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The map label for this gene is gor [H]

Identifier: 99081797

GI number: 99081797

Start: 2061345

End: 2062700

Strand: Reverse

Name: gor [H]

Synonym: TM1040_1957

Alternate gene names: 99081797

Gene position: 2062700-2061345 (Counterclockwise)

Preceding gene: 99081798

Following gene: 99081796

Centisome position: 64.44

GC content: 60.32

Gene sequence:

>1356_bases
ATGAGCTTTGATTACGATCTATTTGTCATTGGAGGTGGCTCCGGTGGGGTGCGCGCGGCGCGGGTTGCCGCGGCAGGCGG
CGCATCGGTGGCGCTGGCCGAAGAGGACCGCTATGGCGGCACCTGCGTCATCCGGGGCTGTGTCCCCAAAAAGCTGATGG
TCTTTGCGTCGGAATACTCCGGTATGGTCGAAGACGGCCGCGCCTATGGCTGGGATCTGGAGAACAAGGGCTTTGATTGG
GATCACTTCAAGCAGAAGCTCAACACCGAGCTGGACCGCCTTGAGGGGATCTATCGCAACCTTCTGAAGAACTCCGGCGT
GGAGAGCTTTGATGCGCGCGCCAAACTTGCCGATGCCCATACGGTTGAATTGTCGGACGGGACGCGCAAGACCGCCAAAC
ACATCCTGATTGCCACCGGCGGCCGTCCTTGGGTGCCGGAGTTTCCGGGGTCGGAGCTGGCGATCACCTCGAACGAGATG
TTCCATCTCGAGAAGCTCCCCGAGAGCATTCTCATCGTGGGGGGCGGCTATATTGCCTCAGAATTTGCGGGCATCATGAA
TGGTCTTGGCGTCAAGACCACGCAGTACTACCGCGGCGCCCAGATCCTGCGTGGTTTTGATGACGAGGCACGCGGCCTTG
TGGCGCAGGAGATGATCCAGTCCGGCATCGATCTCAAGCTCGGAACCAACGTGCTGGAGATGCGCCGCGAGGGCGACAAG
ATCTGGGTCAAGGCCACCAATGGCGACGAGGGGCTGTTCGATCAGGTGATGTTTGCCACCGGACGCAAACCCAATGCCGA
CAACCTCGGGCTGGAGGAGCTGGGCATCGCGCGTGGCAGGGGCGGCGAGATCGAGGTGGATCAATACAGCCAGACAGCTG
TGCCGTCGGTCTATGCCATCGGCGATGTGACCGACCGGGTGAACCTCACACCGGTGGCGATCCGCGAGGGCATGGCCTTT
GTGGAAACCGTGTTCAACGGCAACCCCACCAGCCCCGATCACGATCTGATCCCGACCGCTATTTTCACGCAGCCAGAGAT
GGGCACCGTTGGCCTCAGCGAAGAAGAAGCGGCCAAACAGGAAACCATCGAGGTCTACGCGACCTCTTTCAAACCGATGC
AGCAGAGCTTTGCCGGGCGGGCGCAGAGAGTGCTCATGAAGCTGATCGTGAGTCAGGCGACCCGCAAGGTGCTGGGCTGT
CACATTGTCGCACCGGGCGCCGGTGAGATGATCCAATTGGCGGGGATTGCCGTAAAAATGGGGGCAACCAAGGAAGATTT
CGACCGCACTGTTGCGGTTCACCCGACCATGTCGGAAGAATTGGTGACGCTAAAAACCCCTGTGCGGACGATCTGA

Upstream 100 bases:

>100_bases
GCATCTGTTTGAAAACGCCGACCTGAGCCCCACTTGCGAGTCTGGCAATTCACCGCGCGCTGTGGGATACCTCGCGCAAG
ATATAAGAAGGGCGACGCAT

Downstream 100 bases:

>100_bases
ACCAATTTCAGAGTTTGGTCGCGACGCTGATCTTGAATTTCAGCGCCGTGACCACAGGTTACAGGGCAATATCCGCTGTA
TCAGCGGGGAGAGATGGATA

Product: NADPH-glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MSFDYDLFVIGGGSGGVRAARVAAAGGASVALAEEDRYGGTCVIRGCVPKKLMVFASEYSGMVEDGRAYGWDLENKGFDW
DHFKQKLNTELDRLEGIYRNLLKNSGVESFDARAKLADAHTVELSDGTRKTAKHILIATGGRPWVPEFPGSELAITSNEM
FHLEKLPESILIVGGGYIASEFAGIMNGLGVKTTQYYRGAQILRGFDDEARGLVAQEMIQSGIDLKLGTNVLEMRREGDK
IWVKATNGDEGLFDQVMFATGRKPNADNLGLEELGIARGRGGEIEVDQYSQTAVPSVYAIGDVTDRVNLTPVAIREGMAF
VETVFNGNPTSPDHDLIPTAIFTQPEMGTVGLSEEEAAKQETIEVYATSFKPMQQSFAGRAQRVLMKLIVSQATRKVLGC
HIVAPGAGEMIQLAGIAVKMGATKEDFDRTVAVHPTMSEELVTLKTPVRTI

Sequences:

>Translated_451_residues
MSFDYDLFVIGGGSGGVRAARVAAAGGASVALAEEDRYGGTCVIRGCVPKKLMVFASEYSGMVEDGRAYGWDLENKGFDW
DHFKQKLNTELDRLEGIYRNLLKNSGVESFDARAKLADAHTVELSDGTRKTAKHILIATGGRPWVPEFPGSELAITSNEM
FHLEKLPESILIVGGGYIASEFAGIMNGLGVKTTQYYRGAQILRGFDDEARGLVAQEMIQSGIDLKLGTNVLEMRREGDK
IWVKATNGDEGLFDQVMFATGRKPNADNLGLEELGIARGRGGEIEVDQYSQTAVPSVYAIGDVTDRVNLTPVAIREGMAF
VETVFNGNPTSPDHDLIPTAIFTQPEMGTVGLSEEEAAKQETIEVYATSFKPMQQSFAGRAQRVLMKLIVSQATRKVLGC
HIVAPGAGEMIQLAGIAVKMGATKEDFDRTVAVHPTMSEELVTLKTPVRTI
>Mature_450_residues
SFDYDLFVIGGGSGGVRAARVAAAGGASVALAEEDRYGGTCVIRGCVPKKLMVFASEYSGMVEDGRAYGWDLENKGFDWD
HFKQKLNTELDRLEGIYRNLLKNSGVESFDARAKLADAHTVELSDGTRKTAKHILIATGGRPWVPEFPGSELAITSNEMF
HLEKLPESILIVGGGYIASEFAGIMNGLGVKTTQYYRGAQILRGFDDEARGLVAQEMIQSGIDLKLGTNVLEMRREGDKI
WVKATNGDEGLFDQVMFATGRKPNADNLGLEELGIARGRGGEIEVDQYSQTAVPSVYAIGDVTDRVNLTPVAIREGMAFV
ETVFNGNPTSPDHDLIPTAIFTQPEMGTVGLSEEEAAKQETIEVYATSFKPMQQSFAGRAQRVLMKLIVSQATRKVLGCH
IVAPGAGEMIQLAGIAVKMGATKEDFDRTVAVHPTMSEELVTLKTPVRTI

Specific function: Maintains High Levels Of Reduced Glutathione In The Cytosol. [C]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=460, Percent_Identity=40.6521739130435, Blast_Score=311, Evalue=9e-85,
Organism=Homo sapiens, GI22035672, Length=476, Percent_Identity=38.4453781512605, Blast_Score=265, Evalue=8e-71,
Organism=Homo sapiens, GI148277065, Length=434, Percent_Identity=33.8709677419355, Blast_Score=232, Evalue=6e-61,
Organism=Homo sapiens, GI33519430, Length=434, Percent_Identity=33.8709677419355, Blast_Score=232, Evalue=6e-61,
Organism=Homo sapiens, GI33519428, Length=434, Percent_Identity=33.8709677419355, Blast_Score=232, Evalue=6e-61,
Organism=Homo sapiens, GI33519426, Length=434, Percent_Identity=33.8709677419355, Blast_Score=232, Evalue=6e-61,
Organism=Homo sapiens, GI148277071, Length=434, Percent_Identity=33.8709677419355, Blast_Score=231, Evalue=7e-61,
Organism=Homo sapiens, GI291045266, Length=476, Percent_Identity=34.0336134453782, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI91199540, Length=462, Percent_Identity=32.2510822510823, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI291045268, Length=473, Percent_Identity=31.5010570824524, Blast_Score=187, Evalue=1e-47,
Organism=Escherichia coli, GI1789915, Length=431, Percent_Identity=38.9791183294664, Blast_Score=291, Evalue=7e-80,
Organism=Escherichia coli, GI1786307, Length=452, Percent_Identity=29.2035398230088, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI87082354, Length=467, Percent_Identity=28.9079229122056, Blast_Score=156, Evalue=3e-39,
Organism=Escherichia coli, GI87081717, Length=456, Percent_Identity=25.6578947368421, Blast_Score=131, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI71983419, Length=453, Percent_Identity=38.6313465783664, Blast_Score=268, Evalue=3e-72,
Organism=Caenorhabditis elegans, GI71983429, Length=453, Percent_Identity=38.6313465783664, Blast_Score=268, Evalue=4e-72,
Organism=Caenorhabditis elegans, GI17557007, Length=477, Percent_Identity=33.9622641509434, Blast_Score=250, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI71982272, Length=479, Percent_Identity=33.8204592901879, Blast_Score=233, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI32565766, Length=454, Percent_Identity=31.057268722467, Blast_Score=188, Evalue=5e-48,
Organism=Saccharomyces cerevisiae, GI6325166, Length=461, Percent_Identity=37.527114967462, Blast_Score=284, Evalue=2e-77,
Organism=Saccharomyces cerevisiae, GI6321091, Length=461, Percent_Identity=30.1518438177874, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6325240, Length=474, Percent_Identity=24.8945147679325, Blast_Score=134, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24640553, Length=476, Percent_Identity=36.1344537815126, Blast_Score=256, Evalue=3e-68,
Organism=Drosophila melanogaster, GI24640549, Length=476, Percent_Identity=36.1344537815126, Blast_Score=255, Evalue=4e-68,
Organism=Drosophila melanogaster, GI24640551, Length=476, Percent_Identity=36.1344537815126, Blast_Score=255, Evalue=4e-68,
Organism=Drosophila melanogaster, GI17737741, Length=478, Percent_Identity=33.8912133891213, Blast_Score=244, Evalue=8e-65,
Organism=Drosophila melanogaster, GI21358499, Length=464, Percent_Identity=32.9741379310345, Blast_Score=214, Evalue=7e-56,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006324
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 48852; Mature: 48721

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFDYDLFVIGGGSGGVRAARVAAAGGASVALAEEDRYGGTCVIRGCVPKKLMVFASEYS
CCCCEEEEEEECCCCCCEEEEEEECCCCEEEEECCCCCCCEEEEECCCCHHHHHHHHHHC
GMVEDGRAYGWDLENKGFDWDHFKQKLNTELDRLEGIYRNLLKNSGVESFDARAKLADAH
CCHHCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHECCCCE
TVELSDGTRKTAKHILIATGGRPWVPEFPGSELAITSNEMFHLEKLPESILIVGGGYIAS
EEEECCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCHHHHHCCCEEEEEECCHHHH
EFAGIMNGLGVKTTQYYRGAQILRGFDDEARGLVAQEMIQSGIDLKLGTNVLEMRREGDK
HHHHHHHCCCCCCHHHHCCHHHHCCCCHHHHHHHHHHHHHCCCCEEECCHHHHHHCCCCE
IWVKATNGDEGLFDQVMFATGRKPNADNLGLEELGIARGRGGEIEVDQYSQTAVPSVYAI
EEEEECCCCCCHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCEEEECCCCCCCCCCEEEE
GDVTDRVNLTPVAIREGMAFVETVFNGNPTSPDHDLIPTAIFTQPEMGTVGLSEEEAAKQ
CCCCCCCCCCHHHHHHCHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCHHHHHHH
ETIEVYATSFKPMQQSFAGRAQRVLMKLIVSQATRKVLGCHIVAPGAGEMIQLAGIAVKM
HEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCEEEEEEEEEEE
GATKEDFDRTVAVHPTMSEELVTLKTPVRTI
CCCHHHHCCEEEECCCCCCCEEEECCCCCCC
>Mature Secondary Structure 
SFDYDLFVIGGGSGGVRAARVAAAGGASVALAEEDRYGGTCVIRGCVPKKLMVFASEYS
CCCEEEEEEECCCCCCEEEEEEECCCCEEEEECCCCCCCEEEEECCCCHHHHHHHHHHC
GMVEDGRAYGWDLENKGFDWDHFKQKLNTELDRLEGIYRNLLKNSGVESFDARAKLADAH
CCHHCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHECCCCE
TVELSDGTRKTAKHILIATGGRPWVPEFPGSELAITSNEMFHLEKLPESILIVGGGYIAS
EEEECCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCHHHHHCCCEEEEEECCHHHH
EFAGIMNGLGVKTTQYYRGAQILRGFDDEARGLVAQEMIQSGIDLKLGTNVLEMRREGDK
HHHHHHHCCCCCCHHHHCCHHHHCCCCHHHHHHHHHHHHHCCCCEEECCHHHHHHCCCCE
IWVKATNGDEGLFDQVMFATGRKPNADNLGLEELGIARGRGGEIEVDQYSQTAVPSVYAI
EEEEECCCCCCHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCEEEECCCCCCCCCCEEEE
GDVTDRVNLTPVAIREGMAFVETVFNGNPTSPDHDLIPTAIFTQPEMGTVGLSEEEAAKQ
CCCCCCCCCCHHHHHHCHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCHHHHHHH
ETIEVYATSFKPMQQSFAGRAQRVLMKLIVSQATRKVLGCHIVAPGAGEMIQLAGIAVKM
HEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCEEEEEEEEEEE
GATKEDFDRTVAVHPTMSEELVTLKTPVRTI
CCCHHHHCCEEEECCCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7538273 [H]