Click here to switch to the map view.

The map label for this gene is atoC [H]

Identifier: 99080246

GI number: 99080246

Start: 414942

End: 416294

Strand: Direct

Name: atoC [H]

Synonym: TM1040_0405

Alternate gene names: 99080246

Gene position: 414942-416294 (Clockwise)

Preceding gene: 99080245

Following gene: 99080256

Centisome position: 12.96

GC content: 58.76

Gene sequence:

>1353_bases
ATGAACGTCTCCAGCGTCATTCGCGACGAATACTCTGAATCGCTGTCGTCAGCGTCGATCCTTGTGATTGATGACGAACC
CGGGATGCGTCATTTCATGACAAAAATCCTGGAACCCCGCTGCAAGCGCGTGGAGCAGGCCGCCTCGGCGGCCGAGGCGT
CGGATATTCTCGACAAGGCCCATTTCGACCTCATTGTGCTTGATAACATCATGCCGGGCAAAACCGGCCTTGATTGGGTG
GCTGAACAGCGCCGGGTCGGTTTGTTTGCCGATACCATCCTGGTCACAGCCTATGCGGACCTCGATACGGCGATTCAGGC
GCTGCGGATCGGAATTGCAGATTTTGTGCTCAAGCCGTTTCGCGCCAATCAGATCCTCAATGCGGTGGCGCGCGCCCTCG
ACCGCAAGTACCTGCGGCGTGAAAACTATCTATTGAAACACGAGCTCTCTGCCGAGAAATCCAGCGCGCGGGGGCGTCTT
CTCGGAAAATCTGCCGCCATTGAGAAGGTGCGAAAGATGTTGCAGCGTCTCGCGCCGCTGCCGACGCCGGTGCTGTTTAC
GGGGGCGTCGGGAACCGGCAAGGAGATCGCGGCCCGCACACTGCATTCGCTGTCGGATCGCGCAGAGCAGCCCTTTGTTG
CCATCAACTGTGCCAGCCTGTCGCCGGATCGGCTTGCCGAAGAGCTTTTCGGCGTCGTGGACGCGCAAGATCGCCGCCGT
GATGGGCTGTTTTTGCATGCAGATGGTGGCACGCTGTTTTTGGATGAGGTGGCGCAGATGCCCGAACAGGTGCAGGCGGC
CCTGTTGCGGGTTCTGGAGGATCAAAAGGTTCGCCCGGTAGGCGCCGAACGTGATATTCCGCTCAACCTGCGCTTTTTGT
TGGCCACCAATGCGGATCTGCTGCAGGCGGTCGAGGAGGGAAAATTCCGCGCTGACCTTTATCACCGGATCAATGTGGTC
AATATCGAGATGCCCGCCCTCAAAGAGCGCATCGAGGATATTGTGGAGCTGGCCGCGCTGTTCATGGATCAATTTGCGCT
GAGCCTTGGCATGCCCGCGCTGGAACTTGATGAGGAAACACTTCTGAAATTCTCACGCTATGCGTGGCCAGGTAATGTGC
GCGAGTTGCGCAATCTGATCGAACGCTCGGTTATCCTTGGCGCTTTTCCCGAAGAGTTTTCCGGCACGGGTTCTGTGATC
GGAGCCGCCGCCGTCGAAAACCTCGATATGGTCATGCAGCGCCACATCATGCACGTGTTGGACGCCTGCGATGGGAACCG
GGCAGAGGCGGCCCGACGACTGGGAGTGTCGCGCAAGACCGTCGACAGGAAATGCGCAAGCTGGGGGCTATAG

Upstream 100 bases:

>100_bases
CGTCATCGCCGTGGGCGCAGATCTTGCGCTGGAGCAGGCAGGGTATTCGGCGCAGGAGCAAAACTCCGGCACCGCCGTGC
GCCTGAACTGACACCCTCAG

Downstream 100 bases:

>100_bases
CGCCGCCTGCGTCTTGCGCGAAACAGCGCGTTATCTCTGATCCGGGTCATCCGCGTCAGTTGGCTCTGGCAGCCAGATCA
GGAACTCCGCCCCCCGCGCG

Product: two component, sigma54 specific, Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MNVSSVIRDEYSESLSSASILVIDDEPGMRHFMTKILEPRCKRVEQAASAAEASDILDKAHFDLIVLDNIMPGKTGLDWV
AEQRRVGLFADTILVTAYADLDTAIQALRIGIADFVLKPFRANQILNAVARALDRKYLRRENYLLKHELSAEKSSARGRL
LGKSAAIEKVRKMLQRLAPLPTPVLFTGASGTGKEIAARTLHSLSDRAEQPFVAINCASLSPDRLAEELFGVVDAQDRRR
DGLFLHADGGTLFLDEVAQMPEQVQAALLRVLEDQKVRPVGAERDIPLNLRFLLATNADLLQAVEEGKFRADLYHRINVV
NIEMPALKERIEDIVELAALFMDQFALSLGMPALELDEETLLKFSRYAWPGNVRELRNLIERSVILGAFPEEFSGTGSVI
GAAAVENLDMVMQRHIMHVLDACDGNRAEAARRLGVSRKTVDRKCASWGL

Sequences:

>Translated_450_residues
MNVSSVIRDEYSESLSSASILVIDDEPGMRHFMTKILEPRCKRVEQAASAAEASDILDKAHFDLIVLDNIMPGKTGLDWV
AEQRRVGLFADTILVTAYADLDTAIQALRIGIADFVLKPFRANQILNAVARALDRKYLRRENYLLKHELSAEKSSARGRL
LGKSAAIEKVRKMLQRLAPLPTPVLFTGASGTGKEIAARTLHSLSDRAEQPFVAINCASLSPDRLAEELFGVVDAQDRRR
DGLFLHADGGTLFLDEVAQMPEQVQAALLRVLEDQKVRPVGAERDIPLNLRFLLATNADLLQAVEEGKFRADLYHRINVV
NIEMPALKERIEDIVELAALFMDQFALSLGMPALELDEETLLKFSRYAWPGNVRELRNLIERSVILGAFPEEFSGTGSVI
GAAAVENLDMVMQRHIMHVLDACDGNRAEAARRLGVSRKTVDRKCASWGL
>Mature_450_residues
MNVSSVIRDEYSESLSSASILVIDDEPGMRHFMTKILEPRCKRVEQAASAAEASDILDKAHFDLIVLDNIMPGKTGLDWV
AEQRRVGLFADTILVTAYADLDTAIQALRIGIADFVLKPFRANQILNAVARALDRKYLRRENYLLKHELSAEKSSARGRL
LGKSAAIEKVRKMLQRLAPLPTPVLFTGASGTGKEIAARTLHSLSDRAEQPFVAINCASLSPDRLAEELFGVVDAQDRRR
DGLFLHADGGTLFLDEVAQMPEQVQAALLRVLEDQKVRPVGAERDIPLNLRFLLATNADLLQAVEEGKFRADLYHRINVV
NIEMPALKERIEDIVELAALFMDQFALSLGMPALELDEETLLKFSRYAWPGNVRELRNLIERSVILGAFPEEFSGTGSVI
GAAAVENLDMVMQRHIMHVLDACDGNRAEAARRLGVSRKTVDRKCASWGL

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=452, Percent_Identity=34.7345132743363, Blast_Score=258, Evalue=7e-70,
Organism=Escherichia coli, GI1790437, Length=438, Percent_Identity=34.0182648401827, Blast_Score=241, Evalue=1e-64,
Organism=Escherichia coli, GI1790299, Length=476, Percent_Identity=32.3529411764706, Blast_Score=220, Evalue=1e-58,
Organism=Escherichia coli, GI1788905, Length=439, Percent_Identity=33.9407744874715, Blast_Score=219, Evalue=4e-58,
Organism=Escherichia coli, GI1789233, Length=230, Percent_Identity=42.1739130434783, Blast_Score=188, Evalue=5e-49,
Organism=Escherichia coli, GI1787583, Length=317, Percent_Identity=35.0157728706625, Blast_Score=187, Evalue=8e-49,
Organism=Escherichia coli, GI87082117, Length=257, Percent_Identity=40.4669260700389, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI87081872, Length=236, Percent_Identity=43.6440677966102, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI1789087, Length=353, Percent_Identity=35.1274787535411, Blast_Score=179, Evalue=4e-46,
Organism=Escherichia coli, GI1786524, Length=318, Percent_Identity=35.2201257861635, Blast_Score=175, Evalue=5e-45,
Organism=Escherichia coli, GI87082152, Length=233, Percent_Identity=40.343347639485, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI1789828, Length=274, Percent_Identity=31.3868613138686, Blast_Score=118, Evalue=7e-28,
Organism=Escherichia coli, GI87081858, Length=283, Percent_Identity=29.3286219081272, Blast_Score=110, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 49936; Mature: 49936

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVSSVIRDEYSESLSSASILVIDDEPGMRHFMTKILEPRCKRVEQAASAAEASDILDKA
CCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HFDLIVLDNIMPGKTGLDWVAEQRRVGLFADTILVTAYADLDTAIQALRIGIADFVLKPF
CCCEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
RANQILNAVARALDRKYLRRENYLLKHELSAEKSSARGRLLGKSAAIEKVRKMLQRLAPL
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC
PTPVLFTGASGTGKEIAARTLHSLSDRAEQPFVAINCASLSPDRLAEELFGVVDAQDRRR
CCCEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCC
DGLFLHADGGTLFLDEVAQMPEQVQAALLRVLEDQKVRPVGAERDIPLNLRFLLATNADL
CCEEEEECCCEEHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCHHH
LQAVEEGKFRADLYHRINVVNIEMPALKERIEDIVELAALFMDQFALSLGMPALELDEET
HHHHHHCCHHHHHHHHEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
LLKFSRYAWPGNVRELRNLIERSVILGAFPEEFSGTGSVIGAAAVENLDMVMQRHIMHVL
HHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
DACDGNRAEAARRLGVSRKTVDRKCASWGL
HHCCCCHHHHHHHHCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MNVSSVIRDEYSESLSSASILVIDDEPGMRHFMTKILEPRCKRVEQAASAAEASDILDKA
CCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HFDLIVLDNIMPGKTGLDWVAEQRRVGLFADTILVTAYADLDTAIQALRIGIADFVLKPF
CCCEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
RANQILNAVARALDRKYLRRENYLLKHELSAEKSSARGRLLGKSAAIEKVRKMLQRLAPL
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC
PTPVLFTGASGTGKEIAARTLHSLSDRAEQPFVAINCASLSPDRLAEELFGVVDAQDRRR
CCCEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCC
DGLFLHADGGTLFLDEVAQMPEQVQAALLRVLEDQKVRPVGAERDIPLNLRFLLATNADL
CCEEEEECCCEEHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCHHH
LQAVEEGKFRADLYHRINVVNIEMPALKERIEDIVELAALFMDQFALSLGMPALELDEET
HHHHHHCCHHHHHHHHEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
LLKFSRYAWPGNVRELRNLIERSVILGAFPEEFSGTGSVIGAAAVENLDMVMQRHIMHVL
HHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
DACDGNRAEAARRLGVSRKTVDRKCASWGL
HHCCCCHHHHHHHHCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]