Click here to switch to the map view.

The map label for this gene is murC

Identifier: 99080524

GI number: 99080524

Start: 731311

End: 732720

Strand: Direct

Name: murC

Synonym: TM1040_0683

Alternate gene names: 99080524

Gene position: 731311-732720 (Clockwise)

Preceding gene: 99080523

Following gene: 99080525

Centisome position: 22.85

GC content: 60.99

Gene sequence:

>1410_bases
ATGACCCCTGCCACCAAACTGCCCGGCGACGTCGGCCCGATCCATTTTGTCGGTATTGGCGGCATCGGGATGTCTGGCAT
CGCCGAGGTGCTTTTGAACCTTGGCTATGTGGTGCAGGGCTCGGATCTCAAGTCCTCCAGGATCACCCAGCGGCTCGAAC
GCCTTGGCGCAACGATTTTTGAAGGCCAGCGCGCCGAGAACCTCGAAGATGCCGAGGTCGTGGTGATCTCGTCCGCGATC
AAACCCGGCAACGCCGAACTCGACGAAGCCCGCTTGCGTGGCTTGCCGGTGGTGCGCCGCGCTGAAATGCTGGCCGAGCT
CATGCGGCTCAAGTCCAATATTGCCATTGGCGGCACCCACGGCAAAACCACCACCACCACCATGATGGCAGAGCTGATGG
TGGCGGGTGGCTTTGATCCGACCGTTGTGAACGGAGGCATCATTCATGCCTATGGGTCGAACGCGCGGATGGGGCAGGGC
GAATGGATGGTGGTGGAGGCCGACGAGAGTGACGGCACCTTCAACCGTCTGCCTGCCACGATCGCGGTTGTGACCAATAT
CGACCCCGAGCACATGGAGCATTGGGGCGACTTTGATCGCCTGCGCGACGGATTTTATGAATTTGTCTCCAACCTTCCGT
TCTATGGTCTCGCGGTATGCTGTACCGACCACGCCGAAGTACAGGCGCTTGTTGGCCGGATCACCGATCGCCGCGTTGTC
ACCTACGGGTTCAACGCGCAGGCTGACGTGCGCGCGGTGAACCTCACCTACAAAGGAGGCGTGGCGCATTTCGACATCCT
GCTGCAGGCTGAGGGTCAAAAAATCGAAGGCTGTACGCTGCCGATGCCTGGGGATCACAATGTCTCCAACGCGCTCTCTG
CGGTGGCCGTCTGTCGTCACCTCGGCATGAAGCGCGAAGAGATCCGCACAGCCCTTGCCGCCTTTGGTGGGGTCAATCGT
CGCTTTACCAAAGTGGGCGAAGTGGATGGTGTCACCATCATTGATGATTACGGCCATCACCCGGTGGAAATTGCCGCCGT
CCTCAAAGCTGCGCGACAAGCCATCGGCACCGAGGGCGAGGGGCGCGTGATCGCCGTCCACCAGCCGCACCGCTATTCGA
GGCTCTCCAACCTCTTTGACGATTTCTGCGCCTGTTTCAATGACGCCGATGTCGTGGCCATAGCCGAGGTGTTTGCCGCC
GGCGAAGATCCCATCGAAGGTGCGAGCCGCGACGATCTGGTGGCAGGGTTGATCCGGCATGGTCATCGCCATGCCCGCGC
GATCCTCAACGAAGATGACCTGCTGCGCCTCGTGCGTGAACAGACGCGCCCCGGTGACATGGTGGTGTGCCTTGGTGCAG
GGACGATTTCGGCATGGGCAAACGGATTGCCCGAGAGGCTTCGGGGGTGA

Upstream 100 bases:

>100_bases
GGGCCACGCAGATGGCCCATGCCGCTTTGAGCACAGGCATTCCAGATGCCACGGAACGTCTTGTGGCGCGTGTTGAACAT
TTGTCCGAGGAAGCTGCCCC

Downstream 100 bases:

>100_bases
ACCCGGGCGCCCTCCTGCCCCGGATGGCACAGGGTGGCGAGGCTGTCTGCGGTCCGCGCCCGTGCCGTATGGTCCGACAT
TGCGCCGACCAGACGGTAAG

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MTPATKLPGDVGPIHFVGIGGIGMSGIAEVLLNLGYVVQGSDLKSSRITQRLERLGATIFEGQRAENLEDAEVVVISSAI
KPGNAELDEARLRGLPVVRRAEMLAELMRLKSNIAIGGTHGKTTTTTMMAELMVAGGFDPTVVNGGIIHAYGSNARMGQG
EWMVVEADESDGTFNRLPATIAVVTNIDPEHMEHWGDFDRLRDGFYEFVSNLPFYGLAVCCTDHAEVQALVGRITDRRVV
TYGFNAQADVRAVNLTYKGGVAHFDILLQAEGQKIEGCTLPMPGDHNVSNALSAVAVCRHLGMKREEIRTALAAFGGVNR
RFTKVGEVDGVTIIDDYGHHPVEIAAVLKAARQAIGTEGEGRVIAVHQPHRYSRLSNLFDDFCACFNDADVVAIAEVFAA
GEDPIEGASRDDLVAGLIRHGHRHARAILNEDDLLRLVREQTRPGDMVVCLGAGTISAWANGLPERLRG

Sequences:

>Translated_469_residues
MTPATKLPGDVGPIHFVGIGGIGMSGIAEVLLNLGYVVQGSDLKSSRITQRLERLGATIFEGQRAENLEDAEVVVISSAI
KPGNAELDEARLRGLPVVRRAEMLAELMRLKSNIAIGGTHGKTTTTTMMAELMVAGGFDPTVVNGGIIHAYGSNARMGQG
EWMVVEADESDGTFNRLPATIAVVTNIDPEHMEHWGDFDRLRDGFYEFVSNLPFYGLAVCCTDHAEVQALVGRITDRRVV
TYGFNAQADVRAVNLTYKGGVAHFDILLQAEGQKIEGCTLPMPGDHNVSNALSAVAVCRHLGMKREEIRTALAAFGGVNR
RFTKVGEVDGVTIIDDYGHHPVEIAAVLKAARQAIGTEGEGRVIAVHQPHRYSRLSNLFDDFCACFNDADVVAIAEVFAA
GEDPIEGASRDDLVAGLIRHGHRHARAILNEDDLLRLVREQTRPGDMVVCLGAGTISAWANGLPERLRG
>Mature_468_residues
TPATKLPGDVGPIHFVGIGGIGMSGIAEVLLNLGYVVQGSDLKSSRITQRLERLGATIFEGQRAENLEDAEVVVISSAIK
PGNAELDEARLRGLPVVRRAEMLAELMRLKSNIAIGGTHGKTTTTTMMAELMVAGGFDPTVVNGGIIHAYGSNARMGQGE
WMVVEADESDGTFNRLPATIAVVTNIDPEHMEHWGDFDRLRDGFYEFVSNLPFYGLAVCCTDHAEVQALVGRITDRRVVT
YGFNAQADVRAVNLTYKGGVAHFDILLQAEGQKIEGCTLPMPGDHNVSNALSAVAVCRHLGMKREEIRTALAAFGGVNRR
FTKVGEVDGVTIIDDYGHHPVEIAAVLKAARQAIGTEGEGRVIAVHQPHRYSRLSNLFDDFCACFNDADVVAIAEVFAAG
EDPIEGASRDDLVAGLIRHGHRHARAILNEDDLLRLVREQTRPGDMVVCLGAGTISAWANGLPERLRG

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=462, Percent_Identity=43.5064935064935, Blast_Score=304, Evalue=8e-84,
Organism=Escherichia coli, GI1790680, Length=455, Percent_Identity=27.9120879120879, Blast_Score=158, Evalue=7e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_SILST (Q1GIV0)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_612678.1
- ProteinModelPortal:   Q1GIV0
- SMR:   Q1GIV0
- STRING:   Q1GIV0
- GeneID:   4077291
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_0683
- NMPDR:   fig|292414.1.peg.2789
- eggNOG:   COG0773
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- PhylomeDB:   Q1GIV0
- ProtClustDB:   PRK00421
- BioCyc:   SSP292414:TM1040_0683-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 50550; Mature: 50419

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPATKLPGDVGPIHFVGIGGIGMSGIAEVLLNLGYVVQGSDLKSSRITQRLERLGATIF
CCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHCCHHH
EGQRAENLEDAEVVVISSAIKPGNAELDEARLRGLPVVRRAEMLAELMRLKSNIAIGGTH
CCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHCCEEEECCC
GKTTTTTMMAELMVAGGFDPTVVNGGIIHAYGSNARMGQGEWMVVEADESDGTFNRLPAT
CCCHHHHHHHHHHHHCCCCCEEECCCEEEEECCCCCCCCCCEEEEEECCCCCCHHHCCEE
IAVVTNIDPEHMEHWGDFDRLRDGFYEFVSNLPFYGLAVCCTDHAEVQALVGRITDRRVV
EEEEECCCHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHCCCEEE
TYGFNAQADVRAVNLTYKGGVAHFDILLQAEGQKIEGCTLPMPGDHNVSNALSAVAVCRH
EECCCCCCCEEEEEEEEECCCEEEEEEEEECCCEECCCCCCCCCCCCHHHHHHHHHHHHH
LGMKREEIRTALAAFGGVNRRFTKVGEVDGVTIIDDYGHHPVEIAAVLKAARQAIGTEGE
HCCCHHHHHHHHHHHCCCCHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCC
GRVIAVHQPHRYSRLSNLFDDFCACFNDADVVAIAEVFAAGEDPIEGASRDDLVAGLIRH
CEEEEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
GHRHARAILNEDDLLRLVREQTRPGDMVVCLGAGTISAWANGLPERLRG
CHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEECCHHHHHHCCCHHHHCC
>Mature Secondary Structure 
TPATKLPGDVGPIHFVGIGGIGMSGIAEVLLNLGYVVQGSDLKSSRITQRLERLGATIF
CCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHCCHHH
EGQRAENLEDAEVVVISSAIKPGNAELDEARLRGLPVVRRAEMLAELMRLKSNIAIGGTH
CCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHCCEEEECCC
GKTTTTTMMAELMVAGGFDPTVVNGGIIHAYGSNARMGQGEWMVVEADESDGTFNRLPAT
CCCHHHHHHHHHHHHCCCCCEEECCCEEEEECCCCCCCCCCEEEEEECCCCCCHHHCCEE
IAVVTNIDPEHMEHWGDFDRLRDGFYEFVSNLPFYGLAVCCTDHAEVQALVGRITDRRVV
EEEEECCCHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHCCCEEE
TYGFNAQADVRAVNLTYKGGVAHFDILLQAEGQKIEGCTLPMPGDHNVSNALSAVAVCRH
EECCCCCCCEEEEEEEEECCCEEEEEEEEECCCEECCCCCCCCCCCCHHHHHHHHHHHHH
LGMKREEIRTALAAFGGVNRRFTKVGEVDGVTIIDDYGHHPVEIAAVLKAARQAIGTEGE
HCCCHHHHHHHHHHHCCCCHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCC
GRVIAVHQPHRYSRLSNLFDDFCACFNDADVVAIAEVFAAGEDPIEGASRDDLVAGLIRH
CEEEEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
GHRHARAILNEDDLLRLVREQTRPGDMVVCLGAGTISAWANGLPERLRG
CHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEECCHHHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA