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The map label for this gene is fumC [H]

Identifier: 99081293

GI number: 99081293

Start: 1550169

End: 1551566

Strand: Direct

Name: fumC [H]

Synonym: TM1040_1452

Alternate gene names: 99081293

Gene position: 1550169-1551566 (Clockwise)

Preceding gene: 99081291

Following gene: 99081294

Centisome position: 48.43

GC content: 60.8

Gene sequence:

>1398_bases
ATGTCGAACACCCGCACCGAAACCGACAGCTTTGGCCCGCTTGAGGTCCCTTCCGACAAATACTGGGGGGCGCAGACTCA
GCGTTCGATCATGAACTTTCCCATTGGCTGGGAAAAACAGCCTGTCGCCATCGTGCGCGCGCTTGGCGTGATCAAGAAGG
CCTGCGCCATGGCCAACAAAGCTTCGGGCAAGCTGGACGCCAAGATCGCAGATGCGGTGATCCAGGCCGCAGGCGAAGTG
GTTGAGGGCAAGTTCGACGACAACTTCCCGCTCGTGGTCTGGCAGACCGGGTCCGGCACCCAGTCCAACATGAACTCCAA
CGAGGTGATCGCCAACCGCGCGATCGAGATCCTCGGCGGCGTCATTGGCTCCAAAGATCCAGTCCACCCGAACGATCACT
GCAACATGGGGCAGTCCTCCAACGACACGTTCCCGACTGCCATGCATATCGCCACCGCAATGTCCGTGCGCGACGTGTTG
GTGCCGGGCCTCACGAAACTGGCCGAGGGGCTGGAAGCCAAGGCCGAGGAATTCAAAGACATCATCAAGATCGGCCGCAC
CCACACGCAGGATGCAACGCCGCTCACACTGGGTCAGGAATTCGGCGGCTACGCGCATCAGATCCGTCAGGGTCTGGCCC
GGGTTGAGGCTGCAATGCCCGGCATCTACGAGCTGGCACAGGGCGGCACCGCAGTTGGCACCGGTCTCAATACCGTAGAA
GGCTGGGGCGAGGAAGTCGCTGCAAACATGGCAGAAATCACCGGTTTGCCGTTTGTGACCGCGCCCAACAAGTTCGAAGC
CCTCGCAGCGCATGACGCGATGGTTTTCCTCTCTGGCGCGCTCGCGACCATCGCTGGCAGCTGCTACAAGATCGCCAACG
ACATTCGGTTCCTCGGCTCTGGCCCGCGCTCCGGTCTGGGCGAGCTGATCCTGCCAGAGAACGAACCCGGCTCTTCGATC
ATGCCGGGCAAAGTGAACCCGACCCAGGCCGAGGCGCTCACTCAGGTGGCAGCACATGTCATGGGCAATGACGCCGCGAT
CAAATTTGCGGGCTCTCAGGGTCACTTTGAACTGAACGTCTACAACCCGATGATGTCCTATAACCTCTTGCAGTCCATCC
AGCTCCTCGGCGACGCGGCCGACAGCTTTACCGAGCGGATGCTGAGCGGCATTCAGGCCAACGAGCCGCGCATCGACAAG
CTGATGAAAGAAAGCCTGATGCTGGTGACCGCGCTGGCACCGACCATCGGCTACGACAACGCCACCACGGTCGCCAAGAC
CGCGCATAAAAACGGCACCACCCTCAAGGAAGAGGCGATCAAACTCGGCTTTGTGGACGAAGAGACCTTTGACAAGGTTG
TCCGCCCCGAGCAGATGATCGGCCCCAAGGCGAAGTGA

Upstream 100 bases:

>100_bases
TCAGAACAATTGCGTCGCGCCGCCAGCAGGGGTAAACGGCATACATCAGTATACCACTTGAATGTTCCAAGTGGCCGAAC
CAGCGACGGAGACAGACACG

Downstream 100 bases:

>100_bases
TGGGAAAACCGGTAAACCTGAACCGGTTCAGAAAAGAAAAAGTGCGGGCCGAGAAAAAGGCCCGCGCTGACCAAAATGCT
GTGAAATTCGGCCGCAGCAA

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MSNTRTETDSFGPLEVPSDKYWGAQTQRSIMNFPIGWEKQPVAIVRALGVIKKACAMANKASGKLDAKIADAVIQAAGEV
VEGKFDDNFPLVVWQTGSGTQSNMNSNEVIANRAIEILGGVIGSKDPVHPNDHCNMGQSSNDTFPTAMHIATAMSVRDVL
VPGLTKLAEGLEAKAEEFKDIIKIGRTHTQDATPLTLGQEFGGYAHQIRQGLARVEAAMPGIYELAQGGTAVGTGLNTVE
GWGEEVAANMAEITGLPFVTAPNKFEALAAHDAMVFLSGALATIAGSCYKIANDIRFLGSGPRSGLGELILPENEPGSSI
MPGKVNPTQAEALTQVAAHVMGNDAAIKFAGSQGHFELNVYNPMMSYNLLQSIQLLGDAADSFTERMLSGIQANEPRIDK
LMKESLMLVTALAPTIGYDNATTVAKTAHKNGTTLKEEAIKLGFVDEETFDKVVRPEQMIGPKAK

Sequences:

>Translated_465_residues
MSNTRTETDSFGPLEVPSDKYWGAQTQRSIMNFPIGWEKQPVAIVRALGVIKKACAMANKASGKLDAKIADAVIQAAGEV
VEGKFDDNFPLVVWQTGSGTQSNMNSNEVIANRAIEILGGVIGSKDPVHPNDHCNMGQSSNDTFPTAMHIATAMSVRDVL
VPGLTKLAEGLEAKAEEFKDIIKIGRTHTQDATPLTLGQEFGGYAHQIRQGLARVEAAMPGIYELAQGGTAVGTGLNTVE
GWGEEVAANMAEITGLPFVTAPNKFEALAAHDAMVFLSGALATIAGSCYKIANDIRFLGSGPRSGLGELILPENEPGSSI
MPGKVNPTQAEALTQVAAHVMGNDAAIKFAGSQGHFELNVYNPMMSYNLLQSIQLLGDAADSFTERMLSGIQANEPRIDK
LMKESLMLVTALAPTIGYDNATTVAKTAHKNGTTLKEEAIKLGFVDEETFDKVVRPEQMIGPKAK
>Mature_464_residues
SNTRTETDSFGPLEVPSDKYWGAQTQRSIMNFPIGWEKQPVAIVRALGVIKKACAMANKASGKLDAKIADAVIQAAGEVV
EGKFDDNFPLVVWQTGSGTQSNMNSNEVIANRAIEILGGVIGSKDPVHPNDHCNMGQSSNDTFPTAMHIATAMSVRDVLV
PGLTKLAEGLEAKAEEFKDIIKIGRTHTQDATPLTLGQEFGGYAHQIRQGLARVEAAMPGIYELAQGGTAVGTGLNTVEG
WGEEVAANMAEITGLPFVTAPNKFEALAAHDAMVFLSGALATIAGSCYKIANDIRFLGSGPRSGLGELILPENEPGSSIM
PGKVNPTQAEALTQVAAHVMGNDAAIKFAGSQGHFELNVYNPMMSYNLLQSIQLLGDAADSFTERMLSGIQANEPRIDKL
MKESLMLVTALAPTIGYDNATTVAKTAHKNGTTLKEEAIKLGFVDEETFDKVVRPEQMIGPKAK

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=461, Percent_Identity=68.3297180043384, Blast_Score=631, Evalue=0.0,
Organism=Homo sapiens, GI266458395, Length=66, Percent_Identity=53.030303030303, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1787896, Length=461, Percent_Identity=56.6160520607375, Blast_Score=524, Evalue=1e-150,
Organism=Escherichia coli, GI87082375, Length=467, Percent_Identity=39.4004282655246, Blast_Score=330, Evalue=1e-91,
Organism=Caenorhabditis elegans, GI17553882, Length=465, Percent_Identity=66.6666666666667, Blast_Score=634, Evalue=0.0,
Organism=Caenorhabditis elegans, GI32565146, Length=328, Percent_Identity=67.3780487804878, Blast_Score=452, Evalue=1e-127,
Organism=Saccharomyces cerevisiae, GI6324993, Length=464, Percent_Identity=64.4396551724138, Blast_Score=606, Evalue=1e-174,
Organism=Drosophila melanogaster, GI24640179, Length=462, Percent_Identity=64.7186147186147, Blast_Score=617, Evalue=1e-177,
Organism=Drosophila melanogaster, GI24640177, Length=462, Percent_Identity=64.7186147186147, Blast_Score=617, Evalue=1e-177,
Organism=Drosophila melanogaster, GI78710009, Length=463, Percent_Identity=61.5550755939525, Blast_Score=593, Evalue=1e-169,
Organism=Drosophila melanogaster, GI24662684, Length=463, Percent_Identity=59.6112311015119, Blast_Score=570, Evalue=1e-163,
Organism=Drosophila melanogaster, GI24583245, Length=465, Percent_Identity=52.6881720430108, Blast_Score=499, Evalue=1e-141,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 49472; Mature: 49341

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNTRTETDSFGPLEVPSDKYWGAQTQRSIMNFPIGWEKQPVAIVRALGVIKKACAMANK
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
ASGKLDAKIADAVIQAAGEVVEGKFDDNFPLVVWQTGSGTQSNMNSNEVIANRAIEILGG
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHH
VIGSKDPVHPNDHCNMGQSSNDTFPTAMHIATAMSVRDVLVPGLTKLAEGLEAKAEEFKD
HHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIKIGRTHTQDATPLTLGQEFGGYAHQIRQGLARVEAAMPGIYELAQGGTAVGTGLNTVE
HHHHCCCCCCCCCCEEHHHHHCHHHHHHHHHHHHHHHHCCCHHHHHCCCCEECCCCCHHH
GWGEEVAANMAEITGLPFVTAPNKFEALAAHDAMVFLSGALATIAGSCYKIANDIRFLGS
HHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GPRSGLGELILPENEPGSSIMPGKVNPTQAEALTQVAAHVMGNDAAIKFAGSQGHFELNV
CCCCCCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEE
YNPMMSYNLLQSIQLLGDAADSFTERMLSGIQANEPRIDKLMKESLMLVTALAPTIGYDN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
ATTVAKTAHKNGTTLKEEAIKLGFVDEETFDKVVRPEQMIGPKAK
CHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHHHCCCHHHCCCCCC
>Mature Secondary Structure 
SNTRTETDSFGPLEVPSDKYWGAQTQRSIMNFPIGWEKQPVAIVRALGVIKKACAMANK
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
ASGKLDAKIADAVIQAAGEVVEGKFDDNFPLVVWQTGSGTQSNMNSNEVIANRAIEILGG
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHH
VIGSKDPVHPNDHCNMGQSSNDTFPTAMHIATAMSVRDVLVPGLTKLAEGLEAKAEEFKD
HHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIKIGRTHTQDATPLTLGQEFGGYAHQIRQGLARVEAAMPGIYELAQGGTAVGTGLNTVE
HHHHCCCCCCCCCCEEHHHHHCHHHHHHHHHHHHHHHHCCCHHHHHCCCCEECCCCCHHH
GWGEEVAANMAEITGLPFVTAPNKFEALAAHDAMVFLSGALATIAGSCYKIANDIRFLGS
HHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GPRSGLGELILPENEPGSSIMPGKVNPTQAEALTQVAAHVMGNDAAIKFAGSQGHFELNV
CCCCCCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEE
YNPMMSYNLLQSIQLLGDAADSFTERMLSGIQANEPRIDKLMKESLMLVTALAPTIGYDN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
ATTVAKTAHKNGTTLKEEAIKLGFVDEETFDKVVRPEQMIGPKAK
CHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHHHCCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]