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The map label for this gene is nadA [H]

Identifier: 99082090

GI number: 99082090

Start: 2364425

End: 2365480

Strand: Reverse

Name: nadA [H]

Synonym: TM1040_2250

Alternate gene names: 99082090

Gene position: 2365480-2364425 (Counterclockwise)

Preceding gene: 99082094

Following gene: 99082089

Centisome position: 73.9

GC content: 59.94

Gene sequence:

>1056_bases
ATGTCGCTAGATATTCCCGTGCTGCGCAGTGAATTGTCTCAGCACTACGATCTCACTCCGAACCCCGAACTCGCAGAAGC
CATGTCTGATGTCTATCAGCGCATGTCGCGCGTGGTGTCGCCCGTCGATTGGGTGCTTTATGCGCCCTACGTCAAGGCCA
TCAATGAGCTCAAGGCCAAGCGCAACGCCGTGATCCTCGGCCACAACTACATGACGCCCGAGATCTTTCACGGCATCTCC
GACTTTGTGGGCGACAGTCTGCAGCTCGCGATCAAGGCGACCGAGGTCGAGGCCGATGTGATCGTGCAATGCGGCGTGCA
TTTCATGGCCGAAACCTCCAAGATCCTGAGCCCCTCCAAAACGGTGCTGATGCCCGACATGGATGCAGGGTGCAGCCTTG
CGGAGTCGATCACCGCCGAAGGGGTCGAGGAGATGCGCCGCCGTTACCCCGGCGCGCCGGTTGTGTCTTATGTGAACACC
ACCGCCGAGGTGAAAGCGGCCTCCGACATTTGCTGTACATCCTCCAACGCGGCCCAGATCGTCGGCGCAATGGAAAGCGA
CACGGTCATCATGACGCCGGATCAGTATCTGGCGCAGAATGTGGCCCGCGATGTGCCGCACAAGAACGTGGTCTGGTGGG
AAGGCTCCTGCATCGTGCATGAGCAATACACCGCCAAGGATCTGCGCGATTTCCGCGAATGGAACCCCGGCACCCGGCTG
ATCGCGCACCCCGAATGTCCGCCGGATGTGGTGGCAGAGGCCGATTTCTCCGGTTCCACCAGCGGCATCCTCAAATACGT
GACGGATGAGAAGCCGGAAAAGGCGCTCCTGATCACCGAGTGTTCAATGGCCTCGAACATTGCCGACGCATTGCCCGAAG
TCGAATTTGTCGGCCCCTGCAACATGTGCCCCTACATGAAGAAGATCACGCTGGAGAAAGTCCTCTGGTCGCTGCACTCC
ATGGAGGGTCAGGTCGAGGTCGAGCCCGAAATGGCCGCCAAGGCGCGACACGCGGTGCAGGCGATGATCGACCTGTCGCG
CAAGCTGGGCATCTAA

Upstream 100 bases:

>100_bases
TGTAACCGGGCGCAAGCGCGTGTGTGCAAACCCGTCCGATTTTTTGGTGCCGTTGCGATACGTCTGCGGCCCGCGACCAT
ATGAAGGGGAAAACCCAGCA

Downstream 100 bases:

>100_bases
GCGCAGCATGGAAAGCTCTCAGGACATCCAAAGCAACCGCATCGTCATCATCGGTGCGGGGCTGGGGGCGCTTTATGCGG
CGTTGACGCTCGCGCCGCGC

Product: quinolinate synthetase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MSLDIPVLRSELSQHYDLTPNPELAEAMSDVYQRMSRVVSPVDWVLYAPYVKAINELKAKRNAVILGHNYMTPEIFHGIS
DFVGDSLQLAIKATEVEADVIVQCGVHFMAETSKILSPSKTVLMPDMDAGCSLAESITAEGVEEMRRRYPGAPVVSYVNT
TAEVKAASDICCTSSNAAQIVGAMESDTVIMTPDQYLAQNVARDVPHKNVVWWEGSCIVHEQYTAKDLRDFREWNPGTRL
IAHPECPPDVVAEADFSGSTSGILKYVTDEKPEKALLITECSMASNIADALPEVEFVGPCNMCPYMKKITLEKVLWSLHS
MEGQVEVEPEMAAKARHAVQAMIDLSRKLGI

Sequences:

>Translated_351_residues
MSLDIPVLRSELSQHYDLTPNPELAEAMSDVYQRMSRVVSPVDWVLYAPYVKAINELKAKRNAVILGHNYMTPEIFHGIS
DFVGDSLQLAIKATEVEADVIVQCGVHFMAETSKILSPSKTVLMPDMDAGCSLAESITAEGVEEMRRRYPGAPVVSYVNT
TAEVKAASDICCTSSNAAQIVGAMESDTVIMTPDQYLAQNVARDVPHKNVVWWEGSCIVHEQYTAKDLRDFREWNPGTRL
IAHPECPPDVVAEADFSGSTSGILKYVTDEKPEKALLITECSMASNIADALPEVEFVGPCNMCPYMKKITLEKVLWSLHS
MEGQVEVEPEMAAKARHAVQAMIDLSRKLGI
>Mature_350_residues
SLDIPVLRSELSQHYDLTPNPELAEAMSDVYQRMSRVVSPVDWVLYAPYVKAINELKAKRNAVILGHNYMTPEIFHGISD
FVGDSLQLAIKATEVEADVIVQCGVHFMAETSKILSPSKTVLMPDMDAGCSLAESITAEGVEEMRRRYPGAPVVSYVNTT
AEVKAASDICCTSSNAAQIVGAMESDTVIMTPDQYLAQNVARDVPHKNVVWWEGSCIVHEQYTAKDLRDFREWNPGTRLI
AHPECPPDVVAEADFSGSTSGILKYVTDEKPEKALLITECSMASNIADALPEVEFVGPCNMCPYMKKITLEKVLWSLHSM
EGQVEVEPEMAAKARHAVQAMIDLSRKLGI

Specific function: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate [H]

COG id: COG0379

COG function: function code H; Quinolinate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the quinolinate synthase A family. Type 2 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786964, Length=321, Percent_Identity=30.8411214953271, Blast_Score=146, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003473
- InterPro:   IPR023066 [H]

Pfam domain/function: PF02445 NadA [H]

EC number: =2.5.1.72 [H]

Molecular weight: Translated: 38696; Mature: 38564

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLDIPVLRSELSQHYDLTPNPELAEAMSDVYQRMSRVVSPVDWVLYAPYVKAINELKAK
CCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
RNAVILGHNYMTPEIFHGISDFVGDSLQLAIKATEVEADVIVQCGVHFMAETSKILSPSK
CCEEEEECCCCCHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHCHHHHHHHHHHCCCCC
TVLMPDMDAGCSLAESITAEGVEEMRRRYPGAPVVSYVNTTAEVKAASDICCTSSNAAQI
EEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHCCCCEECCCCHHHH
VGAMESDTVIMTPDQYLAQNVARDVPHKNVVWWEGSCIVHEQYTAKDLRDFREWNPGTRL
EEECCCCEEEECCHHHHHHHHHHHCCCCCEEEECCCEEEECCCCHHHHHHHHHCCCCCEE
IAHPECPPDVVAEADFSGSTSGILKYVTDEKPEKALLITECSMASNIADALPEVEFVGPC
EECCCCCHHHHCCCCCCCCCHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHCCCCEECCCC
NMCPYMKKITLEKVLWSLHSMEGQVEVEPEMAAKARHAVQAMIDLSRKLGI
CCCHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SLDIPVLRSELSQHYDLTPNPELAEAMSDVYQRMSRVVSPVDWVLYAPYVKAINELKAK
CCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
RNAVILGHNYMTPEIFHGISDFVGDSLQLAIKATEVEADVIVQCGVHFMAETSKILSPSK
CCEEEEECCCCCHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHCHHHHHHHHHHCCCCC
TVLMPDMDAGCSLAESITAEGVEEMRRRYPGAPVVSYVNTTAEVKAASDICCTSSNAAQI
EEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHCCCCEECCCCHHHH
VGAMESDTVIMTPDQYLAQNVARDVPHKNVVWWEGSCIVHEQYTAKDLRDFREWNPGTRL
EEECCCCEEEECCHHHHHHHHHHHCCCCCEEEECCCEEEECCCCHHHHHHHHHCCCCCEE
IAHPECPPDVVAEADFSGSTSGILKYVTDEKPEKALLITECSMASNIADALPEVEFVGPC
EECCCCCHHHHCCCCCCCCCHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHCCCCEECCCC
NMCPYMKKITLEKVLWSLHSMEGQVEVEPEMAAKARHAVQAMIDLSRKLGI
CCCHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]