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The map label for this gene is ydhC [H]

Identifier: 99081719

GI number: 99081719

Start: 1976745

End: 1977938

Strand: Direct

Name: ydhC [H]

Synonym: TM1040_1878

Alternate gene names: 99081719

Gene position: 1976745-1977938 (Clockwise)

Preceding gene: 99081708

Following gene: 99081720

Centisome position: 61.76

GC content: 62.06

Gene sequence:

>1194_bases
GTGACACGCAGCACCCCACCGACCATCTGGACCCTGATCCTGCTCTCCGGCCTCTCTGCCCTTGGCATGAACATCTTTCA
GCCGTCCCTGCCTGGTATGGCGGCCTATTTTGGGGTCGAGTATCGCCTGATCGCGCTTTCGGTGCCGTTTTACCTGGCCG
CAAGCACGGTGATCCAGATCGTTGTCGGGCCGATTTCGGACAAGATGGGCCGCCGTCCGGTGATGATGGTCTCCTTGCTG
CTGTTTCTGCTGGCCACGCTGGGCTGTATTTTTGCAACCACGGCCGAGGTGTTTCTCGCTTTTCGGATGGCGCAGGCGGT
GGTGGCCACCTGTATGGTATTGAGCCGCGCCGCGGTGCGCGACATGTATGAAGGGCCCAAGGCCGCGAGCATGATCGGCT
ATGTCACCATGGGGATGACGGTGGTACCGATGGTGGGTCCGGCACTTGGCGGGATCTTGGATCAGGCCTTTGGCTGGCAC
GCAAACTTCTGGCTGCTCTTTGCCACCGCGGCGGTGACGCTGGTGATTTTCTACGCCGATTTCGGCGAGACCGCGACGGC
GAGCGGCAAGCCGTTGATCGCACAGTTTCGCGAATACCCAGCACTGCTGCGCTCGCCCCGCTTCTGGGGCTACTCGCTCG
CGGCGGGCCTGTCGTCAGGTAGCTTCTTTGCCTACCTCGGCGGCAGCCCTTTTGTGGGCACCAATGTCTATGGGCTCAAC
AGTGCAGAACTCGGGATCTATTTCTCCGCGCCTGCGGTGGGCTATTTCCTCGGCAATTTCCTCTCCGGACGGTACTCGGA
GCGCTTTGGCATCAACACGATGGTGTTCTGGGGCGCGATCGTGAACATCTTTGGCGTCGGGCTTTCGCTCAGCATTACGC
TTGCGGGCATGGACACGGTGTGGACCTTCTTTGGACTGATGTGTTTTGTCGGCCTTGGCAACGGCATGGCGATCCCCAAT
GGCACCACCGGTGCGATCAGCGTCCGCCCGCATCTGGCCGGCACAGCGGCGGGACTGTCCTCGGCGATCATGATCGGCGC
CGGTGCGGCGCTGTCGGCCACGGCCAGCTGGCTCCTGGTGCCCGGCTCCAATGCCGCACCTCTGCTTGAGATCATGTTTG
CCAGCGGTTGCCTTGGGTTGGTGGCCATTCTTTACGTGATGCGGCGCGAACGCCAGCTTGGGCTTGCGGCCTGA

Upstream 100 bases:

>100_bases
AGGTGAAGCGCGTCTAGATTGTACCCTTCGGGCAGCAATGTTGGACAAGCCGCCCGCCGCAGCCTAAACGGTTAACACGC
AAACTAAACCGAGACGTATA

Downstream 100 bases:

>100_bases
GATCGGAACGCCCCGACTGAACATAAAGTGTTTCGCTTCGGGCTTTGCCCGAAGCGACCCGCGCGCAAGCGCGCCCCGGT
AGGGGCGCGCTTGCGCGCTT

Product: Bcr/CflA subfamily drug resistance transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 397; Mature: 396

Protein sequence:

>397_residues
MTRSTPPTIWTLILLSGLSALGMNIFQPSLPGMAAYFGVEYRLIALSVPFYLAASTVIQIVVGPISDKMGRRPVMMVSLL
LFLLATLGCIFATTAEVFLAFRMAQAVVATCMVLSRAAVRDMYEGPKAASMIGYVTMGMTVVPMVGPALGGILDQAFGWH
ANFWLLFATAAVTLVIFYADFGETATASGKPLIAQFREYPALLRSPRFWGYSLAAGLSSGSFFAYLGGSPFVGTNVYGLN
SAELGIYFSAPAVGYFLGNFLSGRYSERFGINTMVFWGAIVNIFGVGLSLSITLAGMDTVWTFFGLMCFVGLGNGMAIPN
GTTGAISVRPHLAGTAAGLSSAIMIGAGAALSATASWLLVPGSNAAPLLEIMFASGCLGLVAILYVMRRERQLGLAA

Sequences:

>Translated_397_residues
MTRSTPPTIWTLILLSGLSALGMNIFQPSLPGMAAYFGVEYRLIALSVPFYLAASTVIQIVVGPISDKMGRRPVMMVSLL
LFLLATLGCIFATTAEVFLAFRMAQAVVATCMVLSRAAVRDMYEGPKAASMIGYVTMGMTVVPMVGPALGGILDQAFGWH
ANFWLLFATAAVTLVIFYADFGETATASGKPLIAQFREYPALLRSPRFWGYSLAAGLSSGSFFAYLGGSPFVGTNVYGLN
SAELGIYFSAPAVGYFLGNFLSGRYSERFGINTMVFWGAIVNIFGVGLSLSITLAGMDTVWTFFGLMCFVGLGNGMAIPN
GTTGAISVRPHLAGTAAGLSSAIMIGAGAALSATASWLLVPGSNAAPLLEIMFASGCLGLVAILYVMRRERQLGLAA
>Mature_396_residues
TRSTPPTIWTLILLSGLSALGMNIFQPSLPGMAAYFGVEYRLIALSVPFYLAASTVIQIVVGPISDKMGRRPVMMVSLLL
FLLATLGCIFATTAEVFLAFRMAQAVVATCMVLSRAAVRDMYEGPKAASMIGYVTMGMTVVPMVGPALGGILDQAFGWHA
NFWLLFATAAVTLVIFYADFGETATASGKPLIAQFREYPALLRSPRFWGYSLAAGLSSGSFFAYLGGSPFVGTNVYGLNS
AELGIYFSAPAVGYFLGNFLSGRYSERFGINTMVFWGAIVNIFGVGLSLSITLAGMDTVWTFFGLMCFVGLGNGMAIPNG
TTGAISVRPHLAGTAAGLSSAIMIGAGAALSATASWLLVPGSNAAPLLEIMFASGCLGLVAILYVMRRERQLGLAA

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI48994889, Length=393, Percent_Identity=27.4809160305344, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI1788509, Length=403, Percent_Identity=25.3101736972705, Blast_Score=111, Evalue=9e-26,
Organism=Escherichia coli, GI87082312, Length=341, Percent_Identity=30.4985337243402, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1787065, Length=272, Percent_Identity=26.1029411764706, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1790146, Length=227, Percent_Identity=25.1101321585903, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790794, Length=286, Percent_Identity=24.1258741258741, Blast_Score=69, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 41819; Mature: 41688

Theoretical pI: Translated: 9.04; Mature: 9.04

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRSTPPTIWTLILLSGLSALGMNIFQPSLPGMAAYFGVEYRLIALSVPFYLAASTVIQI
CCCCCCHHHHHHHHHHHHHHHCHHHCCCCCCCHHHHHCCEEEEEEEECHHHHHHHHHHHH
VVGPISDKMGRRPVMMVSLLLFLLATLGCIFATTAEVFLAFRMAQAVVATCMVLSRAAVR
HCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DMYEGPKAASMIGYVTMGMTVVPMVGPALGGILDQAFGWHANFWLLFATAAVTLVIFYAD
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEC
FGETATASGKPLIAQFREYPALLRSPRFWGYSLAAGLSSGSFFAYLGGSPFVGTNVYGLN
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCEEEEECCCCCCCCEEECCC
SAELGIYFSAPAVGYFLGNFLSGRYSERFGINTMVFWGAIVNIFGVGLSLSITLAGMDTV
CCCEEEEECCCHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHCCEEEEEEEECHHHH
WTFFGLMCFVGLGNGMAIPNGTTGAISVRPHLAGTAAGLSSAIMIGAGAALSATASWLLV
HHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHEECCCHHHCCCCEEEE
PGSNAAPLLEIMFASGCLGLVAILYVMRRERQLGLAA
ECCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TRSTPPTIWTLILLSGLSALGMNIFQPSLPGMAAYFGVEYRLIALSVPFYLAASTVIQI
CCCCCHHHHHHHHHHHHHHHCHHHCCCCCCCHHHHHCCEEEEEEEECHHHHHHHHHHHH
VVGPISDKMGRRPVMMVSLLLFLLATLGCIFATTAEVFLAFRMAQAVVATCMVLSRAAVR
HCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DMYEGPKAASMIGYVTMGMTVVPMVGPALGGILDQAFGWHANFWLLFATAAVTLVIFYAD
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEC
FGETATASGKPLIAQFREYPALLRSPRFWGYSLAAGLSSGSFFAYLGGSPFVGTNVYGLN
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCEEEEECCCCCCCCEEECCC
SAELGIYFSAPAVGYFLGNFLSGRYSERFGINTMVFWGAIVNIFGVGLSLSITLAGMDTV
CCCEEEEECCCHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHCCEEEEEEEECHHHH
WTFFGLMCFVGLGNGMAIPNGTTGAISVRPHLAGTAAGLSSAIMIGAGAALSATASWLLV
HHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHEECCCHHHCCCCEEEE
PGSNAAPLLEIMFASGCLGLVAILYVMRRERQLGLAA
ECCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]