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The map label for this gene is hisC

Identifier: 99081941

GI number: 99081941

Start: 2206853

End: 2207941

Strand: Reverse

Name: hisC

Synonym: TM1040_2101

Alternate gene names: 99081941

Gene position: 2207941-2206853 (Counterclockwise)

Preceding gene: 99081942

Following gene: 99081940

Centisome position: 68.98

GC content: 62.44

Gene sequence:

>1089_bases
ATGACCCAAATCACGCCGCAACCCGGTATCATGGACATCGCGCTTTATCAGGGGGGCGCGGCCCACGTGGACGGGGTGAG
CAATGTGACCAAGCTTTCCTCAAATGAGAACCCGCTTGGGCCCAGCCCGGCCGCAGTTGAGGCTATGGCCGAAGCCGCAG
CCACGATGCATCGTTACCCAAGCTCCGATCATGCCACCTTGCGCGCCGCTATCGCCGAGACTCACGGGCTTGATGCCGAG
CGCATCATTTGCGGTGCCGGAAGCGACGAGATTATCGCCTTCCTGTGCCAGTGCTATGCCGGGCCCGGAGACGAGGTGCT
CTATACCGAGCATGGTTTTGCCATGTATCGCATCTCGGCGCTGGCCGCCGGGGCGACCCCGGTGGAGGTCAAGGAACGCG
AGCGTGTAACCGATGTGGATGCGCTCCTTGCGGGCTGCACGGCGCAGACCAAGCTGGTGTTTATCGCCAATCCCAACAAC
CCCACCGGCACGATGATCTCTGAGGCAGAGGTTGCCCGCCTCGCTGACGGTATCCCGGAGGATGCGATCCTCGTTCTGGA
CGGCGCTTATGCTGAATATGTCGAGGGGTTTGACGCAGGTGCTCAGCTGATCGCCGCGCGCCACAACGTCGTGATGACCC
GGACCTTTTCCAAGATCTACGGTCTTGGCGGTGCGCGGGTGGGATGGGCCTATGGCCCACAGGAAATCATCGATGTCCTG
AACCGTGTGCGCGGGCCGTTCAATGTTTCGACAACGGCGCTTGCAGGCGCTGAGGCTGCCGTGCGTGACACTGACTATGT
GCAGCGCTGTCGCCTTGAGAATGCCAAATGGCGAGGCTGGCTGGCGGATCAGCTGGCAGAACTCGGGGTGCCCTCGGATA
CCTCCTGCACCAATTTCATTCTGGCGCGGTTTGCCTCGCAATCCGAGGCCGAGTCCTGTGATGATTTCCTCAAGCAGCGC
GGGCTGATCGTGCGTCGGGTCGCGGGCTACAACCTGCCCACCGCGCTGCGGATCACCATCGGGGATGAGACCGCCTGTCG
TGCGGTGGCCGCAGCGGTGAAGGACTTTAAGGCCGGGGCGGCAGAATGA

Upstream 100 bases:

>100_bases
CGCGCTCCAAAGCGCTGATCCGGTTGCTCACGCAGTTGCGCCTTTTCCCATCGCGCTCTTGGCGTTATGAGGAACAGGTT
CGCCAAGGAGCTCAGACGAT

Downstream 100 bases:

>100_bases
GCGAGATCACCGCCAAGCCCGTCTACAACCGCGTGGCGCTGATCGGTCTTGGGCTGATTGCCTCGTCGATGTTCTGGGCC
ATCAAACGCGCAGGCCTTGC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 362; Mature: 361

Protein sequence:

>362_residues
MTQITPQPGIMDIALYQGGAAHVDGVSNVTKLSSNENPLGPSPAAVEAMAEAAATMHRYPSSDHATLRAAIAETHGLDAE
RIICGAGSDEIIAFLCQCYAGPGDEVLYTEHGFAMYRISALAAGATPVEVKERERVTDVDALLAGCTAQTKLVFIANPNN
PTGTMISEAEVARLADGIPEDAILVLDGAYAEYVEGFDAGAQLIAARHNVVMTRTFSKIYGLGGARVGWAYGPQEIIDVL
NRVRGPFNVSTTALAGAEAAVRDTDYVQRCRLENAKWRGWLADQLAELGVPSDTSCTNFILARFASQSEAESCDDFLKQR
GLIVRRVAGYNLPTALRITIGDETACRAVAAAVKDFKAGAAE

Sequences:

>Translated_362_residues
MTQITPQPGIMDIALYQGGAAHVDGVSNVTKLSSNENPLGPSPAAVEAMAEAAATMHRYPSSDHATLRAAIAETHGLDAE
RIICGAGSDEIIAFLCQCYAGPGDEVLYTEHGFAMYRISALAAGATPVEVKERERVTDVDALLAGCTAQTKLVFIANPNN
PTGTMISEAEVARLADGIPEDAILVLDGAYAEYVEGFDAGAQLIAARHNVVMTRTFSKIYGLGGARVGWAYGPQEIIDVL
NRVRGPFNVSTTALAGAEAAVRDTDYVQRCRLENAKWRGWLADQLAELGVPSDTSCTNFILARFASQSEAESCDDFLKQR
GLIVRRVAGYNLPTALRITIGDETACRAVAAAVKDFKAGAAE
>Mature_361_residues
TQITPQPGIMDIALYQGGAAHVDGVSNVTKLSSNENPLGPSPAAVEAMAEAAATMHRYPSSDHATLRAAIAETHGLDAER
IICGAGSDEIIAFLCQCYAGPGDEVLYTEHGFAMYRISALAAGATPVEVKERERVTDVDALLAGCTAQTKLVFIANPNNP
TGTMISEAEVARLADGIPEDAILVLDGAYAEYVEGFDAGAQLIAARHNVVMTRTFSKIYGLGGARVGWAYGPQEIIDVLN
RVRGPFNVSTTALAGAEAAVRDTDYVQRCRLENAKWRGWLADQLAELGVPSDTSCTNFILARFASQSEAESCDDFLKQRG
LIVRRVAGYNLPTALRITIGDETACRAVAAAVKDFKAGAAE

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=321, Percent_Identity=29.2834890965732, Blast_Score=105, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6322075, Length=341, Percent_Identity=26.3929618768328, Blast_Score=103, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_SILST (Q1GET3)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_614095.1
- ProteinModelPortal:   Q1GET3
- SMR:   Q1GET3
- STRING:   Q1GET3
- GeneID:   4077852
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_2101
- NMPDR:   fig|292414.1.peg.468
- eggNOG:   COG0079
- HOGENOM:   HBG646350
- OMA:   NPANILC
- ProtClustDB:   PRK02731
- BioCyc:   SSP292414:TM1040_2101-MONOMER
- HAMAP:   MF_01023
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 38384; Mature: 38252

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQITPQPGIMDIALYQGGAAHVDGVSNVTKLSSNENPLGPSPAAVEAMAEAAATMHRYP
CCCCCCCCCCEEEEEECCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
SSDHATLRAAIAETHGLDAERIICGAGSDEIIAFLCQCYAGPGDEVLYTEHGFAMYRISA
CCCCHHHHHHHHHHHCCCHHEEEECCCCHHHHHHHHHHHCCCCCCEEEECCCCEEEEHHH
LAAGATPVEVKERERVTDVDALLAGCTAQTKLVFIANPNNPTGTMISEAEVARLADGIPE
HHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCEEHHHHHHHHHCCCCC
DAILVLDGAYAEYVEGFDAGAQLIAARHNVVMTRTFSKIYGLGGARVGWAYGPQEIIDVL
CEEEEEECHHHHHHHHHCHHHHHHHHHCCEEEEEHHHHHHCCCCCCCCCCCCHHHHHHHH
NRVRGPFNVSTTALAGAEAAVRDTDYVQRCRLENAKWRGWLADQLAELGVPSDTSCTNFI
HHCCCCCCCCHHHHCCCHHHHCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCHHHHH
LARFASQSEAESCDDFLKQRGLIVRRVAGYNLPTALRITIGDETACRAVAAAVKDFKAGA
HHHHHCCCCHHHHHHHHHHCCCEEEHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCC
AE
CC
>Mature Secondary Structure 
TQITPQPGIMDIALYQGGAAHVDGVSNVTKLSSNENPLGPSPAAVEAMAEAAATMHRYP
CCCCCCCCCEEEEEECCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
SSDHATLRAAIAETHGLDAERIICGAGSDEIIAFLCQCYAGPGDEVLYTEHGFAMYRISA
CCCCHHHHHHHHHHHCCCHHEEEECCCCHHHHHHHHHHHCCCCCCEEEECCCCEEEEHHH
LAAGATPVEVKERERVTDVDALLAGCTAQTKLVFIANPNNPTGTMISEAEVARLADGIPE
HHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCEEHHHHHHHHHCCCCC
DAILVLDGAYAEYVEGFDAGAQLIAARHNVVMTRTFSKIYGLGGARVGWAYGPQEIIDVL
CEEEEEECHHHHHHHHHCHHHHHHHHHCCEEEEEHHHHHHCCCCCCCCCCCCHHHHHHHH
NRVRGPFNVSTTALAGAEAAVRDTDYVQRCRLENAKWRGWLADQLAELGVPSDTSCTNFI
HHCCCCCCCCHHHHCCCHHHHCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCHHHHH
LARFASQSEAESCDDFLKQRGLIVRRVAGYNLPTALRITIGDETACRAVAAAVKDFKAGA
HHHHHCCCCHHHHHHHHHHCCCEEEHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCC
AE
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA