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The map label for this gene is ggt [H]

Identifier: 99080323

GI number: 99080323

Start: 503457

End: 504770

Strand: Direct

Name: ggt [H]

Synonym: TM1040_0482

Alternate gene names: 99080323

Gene position: 503457-504770 (Clockwise)

Preceding gene: 99080321

Following gene: 99080324

Centisome position: 15.73

GC content: 62.63

Gene sequence:

>1314_bases
GTGGGCACGCCCGGCACACCGGCCTTGCTGGAGGCGGCCCATCGCAAATGGGGCCGCGCCAACTGGGGCGGGCTCTTTAC
CGATGCGATCCGTCTGGCTGAACTGGGTTTTGCCGTTTCCCCACGGATGGCGGACTCGATTGCCAATGATGCCGAACGGC
TGGGTCGGTTCCCGGAGACCGCAGCCTATTTTCTGCCCGAAGGCATCCCGCTTGCGGCGGGTGAGGTGATCACCAACCAG
CCCTACGCCAATGTGCTGCGTCGCATCGCGATGGAGGGGACGCGGGCCTTCTATTCAGGCCCGGTGGCTGCCGATATCGT
GCGCGCCGTACAGGGCGCGACCGGGAACCCCGGCGTCCTCTCAGAGCTGGATCTGGCGCTCTATCAGGTCAAAGAGCGTC
CGGCAGTCTGTGCCAGCTACCGCGCCTTTGAGGCCTGTGGCATGGGGCCGCCTTCGTCTGGCGCGCTTACTGTCGGGCAA
ATCCTGGGCATGCTAGAGCCTTATGACCTGGCAGCGCTGGGCCCAGACAGCCCCGAGAGCTGGCGTCTGATCGGGGACGC
CTCGCGCCTCGCATTTGCAGACCGCGGCCGTTACATGGCTGACAGCGATTATGTCCCGGTGCCCACCAAAGGTCTGCTGG
ACCCGGAGTACCTCTCCAAACGCGCGGCGTTGCTCGAAGGCGATGCGGCCTTGGAGACTGTCGCCCCTGGCGCGCCTGAG
TTCGATCATGCGCTGATCTGGGCCGATGATGAGAGCATCGAGTTTCCCTCGACCTCGCATATCTCGATTGTCGATCAATA
CGGCAATGTGCTGTCGATGACGACCACGATCGAAAACGGCTTTGGATCGCGTTTGATGACAAACGGGTTCTTGCTCAATA
ACGAACTGACGGATTTCTCATTCCGCAGCCACCGCGACGGGGTGCCGATTGCAAACCGTCTCGAGCCCGGAAAACGCCCG
CGCTCCTCGATGGCGCCGACCATTGTGATGCAGGATGGCAAACCCGTTCTTGCGATTGGCTCTCCGGGGGGGAGCCGTAT
CATCGGTTACGTGGCAACGGCGATCATCGGCTGGGCCGACTGGGGGCTCGACATTCAAGACGCAATCTCGCTGCCTCACG
CTGTAAACCGGTTCGGCACTTACGATCTTGAGGCAGGCACCGGAGCCGAGGCGCTCGAAGCCGCGCTCACGGACATGGGG
TACCAGGTAAATGTGCGTGACCTGACCTCGGGCCTACATGCGATCGAAATCGATAATGGCCTGAAGGGAGGCGCGGATCC
CCGCCGTGAAGGCATTGCGCTTGGTGACGAGTAG

Upstream 100 bases:

>100_bases
CGGGCGCGAAACCGCGCCGCTCGCGGCCACGCCGACGCTGTTTCAGGATGAAAACGGCGAACCGCTCAAGTTTTTCGATG
CTGTCGTCGGAGGCCGTTCG

Downstream 100 bases:

>100_bases
GGCAGGGGCTTTGCCCCTCCTGACCTGACGGTCAGTTCACCCCAGGATATTTTGTGTTAGAAGAATGACGCTGCAGATCC
TTCTTCTAACCGCAAATATC

Product: gamma-glutamyltransferase 1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MGTPGTPALLEAAHRKWGRANWGGLFTDAIRLAELGFAVSPRMADSIANDAERLGRFPETAAYFLPEGIPLAAGEVITNQ
PYANVLRRIAMEGTRAFYSGPVAADIVRAVQGATGNPGVLSELDLALYQVKERPAVCASYRAFEACGMGPPSSGALTVGQ
ILGMLEPYDLAALGPDSPESWRLIGDASRLAFADRGRYMADSDYVPVPTKGLLDPEYLSKRAALLEGDAALETVAPGAPE
FDHALIWADDESIEFPSTSHISIVDQYGNVLSMTTTIENGFGSRLMTNGFLLNNELTDFSFRSHRDGVPIANRLEPGKRP
RSSMAPTIVMQDGKPVLAIGSPGGSRIIGYVATAIIGWADWGLDIQDAISLPHAVNRFGTYDLEAGTGAEALEAALTDMG
YQVNVRDLTSGLHAIEIDNGLKGGADPRREGIALGDE

Sequences:

>Translated_437_residues
MGTPGTPALLEAAHRKWGRANWGGLFTDAIRLAELGFAVSPRMADSIANDAERLGRFPETAAYFLPEGIPLAAGEVITNQ
PYANVLRRIAMEGTRAFYSGPVAADIVRAVQGATGNPGVLSELDLALYQVKERPAVCASYRAFEACGMGPPSSGALTVGQ
ILGMLEPYDLAALGPDSPESWRLIGDASRLAFADRGRYMADSDYVPVPTKGLLDPEYLSKRAALLEGDAALETVAPGAPE
FDHALIWADDESIEFPSTSHISIVDQYGNVLSMTTTIENGFGSRLMTNGFLLNNELTDFSFRSHRDGVPIANRLEPGKRP
RSSMAPTIVMQDGKPVLAIGSPGGSRIIGYVATAIIGWADWGLDIQDAISLPHAVNRFGTYDLEAGTGAEALEAALTDMG
YQVNVRDLTSGLHAIEIDNGLKGGADPRREGIALGDE
>Mature_436_residues
GTPGTPALLEAAHRKWGRANWGGLFTDAIRLAELGFAVSPRMADSIANDAERLGRFPETAAYFLPEGIPLAAGEVITNQP
YANVLRRIAMEGTRAFYSGPVAADIVRAVQGATGNPGVLSELDLALYQVKERPAVCASYRAFEACGMGPPSSGALTVGQI
LGMLEPYDLAALGPDSPESWRLIGDASRLAFADRGRYMADSDYVPVPTKGLLDPEYLSKRAALLEGDAALETVAPGAPEF
DHALIWADDESIEFPSTSHISIVDQYGNVLSMTTTIENGFGSRLMTNGFLLNNELTDFSFRSHRDGVPIANRLEPGKRPR
SSMAPTIVMQDGKPVLAIGSPGGSRIIGYVATAIIGWADWGLDIQDAISLPHAVNRFGTYDLEAGTGAEALEAALTDMGY
QVNVRDLTSGLHAIEIDNGLKGGADPRREGIALGDE

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=392, Percent_Identity=30.6122448979592, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI73915090, Length=392, Percent_Identity=30.6122448979592, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI73915096, Length=392, Percent_Identity=30.6122448979592, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI73915094, Length=392, Percent_Identity=30.6122448979592, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI113429324, Length=392, Percent_Identity=28.8265306122449, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI113429326, Length=397, Percent_Identity=28.463476070529, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI109148539, Length=451, Percent_Identity=27.0509977827051, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI30581157, Length=128, Percent_Identity=41.40625, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI30581155, Length=128, Percent_Identity=41.40625, Blast_Score=83, Evalue=5e-16,
Organism=Escherichia coli, GI1789856, Length=446, Percent_Identity=33.4080717488789, Blast_Score=213, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17542894, Length=417, Percent_Identity=29.9760191846523, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI72000294, Length=401, Percent_Identity=28.927680798005, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI212646519, Length=401, Percent_Identity=28.927680798005, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI193208247, Length=440, Percent_Identity=28.1818181818182, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI193208245, Length=440, Percent_Identity=28.1818181818182, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17506189, Length=440, Percent_Identity=24.3181818181818, Blast_Score=89, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6323330, Length=216, Percent_Identity=31.9444444444444, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI161077496, Length=371, Percent_Identity=29.3800539083558, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI18859893, Length=366, Percent_Identity=29.2349726775956, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24642670, Length=451, Percent_Identity=23.059866962306, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24642666, Length=451, Percent_Identity=23.059866962306, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI161077878, Length=451, Percent_Identity=23.059866962306, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI45551474, Length=451, Percent_Identity=23.059866962306, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI161077880, Length=451, Percent_Identity=23.059866962306, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 46477; Mature: 46346

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTPGTPALLEAAHRKWGRANWGGLFTDAIRLAELGFAVSPRMADSIANDAERLGRFPET
CCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCH
AAYFLPEGIPLAAGEVITNQPYANVLRRIAMEGTRAFYSGPVAADIVRAVQGATGNPGVL
HHHHCCCCCCCCCCHHHCCCHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHCCCCCCCCH
SELDLALYQVKERPAVCASYRAFEACGMGPPSSGALTVGQILGMLEPYDLAALGPDSPES
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCEEHHHHHCCCCCCCEEECCCCCCCC
WRLIGDASRLAFADRGRYMADSDYVPVPTKGLLDPEYLSKRAALLEGDAALETVAPGAPE
EEEEECHHHHHHHHCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHCCCCCCC
FDHALIWADDESIEFPSTSHISIVDQYGNVLSMTTTIENGFGSRLMTNGFLLNNELTDFS
CCCEEEEECCCCCCCCCCCCEEEEECCCCEEEEEEECCCCCCCHHHHCCEEECCCCCCCC
FRSHRDGVPIANRLEPGKRPRSSMAPTIVMQDGKPVLAIGSPGGSRIIGYVATAIIGWAD
HHCCCCCCCCHHCCCCCCCCCCCCCCEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHH
WGLDIQDAISLPHAVNRFGTYDLEAGTGAEALEAALTDMGYQVNVRDLTSGLHAIEIDNG
CCCCHHHHHCCCHHHHHCCCEECCCCCCHHHHHHHHHHCCCEEEHHHHHCCCEEEEECCC
LKGGADPRREGIALGDE
CCCCCCCHHCCCCCCCC
>Mature Secondary Structure 
GTPGTPALLEAAHRKWGRANWGGLFTDAIRLAELGFAVSPRMADSIANDAERLGRFPET
CCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCH
AAYFLPEGIPLAAGEVITNQPYANVLRRIAMEGTRAFYSGPVAADIVRAVQGATGNPGVL
HHHHCCCCCCCCCCHHHCCCHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHCCCCCCCCH
SELDLALYQVKERPAVCASYRAFEACGMGPPSSGALTVGQILGMLEPYDLAALGPDSPES
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCEEHHHHHCCCCCCCEEECCCCCCCC
WRLIGDASRLAFADRGRYMADSDYVPVPTKGLLDPEYLSKRAALLEGDAALETVAPGAPE
EEEEECHHHHHHHHCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHCCCCCCC
FDHALIWADDESIEFPSTSHISIVDQYGNVLSMTTTIENGFGSRLMTNGFLLNNELTDFS
CCCEEEEECCCCCCCCCCCCEEEEECCCCEEEEEEECCCCCCCHHHHCCEEECCCCCCCC
FRSHRDGVPIANRLEPGKRPRSSMAPTIVMQDGKPVLAIGSPGGSRIIGYVATAIIGWAD
HHCCCCCCCCHHCCCCCCCCCCCCCCEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHH
WGLDIQDAISLPHAVNRFGTYDLEAGTGAEALEAALTDMGYQVNVRDLTSGLHAIEIDNG
CCCCHHHHHCCCHHHHHCCCEECCCCCCHHHHHHHHHHCCCEEEHHHHHCCCEEEEECCC
LKGGADPRREGIALGDE
CCCCCCCHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA