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The map label for this gene is hcrC [H]

Identifier: 99080340

GI number: 99080340

Start: 523693

End: 525096

Strand: Reverse

Name: hcrC [H]

Synonym: TM1040_0499

Alternate gene names: 99080340

Gene position: 525096-523693 (Counterclockwise)

Preceding gene: 99080342

Following gene: 99080339

Centisome position: 16.4

GC content: 62.61

Gene sequence:

>1404_bases
ATGACGATTACCTTTCATCTCAATGGTGAACAGGTCTCGCTTGCGAAACCGGACCCCACCACGACGCTTCTGGACTGGCT
GCGAGAAGAGCGCGGCCTCACCGGCACCAAAGAAGGCTGTAACGAGGGCGACTGCGGGGCCTGCACGGTCATGGTGACTG
ATCAGAGCGGCGCCAAGGCGCTCAATGCCTGCATTCTCTTTCTGCCTCAGTTGCATGGCAAATCCGTGCGCACCGTGGAA
GGTGTCGCAGCACCAATAGGCACGCTGCATCCGGTTCAGCGTGCGATGATCGACCATCACGGCAGCCAGTGCGGCTTCTG
CACGCCAGGATTTGTGATGTCGATGGTCACCGCGCATACAAATGGCGCCACAGACCATGACGATCAGCTTGCCGGCAATC
TCTGCCGCTGCACCGGCTATGCGCCGATCATCCGTGCTGCCGAGGCCGCTCAGGACGCGCCCGTCCCTGATCATATCGCG
CAGGATCGCAGTTTCACCTTTTCAGAAATACCTCTGGGGGAGGACGCAGACCGAGGGGCAGAGCCCCCAAACGCCCTGCG
TCCCTGCTCTTCGGATGATCTGGCCAGAGTTTACGCAGCCCGCCCCGAGGCCACGCTGATTGCTGGCGCCACTGATGTGG
GGCTTTGGGTCACAAAGCATCTGCGCCAGCTGCGGGATGTGATTTTTCTGGACGGCTGTCGCGACCTCAAGAAGATCACA
ATCAGCGACGCGGAGGTGCGCATCGGTGCCATGGCCGATATGAACCACCTGCGCGCCGCCCTTGCGCCCTTGCACCCGTC
CTATGCCGAGATGCTGCGCCGCTATGCCAGCCAACAGGTACGCGCGGCCGCCACGCTTGGGGGCAATATCGCCAATGGCT
CTCCCATCGGGGACAACCCGCCCGCGCTCATCGCCCTGCGCGCCACACTGCATCTGCGCAAGGGCGACATGCGCCGGAGC
CTGCCGCTGCAGGACTTCTTCATAGACTACGGCAAGCAGGACCGCGCGCCCGGCGAATTCATCGAAGCCGTGAGCTTTGA
CCGGCAGCCCGACAGCCTGCGGGTCTACAAGCTCTCAAAACGGTTTGATCAGGACATCTCGGCGGTGCTGGGCGCCTTCA
ATGTGACCGTCGTGAACGGCAATGTCACGGCTGCTGTGATTGCCTTTGGCGGCATGGCGGCCATTCCCAAACGCGCCACC
CACGTCGAGGAGGCACTGGTCGGTCGCCCCTGGACAGAGGCGACGCTTGTGGCTGCACAGGCCACGTTTGATCACGATTT
CACGCCCCTGAGCGATATGCGCGCGTCTGCCGCCTACCGGCTCGACTGCGCACGCAATATGCTCCGGCGCTACTTCTCCG
ACCTGAACGGAGCGCCGGAACATGTGCTGGAGGTCCAGCCATGA

Upstream 100 bases:

>100_bases
AAGCTGGGCGCATCATCCACCAATACTCCCGCAGGCCTTCTACGTCGCATCGAGGGCCGCGCCGCATGGGACAACCGGGT
ACCGCGACGGGCTTTTCAAG

Downstream 100 bases:

>100_bases
GTGTGTCCACCCCCCTGCCCCATGATGCCGCCGCCCTGCACGTCACGGGCCAGGCCCGCTACGTGGATGACATCCCCACC
CCCAAGGGCACACTGCATCT

Product: molybdopterin dehydrogenase, FAD-binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MTITFHLNGEQVSLAKPDPTTTLLDWLREERGLTGTKEGCNEGDCGACTVMVTDQSGAKALNACILFLPQLHGKSVRTVE
GVAAPIGTLHPVQRAMIDHHGSQCGFCTPGFVMSMVTAHTNGATDHDDQLAGNLCRCTGYAPIIRAAEAAQDAPVPDHIA
QDRSFTFSEIPLGEDADRGAEPPNALRPCSSDDLARVYAARPEATLIAGATDVGLWVTKHLRQLRDVIFLDGCRDLKKIT
ISDAEVRIGAMADMNHLRAALAPLHPSYAEMLRRYASQQVRAAATLGGNIANGSPIGDNPPALIALRATLHLRKGDMRRS
LPLQDFFIDYGKQDRAPGEFIEAVSFDRQPDSLRVYKLSKRFDQDISAVLGAFNVTVVNGNVTAAVIAFGGMAAIPKRAT
HVEEALVGRPWTEATLVAAQATFDHDFTPLSDMRASAAYRLDCARNMLRRYFSDLNGAPEHVLEVQP

Sequences:

>Translated_467_residues
MTITFHLNGEQVSLAKPDPTTTLLDWLREERGLTGTKEGCNEGDCGACTVMVTDQSGAKALNACILFLPQLHGKSVRTVE
GVAAPIGTLHPVQRAMIDHHGSQCGFCTPGFVMSMVTAHTNGATDHDDQLAGNLCRCTGYAPIIRAAEAAQDAPVPDHIA
QDRSFTFSEIPLGEDADRGAEPPNALRPCSSDDLARVYAARPEATLIAGATDVGLWVTKHLRQLRDVIFLDGCRDLKKIT
ISDAEVRIGAMADMNHLRAALAPLHPSYAEMLRRYASQQVRAAATLGGNIANGSPIGDNPPALIALRATLHLRKGDMRRS
LPLQDFFIDYGKQDRAPGEFIEAVSFDRQPDSLRVYKLSKRFDQDISAVLGAFNVTVVNGNVTAAVIAFGGMAAIPKRAT
HVEEALVGRPWTEATLVAAQATFDHDFTPLSDMRASAAYRLDCARNMLRRYFSDLNGAPEHVLEVQP
>Mature_466_residues
TITFHLNGEQVSLAKPDPTTTLLDWLREERGLTGTKEGCNEGDCGACTVMVTDQSGAKALNACILFLPQLHGKSVRTVEG
VAAPIGTLHPVQRAMIDHHGSQCGFCTPGFVMSMVTAHTNGATDHDDQLAGNLCRCTGYAPIIRAAEAAQDAPVPDHIAQ
DRSFTFSEIPLGEDADRGAEPPNALRPCSSDDLARVYAARPEATLIAGATDVGLWVTKHLRQLRDVIFLDGCRDLKKITI
SDAEVRIGAMADMNHLRAALAPLHPSYAEMLRRYASQQVRAAATLGGNIANGSPIGDNPPALIALRATLHLRKGDMRRSL
PLQDFFIDYGKQDRAPGEFIEAVSFDRQPDSLRVYKLSKRFDQDISAVLGAFNVTVVNGNVTAAVIAFGGMAAIPKRATH
VEEALVGRPWTEATLVAAQATFDHDFTPLSDMRASAAYRLDCARNMLRRYFSDLNGAPEHVLEVQP

Specific function: Catalyzes reductive dehydroxylation of 4-hydroxybenzoyl- CoA. Reaction is not reversible [H]

COG id: COG4630

COG function: function code F; Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=478, Percent_Identity=29.4979079497908, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI71773480, Length=484, Percent_Identity=27.8925619834711, Blast_Score=135, Evalue=8e-32,
Organism=Escherichia coli, GI1786480, Length=169, Percent_Identity=39.0532544378698, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI1789231, Length=274, Percent_Identity=28.4671532846715, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1789232, Length=150, Percent_Identity=40, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17540638, Length=541, Percent_Identity=29.3900184842884, Blast_Score=192, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI17539860, Length=466, Percent_Identity=26.3948497854077, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI32566215, Length=462, Percent_Identity=26.1904761904762, Blast_Score=127, Evalue=9e-30,
Organism=Drosophila melanogaster, GI17737937, Length=477, Percent_Identity=32.4947589098532, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24647201, Length=518, Percent_Identity=27.027027027027, Blast_Score=141, Evalue=9e-34,
Organism=Drosophila melanogaster, GI24647199, Length=497, Percent_Identity=26.1569416498994, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24647197, Length=465, Percent_Identity=27.9569892473118, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24647195, Length=328, Percent_Identity=29.8780487804878, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24647193, Length=454, Percent_Identity=24.4493392070485, Blast_Score=99, Evalue=9e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR006058
- InterPro:   IPR017606
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.3.99.20 [H]

Molecular weight: Translated: 50504; Mature: 50373

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTITFHLNGEQVSLAKPDPTTTLLDWLREERGLTGTKEGCNEGDCGACTVMVTDQSGAKA
CEEEEEECCCEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCHHH
LNACILFLPQLHGKSVRTVEGVAAPIGTLHPVQRAMIDHHGSQCGFCTPGFVMSMVTAHT
HHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCC
NGATDHDDQLAGNLCRCTGYAPIIRAAEAAQDAPVPDHIAQDRSFTFSEIPLGEDADRGA
CCCCCCCHHHHCCHHHHCCCHHHHHHHHHHCCCCCCHHHHCCCCCEEECCCCCCCCCCCC
EPPNALRPCSSDDLARVYAARPEATLIAGATDVGLWVTKHLRQLRDVIFLDGCRDLKKIT
CCCHHCCCCCCCCHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHEECCCCCHHHEEE
ISDAEVRIGAMADMNHLRAALAPLHPSYAEMLRRYASQQVRAAATLGGNIANGSPIGDNP
ECCCEEEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
PALIALRATLHLRKGDMRRSLPLQDFFIDYGKQDRAPGEFIEAVSFDRQPDSLRVYKLSK
CEEEEEEEEHHECCCCHHHCCCHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCEEEEEHHH
RFDQDISAVLGAFNVTVVNGNVTAAVIAFGGMAAIPKRATHVEEALVGRPWTEATLVAAQ
HHHHHHHHHHCCEEEEEECCCCEEEEEECCCHHHCCHHHHHHHHHHHCCCCCHHEEEEEE
ATFDHDFTPLSDMRASAAYRLDCARNMLRRYFSDLNGAPEHVLEVQP
ECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCEECCC
>Mature Secondary Structure 
TITFHLNGEQVSLAKPDPTTTLLDWLREERGLTGTKEGCNEGDCGACTVMVTDQSGAKA
EEEEEECCCEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCHHH
LNACILFLPQLHGKSVRTVEGVAAPIGTLHPVQRAMIDHHGSQCGFCTPGFVMSMVTAHT
HHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCC
NGATDHDDQLAGNLCRCTGYAPIIRAAEAAQDAPVPDHIAQDRSFTFSEIPLGEDADRGA
CCCCCCCHHHHCCHHHHCCCHHHHHHHHHHCCCCCCHHHHCCCCCEEECCCCCCCCCCCC
EPPNALRPCSSDDLARVYAARPEATLIAGATDVGLWVTKHLRQLRDVIFLDGCRDLKKIT
CCCHHCCCCCCCCHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHEECCCCCHHHEEE
ISDAEVRIGAMADMNHLRAALAPLHPSYAEMLRRYASQQVRAAATLGGNIANGSPIGDNP
ECCCEEEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
PALIALRATLHLRKGDMRRSLPLQDFFIDYGKQDRAPGEFIEAVSFDRQPDSLRVYKLSK
CEEEEEEEEHHECCCCHHHCCCHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCEEEEEHHH
RFDQDISAVLGAFNVTVVNGNVTAAVIAFGGMAAIPKRATHVEEALVGRPWTEATLVAAQ
HHHHHHHHHHCCEEEEEECCCCEEEEEECCCHHHCCHHHHHHHHHHHCCCCCHHEEEEEE
ATFDHDFTPLSDMRASAAYRLDCARNMLRRYFSDLNGAPEHVLEVQP
ECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9490068 [H]