Click here to switch to the map view.

The map label for this gene is trpD

Identifier: 99080981

GI number: 99080981

Start: 1226005

End: 1227027

Strand: Reverse

Name: trpD

Synonym: TM1040_1140

Alternate gene names: 99080981

Gene position: 1227027-1226005 (Counterclockwise)

Preceding gene: 99080982

Following gene: 99080980

Centisome position: 38.33

GC content: 64.03

Gene sequence:

>1023_bases
ATGAGTGATGCGTTGAAACCCCTGATCGGTCTGGCCGCGGATCGCGCCCTGACCCGAACCGAAGCCGAAACCGCCTTTGC
CGCGCTGTTCAATGGCGAAGCCACGCCAAGCCAGATGGGCGGTCTTTTGATGGCCCTGCGCACCCGCGGCGAGACGGTGG
ACGAATATGCCGCCGCCGCCGCCGTGATGCGTGCAAAATGCAACAAGGTCTCGGCCCCCGCAGATGCGATGGACATCGTT
GGCACCGGCGGTGATGGCAAAGGCACGCTCAATATCTCGACCGCAACCGCCTTTGTGGTTGCCGGTGCAGGCGTGCCCGT
CGCCAAACACGGCAACCGCAACCTGTCGTCCAAATCCGGCGCCGCAGATGCGCTCACCGAGATGGGCATTCAGGTCATGG
TTGGCCCGAAAGTGGTCGAAAAGTCCCTCAAAGAGGCGGGCATCTGTTTCATGATGGCGCCCATGCATCACCCGGCAATC
GCCCATGTGATGCCCACCCGTCAGGAGCTTGGCACGCGGACGATTTTCAACATCCTCGGCCCGCTCACCAACCCCGCAGA
TGTCAAACGCCAACTCACCGGTGCCTTCAGCCGTGACCTGATCCGACCGATGGCGGAGACGCTGAAACAGCTCGGCTCCG
AGGTCGCATGGCTGGTGCATGGCTCTGACGGGACTGATGAGCTCACGATCACGGGTGTCAGCTGGGTTGCGGGTCTCTCG
GAGGATGGCAACATCTCCGAATTCGAGGTCCACCCCGAAGAGGCAGGCCTGCCGGAGCATCCTTTTGAGGCCATCGTCGG
TGGCACGCCCGCCGAGAACGCCGCCGCCTTCCGCGCCCTCCTCGAAGGCACGCCCTCGGCCTACCGGGATGCGGTGCTTT
TGAACTCTGCCGCAGCACTCAAGGTGGCCGGCGTGGTGTCGTCGCTCAAGGAGGGCGCGGAACGCGCTGCCGAAAGCATC
GACAGCGGTGCCGCTCTGGGCAAGGTGACGGCGGTTGCACGGATCACGTCGGAGGCCAGCTGA

Upstream 100 bases:

>100_bases
AGCTGCCCATCCACGGCGTGCAGTTCCACCCGGAATCCATTGCCTCCGAGCATGGGCATGCGCTGCTGCAAAACTTCCTG
AATGAAATGAAAGTGCCGGC

Downstream 100 bases:

>100_bases
TGGCCCCGCAAGACCACGCCTCAGCCCTGCGGCCTGCGGTCGGGGGCTGGGCGGAGCTGCCCTTCTTTGAAACCCACTGG
CCCCGGATCGAGGCAGCGCT

Product: anthranilate phosphoribosyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MSDALKPLIGLAADRALTRTEAETAFAALFNGEATPSQMGGLLMALRTRGETVDEYAAAAAVMRAKCNKVSAPADAMDIV
GTGGDGKGTLNISTATAFVVAGAGVPVAKHGNRNLSSKSGAADALTEMGIQVMVGPKVVEKSLKEAGICFMMAPMHHPAI
AHVMPTRQELGTRTIFNILGPLTNPADVKRQLTGAFSRDLIRPMAETLKQLGSEVAWLVHGSDGTDELTITGVSWVAGLS
EDGNISEFEVHPEEAGLPEHPFEAIVGGTPAENAAAFRALLEGTPSAYRDAVLLNSAAALKVAGVVSSLKEGAERAAESI
DSGAALGKVTAVARITSEAS

Sequences:

>Translated_340_residues
MSDALKPLIGLAADRALTRTEAETAFAALFNGEATPSQMGGLLMALRTRGETVDEYAAAAAVMRAKCNKVSAPADAMDIV
GTGGDGKGTLNISTATAFVVAGAGVPVAKHGNRNLSSKSGAADALTEMGIQVMVGPKVVEKSLKEAGICFMMAPMHHPAI
AHVMPTRQELGTRTIFNILGPLTNPADVKRQLTGAFSRDLIRPMAETLKQLGSEVAWLVHGSDGTDELTITGVSWVAGLS
EDGNISEFEVHPEEAGLPEHPFEAIVGGTPAENAAAFRALLEGTPSAYRDAVLLNSAAALKVAGVVSSLKEGAERAAESI
DSGAALGKVTAVARITSEAS
>Mature_339_residues
SDALKPLIGLAADRALTRTEAETAFAALFNGEATPSQMGGLLMALRTRGETVDEYAAAAAVMRAKCNKVSAPADAMDIVG
TGGDGKGTLNISTATAFVVAGAGVPVAKHGNRNLSSKSGAADALTEMGIQVMVGPKVVEKSLKEAGICFMMAPMHHPAIA
HVMPTRQELGTRTIFNILGPLTNPADVKRQLTGAFSRDLIRPMAETLKQLGSEVAWLVHGSDGTDELTITGVSWVAGLSE
DGNISEFEVHPEEAGLPEHPFEAIVGGTPAENAAAFRALLEGTPSAYRDAVLLNSAAALKVAGVVSSLKEGAERAAESID
SGAALGKVTAVARITSEAS

Specific function: Tryptophan biosynthesis; first step. Tryptophan biosynthesis; second step. [C]

COG id: COG0547

COG function: function code E; Anthranilate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate phosphoribosyltransferase family

Homologues:

Organism=Escherichia coli, GI1787517, Length=334, Percent_Identity=39.5209580838323, Blast_Score=210, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6320561, Length=322, Percent_Identity=33.2298136645963, Blast_Score=131, Evalue=1e-31,

Paralogues:

None

Copy number: 945 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 900 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRPD_SILST (Q1GHJ3)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_613135.1
- ProteinModelPortal:   Q1GHJ3
- SMR:   Q1GHJ3
- STRING:   Q1GHJ3
- GeneID:   4078436
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_1140
- NMPDR:   fig|292414.1.peg.3725
- eggNOG:   COG0547
- HOGENOM:   HBG559996
- OMA:   ATPSQMG
- PhylomeDB:   Q1GHJ3
- ProtClustDB:   PRK00188
- BioCyc:   SSP292414:TM1040_1140-MONOMER
- HAMAP:   MF_00211
- InterPro:   IPR005940
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- Gene3D:   G3DSA:1.20.970.10
- Gene3D:   G3DSA:3.40.1030.10
- TIGRFAMs:   TIGR01245

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; SSF47648 Glyco_trans_3; SSF52418 Glyco_trans_3

EC number: =2.4.2.18

Molecular weight: Translated: 34984; Mature: 34853

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDALKPLIGLAADRALTRTEAETAFAALFNGEATPSQMGGLLMALRTRGETVDEYAAAA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHH
AVMRAKCNKVSAPADAMDIVGTGGDGKGTLNISTATAFVVAGAGVPVAKHGNRNLSSKSG
HHHHHHHCCCCCCCCHHHEEECCCCCCEEEEEEHHEEEEEECCCCCEECCCCCCCCCCCC
AADALTEMGIQVMVGPKVVEKSLKEAGICFMMAPMHHPAIAHVMPTRQELGTRTIFNILG
HHHHHHHCCCEEEECHHHHHHHHHHCCEEEEECCCCCCHHHHHCCCHHHHHHHHHHHHHC
PLTNPADVKRQLTGAFSRDLIRPMAETLKQLGSEVAWLVHGSDGTDELTITGVSWVAGLS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEEHHHHHCCC
EDGNISEFEVHPEEAGLPEHPFEAIVGGTPAENAAAFRALLEGTPSAYRDAVLLNSAAAL
CCCCCCEEEECCHHCCCCCCCHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCHHHH
KVAGVVSSLKEGAERAAESIDSGAALGKVTAVARITSEAS
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SDALKPLIGLAADRALTRTEAETAFAALFNGEATPSQMGGLLMALRTRGETVDEYAAAA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHH
AVMRAKCNKVSAPADAMDIVGTGGDGKGTLNISTATAFVVAGAGVPVAKHGNRNLSSKSG
HHHHHHHCCCCCCCCHHHEEECCCCCCEEEEEEHHEEEEEECCCCCEECCCCCCCCCCCC
AADALTEMGIQVMVGPKVVEKSLKEAGICFMMAPMHHPAIAHVMPTRQELGTRTIFNILG
HHHHHHHCCCEEEECHHHHHHHHHHCCEEEEECCCCCCHHHHHCCCHHHHHHHHHHHHHC
PLTNPADVKRQLTGAFSRDLIRPMAETLKQLGSEVAWLVHGSDGTDELTITGVSWVAGLS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEEHHHHHCCC
EDGNISEFEVHPEEAGLPEHPFEAIVGGTPAENAAAFRALLEGTPSAYRDAVLLNSAAAL
CCCCCCEEEECCHHCCCCCCCHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCHHHH
KVAGVVSSLKEGAERAAESIDSGAALGKVTAVARITSEAS
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA