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The map label for this gene is cobC [H]

Identifier: 99080295

GI number: 99080295

Start: 472051

End: 472632

Strand: Reverse

Name: cobC [H]

Synonym: TM1040_0454

Alternate gene names: 99080295

Gene position: 472632-472051 (Counterclockwise)

Preceding gene: 99080296

Following gene: 99080294

Centisome position: 14.77

GC content: 60.14

Gene sequence:

>582_bases
ATGATCACGCGTTTTCACATGATACGCCATGGCCCGACCCACGCCAAATCCATGGTGGGCTGGTCGGATTTACCCGCAGA
CCTCTCGGATGCGGCGATGCTGTCTCGGCTGTCGCGCGCCCTCCCCGACACGGCGGTGGTTATTTCGTCAGATCTGAGCC
GGGCCGTTGCCACGGCAGATGCGATCCAGGGATCACGCACCCGCCTGCCCCATACCTCAGATTTGCGCGAAATCCATTTT
GGAGATTGGGAACTGCGCCGTTGGAGCGAGATCGACGCCGAGGACCCGGACCACATTCGCGCCTTTTGGGAGAAGCCCGG
AGACGTCGCCCCCCCAAATGGCGAGAGTTGGAACAGGCTGATGCAACGGGTCTCACGACAGTTCGACAGGCTTGCAGAGA
CCTACAGAGGTCAGGATGTTGTTGTCGTGGGCCACTTCGGCCAGATCCTCTGTCAGGTGCAACGCGCCCTGGGCCTCACG
GCGACCGAGGCTTTTGCCCACAAAATCGACAACCTGTCCCTGAGCCGGATAGATCACGAGAGCACGGGATGGAGTGCCGG
AGCGATCAATCAAATTTTGTGA

Upstream 100 bases:

>100_bases
TTCGCGAGGCGCAGGGACGCTTGAATATTGCGCTCGCCGCTGCGGCGGACACGGTGGTCTTGGTCGCAGCAGGGCTGCCA
ATGACGCTGAAAGGCACGAC

Downstream 100 bases:

>100_bases
TGCGTGAGCGCACAAACATTAGCTTTCCTGATGCATGTGGCGTCGCTAATCTCTCCCCATGACATACACACTCTATATTG
CAGATCGCATGTATTCCAGC

Product: phosphoglycerate mutase

Products: NA

Alternate protein names: Alpha-ribazole-5'-phosphate phosphatase [H]

Number of amino acids: Translated: 193; Mature: 193

Protein sequence:

>193_residues
MITRFHMIRHGPTHAKSMVGWSDLPADLSDAAMLSRLSRALPDTAVVISSDLSRAVATADAIQGSRTRLPHTSDLREIHF
GDWELRRWSEIDAEDPDHIRAFWEKPGDVAPPNGESWNRLMQRVSRQFDRLAETYRGQDVVVVGHFGQILCQVQRALGLT
ATEAFAHKIDNLSLSRIDHESTGWSAGAINQIL

Sequences:

>Translated_193_residues
MITRFHMIRHGPTHAKSMVGWSDLPADLSDAAMLSRLSRALPDTAVVISSDLSRAVATADAIQGSRTRLPHTSDLREIHF
GDWELRRWSEIDAEDPDHIRAFWEKPGDVAPPNGESWNRLMQRVSRQFDRLAETYRGQDVVVVGHFGQILCQVQRALGLT
ATEAFAHKIDNLSLSRIDHESTGWSAGAINQIL
>Mature_193_residues
MITRFHMIRHGPTHAKSMVGWSDLPADLSDAAMLSRLSRALPDTAVVISSDLSRAVATADAIQGSRTRLPHTSDLREIHF
GDWELRRWSEIDAEDPDHIRAFWEKPGDVAPPNGESWNRLMQRVSRQFDRLAETYRGQDVVVVGHFGQILCQVQRALGLT
ATEAFAHKIDNLSLSRIDHESTGWSAGAINQIL

Specific function: Converts N1-(5-phospho-alpha-D-ribosyl)-5,6- dimethylbenzimidazole into N1-alpha-D-ribosyl-5,6- dimethylbenzimidazole; involved in the assembly of the nucleotide loop of cobalamin [H]

COG id: COG0406

COG function: function code G; Fructose-2,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family [H]

Homologues:

Organism=Escherichia coli, GI1786857, Length=182, Percent_Identity=30.2197802197802, Blast_Score=70, Evalue=9e-14,
Organism=Escherichia coli, GI1790856, Length=191, Percent_Identity=26.7015706806283, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR017578 [H]

Pfam domain/function: PF00300 PGAM [H]

EC number: =3.1.3.73 [H]

Molecular weight: Translated: 21603; Mature: 21603

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITRFHMIRHGPTHAKSMVGWSDLPADLSDAAMLSRLSRALPDTAVVISSDLSRAVATAD
CCCHHHHHHCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHH
AIQGSRTRLPHTSDLREIHFGDWELRRWSEIDAEDPDHIRAFWEKPGDVAPPNGESWNRL
HHCCCCCCCCCCCCHHHHCCCCCHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHH
MQRVSRQFDRLAETYRGQDVVVVGHFGQILCQVQRALGLTATEAFAHKIDNLSLSRIDHE
HHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHCCCC
STGWSAGAINQIL
CCCCCCCHHHHCC
>Mature Secondary Structure
MITRFHMIRHGPTHAKSMVGWSDLPADLSDAAMLSRLSRALPDTAVVISSDLSRAVATAD
CCCHHHHHHCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHH
AIQGSRTRLPHTSDLREIHFGDWELRRWSEIDAEDPDHIRAFWEKPGDVAPPNGESWNRL
HHCCCCCCCCCCCCHHHHCCCCCHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHH
MQRVSRQFDRLAETYRGQDVVVVGHFGQILCQVQRALGLTATEAFAHKIDNLSLSRIDHE
HHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHCCCC
STGWSAGAINQIL
CCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503 [H]