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The map label for this gene is xdhA [H]

Identifier: 99080339

GI number: 99080339

Start: 521348

End: 523696

Strand: Reverse

Name: xdhA [H]

Synonym: TM1040_0498

Alternate gene names: 99080339

Gene position: 523696-521348 (Counterclockwise)

Preceding gene: 99080340

Following gene: 99080338

Centisome position: 16.36

GC content: 61.35

Gene sequence:

>2349_bases
ATGAGTGTGTCCACCCCCCTGCCCCATGATGCCGCCGCCCTGCACGTCACGGGCCAGGCCCGCTACGTGGATGACATCCC
CACCCCCAAGGGCACACTGCATCTTGCCTTTGGTCTTGCGCCGATCGCCAGCGGCTCCATCACCGCGATGAACCTTGCCG
AGGTGCACGCTTCGGACGGTGTGGTGGCAGTGCTGACCGCGGACGATCTGCCCTTTGACAATGATGTTTCTCCCTCAGCC
CATGATGAGCCGCTCCTGGCCAAGGGCGAGGTGCACTACCTCGGCCAGCCCGTCTTTTTGGTGGTTGCCACCTCTCATCG
CGCTGCACGCGTTGCGGCGCGCAAGGGCGATATCGAATACCGCAAAACCGACGCGCTCTTGAGTGTGGAGGCGGCACTGG
CAGCAGACAGCCGCTTTGAAGACGGCCCGCGCATCTATGAGAAAGGCGATGCCCCCGCAGCCATTCAGGCCTCTTTGCAT
GTGATCGAAGACAGCTTCGACATTGGTGGTCAGGAGCATTTCTATCTCGAGGGTCAGGCGGCGCTGGCGCTGCCGCAAGA
AGATGGCGGCATGATCGTCAATTCGTCCACCCAGCACCCAACCGAAATACAGCACAAGGTGGCCGAGGCGATTGGACTGC
CGATGCACGCAGTCCGGGTCGAGACCCGACGCATGGGCGGCGGCTTTGGCGGCAAGGAAAGCCAGGGCAATGCCCTGGCA
GTGGCCTGCGCCGTAGCCGCGCGCCTCACCGGCAAAGCCTGCAAGATGCGCTATGACCGCGACGATGACATGACCATCAC
CGGCAAGCGCCACTCGTTCCGGATCTCTTATCGCGCCGGTTTTGACGCAGAGGGGCGGATCACGGGCGTCGAGTTCACTC
ATTTGGTCAATTGCGGCTGGGCGCAAGACCTGTCGCTACCGGTGGCAGATCGCGCCATGCTGCATGCGGACAACGCCTAT
GCAATCCCTGCGATCCGCATTGAGAGCCATCGGCTGAAAACCAACCTGCAAAGCGCCACAGCGTATCGCGGCTTTGGCGG
CCCTCAAGGCATGGTCGGCATCGAGCGGGTGATGGATCATGCCGCACAGGTCTTGGGGATGGATCCGGTCGAGCTGCGGG
TACGCAACTACTATGCCGCCCCCCTTGCGTCCAAAGGGGGCTCTGCCCCCCGGTCTGCGACCTCCCCCCGGGATATTTCT
GGAAAAGAGAAGGACAATACCACTCCCTATGGCATGGAAGTGATAGATTTCGAGCTGCATGAGATGACCGCGCAGCTCGT
GAAATCCGCCGATTATGCCGCGCGCAAGGCGGAGATTTCGGCCTGGAACGCGCGCCATGACCGTTTGAAGCGCGGCCTGG
CCTTCTCACCGGTGAAATTCGGGATCTCCTTTACGCTCACCCACCTGAATCAGGCGGGCGCCTTGGTGCACGTCTATCAG
GATGGCTCCATCCATCTCAATCACGGTGGCACCGAGATGGGACAGGGGCTGTTTCAAAAGGTGGCCCAAGTGGCGGCTGC
ACGTTTTGGGGTCGACCTCGGGCGGGTGAAGATCACAGCGACTGACACCGCAAAGGTACCAAATACCTCGGCCACCGCAG
CCTCCTCGGGCTCTGATCTCAATGGGATGGCGGTGAAAGCCGCCTGTGACATCATTCGCGACCGCATGGCGGCGCATCTG
GCCGAAGTCTATCAACAGCCGCAATCCGCAGTTTCGTTTGAGAAGGATCAGGTGCGCATCGGCTCTGAACGGATCAGTTT
TGAGGCGGCGGCGATGCAGTGTTACACGGGCCGGGTGAGTCTCTCGGCAACGGGGTTTTACAAAACGCCCTCGCTGGAGT
GGGACCGGATCAAGGGAGCCGGACGGCCGTTTTTCTATTTCGCCTATGGGGCAGCGATCACCGAAGTGGTGGTCGACCGG
CTGACCGGCGAAAACCGCATTCTGCGCGCCGATATCTTGCATGATGCGGGCGCCTCGCTGAACCCAGCACTCGATATCGG
ACAAGTGGAAGGCGCTTATGTTCAGGGCGCAGGCTGGCTCACGACCGAAGAGCTTGTCTGGGACGAGACCGGGCGACTTC
GCACCCATGCGCCATCTACCTACAAGATCCCGGCCTGCTCTGACCGGCCCGATGTGTTCAACGTGGCGCTCTATGACGGA
TCAAACCGCGAAGAGACCATCTATCGCTCCAAAGCGGTGGGCGAGCCACCGTTTATGCTGGGCATTTCGGCCTGGCTTGC
GCTCTCGGATGCGGTGTCTCGTTTCGGCGAAGGGCATCCACATTTGAACGCGCCTGCGACGGCGGAAGAGATCTGGCGGG
CAACAGAGACACTACGCCATGGGGTTTGA

Upstream 100 bases:

>100_bases
GCGCGTCTGCCGCCTACCGGCTCGACTGCGCACGCAATATGCTCCGGCGCTACTTCTCCGACCTGAACGGAGCGCCGGAA
CATGTGCTGGAGGTCCAGCC

Downstream 100 bases:

>100_bases
CGTCGAAGCGCTGAAGGCGGCCTTAGAGGCCCATGGTCGGGTGATCCGCGTGGTGGTGGCCGAGGTCAAAGGCTCTGCGC
CGCGTGAAGTCGGTGCAGCC

Product: xanthine dehydrogenase, molybdenum binding subunit apoprotein / xanthine oxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 782; Mature: 781

Protein sequence:

>782_residues
MSVSTPLPHDAAALHVTGQARYVDDIPTPKGTLHLAFGLAPIASGSITAMNLAEVHASDGVVAVLTADDLPFDNDVSPSA
HDEPLLAKGEVHYLGQPVFLVVATSHRAARVAARKGDIEYRKTDALLSVEAALAADSRFEDGPRIYEKGDAPAAIQASLH
VIEDSFDIGGQEHFYLEGQAALALPQEDGGMIVNSSTQHPTEIQHKVAEAIGLPMHAVRVETRRMGGGFGGKESQGNALA
VACAVAARLTGKACKMRYDRDDDMTITGKRHSFRISYRAGFDAEGRITGVEFTHLVNCGWAQDLSLPVADRAMLHADNAY
AIPAIRIESHRLKTNLQSATAYRGFGGPQGMVGIERVMDHAAQVLGMDPVELRVRNYYAAPLASKGGSAPRSATSPRDIS
GKEKDNTTPYGMEVIDFELHEMTAQLVKSADYAARKAEISAWNARHDRLKRGLAFSPVKFGISFTLTHLNQAGALVHVYQ
DGSIHLNHGGTEMGQGLFQKVAQVAAARFGVDLGRVKITATDTAKVPNTSATAASSGSDLNGMAVKAACDIIRDRMAAHL
AEVYQQPQSAVSFEKDQVRIGSERISFEAAAMQCYTGRVSLSATGFYKTPSLEWDRIKGAGRPFFYFAYGAAITEVVVDR
LTGENRILRADILHDAGASLNPALDIGQVEGAYVQGAGWLTTEELVWDETGRLRTHAPSTYKIPACSDRPDVFNVALYDG
SNREETIYRSKAVGEPPFMLGISAWLALSDAVSRFGEGHPHLNAPATAEEIWRATETLRHGV

Sequences:

>Translated_782_residues
MSVSTPLPHDAAALHVTGQARYVDDIPTPKGTLHLAFGLAPIASGSITAMNLAEVHASDGVVAVLTADDLPFDNDVSPSA
HDEPLLAKGEVHYLGQPVFLVVATSHRAARVAARKGDIEYRKTDALLSVEAALAADSRFEDGPRIYEKGDAPAAIQASLH
VIEDSFDIGGQEHFYLEGQAALALPQEDGGMIVNSSTQHPTEIQHKVAEAIGLPMHAVRVETRRMGGGFGGKESQGNALA
VACAVAARLTGKACKMRYDRDDDMTITGKRHSFRISYRAGFDAEGRITGVEFTHLVNCGWAQDLSLPVADRAMLHADNAY
AIPAIRIESHRLKTNLQSATAYRGFGGPQGMVGIERVMDHAAQVLGMDPVELRVRNYYAAPLASKGGSAPRSATSPRDIS
GKEKDNTTPYGMEVIDFELHEMTAQLVKSADYAARKAEISAWNARHDRLKRGLAFSPVKFGISFTLTHLNQAGALVHVYQ
DGSIHLNHGGTEMGQGLFQKVAQVAAARFGVDLGRVKITATDTAKVPNTSATAASSGSDLNGMAVKAACDIIRDRMAAHL
AEVYQQPQSAVSFEKDQVRIGSERISFEAAAMQCYTGRVSLSATGFYKTPSLEWDRIKGAGRPFFYFAYGAAITEVVVDR
LTGENRILRADILHDAGASLNPALDIGQVEGAYVQGAGWLTTEELVWDETGRLRTHAPSTYKIPACSDRPDVFNVALYDG
SNREETIYRSKAVGEPPFMLGISAWLALSDAVSRFGEGHPHLNAPATAEEIWRATETLRHGV
>Mature_781_residues
SVSTPLPHDAAALHVTGQARYVDDIPTPKGTLHLAFGLAPIASGSITAMNLAEVHASDGVVAVLTADDLPFDNDVSPSAH
DEPLLAKGEVHYLGQPVFLVVATSHRAARVAARKGDIEYRKTDALLSVEAALAADSRFEDGPRIYEKGDAPAAIQASLHV
IEDSFDIGGQEHFYLEGQAALALPQEDGGMIVNSSTQHPTEIQHKVAEAIGLPMHAVRVETRRMGGGFGGKESQGNALAV
ACAVAARLTGKACKMRYDRDDDMTITGKRHSFRISYRAGFDAEGRITGVEFTHLVNCGWAQDLSLPVADRAMLHADNAYA
IPAIRIESHRLKTNLQSATAYRGFGGPQGMVGIERVMDHAAQVLGMDPVELRVRNYYAAPLASKGGSAPRSATSPRDISG
KEKDNTTPYGMEVIDFELHEMTAQLVKSADYAARKAEISAWNARHDRLKRGLAFSPVKFGISFTLTHLNQAGALVHVYQD
GSIHLNHGGTEMGQGLFQKVAQVAAARFGVDLGRVKITATDTAKVPNTSATAASSGSDLNGMAVKAACDIIRDRMAAHLA
EVYQQPQSAVSFEKDQVRIGSERISFEAAAMQCYTGRVSLSATGFYKTPSLEWDRIKGAGRPFFYFAYGAAITEVVVDRL
TGENRILRADILHDAGASLNPALDIGQVEGAYVQGAGWLTTEELVWDETGRLRTHAPSTYKIPACSDRPDVFNVALYDGS
NREETIYRSKAVGEPPFMLGISAWLALSDAVSRFGEGHPHLNAPATAEEIWRATETLRHGV

Specific function: Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) [H]

COG id: COG4631

COG function: function code F; Xanthine dehydrogenase, molybdopterin-binding subunit B

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=783, Percent_Identity=41.1238825031928, Blast_Score=546, Evalue=1e-155,
Organism=Homo sapiens, GI71773480, Length=781, Percent_Identity=35.7234314980794, Blast_Score=459, Evalue=1e-129,
Organism=Escherichia coli, GI1789230, Length=753, Percent_Identity=26.8260292164675, Blast_Score=222, Evalue=8e-59,
Organism=Escherichia coli, GI1789246, Length=778, Percent_Identity=26.2210796915167, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI1786478, Length=755, Percent_Identity=25.6953642384106, Blast_Score=120, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17540638, Length=782, Percent_Identity=38.7468030690537, Blast_Score=515, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI32566215, Length=734, Percent_Identity=32.1525885558583, Blast_Score=341, Evalue=8e-94,
Organism=Caenorhabditis elegans, GI17539860, Length=762, Percent_Identity=31.496062992126, Blast_Score=318, Evalue=7e-87,
Organism=Drosophila melanogaster, GI17737937, Length=782, Percent_Identity=39.6419437340153, Blast_Score=544, Evalue=1e-154,
Organism=Drosophila melanogaster, GI24647199, Length=783, Percent_Identity=30.0127713920817, Blast_Score=305, Evalue=9e-83,
Organism=Drosophila melanogaster, GI24647193, Length=785, Percent_Identity=29.5541401273885, Blast_Score=285, Evalue=7e-77,
Organism=Drosophila melanogaster, GI24647201, Length=783, Percent_Identity=30.2681992337165, Blast_Score=276, Evalue=3e-74,
Organism=Drosophila melanogaster, GI24647195, Length=795, Percent_Identity=27.2955974842767, Blast_Score=259, Evalue=4e-69,
Organism=Drosophila melanogaster, GI24647197, Length=784, Percent_Identity=27.2959183673469, Blast_Score=258, Evalue=2e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 84135; Mature: 84003

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVSTPLPHDAAALHVTGQARYVDDIPTPKGTLHLAFGLAPIASGSITAMNLAEVHASDG
CCCCCCCCCCCEEEEEECCEEEECCCCCCCCEEEEEEECCCCCCCCEEEEEEEEEECCCC
VVAVLTADDLPFDNDVSPSAHDEPLLAKGEVHYLGQPVFLVVATSHRAARVAARKGDIEY
EEEEEEECCCCCCCCCCCCCCCCCCEECCCEEECCCCEEEEEECCCCHHHHHHHCCCCEE
RKTDALLSVEAALAADSRFEDGPRIYEKGDAPAAIQASLHVIEDSFDIGGQEHFYLEGQA
ECCCHHEEEHHHHHCCCCCCCCCCEEECCCCCCEEEEEEEEEECCCCCCCCEEEEECCCE
ALALPQEDGGMIVNSSTQHPTEIQHKVAEAIGLPMHAVRVETRRMGGGFGGKESQGNALA
EEEECCCCCCEEEECCCCCCHHHHHHHHHHHCCCHHEEEEEHHHCCCCCCCCCCCCCEEE
VACAVAARLTGKACKMRYDRDDDMTITGKRHSFRISYRAGFDAEGRITGVEFTHLVNCGW
HHHHHHHHHCCHHHEEECCCCCCEEEECCCEEEEEEEECCCCCCCCEEEEEEEEEEECCC
AQDLSLPVADRAMLHADNAYAIPAIRIESHRLKTNLQSATAYRGFGGPQGMVGIERVMDH
CCCCCCCCCCHHEEECCCCEEEEEEEEECHHHHHCHHHHHHCCCCCCCCCCHHHHHHHHH
AAQVLGMDPVELRVRNYYAAPLASKGGSAPRSATSPRDISGKEKDNTTPYGMEVIDFELH
HHHHHCCCHHHEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHH
EMTAQLVKSADYAARKAEISAWNARHDRLKRGLAFSPVKFGISFTLTHLNQAGALVHVYQ
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCEEECEEEEEEEECCCCCEEEEEE
DGSIHLNHGGTEMGQGLFQKVAQVAAARFGVDLGRVKITATDTAKVPNTSATAASSGSDL
CCEEEEECCCCHHHHHHHHHHHHHHHHHHCCEECEEEEEECCCCCCCCCCCCCCCCCCCC
NGMAVKAACDIIRDRMAAHLAEVYQQPQSAVSFEKDQVRIGSERISFEAAAMQCYTGRVS
CCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCEEECCHHHEEEHHHEEEEECEEE
LSATGFYKTPSLEWDRIKGAGRPFFYFAYGAAITEVVVDRLTGENRILRADILHDAGASL
EEECCEEECCCCCHHHHCCCCCCEEEEEHHHHHHHHHHHHHCCCCEEEEEEEHHCCCCCC
NPALDIGQVEGAYVQGAGWLTTEELVWDETGRLRTHAPSTYKIPACSDRPDVFNVALYDG
CCCCCCCCCCCEEEECCCCEEEHHHEECCCCCEEECCCCEEECCCCCCCCCEEEEEEECC
SNREETIYRSKAVGEPPFMLGISAWLALSDAVSRFGEGHPHLNAPATAEEIWRATETLRH
CCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
GV
CC
>Mature Secondary Structure 
SVSTPLPHDAAALHVTGQARYVDDIPTPKGTLHLAFGLAPIASGSITAMNLAEVHASDG
CCCCCCCCCCEEEEEECCEEEECCCCCCCCEEEEEEECCCCCCCCEEEEEEEEEECCCC
VVAVLTADDLPFDNDVSPSAHDEPLLAKGEVHYLGQPVFLVVATSHRAARVAARKGDIEY
EEEEEEECCCCCCCCCCCCCCCCCCEECCCEEECCCCEEEEEECCCCHHHHHHHCCCCEE
RKTDALLSVEAALAADSRFEDGPRIYEKGDAPAAIQASLHVIEDSFDIGGQEHFYLEGQA
ECCCHHEEEHHHHHCCCCCCCCCCEEECCCCCCEEEEEEEEEECCCCCCCCEEEEECCCE
ALALPQEDGGMIVNSSTQHPTEIQHKVAEAIGLPMHAVRVETRRMGGGFGGKESQGNALA
EEEECCCCCCEEEECCCCCCHHHHHHHHHHHCCCHHEEEEEHHHCCCCCCCCCCCCCEEE
VACAVAARLTGKACKMRYDRDDDMTITGKRHSFRISYRAGFDAEGRITGVEFTHLVNCGW
HHHHHHHHHCCHHHEEECCCCCCEEEECCCEEEEEEEECCCCCCCCEEEEEEEEEEECCC
AQDLSLPVADRAMLHADNAYAIPAIRIESHRLKTNLQSATAYRGFGGPQGMVGIERVMDH
CCCCCCCCCCHHEEECCCCEEEEEEEEECHHHHHCHHHHHHCCCCCCCCCCHHHHHHHHH
AAQVLGMDPVELRVRNYYAAPLASKGGSAPRSATSPRDISGKEKDNTTPYGMEVIDFELH
HHHHHCCCHHHEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHH
EMTAQLVKSADYAARKAEISAWNARHDRLKRGLAFSPVKFGISFTLTHLNQAGALVHVYQ
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCEEECEEEEEEEECCCCCEEEEEE
DGSIHLNHGGTEMGQGLFQKVAQVAAARFGVDLGRVKITATDTAKVPNTSATAASSGSDL
CCEEEEECCCCHHHHHHHHHHHHHHHHHHCCEECEEEEEECCCCCCCCCCCCCCCCCCCC
NGMAVKAACDIIRDRMAAHLAEVYQQPQSAVSFEKDQVRIGSERISFEAAAMQCYTGRVS
CCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCEEECCHHHEEEHHHEEEEECEEE
LSATGFYKTPSLEWDRIKGAGRPFFYFAYGAAITEVVVDRLTGENRILRADILHDAGASL
EEECCEEECCCCCHHHHCCCCCCEEEEEHHHHHHHHHHHHHCCCCEEEEEEEHHCCCCCC
NPALDIGQVEGAYVQGAGWLTTEELVWDETGRLRTHAPSTYKIPACSDRPDVFNVALYDG
CCCCCCCCCCCEEEECCCCEEEHHHEECCCCCEEECCCCEEECCCCCCCCCEEEEEEECC
SNREETIYRSKAVGEPPFMLGISAWLALSDAVSRFGEGHPHLNAPATAEEIWRATETLRH
CCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
GV
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]