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The map label for this gene is trpE [H]

Identifier: 99080984

GI number: 99080984

Start: 1229411

End: 1230922

Strand: Reverse

Name: trpE [H]

Synonym: TM1040_1143

Alternate gene names: 99080984

Gene position: 1230922-1229411 (Counterclockwise)

Preceding gene: 99080985

Following gene: 99080982

Centisome position: 38.46

GC content: 62.96

Gene sequence:

>1512_bases
ATGGCCCTGATCCCCGATTTCGACAGTTTCGCCAAAGCCTATGAGGCGGGCGAAAACCAGGTGGTCTACACACGGCTTGC
CGCCGATCTGGATACGCCCGTCTCCTTGATGCTGAAGCTCACCGGCGCGCAGAAGGATGCCTTCATGCTGGAATCGGTGA
CCGGCGGCGAGGTCCGCGGGCGCTATTCCATCATCGGCATGAAGCCTGACCTGATCTGGCGTGCGCGGGGCGAACAGGCC
GAAATCAACCGCGCCGCGCGGTTCGATCCCGAGGGCTTTGCCCCGCTCGACGGCAACCCACTTGATACACTGCGCGCGCT
ACTGGCCGAGAGCCGCATCGACCTGCCGGATGATCTGCCACAGGCGGCGGCGGGGCTGTTTGGCTATCTGGGCTATGACA
TGATCCGCCATGTGGAGCATCTGCCGGATGTGAACCCCGACCCGCTTGGCCTGCCGGACGCGGTGATGATCCGCCCCTCC
GTGGTGGCCGTGCTGGACGGTGTCAAAGGCGAGGTCACAGTGGTCTCTCCCGCCTGGGTCAGCGAAGGCCAGTCGGCGCG
CGCGGCCTATGCTCAGGCTGCCGAACGCGTGATGGATGCGGTGCGTGATCTTGAACGTGCCATGCCCGCCGAGACCCGCG
ATCTGGGCGAGGCGCGCGAGGTCGCGCCCCCGGTCTCCAACTTCACCAAGGACGGCTACATGGCCGCCGTGGAGAAGGCC
AAGGACTACATCCGTGCCGGCGACATCTTTCAGGTAGTGCCCGCACAGCGCTGGACGCAGGAGTTCCCGCAGCCGCCCTT
CGCGCTCTATCGTTCGCTGCGACGCACCAACCCCTCGCCGTTCATGTTCTACTTCAACTTCGGCGGTTTTCAGGTGATCG
GCGCCAGCCCCGAGATCCTCGTTCGGGTCTTTGGCAACGAGGTCACCATTCGCCCCATTGCTGGCACCCGTCCGCGCGGC
GCAACCCCCGAAGAAGACAAAGCGCTGGAACAGGATCTGCTTGCCGACAAGAAAGAGTTGGCCGAGCACCTGATGCTCTT
GGATCTGGGCCGTAACGACGTGGGCCGCGTTGCCAAGATCGGCACCGTGAAACCCACCGAGGAATTCATCATCGAGCGCT
ACAGCCACGTGATGCATATCGTTTCGAATGTTGTTGGCGAACTCCACGAGGACAAAGACGCGCTCGATGCATTTTTTGCA
GGCATGCCTGCGGGTACGGTTTCCGGAGCGCCCAAGGTGCGTGCGATGGAGATCATCGACGAGCTCGAACCCGAAAAGCG
CGGCATCTATGGCGGTGGCGTCGGCTATTTCAGCGCTGGCGGCGACATGGACATGTGTATCGCGCTGCGCACAGCCATCG
TGAAGGATCAGAACCTCTATATTCAGGCCGGGGGCGGCGTCGTCTATGACAGCGACCCGGAGGCCGAATATATGGAGACC
GTGCATAAATCGAACGCGATCCGCCGTGCGGCTGCAGATGCGGCGCGCTTTACCGGCAACGGCAACCGCTGA

Upstream 100 bases:

>100_bases
TGCAATCGGTTCAGACCCGCGCCCGTCCGCAGGTCAACCAACAGGCCGTGAATGCTGTTCACGCCAACTTCCAGTAACTC
AGTACGAGGCGCATGCGCTT

Downstream 100 bases:

>100_bases
GCTAAATGCCCAGCAGGGAAAAGAAAAACGCGCTCCCGAGATCCTCGTGGAGCGCGTTTTTTTTGACATTCGGCTGTCGC
ATTGGCCGACGGTATTAGTT

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 503; Mature: 502

Protein sequence:

>503_residues
MALIPDFDSFAKAYEAGENQVVYTRLAADLDTPVSLMLKLTGAQKDAFMLESVTGGEVRGRYSIIGMKPDLIWRARGEQA
EINRAARFDPEGFAPLDGNPLDTLRALLAESRIDLPDDLPQAAAGLFGYLGYDMIRHVEHLPDVNPDPLGLPDAVMIRPS
VVAVLDGVKGEVTVVSPAWVSEGQSARAAYAQAAERVMDAVRDLERAMPAETRDLGEAREVAPPVSNFTKDGYMAAVEKA
KDYIRAGDIFQVVPAQRWTQEFPQPPFALYRSLRRTNPSPFMFYFNFGGFQVIGASPEILVRVFGNEVTIRPIAGTRPRG
ATPEEDKALEQDLLADKKELAEHLMLLDLGRNDVGRVAKIGTVKPTEEFIIERYSHVMHIVSNVVGELHEDKDALDAFFA
GMPAGTVSGAPKVRAMEIIDELEPEKRGIYGGGVGYFSAGGDMDMCIALRTAIVKDQNLYIQAGGGVVYDSDPEAEYMET
VHKSNAIRRAAADAARFTGNGNR

Sequences:

>Translated_503_residues
MALIPDFDSFAKAYEAGENQVVYTRLAADLDTPVSLMLKLTGAQKDAFMLESVTGGEVRGRYSIIGMKPDLIWRARGEQA
EINRAARFDPEGFAPLDGNPLDTLRALLAESRIDLPDDLPQAAAGLFGYLGYDMIRHVEHLPDVNPDPLGLPDAVMIRPS
VVAVLDGVKGEVTVVSPAWVSEGQSARAAYAQAAERVMDAVRDLERAMPAETRDLGEAREVAPPVSNFTKDGYMAAVEKA
KDYIRAGDIFQVVPAQRWTQEFPQPPFALYRSLRRTNPSPFMFYFNFGGFQVIGASPEILVRVFGNEVTIRPIAGTRPRG
ATPEEDKALEQDLLADKKELAEHLMLLDLGRNDVGRVAKIGTVKPTEEFIIERYSHVMHIVSNVVGELHEDKDALDAFFA
GMPAGTVSGAPKVRAMEIIDELEPEKRGIYGGGVGYFSAGGDMDMCIALRTAIVKDQNLYIQAGGGVVYDSDPEAEYMET
VHKSNAIRRAAADAARFTGNGNR
>Mature_502_residues
ALIPDFDSFAKAYEAGENQVVYTRLAADLDTPVSLMLKLTGAQKDAFMLESVTGGEVRGRYSIIGMKPDLIWRARGEQAE
INRAARFDPEGFAPLDGNPLDTLRALLAESRIDLPDDLPQAAAGLFGYLGYDMIRHVEHLPDVNPDPLGLPDAVMIRPSV
VAVLDGVKGEVTVVSPAWVSEGQSARAAYAQAAERVMDAVRDLERAMPAETRDLGEAREVAPPVSNFTKDGYMAAVEKAK
DYIRAGDIFQVVPAQRWTQEFPQPPFALYRSLRRTNPSPFMFYFNFGGFQVIGASPEILVRVFGNEVTIRPIAGTRPRGA
TPEEDKALEQDLLADKKELAEHLMLLDLGRNDVGRVAKIGTVKPTEEFIIERYSHVMHIVSNVVGELHEDKDALDAFFAG
MPAGTVSGAPKVRAMEIIDELEPEKRGIYGGGVGYFSAGGDMDMCIALRTAIVKDQNLYIQAGGGVVYDSDPEAEYMETV
HKSNAIRRAAADAARFTGNGNR

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=386, Percent_Identity=37.8238341968912, Blast_Score=247, Evalue=1e-66,
Organism=Escherichia coli, GI1788114, Length=445, Percent_Identity=32.3595505617978, Blast_Score=225, Evalue=4e-60,
Organism=Escherichia coli, GI87082077, Length=263, Percent_Identity=26.9961977186312, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1786809, Length=213, Percent_Identity=28.6384976525822, Blast_Score=83, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6320935, Length=497, Percent_Identity=38.430583501006, Blast_Score=294, Evalue=3e-80,
Organism=Saccharomyces cerevisiae, GI6324361, Length=422, Percent_Identity=25.1184834123223, Blast_Score=99, Evalue=2e-21,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 54951; Mature: 54820

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALIPDFDSFAKAYEAGENQVVYTRLAADLDTPVSLMLKLTGAQKDAFMLESVTGGEVRG
CCCCCCHHHHHHHHHCCCCCEEEEEEHHCCCCCHHHHHHHCCCCCCHHHEECCCCCCCCC
RYSIIGMKPDLIWRARGEQAEINRAARFDPEGFAPLDGNPLDTLRALLAESRIDLPDDLP
EEEEEECCCCEEEECCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHH
QAAAGLFGYLGYDMIRHVEHLPDVNPDPLGLPDAVMIRPSVVAVLDGVKGEVTVVSPAWV
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCHHHHHHCCCCCCEEEECCHHH
SEGQSARAAYAQAAERVMDAVRDLERAMPAETRDLGEAREVAPPVSNFTKDGYMAAVEKA
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHCCCHHHHHHHHH
KDYIRAGDIFQVVPAQRWTQEFPQPPFALYRSLRRTNPSPFMFYFNFGGFQVIGASPEIL
HHHHHCCCEEEECCCHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEECCCEEEECCCHHEE
VRVFGNEVTIRPIAGTRPRGATPEEDKALEQDLLADKKELAEHLMLLDLGRNDVGRVAKI
EEEECCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCC
GTVKPTEEFIIERYSHVMHIVSNVVGELHEDKDALDAFFAGMPAGTVSGAPKVRAMEIID
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
ELEPEKRGIYGGGVGYFSAGGDMDMCIALRTAIVKDQNLYIQAGGGVVYDSDPEAEYMET
HCCHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHCCCCEEEEECCEEEECCCCCHHHHHH
VHKSNAIRRAAADAARFTGNGNR
HHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
ALIPDFDSFAKAYEAGENQVVYTRLAADLDTPVSLMLKLTGAQKDAFMLESVTGGEVRG
CCCCCHHHHHHHHHCCCCCEEEEEEHHCCCCCHHHHHHHCCCCCCHHHEECCCCCCCCC
RYSIIGMKPDLIWRARGEQAEINRAARFDPEGFAPLDGNPLDTLRALLAESRIDLPDDLP
EEEEEECCCCEEEECCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHH
QAAAGLFGYLGYDMIRHVEHLPDVNPDPLGLPDAVMIRPSVVAVLDGVKGEVTVVSPAWV
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCHHHHHHCCCCCCEEEECCHHH
SEGQSARAAYAQAAERVMDAVRDLERAMPAETRDLGEAREVAPPVSNFTKDGYMAAVEKA
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHCCCHHHHHHHHH
KDYIRAGDIFQVVPAQRWTQEFPQPPFALYRSLRRTNPSPFMFYFNFGGFQVIGASPEIL
HHHHHCCCEEEECCCHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEECCCEEEECCCHHEE
VRVFGNEVTIRPIAGTRPRGATPEEDKALEQDLLADKKELAEHLMLLDLGRNDVGRVAKI
EEEECCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCC
GTVKPTEEFIIERYSHVMHIVSNVVGELHEDKDALDAFFAGMPAGTVSGAPKVRAMEIID
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
ELEPEKRGIYGGGVGYFSAGGDMDMCIALRTAIVKDQNLYIQAGGGVVYDSDPEAEYMET
HCCHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHCCCCEEEEECCEEEECCCCCHHHHHH
VHKSNAIRRAAADAARFTGNGNR
HHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA