDMDAYEHGLRGRMDPTQSILRGLNARARAAQSRMIFAEGDDPRVLRAAVTYQRSGFGKALVVGRQDDVK
AKLEEAGLGDAVRELEVVNAANTHHFETYKDFLYERLNRKGFDRKDIHRLVGRDRHVFSALMLAHGHGDGLVSGATRKSA
HVLDRINHVFDADAEHGAAGVTALLHKGRIVLIGDTLVHEWPDENDLATIAERAAGVARHMGLDPRVAFVSFSTFGYPVS
ERAEKMHIAPTVLDKRGVDFEYEGEMTVDVALNAKAQEHYPFQRLSGPANILVVPARHSASISVKLMQEMGGATVVGPIL
SGVDKPIQICSTTSTANDVLNMAVLAACNIG

Sequences:

>Translated_751_residues
MPKAKITDEEALAFHLEPSPGKWEVTATVPMTTQRDLSLAYSPGVAVPCEAIAENPETAYDYTNKGNLVAVISNGTAVLG
LGNLGALGSKPVMEGKSVLFKRFADVNSIDIELDTEDPDEFIKAVRLMGPTFGGINLEDIKAPECFIIEQKLKEEMDIPV
FHDDQHGTAVICAAGLINALHLSGKKIEDVRIVLNGAGAAGIACIELLKSMGARHENCIVCDTKGVIYQGRTEGMNQWKS
AHAVKTELRSLEEAMNGADVFLGVSVKGAVTQDMVKSMADNPVIFAMANPDPEITPEEAHEVRVDAIVATGRSDYPNQVN
NVLGFPYLFRGALDIHARAINDEMKIACAHALARLAREDVPDEVALAYGKSLSFGRDYIIPTPFDPRLIHRIPPAVAKAG
MDTGVARRPIIDMDAYEHGLRGRMDPTQSILRGLNARARAAQSRMIFAEGDDPRVLRAAVTYQRSGFGKALVVGRQDDVK
AKLEEAGLGDAVRELEVVNAANTHHFETYKDFLYERLNRKGFDRKDIHRLVGRDRHVFSALMLAHGHGDGLVSGATRKSA
HVLDRINHVFDADAEHGAAGVTALLHKGRIVLIGDTLVHEWPDENDLATIAERAAGVARHMGLDPRVAFVSFSTFGYPVS
ERAEKMHIAPTVLDKRGVDFEYEGEMTVDVALNAKAQEHYPFQRLSGPANILVVPARHSASISVKLMQEMGGATVVGPIL
SGVDKPIQICSTTSTANDVLNMAVLAACNIG
>Mature_750_residues
PKAKITDEEALAFHLEPSPGKWEVTATVPMTTQRDLSLAYSPGVAVPCEAIAENPETAYDYTNKGNLVAVISNGTAVLGL
GNLGALGSKPVMEGKSVLFKRFADVNSIDIELDTEDPDEFIKAVRLMGPTFGGINLEDIKAPECFIIEQKLKEEMDIPVF
HDDQHGTAVICAAGLINALHLSGKKIEDVRIVLNGAGAAGIACIELLKSMGARHENCIVCDTKGVIYQGRTEGMNQWKSA
HAVKTELRSLEEAMNGADVFLGVSVKGAVTQDMVKSMADNPVIFAMANPDPEITPEEAHEVRVDAIVATGRSDYPNQVNN
VLGFPYLFRGALDIHARAINDEMKIACAHALARLAREDVPDEVALAYGKSLSFGRDYIIPTPFDPRLIHRIPPAVAKAGM
DTGVARRPIIDMDAYEHGLRGRMDPTQSILRGLNARARAAQSRMIFAEGDDPRVLRAAVTYQRSGFGKALVVGRQDDVKA
KLEEAGLGDAVRELEVVNAANTHHFETYKDFLYERLNRKGFDRKDIHRLVGRDRHVFSALMLAHGHGDGLVSGATRKSAH
VLDRINHVFDADAEHGAAGVTALLHKGRIVLIGDTLVHEWPDENDLATIAERAAGVARHMGLDPRVAFVSFSTFGYPVSE
RAEKMHIAPTVLDKRGVDFEYEGEMTVDVALNAKAQEHYPFQRLSGPANILVVPARHSASISVKLMQEMGGATVVGPILS
GVDKPIQICSTTSTANDVLNMAVLAACNIG

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=343, Percent_Identity=27.1137026239067, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI62420882, Length=405, Percent_Identity=25.679012345679, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI62420880, Length=405, Percent_Identity=25.679012345679, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI239049447, Length=405, Percent_Identity=25.679012345679, Blast_Score=84, Evalue=4e-16,
Organism=Escherichia coli, GI1788806, Length=744, Percent_Identity=47.4462365591398, Blast_Score=659, Evalue=0.0,
Organism=Escherichia coli, GI1788635, Length=320, Percent_Identity=26.5625, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1788800, Length=316, Percent_Identity=24.6835443037975, Blast_Score=87, Evalue=5e-18,
Organism=Escherichia coli, GI87081919, Length=327, Percent_Identity=25.0764525993884, Blast_Score=71, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17537199, Length=414, Percent_Identity=25.1207729468599, Blast_Score=77, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6322823, Length=268, Percent_Identity=27.6119402985075, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24646388, Length=401, Percent_Identity=28.428927680798, Blast_Score=91, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24646386, Length=401, Percent_Identity=27.930174563591, Blast_Score=90, Evalue=6e-18,
Organism=Drosophila melanogaster, GI281362674, Length=398, Percent_Identity=27.1356783919598, Blast_Score=87, Evalue=5e-17,
Organism=Drosophila melanogaster, GI281362672, Length=398, Percent_Identity=27.1356783919598, Blast_Score=87, Evalue=6e-17,
Organism=Drosophila melanogaster, GI21356279, Length=398, Percent_Identity=27.1356783919598, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI78707242, Length=415, Percent_Identity=25.3012048192771, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI78707238, Length=415, Percent_Identity=25.3012048192771, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI78707240, Length=352, Percent_Identity=26.4204545454545, Blast_Score=82, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 81324; Mature: 81193

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKAKITDEEALAFHLEPSPGKWEVTATVPMTTQRDLSLAYSPGVAVPCEAIAENPETAY
CCCCCCCCCCEEEEEECCCCCCEEEEEEECCCCCCCCEEEECCCCCCCHHHHHCCCCCCC
DYTNKGNLVAVISNGTAVLGLGNLGALGSKPVMEGKSVLFKRFADVNSIDIELDTEDPDE
CCCCCCCEEEEEECCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCHHH
FIKAVRLMGPTFGGINLEDIKAPECFIIEQKLKEEMDIPVFHDDQHGTAVICAAGLINAL
HHHHHHHHCCCCCCCCHHHCCCCCEEEEHHHHHHHCCCCEEECCCCCCEEEEHHHHHHHH
HLSGKKIEDVRIVLNGAGAAGIACIELLKSMGARHENCIVCDTKGVIYQGRTEGMNQWKS
HCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCEEEECCCCCEEECCHHHHHHHHH
AHAVKTELRSLEEAMNGADVFLGVSVKGAVTQDMVKSMADNPVIFAMANPDPEITPEEAH
HHHHHHHHHHHHHHCCCCEEEEEEEECCHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHH
EVRVDAIVATGRSDYPNQVNNVLGFPYLFRGALDIHARAINDEMKIACAHALARLAREDV
HEEEEEEEECCCCCCCHHHHHHCCCHHHHHCHHHHHHHHCCCHHHHHHHHHHHHHHHHCC
PDEVALAYGKSLSFGRDYIIPTPFDPRLIHRIPPAVAKAGMDTGVARRPIIDMDAYEHGL
CHHHHHHHCCCCCCCCCEECCCCCCCHHHHHCCHHHHHCCCCCCCCCCCEECCHHHHHCC
RGRMDPTQSILRGLNARARAAQSRMIFAEGDDPRVLRAAVTYQRSGFGKALVVGRQDDVK
CCCCCHHHHHHHCCCHHHHHHHCCEEEECCCCCCEEHHHHHHHHCCCCCEEEEECCCCHH
AKLEEAGLGDAVRELEVVNAANTHHFETYKDFLYERLNRKGFDRKDIHRLVGRDRHVFSA
HHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHH
LMLAHGHGDGLVSGATRKSAHVLDRINHVFDADAEHGAAGVTALLHKGRIVLIGDTLVHE
HHHHCCCCCCEECCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEEECHHHHC
WPDENDLATIAERAAGVARHMGLDPRVAFVSFSTFGYPVSERAEKMHIAPTVLDKRGVDF
CCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHEECCHHHHHCCCCCE
EYEGEMTVDVALNAKAQEHYPFQRLSGPANILVVPARHSASISVKLMQEMGGATVVGPIL
EECCCEEEEEEECCCCHHCCCHHHCCCCCCEEEEECCCCCCEEEEEHHHCCCCEEEHHHH
SGVDKPIQICSTTSTANDVLNMAVLAACNIG
HCCCCCCEEEECCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PKAKITDEEALAFHLEPSPGKWEVTATVPMTTQRDLSLAYSPGVAVPCEAIAENPETAY
CCCCCCCCCEEEEEECCCCCCEEEEEEECCCCCCCCEEEECCCCCCCHHHHHCCCCCCC
DYTNKGNLVAVISNGTAVLGLGNLGALGSKPVMEGKSVLFKRFADVNSIDIELDTEDPDE
CCCCCCCEEEEEECCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCHHH
FIKAVRLMGPTFGGINLEDIKAPECFIIEQKLKEEMDIPVFHDDQHGTAVICAAGLINAL
HHHHHHHHCCCCCCCCHHHCCCCCEEEEHHHHHHHCCCCEEECCCCCCEEEEHHHHHHHH
HLSGKKIEDVRIVLNGAGAAGIACIELLKSMGARHENCIVCDTKGVIYQGRTEGMNQWKS
HCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCEEEECCCCCEEECCHHHHHHHHH
AHAVKTELRSLEEAMNGADVFLGVSVKGAVTQDMVKSMADNPVIFAMANPDPEITPEEAH
HHHHHHHHHHHHHHCCCCEEEEEEEECCHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHH
EVRVDAIVATGRSDYPNQVNNVLGFPYLFRGALDIHARAINDEMKIACAHALARLAREDV
HEEEEEEEECCCCCCCHHHHHHCCCHHHHHCHHHHHHHHCCCHHHHHHHHHHHHHHHHCC
PDEVALAYGKSLSFGRDYIIPTPFDPRLIHRIPPAVAKAGMDTGVARRPIIDMDAYEHGL
CHHHHHHHCCCCCCCCCEECCCCCCCHHHHHCCHHHHHCCCCCCCCCCCEECCHHHHHCC
RGRMDPTQSILRGLNARARAAQSRMIFAEGDDPRVLRAAVTYQRSGFGKALVVGRQDDVK
CCCCCHHHHHHHCCCHHHHHHHCCEEEECCCCCCEEHHHHHHHHCCCCCEEEEECCCCHH
AKLEEAGLGDAVRELEVVNAANTHHFETYKDFLYERLNRKGFDRKDIHRLVGRDRHVFSA
HHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHH
LMLAHGHGDGLVSGATRKSAHVLDRINHVFDADAEHGAAGVTALLHKGRIVLIGDTLVHE
HHHHCCCCCCEECCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEEECHHHHC
WPDENDLATIAERAAGVARHMGLDPRVAFVSFSTFGYPVSERAEKMHIAPTVLDKRGVDF
CCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHEECCHHHHHCCCCCE
EYEGEMTVDVALNAKAQEHYPFQRLSGPANILVVPARHSASISVKLMQEMGGATVVGPIL
EECCCEEEEEEECCCCHHCCCHHHCCCCCCEEEEECCCCCCEEEEEHHHCCCCEEEHHHH
SGVDKPIQICSTTSTANDVLNMAVLAACNIG
HCCCCCCEEEECCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9535928; 11481430; 10407149 [H]