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The map label for this gene is ytcI [H]

Identifier: 99080576

GI number: 99080576

Start: 792161

End: 793741

Strand: Direct

Name: ytcI [H]

Synonym: TM1040_0735

Alternate gene names: 99080576

Gene position: 792161-793741 (Clockwise)

Preceding gene: 99080574

Following gene: 99080577

Centisome position: 24.75

GC content: 62.75

Gene sequence:

>1581_bases
TTGGAAAGATTGGAAAAATTGCATACCACCTATGCGCAGAACGCAGGGTTAAACATGACTGAGAAACGCATCATTCCCGG
GCTTACCGCCACAGGCGGGTGGGACATCCCCGAGCGGCTCAATATGGCGGCGCAGGCGATGGATCACCCGGCCGATAAAC
TCGCGATCATTGACCTCACCTCCGGGACCCGCCGTGATGTGTTTCATCGGGAATTGGCCGTAATGGTCGATGGTCTGGCG
CGCACATTGCTGCAACGTGTCGCCCCCGGTGATCGCGTCGGAGTGCTCTTGTCGCAATCACCTTGGTGTGTGGCGGCGCA
TCTGGCGATCTGGAAAATTGGCGCAGTCTCGGTGCCGCTATTTAAACTGTTTCAGCACGACGCCCTTGCCAACCGCGTCG
AGGATGCAGGTGCGAAGTATGTGCTGACCGATCGGGAGGGCGCGGCGCAGCTTGGCGATTTGGCCGAGCCGCTGATTACG
GCAGAGATCGGCGTCGAGGGCGATCCGGTGCCCTTCGCCGACACTGGATCCGAGGACCCGGCGGTCATTATCTATACCTC
CGGTACCACGGGCAAACCCAAGGGAGTCTTGCACGGGCACCGGATGCTGACAGGGCATCTGCCGGGCGTGTCGATCAGTC
ACGACCATCTTGGCCAGCCCGGTGATTGTCTCTGGACGCCTGCGGATTGGGCGTGGATCGGCGGGCTCTTTGATGTCGCA
ATGCCGGGCCTTGCGCTGGGTGTGCCGGTCGTCGCCGCGCGGCTTGATAAGTTTACGCCTGAAACCTGCGCCGAGGTGAT
GCGCTTGGGCGAGGTGCGCAACGTCTTCTTTCCGCCTACCGCCCTGCGCATGCTAAAAGCAGCGGGGCAGGGGCTCGACG
GTTTGCGTTCCGTGGCCTCCGGCGGAGAGCCCCTGGGCGCGGAGATGCTCGCCTGGGGCCAGCGTCACCTGGGCGTCACC
ATCAACGAATTCTACGGCCAGACCGAATGCAACATGACGGTGTCCTCTTGCTGCGCGGACTTCCCCGTGCGCCCTGGCTG
CATCGGGAAACCGGTGCCGGGGCATGTGGTCGAGGTGATCGACGCAGACGGCCAGCCCACCCGTGAGGAAGGCGATGTGG
CGGTGCGCCGTGGTTCCGGGTCGATGATGCTGGAATATTGGAACCGCCCCGACGCCACCGCCGAGAAGTTTCACGGCGAC
TGGCTGGTGACCGGGGATCGCGGCATCTGGGAGGCGGGCTATCTGCGCTTCGTGGGGCGTGAGGATGACGTGATCACCTC
TGCCGGTTACCGCATCGGCCCCTCCGAGATCGAGGATTGTCTGATGACTCACCCGGCCGTTGCCACCGTCGGTGTGGTCG
GCAAGCCCGACGCCCTGCGCACTGAGATCGTCAAGGCCTATGTGGTGCTGAAACCGGACCACGCCCCAAGCGAAAAAGAG
CTGCAGGATTACGTCAAAGAGCGCCTTGCCAGCTATTCCTATCCCCGCGAGATCGCCTTTCTCGACGCTTTGCCGATGAC
GGTTACGGGCAAGGTGATCCGTAAAGAACTCAAGGCGCGGGCTGCGGGGGAGGGGAAGTGA

Upstream 100 bases:

>100_bases
TTTCATGGGGAGAATCCCTTCTTTCATCAGTATGGCGCGACATTGCCAGCGATGAGGTGCGCGCGCTCTGATCTAGATCA
AATGAGACCCTCCTTTCCCT

Downstream 100 bases:

>100_bases
TGAAGGCAAGGAGCCGCAGTTTGAGTGACCAGCATGTCGCTTGGGCGTCGCGCCTGTTTTTTCATACCTGTCCAACATGT
GGCGGAGCGGTGCCGCTTTC

Product: AMP-dependent synthetase and ligase

Products: AMP; diphosphate; acetyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 526; Mature: 526

Protein sequence:

>526_residues
MERLEKLHTTYAQNAGLNMTEKRIIPGLTATGGWDIPERLNMAAQAMDHPADKLAIIDLTSGTRRDVFHRELAVMVDGLA
RTLLQRVAPGDRVGVLLSQSPWCVAAHLAIWKIGAVSVPLFKLFQHDALANRVEDAGAKYVLTDREGAAQLGDLAEPLIT
AEIGVEGDPVPFADTGSEDPAVIIYTSGTTGKPKGVLHGHRMLTGHLPGVSISHDHLGQPGDCLWTPADWAWIGGLFDVA
MPGLALGVPVVAARLDKFTPETCAEVMRLGEVRNVFFPPTALRMLKAAGQGLDGLRSVASGGEPLGAEMLAWGQRHLGVT
INEFYGQTECNMTVSSCCADFPVRPGCIGKPVPGHVVEVIDADGQPTREEGDVAVRRGSGSMMLEYWNRPDATAEKFHGD
WLVTGDRGIWEAGYLRFVGREDDVITSAGYRIGPSEIEDCLMTHPAVATVGVVGKPDALRTEIVKAYVVLKPDHAPSEKE
LQDYVKERLASYSYPREIAFLDALPMTVTGKVIRKELKARAAGEGK

Sequences:

>Translated_526_residues
MERLEKLHTTYAQNAGLNMTEKRIIPGLTATGGWDIPERLNMAAQAMDHPADKLAIIDLTSGTRRDVFHRELAVMVDGLA
RTLLQRVAPGDRVGVLLSQSPWCVAAHLAIWKIGAVSVPLFKLFQHDALANRVEDAGAKYVLTDREGAAQLGDLAEPLIT
AEIGVEGDPVPFADTGSEDPAVIIYTSGTTGKPKGVLHGHRMLTGHLPGVSISHDHLGQPGDCLWTPADWAWIGGLFDVA
MPGLALGVPVVAARLDKFTPETCAEVMRLGEVRNVFFPPTALRMLKAAGQGLDGLRSVASGGEPLGAEMLAWGQRHLGVT
INEFYGQTECNMTVSSCCADFPVRPGCIGKPVPGHVVEVIDADGQPTREEGDVAVRRGSGSMMLEYWNRPDATAEKFHGD
WLVTGDRGIWEAGYLRFVGREDDVITSAGYRIGPSEIEDCLMTHPAVATVGVVGKPDALRTEIVKAYVVLKPDHAPSEKE
LQDYVKERLASYSYPREIAFLDALPMTVTGKVIRKELKARAAGEGK
>Mature_526_residues
MERLEKLHTTYAQNAGLNMTEKRIIPGLTATGGWDIPERLNMAAQAMDHPADKLAIIDLTSGTRRDVFHRELAVMVDGLA
RTLLQRVAPGDRVGVLLSQSPWCVAAHLAIWKIGAVSVPLFKLFQHDALANRVEDAGAKYVLTDREGAAQLGDLAEPLIT
AEIGVEGDPVPFADTGSEDPAVIIYTSGTTGKPKGVLHGHRMLTGHLPGVSISHDHLGQPGDCLWTPADWAWIGGLFDVA
MPGLALGVPVVAARLDKFTPETCAEVMRLGEVRNVFFPPTALRMLKAAGQGLDGLRSVASGGEPLGAEMLAWGQRHLGVT
INEFYGQTECNMTVSSCCADFPVRPGCIGKPVPGHVVEVIDADGQPTREEGDVAVRRGSGSMMLEYWNRPDATAEKFHGD
WLVTGDRGIWEAGYLRFVGREDDVITSAGYRIGPSEIEDCLMTHPAVATVGVVGKPDALRTEIVKAYVVLKPDHAPSEKE
LQDYVKERLASYSYPREIAFLDALPMTVTGKVIRKELKARAAGEGK

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI42544132, Length=541, Percent_Identity=31.0536044362292, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI157311624, Length=541, Percent_Identity=31.4232902033272, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI157311622, Length=541, Percent_Identity=31.4232902033272, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI58082049, Length=541, Percent_Identity=31.7929759704251, Blast_Score=212, Evalue=6e-55,
Organism=Homo sapiens, GI122937307, Length=534, Percent_Identity=31.6479400749064, Blast_Score=208, Evalue=1e-53,
Organism=Homo sapiens, GI115511026, Length=542, Percent_Identity=29.7047970479705, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI38505220, Length=483, Percent_Identity=31.055900621118, Blast_Score=192, Evalue=8e-49,
Organism=Homo sapiens, GI28416953, Length=568, Percent_Identity=29.9295774647887, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI187761345, Length=528, Percent_Identity=27.2727272727273, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI187761343, Length=528, Percent_Identity=27.2727272727273, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI13375727, Length=566, Percent_Identity=27.9151943462898, Blast_Score=145, Evalue=9e-35,
Organism=Homo sapiens, GI8923896, Length=375, Percent_Identity=29.6, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI253970489, Length=375, Percent_Identity=29.6, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI195947378, Length=272, Percent_Identity=28.6764705882353, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI156151445, Length=152, Percent_Identity=32.8947368421053, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI42544134, Length=371, Percent_Identity=25.6064690026954, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI57165412, Length=502, Percent_Identity=22.9083665338645, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI57165410, Length=502, Percent_Identity=22.9083665338645, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI40807491, Length=169, Percent_Identity=31.9526627218935, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1790505, Length=552, Percent_Identity=28.6231884057971, Blast_Score=168, Evalue=6e-43,
Organism=Escherichia coli, GI1788107, Length=366, Percent_Identity=33.0601092896175, Blast_Score=156, Evalue=3e-39,
Organism=Escherichia coli, GI1786529, Length=574, Percent_Identity=28.0487804878049, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI145693145, Length=513, Percent_Identity=26.5107212475634, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI221142682, Length=486, Percent_Identity=26.3374485596708, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1786801, Length=560, Percent_Identity=28.0357142857143, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1786810, Length=526, Percent_Identity=25.4752851711027, Blast_Score=96, Evalue=7e-21,
Organism=Escherichia coli, GI1788595, Length=455, Percent_Identity=26.1538461538462, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17559526, Length=371, Percent_Identity=28.8409703504043, Blast_Score=133, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI32563687, Length=507, Percent_Identity=26.4299802761341, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71983001, Length=513, Percent_Identity=28.8499025341131, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71982997, Length=513, Percent_Identity=28.8499025341131, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17558820, Length=465, Percent_Identity=27.0967741935484, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17557194, Length=516, Percent_Identity=23.4496124031008, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17560140, Length=352, Percent_Identity=26.7045454545455, Blast_Score=111, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI17538037, Length=531, Percent_Identity=23.9171374764595, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71985884, Length=388, Percent_Identity=25, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17531443, Length=467, Percent_Identity=24.6252676659529, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71996755, Length=503, Percent_Identity=25.844930417495, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71994690, Length=370, Percent_Identity=27.027027027027, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71994694, Length=370, Percent_Identity=27.027027027027, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71994703, Length=370, Percent_Identity=27.027027027027, Blast_Score=89, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17564090, Length=335, Percent_Identity=25.3731343283582, Blast_Score=82, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17560308, Length=358, Percent_Identity=26.536312849162, Blast_Score=75, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319264, Length=572, Percent_Identity=27.2727272727273, Blast_Score=157, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6323182, Length=575, Percent_Identity=28, Blast_Score=155, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6319699, Length=372, Percent_Identity=26.6129032258064, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI62472339, Length=536, Percent_Identity=27.6119402985075, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24667955, Length=536, Percent_Identity=27.6119402985075, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI21355225, Length=535, Percent_Identity=26.7289719626168, Blast_Score=138, Evalue=9e-33,
Organism=Drosophila melanogaster, GI24667959, Length=493, Percent_Identity=27.789046653144, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI18859661, Length=479, Percent_Identity=26.5135699373695, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24581924, Length=361, Percent_Identity=28.808864265928, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24648676, Length=550, Percent_Identity=26, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24648260, Length=420, Percent_Identity=25.952380952381, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI21355181, Length=379, Percent_Identity=26.9129287598945, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24653035, Length=392, Percent_Identity=27.2959183673469, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI20130357, Length=385, Percent_Identity=27.012987012987, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24656500, Length=520, Percent_Identity=24.8076923076923, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24648257, Length=364, Percent_Identity=26.3736263736264, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21356947, Length=405, Percent_Identity=23.9506172839506, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI161076582, Length=399, Percent_Identity=25.31328320802, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21356441, Length=326, Percent_Identity=23.6196319018405, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI281365686, Length=345, Percent_Identity=22.6086956521739, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: 6.2.1.1

Molecular weight: Translated: 56759; Mature: 56759

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERLEKLHTTYAQNAGLNMTEKRIIPGLTATGGWDIPERLNMAAQAMDHPADKLAIIDLT
CCHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEC
SGTRRDVFHRELAVMVDGLARTLLQRVAPGDRVGVLLSQSPWCVAAHLAIWKIGAVSVPL
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHCCCHHHH
FKLFQHDALANRVEDAGAKYVLTDREGAAQLGDLAEPLITAEIGVEGDPVPFADTGSEDP
HHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCC
AVIIYTSGTTGKPKGVLHGHRMLTGHLPGVSISHDHLGQPGDCLWTPADWAWIGGLFDVA
EEEEEECCCCCCCCCCEECCEEEEECCCCCCCCHHHCCCCCCEEECCCCHHHHHHHHHHH
MPGLALGVPVVAARLDKFTPETCAEVMRLGEVRNVFFPPTALRMLKAAGQGLDGLRSVAS
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHC
GGEPLGAEMLAWGQRHLGVTINEFYGQTECNMTVSSCCADFPVRPGCIGKPVPGHVVEVI
CCCCCCHHHHHHCHHHCCEEHHHHCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCEEEEE
DADGQPTREEGDVAVRRGSGSMMLEYWNRPDATAEKFHGDWLVTGDRGIWEAGYLRFVGR
ECCCCCCCCCCCEEEEECCCCEEEEECCCCCCCHHHHCCCEEEECCCCCCCCCCEEEECC
EDDVITSAGYRIGPSEIEDCLMTHPAVATVGVVGKPDALRTEIVKAYVVLKPDHAPSEKE
CCCEEECCCCCCCHHHHHHHHHCCCCHHEEECCCCCHHHHHHHHEEEEEECCCCCCCHHH
LQDYVKERLASYSYPREIAFLDALPMTVTGKVIRKELKARAAGEGK
HHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MERLEKLHTTYAQNAGLNMTEKRIIPGLTATGGWDIPERLNMAAQAMDHPADKLAIIDLT
CCHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEC
SGTRRDVFHRELAVMVDGLARTLLQRVAPGDRVGVLLSQSPWCVAAHLAIWKIGAVSVPL
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHCCCHHHH
FKLFQHDALANRVEDAGAKYVLTDREGAAQLGDLAEPLITAEIGVEGDPVPFADTGSEDP
HHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCC
AVIIYTSGTTGKPKGVLHGHRMLTGHLPGVSISHDHLGQPGDCLWTPADWAWIGGLFDVA
EEEEEECCCCCCCCCCEECCEEEEECCCCCCCCHHHCCCCCCEEECCCCHHHHHHHHHHH
MPGLALGVPVVAARLDKFTPETCAEVMRLGEVRNVFFPPTALRMLKAAGQGLDGLRSVAS
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHC
GGEPLGAEMLAWGQRHLGVTINEFYGQTECNMTVSSCCADFPVRPGCIGKPVPGHVVEVI
CCCCCCHHHHHHCHHHCCEEHHHHCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCEEEEE
DADGQPTREEGDVAVRRGSGSMMLEYWNRPDATAEKFHGDWLVTGDRGIWEAGYLRFVGR
ECCCCCCCCCCCEEEEECCCCEEEEECCCCCCCHHHHCCCEEEECCCCCCCCCCEEEECC
EDDVITSAGYRIGPSEIEDCLMTHPAVATVGVVGKPDALRTEIVKAYVVLKPDHAPSEKE
CCCEEECCCCCCCHHHHHHHHHCCCCHHEEECCCCCHHHHHHHHEEEEEECCCCCCCHHH
LQDYVKERLASYSYPREIAFLDALPMTVTGKVIRKELKARAAGEGK
HHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; acetate; CoA

Specific reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA

General reaction: Acid-thiol ligation [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]