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The map label for this gene is trpC [H]

Identifier: 99080979

GI number: 99080979

Start: 1224499

End: 1225308

Strand: Reverse

Name: trpC [H]

Synonym: TM1040_1138

Alternate gene names: 99080979

Gene position: 1225308-1224499 (Counterclockwise)

Preceding gene: 99080980

Following gene: 99080978

Centisome position: 38.28

GC content: 61.36

Gene sequence:

>810_bases
ATGTCTGAGACCATCCTCGACAAAATCAAGGCCTACAAGCTCGAAGAGGTCGCCACCGACAAAGCCGCCAAACCTCTTGC
GGATGTCGAAGCCGAGGCCCGCGCCGCAGATCCCGTACGCGGCTTTGCCGAGCGTCTACAAAAGGCCACGCATCAGGGCT
ATGGACTGATTGCCGAAATCAAAAAAGCGAGCCCTTCCAAGGGTTTGATCCGCGAAGATTTCGACCCTGCCACGCTCGCT
ACAGCCTATGCCGAAGGGGGCGCGAGCTGTCTTTCGGTGCTGACAGATACGCCGAGTTTTCAGGGCGCAAAGGACTATCT
GGTGGCGGCGCGCGCGGCCTGCGATCTGCCCTGCCTGCGCAAGGATTTCATGTACGACACCTATCAGGTGGCCGAAGCCC
GCGCGCTTGGCGCCGACTGTATCCTGATCATCCTCGCCTCTGTCAGCGATGCACAAGCGGCCGAGCTCGAAGCCTGCGCC
TTTGAATGGGGCATGGACGTGCTCTTGGAGGTCCACAACGAAGAAGAACTGGACCGCGCCTGCCTGTTGAAATCGCCCCT
CATGGGCATCAACAACCGCAACCTCAAGACCTTTGAGACCACGCTCGACACCACCCGCACCCTGTCGCGGATGGTGCCGC
CGGATCGCACGATCGTCTGTGAAAGCGGCCTGTTCACGCCCGAGGATCTGGCCGACATGGCCCAGTATGGCGCGCGCAGC
TTCCTCATCGGTGAGAGCCTGATGCGTCAGGAGGATGTGACCGCCGCCACCCGCGCGATCCTTGCAAACCCGCTGACCCC
CTCGCTCTGA

Upstream 100 bases:

>100_bases
GGCTCGCGCGTGTTCTCGGCGATCAACGACTGGCTCACCGCGCGCGGCGAGCCGCCGATCACGTGGGCAGACCCACGTCC
AGCCCAAGGGAGCATCTTCG

Downstream 100 bases:

>100_bases
TCCAATCGAACTGACCCTTTTGATCTGTCCACAGGAGAGACCGCCGATGTCGCTCACACATTTTGACCAGAAGGGCGATG
CCCATATGGTCGACGTCTCC

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 269; Mature: 268

Protein sequence:

>269_residues
MSETILDKIKAYKLEEVATDKAAKPLADVEAEARAADPVRGFAERLQKATHQGYGLIAEIKKASPSKGLIREDFDPATLA
TAYAEGGASCLSVLTDTPSFQGAKDYLVAARAACDLPCLRKDFMYDTYQVAEARALGADCILIILASVSDAQAAELEACA
FEWGMDVLLEVHNEEELDRACLLKSPLMGINNRNLKTFETTLDTTRTLSRMVPPDRTIVCESGLFTPEDLADMAQYGARS
FLIGESLMRQEDVTAATRAILANPLTPSL

Sequences:

>Translated_269_residues
MSETILDKIKAYKLEEVATDKAAKPLADVEAEARAADPVRGFAERLQKATHQGYGLIAEIKKASPSKGLIREDFDPATLA
TAYAEGGASCLSVLTDTPSFQGAKDYLVAARAACDLPCLRKDFMYDTYQVAEARALGADCILIILASVSDAQAAELEACA
FEWGMDVLLEVHNEEELDRACLLKSPLMGINNRNLKTFETTLDTTRTLSRMVPPDRTIVCESGLFTPEDLADMAQYGARS
FLIGESLMRQEDVTAATRAILANPLTPSL
>Mature_268_residues
SETILDKIKAYKLEEVATDKAAKPLADVEAEARAADPVRGFAERLQKATHQGYGLIAEIKKASPSKGLIREDFDPATLAT
AYAEGGASCLSVLTDTPSFQGAKDYLVAARAACDLPCLRKDFMYDTYQVAEARALGADCILIILASVSDAQAAELEACAF
EWGMDVLLEVHNEEELDRACLLKSPLMGINNRNLKTFETTLDTTRTLSRMVPPDRTIVCESGLFTPEDLADMAQYGARSF
LIGESLMRQEDVTAATRAILANPLTPSL

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=259, Percent_Identity=40.5405405405405, Blast_Score=166, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6322638, Length=265, Percent_Identity=36.2264150943396, Blast_Score=147, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 29188; Mature: 29056

Theoretical pI: Translated: 4.41; Mature: 4.41

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETILDKIKAYKLEEVATDKAAKPLADVEAEARAADPVRGFAERLQKATHQGYGLIAEI
CCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHH
KKASPSKGLIREDFDPATLATAYAEGGASCLSVLTDTPSFQGAKDYLVAARAACDLPCLR
HHCCCCCCCHHCCCCCHHHHHHHHHCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHH
KDFMYDTYQVAEARALGADCILIILASVSDAQAAELEACAFEWGMDVLLEVHNEEELDRA
HHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHHCCHHHHHHH
CLLKSPLMGINNRNLKTFETTLDTTRTLSRMVPPDRTIVCESGLFTPEDLADMAQYGARS
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHCCHH
FLIGESLMRQEDVTAATRAILANPLTPSL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SETILDKIKAYKLEEVATDKAAKPLADVEAEARAADPVRGFAERLQKATHQGYGLIAEI
CHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHH
KKASPSKGLIREDFDPATLATAYAEGGASCLSVLTDTPSFQGAKDYLVAARAACDLPCLR
HHCCCCCCCHHCCCCCHHHHHHHHHCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHH
KDFMYDTYQVAEARALGADCILIILASVSDAQAAELEACAFEWGMDVLLEVHNEEELDRA
HHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHHCCHHHHHHH
CLLKSPLMGINNRNLKTFETTLDTTRTLSRMVPPDRTIVCESGLFTPEDLADMAQYGARS
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHCCHH
FLIGESLMRQEDVTAATRAILANPLTPSL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA