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The map label for this gene is purE [H]

Identifier: 99080445

GI number: 99080445

Start: 644794

End: 645282

Strand: Reverse

Name: purE [H]

Synonym: TM1040_0604

Alternate gene names: 99080445

Gene position: 645282-644794 (Counterclockwise)

Preceding gene: 99080448

Following gene: 99080444

Centisome position: 20.16

GC content: 63.8

Gene sequence:

>489_bases
ATGGCCGACATCAAAGTAGGGATCATCATGGGGAGCCAGTCCGACTGGCCCACGATGAAGGAAGCAGCCAACATCCTTGA
CGAACTGGGCGTTGCCTATGAAACGCGGATCGTTTCGGCTCACCGCACGCCGGACCGGTTGTGGGACTATGGCAAGACCG
CAGCAGAGCGCGGCCTGCATGTGATTATCGCAGGCGCGGGCGGCGCGGCGCATTTGCCCGGCATGATGGCGTCAAAGACC
CGTGTGCCCGTGGTTGGCGTGCCCGTCCAGACCCGTGCCTTGTCCGGTGTCGACAGCCTTTATTCGATCGTGCAGATGCC
CAAAGGATTTCCAGTTGCCACCATGGCGATTGGTGCCGCGGGCGCTGCCAACGCAGGCCTGATGGCCGCCGGCATTCTCG
CCACCAGCGACGCCGCGCTGGCAGAACGTCTTGACGCCTGGCGCGACGCGCTTGCCGCCTCCATTCCCGAGGAGCCTACC
GATGACTGA

Upstream 100 bases:

>100_bases
GACCAGAGAGTTTTGCAACTGCAGCAAATCCCCCCGCAACGCATTGCTATTTTGGTCATTTTCGCTAAGGTGCGCGCTCC
TTCCACTGTAGAGGCGAGAT

Downstream 100 bases:

>100_bases
TCTCGACCAAATCCTCGAACCCGGTGCCGTAATCGGCATTCTGGGCGGTGGTCAGCTTGGCCGGATGCTGTCGGTTGCAG
CCTCCCGCCTTGGCTTCACC

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 162; Mature: 161

Protein sequence:

>162_residues
MADIKVGIIMGSQSDWPTMKEAANILDELGVAYETRIVSAHRTPDRLWDYGKTAAERGLHVIIAGAGGAAHLPGMMASKT
RVPVVGVPVQTRALSGVDSLYSIVQMPKGFPVATMAIGAAGAANAGLMAAGILATSDAALAERLDAWRDALAASIPEEPT
DD

Sequences:

>Translated_162_residues
MADIKVGIIMGSQSDWPTMKEAANILDELGVAYETRIVSAHRTPDRLWDYGKTAAERGLHVIIAGAGGAAHLPGMMASKT
RVPVVGVPVQTRALSGVDSLYSIVQMPKGFPVATMAIGAAGAANAGLMAAGILATSDAALAERLDAWRDALAASIPEEPT
DD
>Mature_161_residues
ADIKVGIIMGSQSDWPTMKEAANILDELGVAYETRIVSAHRTPDRLWDYGKTAAERGLHVIIAGAGGAAHLPGMMASKTR
VPVVGVPVQTRALSGVDSLYSIVQMPKGFPVATMAIGAAGAANAGLMAAGILATSDAALAERLDAWRDALAASIPEEPTD
D

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=155, Percent_Identity=62.5806451612903, Blast_Score=167, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6324702, Length=142, Percent_Identity=53.5211267605634, Blast_Score=152, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 16752; Mature: 16621

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADIKVGIIMGSQSDWPTMKEAANILDELGVAYETRIVSAHRTPDRLWDYGKTAAERGLH
CCCEEEEEEECCCCCCCHHHHHHHHHHHHCCHHHHHEEECCCCHHHHHHHCHHHHHCCCE
VIIAGAGGAAHLPGMMASKTRVPVVGVPVQTRALSGVDSLYSIVQMPKGFPVATMAIGAA
EEEECCCCHHHCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCC
GAANAGLMAAGILATSDAALAERLDAWRDALAASIPEEPTDD
CCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
ADIKVGIIMGSQSDWPTMKEAANILDELGVAYETRIVSAHRTPDRLWDYGKTAAERGLH
CCEEEEEEECCCCCCCHHHHHHHHHHHHCCHHHHHEEECCCCHHHHHHHCHHHHHCCCE
VIIAGAGGAAHLPGMMASKTRVPVVGVPVQTRALSGVDSLYSIVQMPKGFPVATMAIGAA
EEEECCCCHHHCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCC
GAANAGLMAAGILATSDAALAERLDAWRDALAASIPEEPTDD
CCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]