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The map label for this gene is hisG [H]

Identifier: 99080346

GI number: 99080346

Start: 532896

End: 533588

Strand: Direct

Name: hisG [H]

Synonym: TM1040_0505

Alternate gene names: 99080346

Gene position: 532896-533588 (Clockwise)

Preceding gene: 99080345

Following gene: 99080349

Centisome position: 16.65

GC content: 58.15

Gene sequence:

>693_bases
ATGAGCATCAAACTCGGTGTGCCGTCCAAGGGACGGCTGATGGAGAAAACCTTCGACTGGTTTGCAAAACGCGGTATCAC
CCTGTCTCGGACCGGTTCTGATCGCGAATACGCCGGCGCAGTAGAAGGCGTTGAGGGCGTAGACCTGGTTCTGCTCTCTG
CTGGCGAAATCCCACGAGAGCTGGCTGCTGGACGTATCCACCTGGGTGTGACCGGTACGGACCTCGTGCACGAGAAGCTG
CCGCGCTGGGAACAGCAGGTCGAAGAGCTCGAGCCTATGGGCTTTGGTGAGGCGGATTTGATCCTTGCGGTGCCGCAGTT
CTGGATCGATGTGGACACGCTCGAAGATCTCGATGCGGTCGCTGCGGCGTTTCGCCGAACCCATGGTCACCGCCTGCGGA
TTGCGACGAAGTACCACCGTTTGATCCGCGAGTTCCTCGCAGATGCCGGAGTTGCGGACTATCAGTTGATTGACAGCCAG
GGCGCAACCGAGGGGACTGTGAAGAACGAAACGGCGGAAATGGTCGCGGATATTACCTCCACCGGTGAAACTCTGCGCGC
AAACCACCTCAAGATCCTCTCGGATGGGTTGGTACTGCGCAGTCAGGCAACGCTGTGGCGCAGCCGCGTTGCAAAATGCA
CGCCTGAAGAGAAGCAAACCCTGCAAACGCTTTTGACAAAGATTGAAGGCTAA

Upstream 100 bases:

>100_bases
ACGCTCTCACGCGCTATCTGGGGCAAGGGGATGAGATCCCTGCCGTGGGCGGTGTCATCCGCCCCGACCTGATCCTGGCT
CTGGAAGGGGAGGCCGAGGC

Downstream 100 bases:

>100_bases
ACTGGGATGCGAGGCTCTGCCTCGCGCTCCGGGATATTTCTCGTTAGAAGAAGGAAGGCTGCGGGATCCGCGGCCTTTCT
TGCTTCTTCTGACCTCAAAT

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 230; Mature: 229

Protein sequence:

>230_residues
MSIKLGVPSKGRLMEKTFDWFAKRGITLSRTGSDREYAGAVEGVEGVDLVLLSAGEIPRELAAGRIHLGVTGTDLVHEKL
PRWEQQVEELEPMGFGEADLILAVPQFWIDVDTLEDLDAVAAAFRRTHGHRLRIATKYHRLIREFLADAGVADYQLIDSQ
GATEGTVKNETAEMVADITSTGETLRANHLKILSDGLVLRSQATLWRSRVAKCTPEEKQTLQTLLTKIEG

Sequences:

>Translated_230_residues
MSIKLGVPSKGRLMEKTFDWFAKRGITLSRTGSDREYAGAVEGVEGVDLVLLSAGEIPRELAAGRIHLGVTGTDLVHEKL
PRWEQQVEELEPMGFGEADLILAVPQFWIDVDTLEDLDAVAAAFRRTHGHRLRIATKYHRLIREFLADAGVADYQLIDSQ
GATEGTVKNETAEMVADITSTGETLRANHLKILSDGLVLRSQATLWRSRVAKCTPEEKQTLQTLLTKIEG
>Mature_229_residues
SIKLGVPSKGRLMEKTFDWFAKRGITLSRTGSDREYAGAVEGVEGVDLVLLSAGEIPRELAAGRIHLGVTGTDLVHEKLP
RWEQQVEELEPMGFGEADLILAVPQFWIDVDTLEDLDAVAAAFRRTHGHRLRIATKYHRLIREFLADAGVADYQLIDSQG
ATEGTVKNETAEMVADITSTGETLRANHLKILSDGLVLRSQATLWRSRVAKCTPEEKQTLQTLLTKIEG

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 25419; Mature: 25288

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIKLGVPSKGRLMEKTFDWFAKRGITLSRTGSDREYAGAVEGVEGVDLVLLSAGEIPRE
CEEECCCCCCCHHHHHHHHHHHHCCCEEEECCCCCHHHHHHCCCCCCEEEEEECCCCHHH
LAAGRIHLGVTGTDLVHEKLPRWEQQVEELEPMGFGEADLILAVPQFWIDVDTLEDLDAV
HHCCEEEEECCCHHHHHHHCCHHHHHHHHHCCCCCCCCHHEEECHHHHEEHHHHHHHHHH
AAAFRRTHGHRLRIATKYHRLIREFLADAGVADYQLIDSQGATEGTVKNETAEMVADITS
HHHHHHCCCCEEEEHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHH
TGETLRANHLKILSDGLVLRSQATLWRSRVAKCTPEEKQTLQTLLTKIEG
CCCHHHHHHHHHHHCCEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SIKLGVPSKGRLMEKTFDWFAKRGITLSRTGSDREYAGAVEGVEGVDLVLLSAGEIPRE
EEECCCCCCCHHHHHHHHHHHHCCCEEEECCCCCHHHHHHCCCCCCEEEEEECCCCHHH
LAAGRIHLGVTGTDLVHEKLPRWEQQVEELEPMGFGEADLILAVPQFWIDVDTLEDLDAV
HHCCEEEEECCCHHHHHHHCCHHHHHHHHHCCCCCCCCHHEEECHHHHEEHHHHHHHHHH
AAAFRRTHGHRLRIATKYHRLIREFLADAGVADYQLIDSQGATEGTVKNETAEMVADITS
HHHHHHCCCCEEEEHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHH
TGETLRANHLKILSDGLVLRSQATLWRSRVAKCTPEEKQTLQTLLTKIEG
CCCHHHHHHHHHHHCCEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA