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The map label for this gene is yeiA [H]

Identifier: 99081341

GI number: 99081341

Start: 1606078

End: 1607382

Strand: Reverse

Name: yeiA [H]

Synonym: TM1040_1500

Alternate gene names: 99081341

Gene position: 1607382-1606078 (Counterclockwise)

Preceding gene: 99081342

Following gene: 99081339

Centisome position: 50.22

GC content: 58.7

Gene sequence:

>1305_bases
ATGGCTGATCTTACAACAGAATTCCTCGGTATCAAATCGCCGAATCCTTTCTGGCTGGCCTCCGCGCCGCCCACCGACAA
AGAATATAACGTGCGCCGCGCCTTTGAGGCGGGCTGGGGCGGTGTGGTCTGGAAGACCCTCGGCGCCGAAGGGCCACCGG
TTGTCAACGTGAACGGGCCGCGGTATGGCGCGATCTGGGGGGCGGACCGCCGTCTTCTGGGGCTCAACAACATCGAACTG
ATCACGGATCGCCCGCTGGATGTGAACCTCGAGGAGATGACCCGCGTCAAAAAGGACTACCCGGATCGCGCGCTGATTGC
GTCGATCATGGTGCCCTGTGAAGAGGCGGCTTGGAAAGCGATCCTGCCGCGTGTGGCGGAAACAGGATGTGACGGGATCG
AGCTCAACTTTGGCTGCCCGCATGGGATGGCCGAGCGCGGCATGGGTTCTGCTGTGGGGCAGGTTCCGGAATACATTCAG
ATGGTCACCGAATGGTGCAAACAGTATTATGACAAGCCGGTGATCGTGAAGCTCACGCCCAATATCACCGACATTCGTCA
TCCGGCGCGGGCCGCGAAGGCCGGCAATGCCGATGCTGTGTCTCTGATCAACACCATCAATTCGATCACCTCGGTCAACC
TTGATGCAATGTCGCCCGAACCGATGATTGGCGGCAAGGGCACCCATGGCGGCTATTGCGGCCCGGCGGTGAAACCGATC
GCCATGAATATGGTGGCCGAAATTTCCCGCGATCCGCAAACCGCAGGTCTGCCTATTTCCGCCATTGGCGGCGTGACAAC
ATGGCGCGATGCGGCGGAGTTCATCGCTCTTGGGGCTGGCAATGTGCAGGTTTGCACGGCGGCCATGACCTATGGGTTCA
AGGTCGTTGAAGAGATGATTTCGGGCCTGTCGGATTGGATGGACGAGAAGGGCTATTCCTCGATCGAGGACTTCCGTGGC
ATGGCGGTTCCGAATGTGACCGACTGGCAGTATCTGGACCTCAACTATGTGACCAAGGCCAAGATCTCTCAGGATGACTG
CATCAAATGCGGACGTTGCTATGCGGCCTGCGAGGATACCTCGCATCAGGCGATTGAGATGTCGGCGGATCGGACCTTTA
CCGTGAAGGACGACGAATGCGTGGCGTGTAACCTGTGCGTCAACGTCTGTCCGGTTGAAGGCTGTATCACCATGGAAGAG
GTTGCCGTGGGCGCCATTGATGAACGCACCGGCAAGGTGGTGAGCGGCGAATATGGCAACTGGACCCAGCACCCTAATAA
TCCGTCTGCAACGGCTGCGGAATAA

Upstream 100 bases:

>100_bases
GCGGCCGAAGATATCCACGCAAGCCTGATGGGCTGAAGCCGCTATGCGCCGCTCCCCCAGGTGGGGCGGCTTGCATAGTT
AGCAAATAGGGAGAGATCAA

Downstream 100 bases:

>100_bases
ACAAAAAAGGGCGGGGGCGCTCCCGCCCGTTGCGGATGCCGGTCTGAAACCGGCACCCGCTCCCCTTGGGCCAAGCGCCG
CGCGTTGCGCGGCGCTCTAT

Product: dihydropyrimidine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MADLTTEFLGIKSPNPFWLASAPPTDKEYNVRRAFEAGWGGVVWKTLGAEGPPVVNVNGPRYGAIWGADRRLLGLNNIEL
ITDRPLDVNLEEMTRVKKDYPDRALIASIMVPCEEAAWKAILPRVAETGCDGIELNFGCPHGMAERGMGSAVGQVPEYIQ
MVTEWCKQYYDKPVIVKLTPNITDIRHPARAAKAGNADAVSLINTINSITSVNLDAMSPEPMIGGKGTHGGYCGPAVKPI
AMNMVAEISRDPQTAGLPISAIGGVTTWRDAAEFIALGAGNVQVCTAAMTYGFKVVEEMISGLSDWMDEKGYSSIEDFRG
MAVPNVTDWQYLDLNYVTKAKISQDDCIKCGRCYAACEDTSHQAIEMSADRTFTVKDDECVACNLCVNVCPVEGCITMEE
VAVGAIDERTGKVVSGEYGNWTQHPNNPSATAAE

Sequences:

>Translated_434_residues
MADLTTEFLGIKSPNPFWLASAPPTDKEYNVRRAFEAGWGGVVWKTLGAEGPPVVNVNGPRYGAIWGADRRLLGLNNIEL
ITDRPLDVNLEEMTRVKKDYPDRALIASIMVPCEEAAWKAILPRVAETGCDGIELNFGCPHGMAERGMGSAVGQVPEYIQ
MVTEWCKQYYDKPVIVKLTPNITDIRHPARAAKAGNADAVSLINTINSITSVNLDAMSPEPMIGGKGTHGGYCGPAVKPI
AMNMVAEISRDPQTAGLPISAIGGVTTWRDAAEFIALGAGNVQVCTAAMTYGFKVVEEMISGLSDWMDEKGYSSIEDFRG
MAVPNVTDWQYLDLNYVTKAKISQDDCIKCGRCYAACEDTSHQAIEMSADRTFTVKDDECVACNLCVNVCPVEGCITMEE
VAVGAIDERTGKVVSGEYGNWTQHPNNPSATAAE
>Mature_433_residues
ADLTTEFLGIKSPNPFWLASAPPTDKEYNVRRAFEAGWGGVVWKTLGAEGPPVVNVNGPRYGAIWGADRRLLGLNNIELI
TDRPLDVNLEEMTRVKKDYPDRALIASIMVPCEEAAWKAILPRVAETGCDGIELNFGCPHGMAERGMGSAVGQVPEYIQM
VTEWCKQYYDKPVIVKLTPNITDIRHPARAAKAGNADAVSLINTINSITSVNLDAMSPEPMIGGKGTHGGYCGPAVKPIA
MNMVAEISRDPQTAGLPISAIGGVTTWRDAAEFIALGAGNVQVCTAAMTYGFKVVEEMISGLSDWMDEKGYSSIEDFRGM
AVPNVTDWQYLDLNYVTKAKISQDDCIKCGRCYAACEDTSHQAIEMSADRTFTVKDDECVACNLCVNVCPVEGCITMEEV
AVGAIDERTGKVVSGEYGNWTQHPNNPSATAAE

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=337, Percent_Identity=36.4985163204748, Blast_Score=219, Evalue=4e-57,
Organism=Escherichia coli, GI87082059, Length=400, Percent_Identity=42.5, Blast_Score=330, Evalue=1e-91,
Organism=Caenorhabditis elegans, GI71984108, Length=333, Percent_Identity=37.5375375375375, Blast_Score=217, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6322633, Length=326, Percent_Identity=28.8343558282209, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24640763, Length=316, Percent_Identity=38.2911392405063, Blast_Score=218, Evalue=5e-57,
Organism=Drosophila melanogaster, GI18858217, Length=316, Percent_Identity=38.2911392405063, Blast_Score=218, Evalue=5e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR012285 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: NA

Molecular weight: Translated: 46918; Mature: 46787

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADLTTEFLGIKSPNPFWLASAPPTDKEYNVRRAFEAGWGGVVWKTLGAEGPPVVNVNGP
CCCCCCHHHCCCCCCCEEEECCCCCCCCCCHHHHHHCCCCCHHHHHCCCCCCCEEEECCC
RYGAIWGADRRLLGLNNIELITDRPLDVNLEEMTRVKKDYPDRALIASIMVPCEEAAWKA
CEEEEECCCCEEECCCCEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHH
ILPRVAETGCDGIELNFGCPHGMAERGMGSAVGQVPEYIQMVTEWCKQYYDKPVIVKLTP
HHHHHHHCCCCCEEEECCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
NITDIRHPARAAKAGNADAVSLINTINSITSVNLDAMSPEPMIGGKGTHGGYCGPAVKPI
CHHHHCCCHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
AMNMVAEISRDPQTAGLPISAIGGVTTWRDAAEFIALGAGNVQVCTAAMTYGFKVVEEMI
HHHHHHHHCCCCCCCCCCHHHHCCCHHHHHHHHHHEECCCCCEEHHHHHHHHHHHHHHHH
SGLSDWMDEKGYSSIEDFRGMAVPNVTDWQYLDLNYVTKAKISQDDCIKCGRCYAACEDT
HHHHHHHHHCCCCHHHHHCCCCCCCCCCCEEEECCEEEECCCCHHHHHHHCCHHHHCCCC
SHQAIEMSADRTFTVKDDECVACNLCVNVCPVEGCITMEEVAVGAIDERTGKVVSGEYGN
CCCEEEECCCCEEEECCCCEEEEEEEEEECCCCCCEEHHHHHHCCHHHCCCCEEECCCCC
WTQHPNNPSATAAE
CCCCCCCCCCCCCC
>Mature Secondary Structure 
ADLTTEFLGIKSPNPFWLASAPPTDKEYNVRRAFEAGWGGVVWKTLGAEGPPVVNVNGP
CCCCCHHHCCCCCCCEEEECCCCCCCCCCHHHHHHCCCCCHHHHHCCCCCCCEEEECCC
RYGAIWGADRRLLGLNNIELITDRPLDVNLEEMTRVKKDYPDRALIASIMVPCEEAAWKA
CEEEEECCCCEEECCCCEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHH
ILPRVAETGCDGIELNFGCPHGMAERGMGSAVGQVPEYIQMVTEWCKQYYDKPVIVKLTP
HHHHHHHCCCCCEEEECCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
NITDIRHPARAAKAGNADAVSLINTINSITSVNLDAMSPEPMIGGKGTHGGYCGPAVKPI
CHHHHCCCHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
AMNMVAEISRDPQTAGLPISAIGGVTTWRDAAEFIALGAGNVQVCTAAMTYGFKVVEEMI
HHHHHHHHCCCCCCCCCCHHHHCCCHHHHHHHHHHEECCCCCEEHHHHHHHHHHHHHHHH
SGLSDWMDEKGYSSIEDFRGMAVPNVTDWQYLDLNYVTKAKISQDDCIKCGRCYAACEDT
HHHHHHHHHCCCCHHHHHCCCCCCCCCCCEEEECCEEEECCCCHHHHHHHCCHHHHCCCC
SHQAIEMSADRTFTVKDDECVACNLCVNVCPVEGCITMEEVAVGAIDERTGKVVSGEYGN
CCCEEEECCCCEEEECCCCEEEEEEEEEECCCCCCEEHHHHHHCCHHHCCCCEEECCCCC
WTQHPNNPSATAAE
CCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 1719366 [H]