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The map label for this gene is ung

Identifier: 99080980

GI number: 99080980

Start: 1225301

End: 1226005

Strand: Reverse

Name: ung

Synonym: TM1040_1139

Alternate gene names: 99080980

Gene position: 1226005-1225301 (Counterclockwise)

Preceding gene: 99080981

Following gene: 99080979

Centisome position: 38.3

GC content: 67.09

Gene sequence:

>705_bases
ATGGCCCCGCAAGACCACGCCTCAGCCCTGCGGCCTGCGGTCGGGGGCTGGGCGGAGCTGCCCTTCTTTGAAACCCACTG
GCCCCGGATCGAGGCAGCGCTTGCACAGGAGACGCGCCAGATCCTGCCCCCTGCGCATCAGCGCTTTGCCGCGCTGGAGC
GTACCCCGCCCGAGTCCACCCGCGTGGTGATCCTTGGTCAGGACCCCTATCCGACGCCGGGCCATGCGCATGGGCTGTCG
TTTTCCGTTGAACCGGATGTGACGCCCCTGCCCCGGTCCTTGCGCAACATCTATCAGGAAATGCGCGACGATCTCGGCAC
CTGCCCGGAAACCGGCGATCTGCGCCCCTGGGCGGCGCAGGGTGTGCTCCTGCTCAATACGGTGCTGTCGGTCCCCGCAG
GCGAGGCCAACGGCCACAAATCGCTGGGCTGGCAAGAGCTGGCCCATCAGGTGCTCGACCTCAGTTCGCGCCGCCCCACG
GCCTATGTGCTCTGGGGCAATCAGGCGCAGAAGCTCGAAAGCCACATTCGTCCCGGCGATCACCTGATCGTCAAGACGGC
CCATCCTTCACCGCTGTCGGCACGCCGGGGCTTTTTCGGCTCGCGCGTGTTCTCGGCGATCAACGACTGGCTCACCGCGC
GCGGCGAGCCGCCGATCACGTGGGCAGACCCACGTCCAGCCCAAGGGAGCATCTTCGATGTCTGA

Upstream 100 bases:

>100_bases
CGCTCAAGGAGGGCGCGGAACGCGCTGCCGAAAGCATCGACAGCGGTGCCGCTCTGGGCAAGGTGACGGCGGTTGCACGG
ATCACGTCGGAGGCCAGCTG

Downstream 100 bases:

>100_bases
GACCATCCTCGACAAAATCAAGGCCTACAAGCTCGAAGAGGTCGCCACCGACAAAGCCGCCAAACCTCTTGCGGATGTCG
AAGCCGAGGCCCGCGCCGCA

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG

Number of amino acids: Translated: 234; Mature: 233

Protein sequence:

>234_residues
MAPQDHASALRPAVGGWAELPFFETHWPRIEAALAQETRQILPPAHQRFAALERTPPESTRVVILGQDPYPTPGHAHGLS
FSVEPDVTPLPRSLRNIYQEMRDDLGTCPETGDLRPWAAQGVLLLNTVLSVPAGEANGHKSLGWQELAHQVLDLSSRRPT
AYVLWGNQAQKLESHIRPGDHLIVKTAHPSPLSARRGFFGSRVFSAINDWLTARGEPPITWADPRPAQGSIFDV

Sequences:

>Translated_234_residues
MAPQDHASALRPAVGGWAELPFFETHWPRIEAALAQETRQILPPAHQRFAALERTPPESTRVVILGQDPYPTPGHAHGLS
FSVEPDVTPLPRSLRNIYQEMRDDLGTCPETGDLRPWAAQGVLLLNTVLSVPAGEANGHKSLGWQELAHQVLDLSSRRPT
AYVLWGNQAQKLESHIRPGDHLIVKTAHPSPLSARRGFFGSRVFSAINDWLTARGEPPITWADPRPAQGSIFDV
>Mature_233_residues
APQDHASALRPAVGGWAELPFFETHWPRIEAALAQETRQILPPAHQRFAALERTPPESTRVVILGQDPYPTPGHAHGLSF
SVEPDVTPLPRSLRNIYQEMRDDLGTCPETGDLRPWAAQGVLLLNTVLSVPAGEANGHKSLGWQELAHQVLDLSSRRPTA
YVLWGNQAQKLESHIRPGDHLIVKTAHPSPLSARRGFFGSRVFSAINDWLTARGEPPITWADPRPAQGSIFDV

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family

Homologues:

Organism=Homo sapiens, GI19718751, Length=208, Percent_Identity=43.2692307692308, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI6224979, Length=208, Percent_Identity=43.2692307692308, Blast_Score=159, Evalue=3e-39,
Organism=Escherichia coli, GI1788934, Length=201, Percent_Identity=46.7661691542289, Blast_Score=167, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI17556304, Length=235, Percent_Identity=40.8510638297872, Blast_Score=164, Evalue=5e-41,
Organism=Saccharomyces cerevisiae, GI6323620, Length=207, Percent_Identity=42.0289855072464, Blast_Score=153, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UNG_SILST (Q1GHJ4)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_613134.1
- ProteinModelPortal:   Q1GHJ4
- SMR:   Q1GHJ4
- STRING:   Q1GHJ4
- GeneID:   4078435
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_1139
- NMPDR:   fig|292414.1.peg.3726
- eggNOG:   COG0692
- HOGENOM:   HBG605450
- OMA:   VMLLNRV
- PhylomeDB:   Q1GHJ4
- ProtClustDB:   CLSK775312
- BioCyc:   SSP292414:TM1040_1139-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00148
- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122
- Gene3D:   G3DSA:3.40.470.10
- PANTHER:   PTHR11264
- TIGRFAMs:   TIGR00628

Pfam domain/function: PF03167 UDG; SSF52141 UDNA_glycsylseSF

EC number: =3.2.2.27

Molecular weight: Translated: 25792; Mature: 25661

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: ACT_SITE 68-68

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPQDHASALRPAVGGWAELPFFETHWPRIEAALAQETRQILPPAHQRFAALERTPPEST
CCCCHHHHHHHHHCCCHHCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCC
RVVILGQDPYPTPGHAHGLSFSVEPDVTPLPRSLRNIYQEMRDDLGTCPETGDLRPWAAQ
EEEEECCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHC
GVLLLNTVLSVPAGEANGHKSLGWQELAHQVLDLSSRRPTAYVLWGNQAQKLESHIRPGD
CHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHCCCCC
HLIVKTAHPSPLSARRGFFGSRVFSAINDWLTARGEPPITWADPRPAQGSIFDV
EEEEEECCCCCCHHHHCHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCC
>Mature Secondary Structure 
APQDHASALRPAVGGWAELPFFETHWPRIEAALAQETRQILPPAHQRFAALERTPPEST
CCCHHHHHHHHHCCCHHCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCC
RVVILGQDPYPTPGHAHGLSFSVEPDVTPLPRSLRNIYQEMRDDLGTCPETGDLRPWAAQ
EEEEECCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHC
GVLLLNTVLSVPAGEANGHKSLGWQELAHQVLDLSSRRPTAYVLWGNQAQKLESHIRPGD
CHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHCCCCC
HLIVKTAHPSPLSARRGFFGSRVFSAINDWLTARGEPPITWADPRPAQGSIFDV
EEEEEECCCCCCHHHHCHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA