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The map label for this gene is ycgM [H]

Identifier: 99080264

GI number: 99080264

Start: 434944

End: 435714

Strand: Direct

Name: ycgM [H]

Synonym: TM1040_0423

Alternate gene names: 99080264

Gene position: 434944-435714 (Clockwise)

Preceding gene: 99080263

Following gene: 99080265

Centisome position: 13.59

GC content: 61.35

Gene sequence:

>771_bases
ATGCACAGCAATGCTTGGCCTTCGGGGGCGAAGCCTCTATCTCTTTTGGTGACAAAGAGAAAAGGACCGCCCATGCCCGC
CGCGCAGCCCGACTATGTGATTGCTCCGCCCCCACAGCCCGCCCTGCCAATTGCCGAGAGCACCGCCCTGTTTCCCGTGC
GCAGGGTCTATTGCATCGGGCGCAATTATGCCGCGCACGCGGTCGAGATGGGACATGACCCGGATCGCGAGCCGCCGTTC
TTTTTCCAGAAAACGCCCGACAGTCTCGATGCTTCGGGGCGCTTTCCCTACCCGGTGATGAGCGAAGACGTCCATCACGA
AGCAGAGCTTTTGGTGGCGCTCGGCAAAGGCGGCGAGAATATCTCTGAGGATGCCGCGCTTGATCATGTCTGGGGCTATG
GGCTGGCGCTTGATATGACCCGTCGCGATCTGCAGGGGATCGCCAAAAAAGCGGGCCGGCCTTGGGAAATTGGGAAATCC
TTTGAACATGCGGCCCCGGTTGCGCCGTTAACGCCGGCCACGACGATCGGGCATCCCGACGCGGGTGTGATGACGCTCAC
CGTGAATGGAACGCCGCGCCAGCAGGGGGATCTCAATCAGATGATCTGGAAGATCCCCGAAATGATCGCGCATCTTTCGC
AGTATTACAGGCTGGCGGCGGGGGATGTGATCCTCACGGGTACGCCTGCGGGTGTTGGCCCGGTTCTGCGCGGTGACCAG
CTTGAGCTCACTTTCGACGGCCTGACCCCGCTTCGGGTTCTGGTGGAGTGA

Upstream 100 bases:

>100_bases
GTCATGTCCAAACGATTGCCCGCGCGACATCCTGCGCGCGGGCAATGACATCCTGCGCGCGGGCAATCCGGGGGCTTTGC
GCGGCACAGGGACATCGGCC

Downstream 100 bases:

>100_bases
CAAGCGCCGATCCCAGGAAACAGGGATTTCATCATGCACCCCCCCTCGGGGCGCCGGGGATTGGCGCGGGTTACATCGCC
GCACTCCATACCCTATCTCT

Product: fumarylacetoacetate (FAA) hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MHSNAWPSGAKPLSLLVTKRKGPPMPAAQPDYVIAPPPQPALPIAESTALFPVRRVYCIGRNYAAHAVEMGHDPDREPPF
FFQKTPDSLDASGRFPYPVMSEDVHHEAELLVALGKGGENISEDAALDHVWGYGLALDMTRRDLQGIAKKAGRPWEIGKS
FEHAAPVAPLTPATTIGHPDAGVMTLTVNGTPRQQGDLNQMIWKIPEMIAHLSQYYRLAAGDVILTGTPAGVGPVLRGDQ
LELTFDGLTPLRVLVE

Sequences:

>Translated_256_residues
MHSNAWPSGAKPLSLLVTKRKGPPMPAAQPDYVIAPPPQPALPIAESTALFPVRRVYCIGRNYAAHAVEMGHDPDREPPF
FFQKTPDSLDASGRFPYPVMSEDVHHEAELLVALGKGGENISEDAALDHVWGYGLALDMTRRDLQGIAKKAGRPWEIGKS
FEHAAPVAPLTPATTIGHPDAGVMTLTVNGTPRQQGDLNQMIWKIPEMIAHLSQYYRLAAGDVILTGTPAGVGPVLRGDQ
LELTFDGLTPLRVLVE
>Mature_256_residues
MHSNAWPSGAKPLSLLVTKRKGPPMPAAQPDYVIAPPPQPALPIAESTALFPVRRVYCIGRNYAAHAVEMGHDPDREPPF
FFQKTPDSLDASGRFPYPVMSEDVHHEAELLVALGKGGENISEDAALDHVWGYGLALDMTRRDLQGIAKKAGRPWEIGKS
FEHAAPVAPLTPATTIGHPDAGVMTLTVNGTPRQQGDLNQMIWKIPEMIAHLSQYYRLAAGDVILTGTPAGVGPVLRGDQ
LELTFDGLTPLRVLVE

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAH family [H]

Homologues:

Organism=Homo sapiens, GI13654274, Length=203, Percent_Identity=40.3940886699507, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI66348062, Length=195, Percent_Identity=41.025641025641, Blast_Score=156, Evalue=1e-38,
Organism=Homo sapiens, GI215422413, Length=195, Percent_Identity=41.025641025641, Blast_Score=156, Evalue=2e-38,
Organism=Homo sapiens, GI156231349, Length=220, Percent_Identity=35.4545454545455, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI40786394, Length=220, Percent_Identity=34.0909090909091, Blast_Score=120, Evalue=8e-28,
Organism=Escherichia coli, GI1787428, Length=200, Percent_Identity=44.5, Blast_Score=170, Evalue=7e-44,
Organism=Caenorhabditis elegans, GI17557057, Length=196, Percent_Identity=38.7755102040816, Blast_Score=147, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6324161, Length=220, Percent_Identity=32.2727272727273, Blast_Score=120, Evalue=3e-28,
Organism=Drosophila melanogaster, GI28571789, Length=203, Percent_Identity=33.4975369458128, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI28572127, Length=201, Percent_Identity=31.3432835820896, Blast_Score=101, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24663695, Length=181, Percent_Identity=31.4917127071823, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002529
- InterPro:   IPR011234 [H]

Pfam domain/function: PF01557 FAA_hydrolase [H]

EC number: NA

Molecular weight: Translated: 27702; Mature: 27702

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSNAWPSGAKPLSLLVTKRKGPPMPAAQPDYVIAPPPQPALPIAESTALFPVRRVYCIG
CCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEECCCCCCCCCCCCCCHHHHEEEEEEEC
RNYAAHAVEMGHDPDREPPFFFQKTPDSLDASGRFPYPVMSEDVHHEAELLVALGKGGEN
CCCHHHHEECCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCHHCCCEEEEEEECCCCCC
ISEDAALDHVWGYGLALDMTRRDLQGIAKKAGRPWEIGKSFEHAAPVAPLTPATTIGHPD
CCHHHHHHHHHCCCEEEHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCCCCCCCC
AGVMTLTVNGTPRQQGDLNQMIWKIPEMIAHLSQYYRLAAGDVILTGTPAGVGPVLRGDQ
CCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCE
LELTFDGLTPLRVLVE
EEEEECCCCCEEEEEC
>Mature Secondary Structure
MHSNAWPSGAKPLSLLVTKRKGPPMPAAQPDYVIAPPPQPALPIAESTALFPVRRVYCIG
CCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEECCCCCCCCCCCCCCHHHHEEEEEEEC
RNYAAHAVEMGHDPDREPPFFFQKTPDSLDASGRFPYPVMSEDVHHEAELLVALGKGGEN
CCCHHHHEECCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCHHCCCEEEEEEECCCCCC
ISEDAALDHVWGYGLALDMTRRDLQGIAKKAGRPWEIGKSFEHAAPVAPLTPATTIGHPD
CCHHHHHHHHHCCCEEEHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCCCCCCCC
AGVMTLTVNGTPRQQGDLNQMIWKIPEMIAHLSQYYRLAAGDVILTGTPAGVGPVLRGDQ
CCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCE
LELTFDGLTPLRVLVE
EEEEECCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503; 10806384 [H]