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The map label for this gene is hisZ [H]

Identifier: 99080345

GI number: 99080345

Start: 531808

End: 532899

Strand: Direct

Name: hisZ [H]

Synonym: TM1040_0504

Alternate gene names: 99080345

Gene position: 531808-532899 (Clockwise)

Preceding gene: 99080344

Following gene: 99080346

Centisome position: 16.61

GC content: 63.37

Gene sequence:

>1092_bases
ATGCCCAACAGATCCCAAATCGAAGCCCGCGCGGCACTATTGCGCCAGCGTTTTGAGGTGGCAGGCGGCGTTGTCGTCGA
TCCGCCGCTGCTGCAGCCTGCCGATGTGCTCCTTGACCTTTACGGCGAGGACATCCGTGCGCGCGCCTATGTGACATCAG
ACGCCCTGCGGGGCGAGCAGATGCTGCGCCCGGATTTCACCCTGCCGATGGTCCAGATGCATATGAAAGGGGGCGCGGAA
CCTGCGCGATATACCTATGCAGGACAAGTGTTTCGCCGCCAGGAGCATGACCCAGAACGTGCCAATGAATTTGTGCAGGT
CGGCTATGAGGTCTTTGACCGCACCGACCCGGCGGACGCGGATGCTGAGGTCTTTGCGCTGTTTCAGCTGCAATTGCGCG
GCCTCGAGCTGCGGGTCGCCACCGGGGATATCGGCATCCTGATGGCCGCCGTCGAGGGGCTCAACACCACCGAGGTGCGC
AAGGCGGCGTTGCGGCGTCACATCTGGCGCCCACGCCGGTTCCGCGCTCTTCTGGATCGTTTTGCCGGACGCACGCCGAT
GTCGGAGAGCCGCAAGAAGCTTTTGTCGACCACCGGTCCGCTGACCGGCAGCGCGCCGGAGATTGGCAAACGCCGCACCG
CCGAGATCGACGCACGGGTCGAGACCCTGCGCGCGGATGCAGGCGCGCCGCCAATCTCTGAACATGAGATGGAGGCGCTG
GAGGCCTTGCTCGCGGTACGTGAAACGGTTCCTTATGCGCTTGAGCAAATGCGCGATATCGCCGTTGATCTACCGGCTAT
CCTGCCTGCCCTTGAACGTTTGGAGGCCCGCTCGGCGGCGATGAAGGCCCGTGGGATTGCAATCGATCAGCTGGATTTCG
AGGCTGCATATGGGCGCACATCGATGGAATACTACGACGGCTTCGTGTTTGGCTTTTATGCGGAGCGCCGCCCGGATCTA
CCACCGATCGCGACAGGGGGGCGCTATGACGCTCTCACGCGCTATCTGGGGCAAGGGGATGAGATCCCTGCCGTGGGCGG
TGTCATCCGCCCCGACCTGATCCTGGCTCTGGAAGGGGAGGCCGAGGCATGA

Upstream 100 bases:

>100_bases
GGAAGGAACGCCCCAGCCAGTTTGAAGTGCCCCGCACGGAACTGGTTGCCAAGGTGCGTGAGATCCTCGTCAGCCAATCC
AGCGATCGGGAGGGCTGAGC

Downstream 100 bases:

>100_bases
GCATCAAACTCGGTGTGCCGTCCAAGGGACGGCTGATGGAGAAAACCTTCGACTGGTTTGCAAAACGCGGTATCACCCTG
TCTCGGACCGGTTCTGATCG

Product: ATP phosphoribosyltransferase regulatory subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MPNRSQIEARAALLRQRFEVAGGVVVDPPLLQPADVLLDLYGEDIRARAYVTSDALRGEQMLRPDFTLPMVQMHMKGGAE
PARYTYAGQVFRRQEHDPERANEFVQVGYEVFDRTDPADADAEVFALFQLQLRGLELRVATGDIGILMAAVEGLNTTEVR
KAALRRHIWRPRRFRALLDRFAGRTPMSESRKKLLSTTGPLTGSAPEIGKRRTAEIDARVETLRADAGAPPISEHEMEAL
EALLAVRETVPYALEQMRDIAVDLPAILPALERLEARSAAMKARGIAIDQLDFEAAYGRTSMEYYDGFVFGFYAERRPDL
PPIATGGRYDALTRYLGQGDEIPAVGGVIRPDLILALEGEAEA

Sequences:

>Translated_363_residues
MPNRSQIEARAALLRQRFEVAGGVVVDPPLLQPADVLLDLYGEDIRARAYVTSDALRGEQMLRPDFTLPMVQMHMKGGAE
PARYTYAGQVFRRQEHDPERANEFVQVGYEVFDRTDPADADAEVFALFQLQLRGLELRVATGDIGILMAAVEGLNTTEVR
KAALRRHIWRPRRFRALLDRFAGRTPMSESRKKLLSTTGPLTGSAPEIGKRRTAEIDARVETLRADAGAPPISEHEMEAL
EALLAVRETVPYALEQMRDIAVDLPAILPALERLEARSAAMKARGIAIDQLDFEAAYGRTSMEYYDGFVFGFYAERRPDL
PPIATGGRYDALTRYLGQGDEIPAVGGVIRPDLILALEGEAEA
>Mature_362_residues
PNRSQIEARAALLRQRFEVAGGVVVDPPLLQPADVLLDLYGEDIRARAYVTSDALRGEQMLRPDFTLPMVQMHMKGGAEP
ARYTYAGQVFRRQEHDPERANEFVQVGYEVFDRTDPADADAEVFALFQLQLRGLELRVATGDIGILMAAVEGLNTTEVRK
AALRRHIWRPRRFRALLDRFAGRTPMSESRKKLLSTTGPLTGSAPEIGKRRTAEIDARVETLRADAGAPPISEHEMEALE
ALLAVRETVPYALEQMRDIAVDLPAILPALERLEARSAAMKARGIAIDQLDFEAAYGRTSMEYYDGFVFGFYAERRPDLP
PIATGGRYDALTRYLGQGDEIPAVGGVIRPDLILALEGEAEA

Specific function: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine [H]

COG id: COG3705

COG function: function code E; ATP phosphoribosyltransferase involved in histidine biosynthesis

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR004516 [H]

Pfam domain/function: PF00587 tRNA-synt_2b [H]

EC number: NA

Molecular weight: Translated: 40279; Mature: 40147

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNRSQIEARAALLRQRFEVAGGVVVDPPLLQPADVLLDLYGEDIRARAYVTSDALRGEQ
CCCHHHHHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHCCCHHHEEEEEHHHHCCHH
MLRPDFTLPMVQMHMKGGAEPARYTYAGQVFRRQEHDPERANEFVQVGYEVFDRTDPADA
HCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCC
DAEVFALFQLQLRGLELRVATGDIGILMAAVEGLNTTEVRKAALRRHIWRPRRFRALLDR
CHHHHHHHHHHHCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHH
FAGRTPMSESRKKLLSTTGPLTGSAPEIGKRRTAEIDARVETLRADAGAPPISEHEMEAL
HCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHH
EALLAVRETVPYALEQMRDIAVDLPAILPALERLEARSAAMKARGIAIDQLDFEAAYGRT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHCCCC
SMEYYDGFVFGFYAERRPDLPPIATGGRYDALTRYLGQGDEIPAVGGVIRPDLILALEGE
HHHHHCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCC
AEA
CCC
>Mature Secondary Structure 
PNRSQIEARAALLRQRFEVAGGVVVDPPLLQPADVLLDLYGEDIRARAYVTSDALRGEQ
CCHHHHHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHCCCHHHEEEEEHHHHCCHH
MLRPDFTLPMVQMHMKGGAEPARYTYAGQVFRRQEHDPERANEFVQVGYEVFDRTDPADA
HCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCC
DAEVFALFQLQLRGLELRVATGDIGILMAAVEGLNTTEVRKAALRRHIWRPRRFRALLDR
CHHHHHHHHHHHCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHH
FAGRTPMSESRKKLLSTTGPLTGSAPEIGKRRTAEIDARVETLRADAGAPPISEHEMEAL
HCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHH
EALLAVRETVPYALEQMRDIAVDLPAILPALERLEARSAAMKARGIAIDQLDFEAAYGRT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHCCCC
SMEYYDGFVFGFYAERRPDLPPIATGGRYDALTRYLGQGDEIPAVGGVIRPDLILALEGE
HHHHHCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCC
AEA
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA