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The map label for this gene is 99080174

Identifier: 99080174

GI number: 99080174

Start: 337542

End: 338690

Strand: Direct

Name: 99080174

Synonym: TM1040_0333

Alternate gene names: NA

Gene position: 337542-338690 (Clockwise)

Preceding gene: 99080172

Following gene: 99080175

Centisome position: 10.55

GC content: 63.01

Gene sequence:

>1149_bases
ATGCCGACACTCTCCGTTGACCCATCCGGAACCTATCTGAGCCTTGAAACCGCCACGGGTACGCAGCGGTTCCATGCGAT
CTGGCTGCGTGACAATGCGCAGGATGCCGAGACCCGCGCGCCGGGGAACGGCCAGCGGTTGATCGCCCTGCGCGATATCC
CCGCTGACACAAGGATCGCCACCGCCCAGATCAACCCGGACGGGGTGGTGCAGGTGCGCTTTGCGCCAGAGGACAAGACC
GTTGACTATGATCTTGCGTGGCTTGAGGCGCATTCCTACGACCGCGCTGCCCCCAGCACCCAAGGGTGGCTCGCCCAAGA
AATCGAGCCATGGGATGCGGGGCTGATGGGCAATGTGCCATGTGGGGATTTTGCGGCGCTCGCCGAGGGTGGTCAGGCGC
TGCGTGACTGGCTTGGGCAGATTGTGCGCTACGGCTTTGCCAAGCTCAAGAATGCCCCGGTGGAGCCGGGCGGGCTGTTC
AAGGTGGTCGATCTCTTTGGCTTTGTGCGCGAGACCAACTACGGGCGGCATTTTGAGGTGCGTACCGAGGTGAACCCCAC
AAACCTTGCCTTCACCGGGCTCGGGCTTCAGGCGCATACGGACAACCCCTACCGCGATCCGGTGCCGACGCTTCAGGTGC
TCTATTGCCTCGAGAGCTCTGCCGCCGGAGGCGAGAACATGGTGGTCGACGGCTTTGCCGCCGCGCTGCGCCTGCGCGAA
GAAGACCCGGAGGGATTTGCGCTTTTGGCGACGCATTGTGCAAAGTTTGAATATGCGGGCGAGGCGAGCGTGTGTCTGAC
CTCTCGGCGTCCGATGATCGAGCTGGCACCGGATGGGGAGCTGATCGGCATTCGGTTCAACAATCGCTCCTGCGCCACCA
TCACGGATGTGCCCTTTGACAAGATGGAGGCGTATTATGCCGCCTACCGACGCCTTGGCGAGATCATTGATGATACGGCG
ATGGAGGTGACGTTCCGGCTCGAGCCGGGTGAGGCCTTTGTGGTCGACAACACCCGTGTTCTGCACGCGCGCAAGGGCTA
TTCGGGCGAGGGGACACGCTGGCTGCAAGGGTGCTACGCCGACAAGGACGGGCTGCGCTCCGCCTATCATGCGATGATGC
GGGATGCGCGCGTGGAGGCTGCGGAATGA

Upstream 100 bases:

>100_bases
TAAGGAAAACCACGTCTCAGGTCATATATTCCTGATTTGTGTTTATTGATTGGCCCTGAGAGACTCCAGTGAAATCGAAA
TCAATCCCGAAGGGCCTCTT

Downstream 100 bases:

>100_bases
AGCCGGATATCGACAGCCTGAACCGCGAGACCATCGTAGCGTTTATCGGGTCGATTTTTGATCGCCGCGGGGACGAGGAA
TATCTGGGCGAGCCTGTGAC

Product: gamma-butyrobetaine,2-oxoglutarate dioxygenase

Products: NA

Alternate protein names: Gamma-butyrobetaine hydroxylase; Gamma-BBH; Gamma-butyrobetaine,2-oxoglutarate dioxygenase [H]

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MPTLSVDPSGTYLSLETATGTQRFHAIWLRDNAQDAETRAPGNGQRLIALRDIPADTRIATAQINPDGVVQVRFAPEDKT
VDYDLAWLEAHSYDRAAPSTQGWLAQEIEPWDAGLMGNVPCGDFAALAEGGQALRDWLGQIVRYGFAKLKNAPVEPGGLF
KVVDLFGFVRETNYGRHFEVRTEVNPTNLAFTGLGLQAHTDNPYRDPVPTLQVLYCLESSAAGGENMVVDGFAAALRLRE
EDPEGFALLATHCAKFEYAGEASVCLTSRRPMIELAPDGELIGIRFNNRSCATITDVPFDKMEAYYAAYRRLGEIIDDTA
MEVTFRLEPGEAFVVDNTRVLHARKGYSGEGTRWLQGCYADKDGLRSAYHAMMRDARVEAAE

Sequences:

>Translated_382_residues
MPTLSVDPSGTYLSLETATGTQRFHAIWLRDNAQDAETRAPGNGQRLIALRDIPADTRIATAQINPDGVVQVRFAPEDKT
VDYDLAWLEAHSYDRAAPSTQGWLAQEIEPWDAGLMGNVPCGDFAALAEGGQALRDWLGQIVRYGFAKLKNAPVEPGGLF
KVVDLFGFVRETNYGRHFEVRTEVNPTNLAFTGLGLQAHTDNPYRDPVPTLQVLYCLESSAAGGENMVVDGFAAALRLRE
EDPEGFALLATHCAKFEYAGEASVCLTSRRPMIELAPDGELIGIRFNNRSCATITDVPFDKMEAYYAAYRRLGEIIDDTA
MEVTFRLEPGEAFVVDNTRVLHARKGYSGEGTRWLQGCYADKDGLRSAYHAMMRDARVEAAE
>Mature_381_residues
PTLSVDPSGTYLSLETATGTQRFHAIWLRDNAQDAETRAPGNGQRLIALRDIPADTRIATAQINPDGVVQVRFAPEDKTV
DYDLAWLEAHSYDRAAPSTQGWLAQEIEPWDAGLMGNVPCGDFAALAEGGQALRDWLGQIVRYGFAKLKNAPVEPGGLFK
VVDLFGFVRETNYGRHFEVRTEVNPTNLAFTGLGLQAHTDNPYRDPVPTLQVLYCLESSAAGGENMVVDGFAAALRLREE
DPEGFALLATHCAKFEYAGEASVCLTSRRPMIELAPDGELIGIRFNNRSCATITDVPFDKMEAYYAAYRRLGEIIDDTAM
EVTFRLEPGEAFVVDNTRVLHARKGYSGEGTRWLQGCYADKDGLRSAYHAMMRDARVEAAE

Specific function: Catalyzes the formation of L-carnitine from gamma- butyrobetaine [H]

COG id: COG2175

COG function: function code Q; Probable taurine catabolism dioxygenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-BBH/TMLD family [H]

Homologues:

Organism=Homo sapiens, GI8922625, Length=361, Percent_Identity=31.0249307479224, Blast_Score=169, Evalue=6e-42,
Organism=Homo sapiens, GI4502369, Length=348, Percent_Identity=27.0114942528736, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI296317249, Length=292, Percent_Identity=28.7671232876712, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17534641, Length=372, Percent_Identity=27.9569892473118, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71992672, Length=363, Percent_Identity=22.5895316804408, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI221329931, Length=388, Percent_Identity=26.2886597938144, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI19922166, Length=367, Percent_Identity=27.2479564032698, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24639015, Length=377, Percent_Identity=28.6472148541114, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24648401, Length=347, Percent_Identity=26.8011527377522, Blast_Score=114, Evalue=8e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012775
- InterPro:   IPR003819 [H]

Pfam domain/function: PF02668 TauD [H]

EC number: =1.14.11.1 [H]

Molecular weight: Translated: 42108; Mature: 41976

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTLSVDPSGTYLSLETATGTQRFHAIWLRDNAQDAETRAPGNGQRLIALRDIPADTRIA
CCCCCCCCCCCEEEEEECCCCCEEEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCEEE
TAQINPDGVVQVRFAPEDKTVDYDLAWLEAHSYDRAAPSTQGWLAQEIEPWDAGLMGNVP
EEEECCCCEEEEEECCCCCCCEEEEEEEEECCCCCCCCCCCCCHHHCCCCCCCCCCCCCC
CGDFAALAEGGQALRDWLGQIVRYGFAKLKNAPVEPGGLFKVVDLFGFVRETNYGRHFEV
CCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEE
RTEVNPTNLAFTGLGLQAHTDNPYRDPVPTLQVLYCLESSAAGGENMVVDGFAAALRLRE
EECCCCCEEEEEECCEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEHHHHHHHEECC
EDPEGFALLATHCAKFEYAGEASVCLTSRRPMIELAPDGELIGIRFNNRSCATITDVPFD
CCCCCEEEEEHHHHHEEECCCCEEEEECCCCEEEECCCCCEEEEEECCCCCEEEECCCHH
KMEAYYAAYRRLGEIIDDTAMEVTFRLEPGEAFVVDNTRVLHARKGYSGEGTRWLQGCYA
HHHHHHHHHHHHHHHHCCCEEEEEEEECCCCEEEECCCEEEEEECCCCCCCCHHHHHHCC
DKDGLRSAYHAMMRDARVEAAE
CHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PTLSVDPSGTYLSLETATGTQRFHAIWLRDNAQDAETRAPGNGQRLIALRDIPADTRIA
CCCCCCCCCCEEEEEECCCCCEEEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCEEE
TAQINPDGVVQVRFAPEDKTVDYDLAWLEAHSYDRAAPSTQGWLAQEIEPWDAGLMGNVP
EEEECCCCEEEEEECCCCCCCEEEEEEEEECCCCCCCCCCCCCHHHCCCCCCCCCCCCCC
CGDFAALAEGGQALRDWLGQIVRYGFAKLKNAPVEPGGLFKVVDLFGFVRETNYGRHFEV
CCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEE
RTEVNPTNLAFTGLGLQAHTDNPYRDPVPTLQVLYCLESSAAGGENMVVDGFAAALRLRE
EECCCCCEEEEEECCEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEHHHHHHHEECC
EDPEGFALLATHCAKFEYAGEASVCLTSRRPMIELAPDGELIGIRFNNRSCATITDVPFD
CCCCCEEEEEHHHHHEEECCCCEEEEECCCCEEEECCCCCEEEEEECCCCCEEEECCCHH
KMEAYYAAYRRLGEIIDDTAMEVTFRLEPGEAFVVDNTRVLHARKGYSGEGTRWLQGCYA
HHHHHHHHHHHHHHHHCCCEEEEEEEECCCCEEEECCCEEEEEECCCCCCCCHHHHHHCC
DKDGLRSAYHAMMRDARVEAAE
CHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]