| Definition | Ruegeria sp. TM1040, complete genome. |
|---|---|
| Accession | NC_008044 |
| Length | 3,200,938 |
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The map label for this gene is coaBC [H]
Identifier: 99080299
GI number: 99080299
Start: 475190
End: 476401
Strand: Direct
Name: coaBC [H]
Synonym: TM1040_0458
Alternate gene names: 99080299
Gene position: 475190-476401 (Clockwise)
Preceding gene: 99080298
Following gene: 99080300
Centisome position: 14.85
GC content: 62.95
Gene sequence:
>1212_bases ATGCTGTCAGGAAAACATATTCTGCTGATCATTGGCGGTGGGATTGCAGCCTATAAGTCTCTGGAACTGATCCGGCGACT GCAGGATCAGGGCGCGCGGGTGACGCCGGTTCTGACCCGCGCCGGAGAGGAATTCGTCACCCCTCTGTCTGTTTCCGCGC TTGCGGGGAACGCCGTGCACCGAGATTTGTTTGACCTCACCGCCGAGGCGGAAATGGGCCACATCCAGCTCTCGCGGAGT GCCGATCTTCTGGTGGTGGCTCCGGCGACGGCTGATCTGATGGCGAAGATGGCGCAGGGTCATGCAAATGACCTCGCCTC CACCTTGTTGCTGGCGACGGATACGCCGATTTTGTTGGCGCCCGCGATGAATGTGCGGATGTGGGAGCATCCTGCTACGC AGCGCAACCTCACCCAGCTCAAAAATGACGGTGTTTCCGTGGTCGGCCCGAATGAAGGCGGAATGGCCTGCGGTGAGTAT GGCGCCGGGCGACTGGCCGAGCCGGAGGAGATCATCGCGGCAATCACCACGCGTCTTGCTGCCGGGCCGCTCGCGGGCAA GCGCATCATCGTAACTTCCGGTCCCACTCACGAGCCCATCGACCCGGTGCGGTATATCGCCAACCGATCCTCCGGGGCGC AGGGCACGGCGTTGGCCCGTGCTCTGCGGGCACTGGGGGCGGAGGTGGTCTTTATCACGGGCCCTGCAACGGTGCGCCCG CCGGAGGGGGTGCAGGTGGTGCCCGTTGAAACCGCCAGCGACATGCACGCGGCTGTTCAGGCGGCGCTGCCCGCGGATGC CGGGGTTTTTGCGGCGGCTGTAGCAGACTGGCGCGTGGCCTCCGCTTCTGACCGCAAGCTCAAGAAAACCAAAGACGGCA TGCCCCGTCTCGCGTTTGAGGAAAACCCCGACATTCTGCGCGAGGTGGCCTCTCAGACGCAGGATCGTCCCGGCCTTGTG GTTGGCTTCGCCGCCGAAACCAATGATGTTGTCGAACACGCAACGGCAAAACGCCTGCGCAAGGGCTGCGACTGGATTGT TGCCAACGATGTTTCCCCCGCGACTGGCATCATGGGGGGAGCCGAAAACGCCGTGATCTTGATTACCGCCGAGGGCGAAG AGCATTGGCCTCGTATGCCAAAAGACCAGGTGGCGCAGCGCCTGGCGGAAAAAATTGCAGCTACACTCACCCCGCCAGTT TCGGGGGGATAA
Upstream 100 bases:
>100_bases GATACACATGTAGCCTTGGCCTTTGCCCTCGTTTTCCCCTTTCACTAGGGGGGGGGAGGGCATAAGTTTGCCGAGCAAAG GCAAGGATCGAGGGCCCATC
Downstream 100 bases:
>100_bases GATCCGGAAAAATTGATTGCCTTCAATTCGGCGTCGATATGTTCTCTCCTTTTTTCTCGCCTAGCGTAAGATTCGACCCT CGCTTTTTTATGCTAAGGCA
Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase
Products: NA
Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]
Number of amino acids: Translated: 403; Mature: 403
Protein sequence:
>403_residues MLSGKHILLIIGGGIAAYKSLELIRRLQDQGARVTPVLTRAGEEFVTPLSVSALAGNAVHRDLFDLTAEAEMGHIQLSRS ADLLVVAPATADLMAKMAQGHANDLASTLLLATDTPILLAPAMNVRMWEHPATQRNLTQLKNDGVSVVGPNEGGMACGEY GAGRLAEPEEIIAAITTRLAAGPLAGKRIIVTSGPTHEPIDPVRYIANRSSGAQGTALARALRALGAEVVFITGPATVRP PEGVQVVPVETASDMHAAVQAALPADAGVFAAAVADWRVASASDRKLKKTKDGMPRLAFEENPDILREVASQTQDRPGLV VGFAAETNDVVEHATAKRLRKGCDWIVANDVSPATGIMGGAENAVILITAEGEEHWPRMPKDQVAQRLAEKIAATLTPPV SGG
Sequences:
>Translated_403_residues MLSGKHILLIIGGGIAAYKSLELIRRLQDQGARVTPVLTRAGEEFVTPLSVSALAGNAVHRDLFDLTAEAEMGHIQLSRS ADLLVVAPATADLMAKMAQGHANDLASTLLLATDTPILLAPAMNVRMWEHPATQRNLTQLKNDGVSVVGPNEGGMACGEY GAGRLAEPEEIIAAITTRLAAGPLAGKRIIVTSGPTHEPIDPVRYIANRSSGAQGTALARALRALGAEVVFITGPATVRP PEGVQVVPVETASDMHAAVQAALPADAGVFAAAVADWRVASASDRKLKKTKDGMPRLAFEENPDILREVASQTQDRPGLV VGFAAETNDVVEHATAKRLRKGCDWIVANDVSPATGIMGGAENAVILITAEGEEHWPRMPKDQVAQRLAEKIAATLTPPV SGG >Mature_403_residues MLSGKHILLIIGGGIAAYKSLELIRRLQDQGARVTPVLTRAGEEFVTPLSVSALAGNAVHRDLFDLTAEAEMGHIQLSRS ADLLVVAPATADLMAKMAQGHANDLASTLLLATDTPILLAPAMNVRMWEHPATQRNLTQLKNDGVSVVGPNEGGMACGEY GAGRLAEPEEIIAAITTRLAAGPLAGKRIIVTSGPTHEPIDPVRYIANRSSGAQGTALARALRALGAEVVFITGPATVRP PEGVQVVPVETASDMHAAVQAALPADAGVFAAAVADWRVASASDRKLKKTKDGMPRLAFEENPDILREVASQTQDRPGLV VGFAAETNDVVEHATAKRLRKGCDWIVANDVSPATGIMGGAENAVILITAEGEEHWPRMPKDQVAQRLAEKIAATLTPPV SGG
Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]
COG id: COG0452
COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]
Homologues:
Organism=Homo sapiens, GI71725351, Length=178, Percent_Identity=33.1460674157303, Blast_Score=90, Evalue=3e-18, Organism=Escherichia coli, GI87082301, Length=396, Percent_Identity=44.9494949494949, Blast_Score=295, Evalue=4e-81, Organism=Caenorhabditis elegans, GI17560194, Length=183, Percent_Identity=32.7868852459016, Blast_Score=84, Evalue=1e-16, Organism=Saccharomyces cerevisiae, GI6322762, Length=192, Percent_Identity=28.6458333333333, Blast_Score=79, Evalue=1e-15, Organism=Drosophila melanogaster, GI24657262, Length=184, Percent_Identity=28.2608695652174, Blast_Score=82, Evalue=7e-16,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005252 - InterPro: IPR007085 - InterPro: IPR003382 [H]
Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]
EC number: =4.1.1.36; =6.3.2.5 [H]
Molecular weight: Translated: 42242; Mature: 42242
Theoretical pI: Translated: 6.06; Mature: 6.06
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.5 %Cys (Translated Protein) 2.7 %Met (Translated Protein) 3.2 %Cys+Met (Translated Protein) 0.5 %Cys (Mature Protein) 2.7 %Met (Mature Protein) 3.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MLSGKHILLIIGGGIAAYKSLELIRRLQDQGARVTPVLTRAGEEFVTPLSVSALAGNAVH CCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEHHHHHCCHHHCCCCCHHHHHCCHHH RDLFDLTAEAEMGHIQLSRSADLLVVAPATADLMAKMAQGHANDLASTLLLATDTPILLA HHHHHHHCCCCCCEEEEECCCCEEEECCCHHHHHHHHHCCCHHHHHHHHHEECCCCEEEE PAMNVRMWEHPATQRNLTQLKNDGVSVVGPNEGGMACGEYGAGRLAEPEEIIAAITTRLA CCCCCEEECCCCCHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH AGPLAGKRIIVTSGPTHEPIDPVRYIANRSSGAQGTALARALRALGAEVVFITGPATVRP CCCCCCCEEEEECCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCC PEGVQVVPVETASDMHAAVQAALPADAGVFAAAVADWRVASASDRKLKKTKDGMPRLAFE CCCCEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHCEECCCCCHHHHHHHCCCCCCCCC ENPDILREVASQTQDRPGLVVGFAAETNDVVEHATAKRLRKGCDWIVANDVSPATGIMGG CCHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCEEEECCCCCHHCCCCC AENAVILITAEGEEHWPRMPKDQVAQRLAEKIAATLTPPVSGG CCCEEEEEEECCHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCC >Mature Secondary Structure MLSGKHILLIIGGGIAAYKSLELIRRLQDQGARVTPVLTRAGEEFVTPLSVSALAGNAVH CCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEHHHHHCCHHHCCCCCHHHHHCCHHH RDLFDLTAEAEMGHIQLSRSADLLVVAPATADLMAKMAQGHANDLASTLLLATDTPILLA HHHHHHHCCCCCCEEEEECCCCEEEECCCHHHHHHHHHCCCHHHHHHHHHEECCCCEEEE PAMNVRMWEHPATQRNLTQLKNDGVSVVGPNEGGMACGEYGAGRLAEPEEIIAAITTRLA CCCCCEEECCCCCHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH AGPLAGKRIIVTSGPTHEPIDPVRYIANRSSGAQGTALARALRALGAEVVFITGPATVRP CCCCCCCEEEEECCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCC PEGVQVVPVETASDMHAAVQAALPADAGVFAAAVADWRVASASDRKLKKTKDGMPRLAFE CCCCEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHCEECCCCCHHHHHHHCCCCCCCCC ENPDILREVASQTQDRPGLVVGFAAETNDVVEHATAKRLRKGCDWIVANDVSPATGIMGG CCHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCEEEECCCCCHHCCCCC AENAVILITAEGEEHWPRMPKDQVAQRLAEKIAATLTPPVSGG CCCEEEEEEECCHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 10952301 [H]