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The map label for this gene is gppA [H]

Identifier: 99081024

GI number: 99081024

Start: 1272519

End: 1273631

Strand: Reverse

Name: gppA [H]

Synonym: TM1040_1183

Alternate gene names: 99081024

Gene position: 1273631-1272519 (Counterclockwise)

Preceding gene: 99081047

Following gene: 99081023

Centisome position: 39.79

GC content: 62.08

Gene sequence:

>1113_bases
ATGGCGCCCAGGCGTTCCAAAGGTACAGGAGCGTTTCCCAGAGCGGTTGAGACCCCTGTACCGGCCCGGCCAGATCCGGA
TGCGCTCTATGCAGCGCTGGATCTTGGCACCAACAGTTGCAGGATGCTGATTGCCCAACCCAAGGGCAGCGGCTTCCATG
TGGTGGACAGTTTTTCAAAGTCGGTGCAGCTCGGCTCCGGCCTTGAAAAGACTGGGCGTTTGTCGCGCTCTTCCATGGCG
CGCACCATTCAGGCGCTGCGCATCTGTCAGCAGAAAATCAATCGCAATCGCGTAAAACGCATGCGGCTTGTTGCGACCGA
AGCCTGTCGGCGCGCAAAGAACGGGCGCGACTTCATGCGCCAGATCAAGCGCGAGACCGGCCTCTCCATGGACATCATCC
AGCCCGAGGAAGAAGCGCGTCTTGCCGTGATTTCCTGCGCGCCGCTTGTATCGACGAAAACCGAACAGCTCTTGGTGGTC
GACATCGGGGGCGGCTCGACTGAACTGGTCTGGATCGATATTTCCTCTGTACCGCGCCGCGACCGCCCGTCGGCGATCAT
GCGGCTGCATGCCGGATTTCACACCGTCGAGAGCCCCTTTCCCGCCGCCAAAGTGGTGGATTGGATTTCGGTGCCGCTGG
GCGTTGCAACCCTGCGGGACCAGTTCAACGACGTGGAGGACGATGCCGCCCGCTTTGCCCTGATGAGCTGGTTCTTCGAG
GAACATCTGGCCGATTTTGCCCCCTACAAGGACGAACAGGCGCGCGAGGGGTTCCAGATCGTCGGCACCTCCGGCACCGT
GACCACCGTGGCGGCCTCACACCTGGGGCTTAAGCGCTATGACCGCACCAAGGTCGATGGGCTGCGGATGACATCCGATC
AGATCGACAAGGTGATCCGCGGCTACCTCGAACTCGGCCCGCAAGGCCGCCGTCGCGATCCTCGTATCGGCGAAGATCGA
CAAGCGCTTATTATGTCCGGTGCCGCGATCCTGCAGGCGCTGTTGCGCTGCTGGCCCACCGATCGCTTGTCGGTGGCAGA
CCGGGGCCTGCGTGAGGGGCTTTTGTACGCGCAGATGAGCGCCGATGGCGTGTTGGAGGACGGCCCTTTCTGA

Upstream 100 bases:

>100_bases
TTTGAATCGGCTTTCCTGGCTGCGCGCCGATACAGTCCCTTGCGGAGAGCCCCCTGCGGACGTACTGTAAATTCAACACG
ATAATCGGAGGGCGTGATTC

Downstream 100 bases:

>100_bases
GGCCCCTTTCTGCGCCGGCAAAACTCGGTTATAGCCCCAAAGCCGCGCCTTTGAGGTGGCGCACGACGTGTAAGAGGAAT
GACCATGGCGAAGAAACCAA

Product: Ppx/GppA phosphatase

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase [H]

Number of amino acids: Translated: 370; Mature: 369

Protein sequence:

>370_residues
MAPRRSKGTGAFPRAVETPVPARPDPDALYAALDLGTNSCRMLIAQPKGSGFHVVDSFSKSVQLGSGLEKTGRLSRSSMA
RTIQALRICQQKINRNRVKRMRLVATEACRRAKNGRDFMRQIKRETGLSMDIIQPEEEARLAVISCAPLVSTKTEQLLVV
DIGGGSTELVWIDISSVPRRDRPSAIMRLHAGFHTVESPFPAAKVVDWISVPLGVATLRDQFNDVEDDAARFALMSWFFE
EHLADFAPYKDEQAREGFQIVGTSGTVTTVAASHLGLKRYDRTKVDGLRMTSDQIDKVIRGYLELGPQGRRRDPRIGEDR
QALIMSGAAILQALLRCWPTDRLSVADRGLREGLLYAQMSADGVLEDGPF

Sequences:

>Translated_370_residues
MAPRRSKGTGAFPRAVETPVPARPDPDALYAALDLGTNSCRMLIAQPKGSGFHVVDSFSKSVQLGSGLEKTGRLSRSSMA
RTIQALRICQQKINRNRVKRMRLVATEACRRAKNGRDFMRQIKRETGLSMDIIQPEEEARLAVISCAPLVSTKTEQLLVV
DIGGGSTELVWIDISSVPRRDRPSAIMRLHAGFHTVESPFPAAKVVDWISVPLGVATLRDQFNDVEDDAARFALMSWFFE
EHLADFAPYKDEQAREGFQIVGTSGTVTTVAASHLGLKRYDRTKVDGLRMTSDQIDKVIRGYLELGPQGRRRDPRIGEDR
QALIMSGAAILQALLRCWPTDRLSVADRGLREGLLYAQMSADGVLEDGPF
>Mature_369_residues
APRRSKGTGAFPRAVETPVPARPDPDALYAALDLGTNSCRMLIAQPKGSGFHVVDSFSKSVQLGSGLEKTGRLSRSSMAR
TIQALRICQQKINRNRVKRMRLVATEACRRAKNGRDFMRQIKRETGLSMDIIQPEEEARLAVISCAPLVSTKTEQLLVVD
IGGGSTELVWIDISSVPRRDRPSAIMRLHAGFHTVESPFPAAKVVDWISVPLGVATLRDQFNDVEDDAARFALMSWFFEE
HLADFAPYKDEQAREGFQIVGTSGTVTTVAASHLGLKRYDRTKVDGLRMTSDQIDKVIRGYLELGPQGRRRDPRIGEDRQ
ALIMSGAAILQALLRCWPTDRLSVADRGLREGLLYAQMSADGVLEDGPF

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=333, Percent_Identity=27.3273273273273, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI1788848, Length=335, Percent_Identity=26.2686567164179, Blast_Score=89, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.40 [H]

Molecular weight: Translated: 40907; Mature: 40776

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPRRSKGTGAFPRAVETPVPARPDPDALYAALDLGTNSCRMLIAQPKGSGFHVVDSFSK
CCCCCCCCCCCCCCCCCCCCCCCCCHHHEEEEECCCCCCEEEEEECCCCCCCCHHHHHHH
SVQLGSGLEKTGRLSRSSMARTIQALRICQQKINRNRVKRMRLVATEACRRAKNGRDFMR
HHHHCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
QIKRETGLSMDIIQPEEEARLAVISCAPLVSTKTEQLLVVDIGGGSTELVWIDISSVPRR
HHHHHHCCEEEEECCCCCCCEEEEEECCCCCCCCCEEEEEEECCCCEEEEEEECCCCCCC
DRPSAIMRLHAGFHTVESPFPAAKVVDWISVPLGVATLRDQFNDVEDDAARFALMSWFFE
CCCHHHHHHHHCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
EHLADFAPYKDEQAREGFQIVGTSGTVTTVAASHLGLKRYDRTKVDGLRMTSDQIDKVIR
HHHHHHCCCCCHHHHCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHH
GYLELGPQGRRRDPRIGEDRQALIMSGAAILQALLRCWPTDRLSVADRGLREGLLYAQMS
HHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCEEEEEC
ADGVLEDGPF
CCCCCCCCCC
>Mature Secondary Structure 
APRRSKGTGAFPRAVETPVPARPDPDALYAALDLGTNSCRMLIAQPKGSGFHVVDSFSK
CCCCCCCCCCCCCCCCCCCCCCCCHHHEEEEECCCCCCEEEEEECCCCCCCCHHHHHHH
SVQLGSGLEKTGRLSRSSMARTIQALRICQQKINRNRVKRMRLVATEACRRAKNGRDFMR
HHHHCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
QIKRETGLSMDIIQPEEEARLAVISCAPLVSTKTEQLLVVDIGGGSTELVWIDISSVPRR
HHHHHHCCEEEEECCCCCCCEEEEEECCCCCCCCCEEEEEEECCCCEEEEEEECCCCCCC
DRPSAIMRLHAGFHTVESPFPAAKVVDWISVPLGVATLRDQFNDVEDDAARFALMSWFFE
CCCHHHHHHHHCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
EHLADFAPYKDEQAREGFQIVGTSGTVTTVAASHLGLKRYDRTKVDGLRMTSDQIDKVIR
HHHHHHCCCCCHHHHCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHH
GYLELGPQGRRRDPRIGEDRQALIMSGAAILQALLRCWPTDRLSVADRGLREGLLYAQMS
HHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCEEEEEC
ADGVLEDGPF
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA