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The map label for this gene is iscS [H]

Identifier: 99081082

GI number: 99081082

Start: 1335882

End: 1336925

Strand: Direct

Name: iscS [H]

Synonym: TM1040_1241

Alternate gene names: 99081082

Gene position: 1335882-1336925 (Clockwise)

Preceding gene: 99081081

Following gene: 99081083

Centisome position: 41.73

GC content: 61.97

Gene sequence:

>1044_bases
ATGACTCGTGTTTATTTAGATCATAACGCCACATCGCCCCTGCGCCACGACGCGCGGGCAGCGATGATCGCGGCCATGGA
TGTGTGCGGCAACCCGTCGTCGGTGCACGCCGAAGGACGCGCGGCCAAGGCCGTGGTGGAGCGTGCCCGGGCCCAGATTG
CAGCGGCCTTTGGCGCCGACGGGGCAGACATCGTGTTTACCTCGGGTTCGACCGAGGGAGCCGCACTTGCGTTGATGGGG
CGTGATCTACACGGATCCGCGCTTGAGCATGACGCTGTAAGGGCTTGGATCAAAGAGGATCTTACAGTTGAGGCTCAGGG
TCGTGTCGCGGTTTTGGACCCGCAGAGTTCCTGTCTTCAGCTTGCCAACTCGGAAACCGGCGTCATCCAGGATCTGCCCG
AAGGGCTTGCGGTCACGGATGCCACGCAGGCCTTTGGAAAGCTGCCGGTCGCCTTCAATTGGATGGGCGCGACGATGGCG
CTCATCTCGGCGCACAAGCTCGGTGGACCCAAGGGTGTCGGGGCGGTTGTGCTGAAGCGCGGGACGGATTTGGCCGCGCA
GATCAAGGGTGGCGGCCAGGAGATGGGGCGCCGCTCCGGGACGGAAAATGTTATTGGAATCGCAGGGTTCGGCGCCGCAG
CTGAAGCAGCCGCGAAGGATCTTGATAACGGTGTCTGGGACCGGGTTGCAGAAATTAGAAATATTCTAGAAAAGGCGGTT
GCGGCCCAGTGCCCGGGCACTATTTTTATTGGCAACGAGGCGCGCCGCCTGCCCAATACCTCGTGTTTTGCGACCCCCGG
CTGGAAGGGCGAGACGCAGGTGATGCAGATGGACCTTGCGGGGTTTGCCATCAGCGCGGGGAGCGCCTGCTCTAGCGGCA
AGGTGCGCGCAAGTGCGGTTCTGACCGCGATGGGATTTGATGAGAAGACAGCTCAGGGAGCGATCCGCGTATCGCTTGGG
GCTGACACGACCGAAACGGATGTGCTGCGGTTTGCAGAAACGTGGTGCGCCAAACAGAAGAAACATCGCGCCCGCTCGGC
GTGA

Upstream 100 bases:

>100_bases
AGTGCCCAATCTCTTCTCCGTGGTCGATGAATAGACCACGCGCGAGGCCCCCCTTGACCTCTGCGTGAATGCAACTGTGA
CTGCCTGAAAATATGACTCC

Downstream 100 bases:

>100_bases
GTGCAGGAGAAGACGATGGCCGCTCTGGACCAATTCGAAGCCAAGGAAGGCGTTGATCAGGAAACCGTGGATGCGGTGCG
CGAGGTCAGCACATATAAAT

Product: aminotransferase, class V

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MTRVYLDHNATSPLRHDARAAMIAAMDVCGNPSSVHAEGRAAKAVVERARAQIAAAFGADGADIVFTSGSTEGAALALMG
RDLHGSALEHDAVRAWIKEDLTVEAQGRVAVLDPQSSCLQLANSETGVIQDLPEGLAVTDATQAFGKLPVAFNWMGATMA
LISAHKLGGPKGVGAVVLKRGTDLAAQIKGGGQEMGRRSGTENVIGIAGFGAAAEAAAKDLDNGVWDRVAEIRNILEKAV
AAQCPGTIFIGNEARRLPNTSCFATPGWKGETQVMQMDLAGFAISAGSACSSGKVRASAVLTAMGFDEKTAQGAIRVSLG
ADTTETDVLRFAETWCAKQKKHRARSA

Sequences:

>Translated_347_residues
MTRVYLDHNATSPLRHDARAAMIAAMDVCGNPSSVHAEGRAAKAVVERARAQIAAAFGADGADIVFTSGSTEGAALALMG
RDLHGSALEHDAVRAWIKEDLTVEAQGRVAVLDPQSSCLQLANSETGVIQDLPEGLAVTDATQAFGKLPVAFNWMGATMA
LISAHKLGGPKGVGAVVLKRGTDLAAQIKGGGQEMGRRSGTENVIGIAGFGAAAEAAAKDLDNGVWDRVAEIRNILEKAV
AAQCPGTIFIGNEARRLPNTSCFATPGWKGETQVMQMDLAGFAISAGSACSSGKVRASAVLTAMGFDEKTAQGAIRVSLG
ADTTETDVLRFAETWCAKQKKHRARSA
>Mature_346_residues
TRVYLDHNATSPLRHDARAAMIAAMDVCGNPSSVHAEGRAAKAVVERARAQIAAAFGADGADIVFTSGSTEGAALALMGR
DLHGSALEHDAVRAWIKEDLTVEAQGRVAVLDPQSSCLQLANSETGVIQDLPEGLAVTDATQAFGKLPVAFNWMGATMAL
ISAHKLGGPKGVGAVVLKRGTDLAAQIKGGGQEMGRRSGTENVIGIAGFGAAAEAAAKDLDNGVWDRVAEIRNILEKAVA
AQCPGTIFIGNEARRLPNTSCFATPGWKGETQVMQMDLAGFAISAGSACSSGKVRASAVLTAMGFDEKTAQGAIRVSLGA
DTTETDVLRFAETWCAKQKKHRARSA

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=382, Percent_Identity=32.9842931937173, Blast_Score=162, Evalue=3e-40,
Organism=Homo sapiens, GI156713448, Length=408, Percent_Identity=29.9019607843137, Blast_Score=142, Evalue=7e-34,
Organism=Escherichia coli, GI48994898, Length=368, Percent_Identity=33.4239130434783, Blast_Score=151, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI25143064, Length=367, Percent_Identity=34.3324250681199, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17533177, Length=316, Percent_Identity=26.5822784810127, Blast_Score=87, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319831, Length=368, Percent_Identity=33.9673913043478, Blast_Score=155, Evalue=8e-39,
Organism=Drosophila melanogaster, GI20129463, Length=366, Percent_Identity=33.6065573770492, Blast_Score=145, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR017772
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 36013; Mature: 35882

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRVYLDHNATSPLRHDARAAMIAAMDVCGNPSSVHAEGRAAKAVVERARAQIAAAFGAD
CEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
GADIVFTSGSTEGAALALMGRDLHGSALEHDAVRAWIKEDLTVEAQGRVAVLDPQSSCLQ
CCEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCEEEECCCEEEECCCHHHHH
LANSETGVIQDLPEGLAVTDATQAFGKLPVAFNWMGATMALISAHKLGGPKGVGAVVLKR
HHCCCCCHHHHCCCCCEEEHHHHHHCCCCEEEEHHHHHHHHHHHHHCCCCCCCCEEEEEC
GTDLAAQIKGGGQEMGRRSGTENVIGIAGFGAAAEAAAKDLDNGVWDRVAEIRNILEKAV
CCCEEEEECCCHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
AAQCPGTIFIGNEARRLPNTSCFATPGWKGETQVMQMDLAGFAISAGSACSSGKVRASAV
HHCCCCEEEECCCHHHCCCCCEEECCCCCCCCEEEEEECCCEEEECCCCCCCCCEEHHHE
LTAMGFDEKTAQGAIRVSLGADTTETDVLRFAETWCAKQKKHRARSA
EEECCCCCHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TRVYLDHNATSPLRHDARAAMIAAMDVCGNPSSVHAEGRAAKAVVERARAQIAAAFGAD
EEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
GADIVFTSGSTEGAALALMGRDLHGSALEHDAVRAWIKEDLTVEAQGRVAVLDPQSSCLQ
CCEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCEEEECCCEEEECCCHHHHH
LANSETGVIQDLPEGLAVTDATQAFGKLPVAFNWMGATMALISAHKLGGPKGVGAVVLKR
HHCCCCCHHHHCCCCCEEEHHHHHHCCCCEEEEHHHHHHHHHHHHHCCCCCCCCEEEEEC
GTDLAAQIKGGGQEMGRRSGTENVIGIAGFGAAAEAAAKDLDNGVWDRVAEIRNILEKAV
CCCEEEEECCCHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
AAQCPGTIFIGNEARRLPNTSCFATPGWKGETQVMQMDLAGFAISAGSACSSGKVRASAV
HHCCCCEEEECCCHHHCCCCCEEECCCCCCCCEEEEEECCCEEEECCCCCCCCCEEHHHE
LTAMGFDEKTAQGAIRVSLGADTTETDVLRFAETWCAKQKKHRARSA
EEECCCCCHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA