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The map label for this gene is crt [H]

Identifier: 99080943

GI number: 99080943

Start: 1182774

End: 1183817

Strand: Reverse

Name: crt [H]

Synonym: TM1040_1102

Alternate gene names: 99080943

Gene position: 1183817-1182774 (Counterclockwise)

Preceding gene: 99080944

Following gene: 99080942

Centisome position: 36.98

GC content: 62.93

Gene sequence:

>1044_bases
ATGAGCGACATCCATATCCGTATCGAAGGGCGCGCAGGGCGCATAACGCTCACCCGCGAAAAGGCCCTCAACGCCCTCTC
TTACGACATGTGCCTTGCGATCGACGCTGCCCTCAAGGACTGGGCCAAGGACGATGCCGTGGCGCTGGTGGTGTTTGACG
CCGCTGGCGACAAGGCCTTCTGCGCGGGCGGTGACATTGCCGAGCTCTACGAGACGGGAACCAAGGGCGATTTTGCCTAT
GGCCGCACATTCTGGCGGGATGAGTACCGCATGAACGCGCGGATCTTTGAGTATCCCAAACCGGTGGTGAGCTTCCTGCA
GGGCTTTACCATGGGCGGCGGTGTTGGCATTGGCTGTCACGGCACGCATCGCGTGGTGGGCGACAGCTCCAAACTCTCGA
TGCCCGAATGCGGGATCGGGCTGGTGCCGGATGTGGGCGGCTCGCTTCTGCTCGCGCTGGCGCCGGGGCGCCTGGGCGAA
TATCTCGGCACCACCGGCTACCGGATGGATGCGGGCGATGCGATTTATGCTGGCTTTGCCGATCACTACATCCCCGAAAC
CACCTGGCCTGCGCTGATCAAGACCCTTGAGGAGACAGGCGATGTCGCAGCTCTCGAGGCCGCCGCACAGCCCGCCCCAG
AGAGCAAGCTGCAGGCGATGCAGGGCGATATCGACGCCACATTTGCAGGCGAAACCGCCGCCGACATCCTGACCGTCCTG
CGCGGGCGAAAGGACAGCTTTGCCGCCGACACCCTCAAGGTGCTGGAACGCGGTGCGCCGCTCTCCATCGCCACCACGGT
CGAGATGATCCACCGCCTGCGCAGCTCCACTGCGACCATGCGCCGGGCCTTGGATCTGGAATATCGTTTCACCTATCGTG
CGATGGATAAGGGCGACCTTCTCGAAGGCGTGCGCGCCCTCATCATCGACAAGGACAAATCGCCCAAGTGGCAATATGCC
GACGGCAACGTGCCTGCGGTCGCCGTGAGCCAGATGCTCCAACCGCTTGGAGCCGAGGCATTGAGTTTTGAGGAGGAGAG
CTAA

Upstream 100 bases:

>100_bases
GCATCAGATCCTTGAAGGCACCAATGAGATCATGCGCGTGATCGTCGCCCGTCATATGCTGGCGGAAAACCACTAAGTGT
CTCAGGAAAGGACCGCCGCC

Downstream 100 bases:

>100_bases
GATGCAAATCGGATTTATCGGACTGGGCAACATGGGCGGCCCGATGGCGGCCAATCTCGCCAAGGCAGGCCATAGCGTTA
CCGGCTTTGACATGGCGGAT

Product: enoyl-CoA hydratase/isomerase

Products: NA

Alternate protein names: Crotonase [H]

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MSDIHIRIEGRAGRITLTREKALNALSYDMCLAIDAALKDWAKDDAVALVVFDAAGDKAFCAGGDIAELYETGTKGDFAY
GRTFWRDEYRMNARIFEYPKPVVSFLQGFTMGGGVGIGCHGTHRVVGDSSKLSMPECGIGLVPDVGGSLLLALAPGRLGE
YLGTTGYRMDAGDAIYAGFADHYIPETTWPALIKTLEETGDVAALEAAAQPAPESKLQAMQGDIDATFAGETAADILTVL
RGRKDSFAADTLKVLERGAPLSIATTVEMIHRLRSSTATMRRALDLEYRFTYRAMDKGDLLEGVRALIIDKDKSPKWQYA
DGNVPAVAVSQMLQPLGAEALSFEEES

Sequences:

>Translated_347_residues
MSDIHIRIEGRAGRITLTREKALNALSYDMCLAIDAALKDWAKDDAVALVVFDAAGDKAFCAGGDIAELYETGTKGDFAY
GRTFWRDEYRMNARIFEYPKPVVSFLQGFTMGGGVGIGCHGTHRVVGDSSKLSMPECGIGLVPDVGGSLLLALAPGRLGE
YLGTTGYRMDAGDAIYAGFADHYIPETTWPALIKTLEETGDVAALEAAAQPAPESKLQAMQGDIDATFAGETAADILTVL
RGRKDSFAADTLKVLERGAPLSIATTVEMIHRLRSSTATMRRALDLEYRFTYRAMDKGDLLEGVRALIIDKDKSPKWQYA
DGNVPAVAVSQMLQPLGAEALSFEEES
>Mature_346_residues
SDIHIRIEGRAGRITLTREKALNALSYDMCLAIDAALKDWAKDDAVALVVFDAAGDKAFCAGGDIAELYETGTKGDFAYG
RTFWRDEYRMNARIFEYPKPVVSFLQGFTMGGGVGIGCHGTHRVVGDSSKLSMPECGIGLVPDVGGSLLLALAPGRLGEY
LGTTGYRMDAGDAIYAGFADHYIPETTWPALIKTLEETGDVAALEAAAQPAPESKLQAMQGDIDATFAGETAADILTVLR
GRKDSFAADTLKVLERGAPLSIATTVEMIHRLRSSTATMRRALDLEYRFTYRAMDKGDLLEGVRALIIDKDKSPKWQYAD
GNVPAVAVSQMLQPLGAEALSFEEES

Specific function: Catalyzes The Reversible Dehydration Of L-Carnitinyl-CoA To Crotobetainyl-CoA. [C]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI37594471, Length=359, Percent_Identity=35.3760445682451, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI37594469, Length=310, Percent_Identity=34.1935483870968, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI194097323, Length=206, Percent_Identity=31.5533980582524, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI221142681, Length=186, Percent_Identity=28.494623655914, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1787659, Length=235, Percent_Identity=24.6808510638298, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI25144157, Length=347, Percent_Identity=32.8530259365994, Blast_Score=187, Evalue=8e-48,
Organism=Caenorhabditis elegans, GI25144160, Length=347, Percent_Identity=32.8530259365994, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17554946, Length=173, Percent_Identity=29.4797687861272, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320241, Length=347, Percent_Identity=28.8184438040346, Blast_Score=137, Evalue=2e-33,
Organism=Drosophila melanogaster, GI28571730, Length=311, Percent_Identity=39.2282958199357, Blast_Score=217, Evalue=8e-57,
Organism=Drosophila melanogaster, GI28571729, Length=311, Percent_Identity=39.2282958199357, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI20129971, Length=183, Percent_Identity=30.0546448087432, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24653477, Length=183, Percent_Identity=30.0546448087432, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.55 [H]

Molecular weight: Translated: 37420; Mature: 37289

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDIHIRIEGRAGRITLTREKALNALSYDMCLAIDAALKDWAKDDAVALVVFDAAGDKAF
CCCEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCEE
CAGGDIAELYETGTKGDFAYGRTFWRDEYRMNARIFEYPKPVVSFLQGFTMGGGVGIGCH
ECCCCHHHHHHCCCCCCCHHCHHHHHHHHHCCCEEEECCHHHHHHHHCCCCCCCEEECCC
GTHRVVGDSSKLSMPECGIGLVPDVGGSLLLALAPGRLGEYLGTTGYRMDAGDAIYAGFA
CCCEEECCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHCCCCCEECCCCEEEECCH
DHYIPETTWPALIKTLEETGDVAALEAAAQPAPESKLQAMQGDIDATFAGETAADILTVL
HHCCCCCHHHHHHHHHHHCCCEEEHHHHCCCCCHHHHHHHHCCCCEEECCHHHHHHHHHH
RGRKDSFAADTLKVLERGAPLSIATTVEMIHRLRSSTATMRRALDLEYRFTYRAMDKGDL
HCCCCCHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCHHH
LEGVRALIIDKDKSPKWQYADGNVPAVAVSQMLQPLGAEALSFEEES
HHHHHEEEEECCCCCCEEECCCCCHHHHHHHHHHHHCCHHHCCCCCC
>Mature Secondary Structure 
SDIHIRIEGRAGRITLTREKALNALSYDMCLAIDAALKDWAKDDAVALVVFDAAGDKAF
CCEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCEE
CAGGDIAELYETGTKGDFAYGRTFWRDEYRMNARIFEYPKPVVSFLQGFTMGGGVGIGCH
ECCCCHHHHHHCCCCCCCHHCHHHHHHHHHCCCEEEECCHHHHHHHHCCCCCCCEEECCC
GTHRVVGDSSKLSMPECGIGLVPDVGGSLLLALAPGRLGEYLGTTGYRMDAGDAIYAGFA
CCCEEECCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHCCCCCEECCCCEEEECCH
DHYIPETTWPALIKTLEETGDVAALEAAAQPAPESKLQAMQGDIDATFAGETAADILTVL
HHCCCCCHHHHHHHHHHHCCCEEEHHHHCCCCCHHHHHHHHCCCCEEECCHHHHHHHHHH
RGRKDSFAADTLKVLERGAPLSIATTVEMIHRLRSSTATMRRALDLEYRFTYRAMDKGDL
HCCCCCHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCHHH
LEGVRALIIDKDKSPKWQYADGNVPAVAVSQMLQPLGAEALSFEEES
HHHHHEEEEECCCCCCEEECCCCCHHHHHHHHHHHHCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]