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The map label for this gene is dcp [H]

Identifier: 99080306

GI number: 99080306

Start: 483198

End: 485213

Strand: Direct

Name: dcp [H]

Synonym: TM1040_0465

Alternate gene names: 99080306

Gene position: 483198-485213 (Clockwise)

Preceding gene: 99080305

Following gene: 99080309

Centisome position: 15.1

GC content: 60.02

Gene sequence:

>2016_bases
ATGACAAATCCGCTGCTTCGCGACTGGCAAACGCCCTTTGGGATTGCCCCGTTCGATCAGATTTCCGACGAAGACTTTGC
GCCTGCGCTTGATGAGGCGCTAAAGGCGCATACTGCGCAGATCGATGCGATTGCCACCAACCCCGCGCCGCCCACATTCG
CCAATGTGATCGAGGCTCTCGAGACGCCATGCCAGCCACTTGAACAGGTGCTGTCGGTGTTTTTCTCGGTGGCCGGGGCG
GACAGCAACCCGGCGCGCGAGGCGCTCCAGCGCGCGTTCTCTCCGAATCTTGCGGCGCATTTCTCGGCCATTACTGCCAA
TAAGGCACTTTATGCACGGGTGCAGGCGGTGTGGGACCAACGCGACACTCTGGACCTGACCGACGAACAGGCCCGTGTCC
TGATGCTCACCCATCGTGGGTTTGTGCGCGGCGGCGCGGCGCTCAATGGCGCGGAAGATACCCGCATGCAGGAGATCAAA
TCCCGCCTTGCGACGCTTGGCACCAATTTCACCCAGAACCTGCTTGCGGATGAGCGGGACTGGTTCATGGAGCTCTCCGA
GGACGATCTTGAGGGGCTTCCTGATTTTGTTGTGAAGGCCGCACGGACCGCGGGGGCCGAAAAAGGCGTTTCCGGGCCGG
TCATTACGCTTGCGCGCTCTATCGTGACGCCTTTCCTGCAGTTCTCGCCGCGCAGGGACCTGCGTGAAAAGGCCTTTCGG
GCCTGGGCTGCACGAGGGGCAAATGGCGGCGCACATGACAACCGGGCGATTGCGGCAGAGATCCTGTCGCTGCGTGAAGA
ACGGGCCAAGCTCTTGGGCTATAGGAATTTTGCGGCCTACAAGCTGGAAACCGAGATGGCCAAAACGCCGGAGGCGGTGC
GTGAGCTGTTGATGGATGTCTGGGGGCCAGCCAAGGCGCAGGCGGACAAGGACGCCGAGGTGTTGACGCGGATGATGCAT
GAGGACGGCATCAATGGCGATCTGGCGCCTTGGGATTGGCATTACTACGCAGAAAAACGTCGCAAGATAGAACATGATCT
CGACGAAGCCGAACTCAAACCATACCTGCAGCTCGACCGGATGATTGAGGCGGCTTTTGCCTGCGCAAATCGTCTGTTTG
GCCTGGAATTCGCACCTCTTGATGTGCCGCTTTATCACAAGGACTGCCGCGCCTGGGAGGTTACGCGGGAAGGCAAGCAT
CTGGCGGTGTTTATTGGGGACTATTTCGCGCGGGGATCAAAGCGGTCCGGCGCGTGGTGTTCGGCTATGCGTGCGCAGGC
GAAATTCCCCGAGGAACAGACGCCAATCGTGGTCAATGTCTGCAACTTTGCCAAAGGCGACCCGGCGTTGTTGTCCTATG
ACGATGCGCGCACGCTGTTCCACGAGTTTGGCCATGCGCTGCACCAGATGCTGTCGAATGTAACCTATGAGAGTGTCTCC
GGGACCTCCGTGGCGCGCGATTTTGTGGAACTCCCGAGCCAGCTCTATGAGCATTGGCTGGAGGTGCCCGAGGTACTGCA
GGAGTTTGCCACCCATGCAGAGACCGGCGCGCCGATGCCGAAGGAGATGCTCGACAAGGTGCTTGGGGCTGCGACCTTCA
ACATGGGGTTCCAGACCGTCGAATATGTGGCGTCCGCATTGGTGGATCTGGAATTTCATGATGGCAGCGCACCCGAGGAT
CCGATGGTCAAACAGGCCGAGGTTCTCGCACAGATCGGCATGCCGGCAGCGATTGTCATGCGCCATGCTACGCCGCAGTT
TGCGCATGTTTTCTCAGGCGACGGGTACTCCTCGGGCTACTACAGCTATATGTGGTCAGAGGTAATGGACGCCGATGCTT
TTGAATCCTTTGAGGAAGCCGGCGGCGCCTTTGATCCTGCACGCGCTGCGGCGCTTGAGGCACACATTCTGTCCAAAGGG
GGCTCTGAGGATGCCGCTGAGCTGTATACGGCGTTCCGGGGGCGACTTCCGGGGGTGGACGCGCTTTTGAAAGGGCGTGG
GCTGGCCGCCAAGTGA

Upstream 100 bases:

>100_bases
CTAGGCAATCCGGGGTCTTAGGCCAGCGAAAACCGAAACACCGCAGACAGATTGCAGGTCCCCGGTGAAGGCGCTAGCGT
CGGTGCAAAGGAGACCTCAT

Downstream 100 bases:

>100_bases
GCGCCCCTTCTGGGGCGCGGCCCCCGATGGGGAGATTTGGGAAAGATGAAGAGGGGCGCCAAGTTGGGCGCCCTTCGTCG
TCAATAGCCGCGGTTCCGGT

Product: peptidyl-dipeptidase Dcp

Products: NA

Alternate protein names: Dipeptidyl carboxypeptidase [H]

Number of amino acids: Translated: 671; Mature: 670

Protein sequence:

>671_residues
MTNPLLRDWQTPFGIAPFDQISDEDFAPALDEALKAHTAQIDAIATNPAPPTFANVIEALETPCQPLEQVLSVFFSVAGA
DSNPAREALQRAFSPNLAAHFSAITANKALYARVQAVWDQRDTLDLTDEQARVLMLTHRGFVRGGAALNGAEDTRMQEIK
SRLATLGTNFTQNLLADERDWFMELSEDDLEGLPDFVVKAARTAGAEKGVSGPVITLARSIVTPFLQFSPRRDLREKAFR
AWAARGANGGAHDNRAIAAEILSLREERAKLLGYRNFAAYKLETEMAKTPEAVRELLMDVWGPAKAQADKDAEVLTRMMH
EDGINGDLAPWDWHYYAEKRRKIEHDLDEAELKPYLQLDRMIEAAFACANRLFGLEFAPLDVPLYHKDCRAWEVTREGKH
LAVFIGDYFARGSKRSGAWCSAMRAQAKFPEEQTPIVVNVCNFAKGDPALLSYDDARTLFHEFGHALHQMLSNVTYESVS
GTSVARDFVELPSQLYEHWLEVPEVLQEFATHAETGAPMPKEMLDKVLGAATFNMGFQTVEYVASALVDLEFHDGSAPED
PMVKQAEVLAQIGMPAAIVMRHATPQFAHVFSGDGYSSGYYSYMWSEVMDADAFESFEEAGGAFDPARAAALEAHILSKG
GSEDAAELYTAFRGRLPGVDALLKGRGLAAK

Sequences:

>Translated_671_residues
MTNPLLRDWQTPFGIAPFDQISDEDFAPALDEALKAHTAQIDAIATNPAPPTFANVIEALETPCQPLEQVLSVFFSVAGA
DSNPAREALQRAFSPNLAAHFSAITANKALYARVQAVWDQRDTLDLTDEQARVLMLTHRGFVRGGAALNGAEDTRMQEIK
SRLATLGTNFTQNLLADERDWFMELSEDDLEGLPDFVVKAARTAGAEKGVSGPVITLARSIVTPFLQFSPRRDLREKAFR
AWAARGANGGAHDNRAIAAEILSLREERAKLLGYRNFAAYKLETEMAKTPEAVRELLMDVWGPAKAQADKDAEVLTRMMH
EDGINGDLAPWDWHYYAEKRRKIEHDLDEAELKPYLQLDRMIEAAFACANRLFGLEFAPLDVPLYHKDCRAWEVTREGKH
LAVFIGDYFARGSKRSGAWCSAMRAQAKFPEEQTPIVVNVCNFAKGDPALLSYDDARTLFHEFGHALHQMLSNVTYESVS
GTSVARDFVELPSQLYEHWLEVPEVLQEFATHAETGAPMPKEMLDKVLGAATFNMGFQTVEYVASALVDLEFHDGSAPED
PMVKQAEVLAQIGMPAAIVMRHATPQFAHVFSGDGYSSGYYSYMWSEVMDADAFESFEEAGGAFDPARAAALEAHILSKG
GSEDAAELYTAFRGRLPGVDALLKGRGLAAK
>Mature_670_residues
TNPLLRDWQTPFGIAPFDQISDEDFAPALDEALKAHTAQIDAIATNPAPPTFANVIEALETPCQPLEQVLSVFFSVAGAD
SNPAREALQRAFSPNLAAHFSAITANKALYARVQAVWDQRDTLDLTDEQARVLMLTHRGFVRGGAALNGAEDTRMQEIKS
RLATLGTNFTQNLLADERDWFMELSEDDLEGLPDFVVKAARTAGAEKGVSGPVITLARSIVTPFLQFSPRRDLREKAFRA
WAARGANGGAHDNRAIAAEILSLREERAKLLGYRNFAAYKLETEMAKTPEAVRELLMDVWGPAKAQADKDAEVLTRMMHE
DGINGDLAPWDWHYYAEKRRKIEHDLDEAELKPYLQLDRMIEAAFACANRLFGLEFAPLDVPLYHKDCRAWEVTREGKHL
AVFIGDYFARGSKRSGAWCSAMRAQAKFPEEQTPIVVNVCNFAKGDPALLSYDDARTLFHEFGHALHQMLSNVTYESVSG
TSVARDFVELPSQLYEHWLEVPEVLQEFATHAETGAPMPKEMLDKVLGAATFNMGFQTVEYVASALVDLEFHDGSAPEDP
MVKQAEVLAQIGMPAAIVMRHATPQFAHVFSGDGYSSGYYSYMWSEVMDADAFESFEEAGGAFDPARAAALEAHILSKGG
SEDAAELYTAFRGRLPGVDALLKGRGLAAK

Specific function: Removes dipeptides from the C-termini of N-blocked tripeptides, tetrapeptides and larger peptides [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=582, Percent_Identity=28.6941580756014, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI14149738, Length=575, Percent_Identity=27.304347826087, Blast_Score=201, Evalue=3e-51,
Organism=Homo sapiens, GI156105687, Length=670, Percent_Identity=26.2686567164179, Blast_Score=154, Evalue=3e-37,
Organism=Escherichia coli, GI1787819, Length=679, Percent_Identity=37.8497790868925, Blast_Score=422, Evalue=1e-119,
Organism=Escherichia coli, GI1789913, Length=693, Percent_Identity=34.0548340548341, Blast_Score=354, Evalue=1e-98,
Organism=Caenorhabditis elegans, GI32565901, Length=550, Percent_Identity=21.8181818181818, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71999758, Length=469, Percent_Identity=23.0277185501066, Blast_Score=80, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319793, Length=587, Percent_Identity=25.3833049403748, Blast_Score=177, Evalue=6e-45,
Organism=Saccharomyces cerevisiae, GI6322715, Length=454, Percent_Identity=25.7709251101322, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI21356111, Length=493, Percent_Identity=25.9634888438134, Blast_Score=150, Evalue=4e-36,
Organism=Drosophila melanogaster, GI20129717, Length=603, Percent_Identity=24.0464344941957, Blast_Score=134, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.15.5 [H]

Molecular weight: Translated: 74090; Mature: 73959

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNPLLRDWQTPFGIAPFDQISDEDFAPALDEALKAHTAQIDAIATNPAPPTFANVIEAL
CCCCCCHHCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHH
ETPCQPLEQVLSVFFSVAGADSNPAREALQRAFSPNLAAHFSAITANKALYARVQAVWDQ
HCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC
RDTLDLTDEQARVLMLTHRGFVRGGAALNGAEDTRMQEIKSRLATLGTNFTQNLLADERD
CCCCCCCCCCCEEEEEECCCHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCHH
WFMELSEDDLEGLPDFVVKAARTAGAEKGVSGPVITLARSIVTPFLQFSPRRDLREKAFR
HHHHCCCHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHH
AWAARGANGGAHDNRAIAAEILSLREERAKLLGYRNFAAYKLETEMAKTPEAVRELLMDV
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHEEEHHHHHCCHHHHHHHHHHH
WGPAKAQADKDAEVLTRMMHEDGINGDLAPWDWHYYAEKRRKIEHDLDEAELKPYLQLDR
CCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHCCHHHHHHH
MIEAAFACANRLFGLEFAPLDVPLYHKDCRAWEVTREGKHLAVFIGDYFARGSKRSGAWC
HHHHHHHHHHHHCCCEECCCCCCCCCCCCCCEEEECCCCEEEEEEEHHHHCCCCCCCHHH
SAMRAQAKFPEEQTPIVVNVCNFAKGDPALLSYDDARTLFHEFGHALHQMLSNVTYESVS
HHHHHHHCCCCCCCCEEEEECCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHCCHHCCC
GTSVARDFVELPSQLYEHWLEVPEVLQEFATHAETGAPMPKEMLDKVLGAATFNMGFQTV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHH
EYVASALVDLEFHDGSAPEDPMVKQAEVLAQIGMPAAIVMRHATPQFAHVFSGDGYSSGY
HHHHHHHHEEEECCCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCHHHHHCCCCCCCCCH
YSYMWSEVMDADAFESFEEAGGAFDPARAAALEAHILSKGGSEDAAELYTAFRGRLPGVD
HHHHHHHHHCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHH
ALLKGRGLAAK
HHHCCCCCCCC
>Mature Secondary Structure 
TNPLLRDWQTPFGIAPFDQISDEDFAPALDEALKAHTAQIDAIATNPAPPTFANVIEAL
CCCCCHHCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHH
ETPCQPLEQVLSVFFSVAGADSNPAREALQRAFSPNLAAHFSAITANKALYARVQAVWDQ
HCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC
RDTLDLTDEQARVLMLTHRGFVRGGAALNGAEDTRMQEIKSRLATLGTNFTQNLLADERD
CCCCCCCCCCCEEEEEECCCHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCHH
WFMELSEDDLEGLPDFVVKAARTAGAEKGVSGPVITLARSIVTPFLQFSPRRDLREKAFR
HHHHCCCHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHH
AWAARGANGGAHDNRAIAAEILSLREERAKLLGYRNFAAYKLETEMAKTPEAVRELLMDV
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHEEEHHHHHCCHHHHHHHHHHH
WGPAKAQADKDAEVLTRMMHEDGINGDLAPWDWHYYAEKRRKIEHDLDEAELKPYLQLDR
CCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHCCHHHHHHH
MIEAAFACANRLFGLEFAPLDVPLYHKDCRAWEVTREGKHLAVFIGDYFARGSKRSGAWC
HHHHHHHHHHHHCCCEECCCCCCCCCCCCCCEEEECCCCEEEEEEEHHHHCCCCCCCHHH
SAMRAQAKFPEEQTPIVVNVCNFAKGDPALLSYDDARTLFHEFGHALHQMLSNVTYESVS
HHHHHHHCCCCCCCCEEEEECCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHCCHHCCC
GTSVARDFVELPSQLYEHWLEVPEVLQEFATHAETGAPMPKEMLDKVLGAATFNMGFQTV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHH
EYVASALVDLEFHDGSAPEDPMVKQAEVLAQIGMPAAIVMRHATPQFAHVFSGDGYSSGY
HHHHHHHHEEEECCCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCHHHHHCCCCCCCCCH
YSYMWSEVMDADAFESFEEAGGAFDPARAAALEAHILSKGGSEDAAELYTAFRGRLPGVD
HHHHHHHHHCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHH
ALLKGRGLAAK
HHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1537804; 11677609 [H]