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The map label for this gene is folP-A [H]

Identifier: 99082146

GI number: 99082146

Start: 2424802

End: 2425797

Strand: Reverse

Name: folP-A [H]

Synonym: TM1040_2306

Alternate gene names: 99082146

Gene position: 2425797-2424802 (Counterclockwise)

Preceding gene: 99082147

Following gene: 99082145

Centisome position: 75.78

GC content: 63.05

Gene sequence:

>996_bases
GTGAGTTACTACCGCCCCCTGGTTCGTCATGGAGATGCGCGCCCCGAGGGCGCCATTCATCTCGCCGGCAGCGCGCTCTG
GTTCACTGAAGTCGAAGTTCTGGATCGCAGCGCGCCACCGCGTATCGTGCCAGCGGGCCTGTTGCCCGAAGAGATCAGGT
TTCGCCTGATGAGCCGCCGCGCAGCGATTGCAGGGCTCGACATGACGCAGCCGCAGATCATGGGCATCCTCAATGTGACC
CCGGACAGTTTCTCGGATGGCGGCCAGTTCGACGAAGTGGATGTCGCTTGCGATGCGGCGCTGCAGATGGTGGCGGATGG
GGCGTCGATCATCGACGTCGGCGGCGAGAGCACCCGCCCCGGCGCAGCAGAGGTCGAGGAGCTTGCAGAAATCACCCGCA
CCGCTCCGGTGATCGCCGCCATTCGCGACCAAAGCGATGTTGCGATCTCCATTGACACGCGCAAAGCCACCGTGGGCATG
GAAGCGCTGGAGGCGGGGGCATCACTCATCAATGATGTGTCGGGCTTTACGTTCGATGCGGCCCTGGCGCCGCTGGCGGC
ACAGGCCGGGGTTCCTGTCTGTGTGATGCATGCGCAGGGCGATCCCAAGACCATGCAGGACAATCCGCACTACGAAAACG
TGGTGCTCGACGTCTATGATTTCCTTGCCGCGCAGGTCGACCAGCTCGAGGCGATCGGGGTGCTGCGCGAGCAAATCGTG
ATTGATCCCGGTATCGGATTTGGCAAGACGGAGGCGCATAACCTGGCGCTCCTGCGCAATCTGAGCCTGTTTCACGGCAT
TGGTTGTCCGATCCTTCTGGGCGTGTCGCGCAAGGGATTCATCGGCGCGATTGGCAAAGAACCGCAAGCTGCACGCCGCG
CGCCCGGATCTATTGCCGTGGGGCTTGCGGGTTTTGCTCAAGGCGTGCAATTGCTACGGGTGCATGATGTGGCAGAGACG
GCGCAGGCGCTGCGCCTGTGGCAGGCCACACGATAG

Upstream 100 bases:

>100_bases
CTTCTACTTTCGAAGCAGAAGAAATGATCGTGATTGGCGCGGAGCTGCCGGAGAACCCCGGCGTGCCTCTGCGGGCCCAT
GCTGAGGAGCAACATACCCT

Downstream 100 bases:

>100_bases
AAAGAGATCACGGCAGCAGTTGGAATGTCCGGCGCTGCGCTGGGCAGGGGAGCAGCTTTGATGCGGAAACTCTTTGGAAC
CGATGGCGTGCGTGGCAAGG

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MSYYRPLVRHGDARPEGAIHLAGSALWFTEVEVLDRSAPPRIVPAGLLPEEIRFRLMSRRAAIAGLDMTQPQIMGILNVT
PDSFSDGGQFDEVDVACDAALQMVADGASIIDVGGESTRPGAAEVEELAEITRTAPVIAAIRDQSDVAISIDTRKATVGM
EALEAGASLINDVSGFTFDAALAPLAAQAGVPVCVMHAQGDPKTMQDNPHYENVVLDVYDFLAAQVDQLEAIGVLREQIV
IDPGIGFGKTEAHNLALLRNLSLFHGIGCPILLGVSRKGFIGAIGKEPQAARRAPGSIAVGLAGFAQGVQLLRVHDVAET
AQALRLWQATR

Sequences:

>Translated_331_residues
MSYYRPLVRHGDARPEGAIHLAGSALWFTEVEVLDRSAPPRIVPAGLLPEEIRFRLMSRRAAIAGLDMTQPQIMGILNVT
PDSFSDGGQFDEVDVACDAALQMVADGASIIDVGGESTRPGAAEVEELAEITRTAPVIAAIRDQSDVAISIDTRKATVGM
EALEAGASLINDVSGFTFDAALAPLAAQAGVPVCVMHAQGDPKTMQDNPHYENVVLDVYDFLAAQVDQLEAIGVLREQIV
IDPGIGFGKTEAHNLALLRNLSLFHGIGCPILLGVSRKGFIGAIGKEPQAARRAPGSIAVGLAGFAQGVQLLRVHDVAET
AQALRLWQATR
>Mature_330_residues
SYYRPLVRHGDARPEGAIHLAGSALWFTEVEVLDRSAPPRIVPAGLLPEEIRFRLMSRRAAIAGLDMTQPQIMGILNVTP
DSFSDGGQFDEVDVACDAALQMVADGASIIDVGGESTRPGAAEVEELAEITRTAPVIAAIRDQSDVAISIDTRKATVGME
ALEAGASLINDVSGFTFDAALAPLAAQAGVPVCVMHAQGDPKTMQDNPHYENVVLDVYDFLAAQVDQLEAIGVLREQIVI
DPGIGFGKTEAHNLALLRNLSLFHGIGCPILLGVSRKGFIGAIGKEPQAARRAPGSIAVGLAGFAQGVQLLRVHDVAETA
QALRLWQATR

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=265, Percent_Identity=46.0377358490566, Blast_Score=239, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6324073, Length=352, Percent_Identity=32.9545454545455, Blast_Score=166, Evalue=3e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 35057; Mature: 34926

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYYRPLVRHGDARPEGAIHLAGSALWFTEVEVLDRSAPPRIVPAGLLPEEIRFRLMSRR
CCCCHHHHHCCCCCCCCEEEECCCEEEHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHH
AAIAGLDMTQPQIMGILNVTPDSFSDGGQFDEVDVACDAALQMVADGASIIDVGGESTRP
HHHHCCCCCCHHHEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCC
GAAEVEELAEITRTAPVIAAIRDQSDVAISIDTRKATVGMEALEAGASLINDVSGFTFDA
CHHHHHHHHHHHHHCHHEEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCHHH
ALAPLAAQAGVPVCVMHAQGDPKTMQDNPHYENVVLDVYDFLAAQVDQLEAIGVLREQIV
HHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
IDPGIGFGKTEAHNLALLRNLSLFHGIGCPILLGVSRKGFIGAIGKEPQAARRAPGSIAV
ECCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCEECCCCCCHHHHCCCCCEEE
GLAGFAQGVQLLRVHDVAETAQALRLWQATR
EHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SYYRPLVRHGDARPEGAIHLAGSALWFTEVEVLDRSAPPRIVPAGLLPEEIRFRLMSRR
CCCHHHHHCCCCCCCCEEEECCCEEEHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHH
AAIAGLDMTQPQIMGILNVTPDSFSDGGQFDEVDVACDAALQMVADGASIIDVGGESTRP
HHHHCCCCCCHHHEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCC
GAAEVEELAEITRTAPVIAAIRDQSDVAISIDTRKATVGMEALEAGASLINDVSGFTFDA
CHHHHHHHHHHHHHCHHEEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCHHH
ALAPLAAQAGVPVCVMHAQGDPKTMQDNPHYENVVLDVYDFLAAQVDQLEAIGVLREQIV
HHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
IDPGIGFGKTEAHNLALLRNLSLFHGIGCPILLGVSRKGFIGAIGKEPQAARRAPGSIAV
ECCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCEECCCCCCHHHHCCCCCEEE
GLAGFAQGVQLLRVHDVAETAQALRLWQATR
EHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]