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The map label for this gene is lldD [H]

Identifier: 99080060

GI number: 99080060

Start: 234369

End: 235532

Strand: Reverse

Name: lldD [H]

Synonym: TM1040_0219

Alternate gene names: 99080060

Gene position: 235532-234369 (Counterclockwise)

Preceding gene: 161899031

Following gene: 99080058

Centisome position: 7.36

GC content: 59.62

Gene sequence:

>1164_bases
ATGCCAGTGATCACCAACATCGAAGATCTCAAGCGTATTTATGCGCGGCGTGTGCCAAAGATGTTTTATGATTACGCGGA
AAGCGGATCCTGGACCGAACAGACCTTTCGCGAGAACAGCACGGACTTCGACCAGATCCGGCTGCGGCAGCGGGTGGCGG
TCGACATGGCGGGGCGCTCGACAGCCTCGCAGATGATCGGTCAGGATGTCGCCATGCCCGTGGCTCTGGCGCCGGTTGGG
CTGACGGGCATGCAATGTGCGGATGGCGAAATTAAAGCGGCCCGCGCAGCCGAAGCCTTTGGCGTGCCCTTCACGCTCTC
GACGATGTCGATCAACTCGATCGAAGAAGTCTCAGAAGCGACCAGTAAGCCCTTCTGGTTCCAGCTTTATACCATGAAGG
ACGACGACTACATCCGCCGCCTGATCGCGCGTGCAAAGGATGCAAATTGCTCGGCTCTGGTGATCACGCTCGACCTGCAG
ATCCTTGGCCAGCGCCACAAAGACCTGAAAAACGGCCTTTCTGCGCCGCCCAAGCTCACCCCAAAAACCATCGCAAATCT
GATGACGAAATGGGCCTGGGGCATCGAAATGCTCGGCGCAAAGCGACGCAATTTCGGCAATATCGTCGGCCACGTCGAGG
GGGTCTCGGATGCGTCCTCGCTGGGGTCCTGGACGGCCGAGCAATTCGACCCTTCGCTGGATTGGGGCAAGATCGAAAAA
CTCAAGGAAATGTGGGGTGGCAAAGTCATCCTCAAAGGTATCCTGGATGAGGAAGACGCCAAGATGGCGGCAAAGGTCGG
CGCGGATGCGATCACCGTCTCCAACCATGGTGGGCGGCAGTTGGACGGGGCGCTCTCGTCGATTCGCATGCTGCCCCGGA
TCATGGACGCGGTCGGCGATCAGGTGGAGGTTCACCTCGACAGTGGCATCCGCTCCGGTCAGGACGTCCTGAAGGCGCTG
GCGCTTGGGGCGACCGGCACCATGATTGGGCGAGCCTTTGTGTATGGGTTGGGCGCCATGGGACAAAAGGGTGTGACCCG
TGCCCTTGAGGTGATCCACAAGGAGCTCGATACCTCCATGGCGCTCTGTGGCGAGAAACACGTTACCGACCTTGGTCGCC
ACAACCTCTTGGTGCCAGAGGATTTCACCGGTCGCTGGGCCTGA

Upstream 100 bases:

>100_bases
AGAAATCCGTAAATGCATAGTTACGACAGGCTGGCTTGCCAGCACAGTCAGATATTGGTAAGAAAACATTACCAGTTCTG
CGCAGGTCGAGGAGCCCCCC

Downstream 100 bases:

>100_bases
ACCCTGGTCGACACACCCCGGGGCAGCCATGTTGCCCCGGTAGCATTCAGGCAATCAGCTCGGATTTCCGCGCACTGGCG
CGCAGGGCGGGCACCAAAAG

Product: L-lactate dehydrogenase (cytochrome)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 386

Protein sequence:

>387_residues
MPVITNIEDLKRIYARRVPKMFYDYAESGSWTEQTFRENSTDFDQIRLRQRVAVDMAGRSTASQMIGQDVAMPVALAPVG
LTGMQCADGEIKAARAAEAFGVPFTLSTMSINSIEEVSEATSKPFWFQLYTMKDDDYIRRLIARAKDANCSALVITLDLQ
ILGQRHKDLKNGLSAPPKLTPKTIANLMTKWAWGIEMLGAKRRNFGNIVGHVEGVSDASSLGSWTAEQFDPSLDWGKIEK
LKEMWGGKVILKGILDEEDAKMAAKVGADAITVSNHGGRQLDGALSSIRMLPRIMDAVGDQVEVHLDSGIRSGQDVLKAL
ALGATGTMIGRAFVYGLGAMGQKGVTRALEVIHKELDTSMALCGEKHVTDLGRHNLLVPEDFTGRWA

Sequences:

>Translated_387_residues
MPVITNIEDLKRIYARRVPKMFYDYAESGSWTEQTFRENSTDFDQIRLRQRVAVDMAGRSTASQMIGQDVAMPVALAPVG
LTGMQCADGEIKAARAAEAFGVPFTLSTMSINSIEEVSEATSKPFWFQLYTMKDDDYIRRLIARAKDANCSALVITLDLQ
ILGQRHKDLKNGLSAPPKLTPKTIANLMTKWAWGIEMLGAKRRNFGNIVGHVEGVSDASSLGSWTAEQFDPSLDWGKIEK
LKEMWGGKVILKGILDEEDAKMAAKVGADAITVSNHGGRQLDGALSSIRMLPRIMDAVGDQVEVHLDSGIRSGQDVLKAL
ALGATGTMIGRAFVYGLGAMGQKGVTRALEVIHKELDTSMALCGEKHVTDLGRHNLLVPEDFTGRWA
>Mature_386_residues
PVITNIEDLKRIYARRVPKMFYDYAESGSWTEQTFRENSTDFDQIRLRQRVAVDMAGRSTASQMIGQDVAMPVALAPVGL
TGMQCADGEIKAARAAEAFGVPFTLSTMSINSIEEVSEATSKPFWFQLYTMKDDDYIRRLIARAKDANCSALVITLDLQI
LGQRHKDLKNGLSAPPKLTPKTIANLMTKWAWGIEMLGAKRRNFGNIVGHVEGVSDASSLGSWTAEQFDPSLDWGKIEKL
KEMWGGKVILKGILDEEDAKMAAKVGADAITVSNHGGRQLDGALSSIRMLPRIMDAVGDQVEVHLDSGIRSGQDVLKALA
LGATGTMIGRAFVYGLGAMGQKGVTRALEVIHKELDTSMALCGEKHVTDLGRHNLLVPEDFTGRWA

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=369, Percent_Identity=35.7723577235772, Blast_Score=235, Evalue=6e-62,
Organism=Homo sapiens, GI54234014, Length=363, Percent_Identity=34.1597796143251, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI7705393, Length=363, Percent_Identity=34.1597796143251, Blast_Score=203, Evalue=2e-52,
Organism=Escherichia coli, GI1790033, Length=376, Percent_Identity=41.2234042553192, Blast_Score=319, Evalue=2e-88,
Organism=Caenorhabditis elegans, GI193208036, Length=374, Percent_Identity=32.620320855615, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI32566217, Length=291, Percent_Identity=31.2714776632302, Blast_Score=142, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6323587, Length=379, Percent_Identity=31.9261213720317, Blast_Score=173, Evalue=3e-44,
Organism=Drosophila melanogaster, GI281363140, Length=369, Percent_Identity=36.3143631436314, Blast_Score=221, Evalue=9e-58,
Organism=Drosophila melanogaster, GI78707190, Length=369, Percent_Identity=36.3143631436314, Blast_Score=221, Evalue=9e-58,
Organism=Drosophila melanogaster, GI78707188, Length=366, Percent_Identity=36.6120218579235, Blast_Score=220, Evalue=1e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 42344; Mature: 42213

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVITNIEDLKRIYARRVPKMFYDYAESGSWTEQTFRENSTDFDQIRLRQRVAVDMAGRS
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHCCCH
TASQMIGQDVAMPVALAPVGLTGMQCADGEIKAARAAEAFGVPFTLSTMSINSIEEVSEA
HHHHHHHHHHCCCHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHH
TSKPFWFQLYTMKDDDYIRRLIARAKDANCSALVITLDLQILGQRHKDLKNGLSAPPKLT
HCCCEEEEEEEECCHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHHHHHHHCCCCCCCCCC
PKTIANLMTKWAWGIEMLGAKRRNFGNIVGHVEGVSDASSLGSWTAEQFDPSLDWGKIEK
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHCCCCHHHCCCCCCHHHHHH
LKEMWGGKVILKGILDEEDAKMAAKVGADAITVSNHGGRQLDGALSSIRMLPRIMDAVGD
HHHHHCCCEEEHHHCCCHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCC
QVEVHLDSGIRSGQDVLKALALGATGTMIGRAFVYGLGAMGQKGVTRALEVIHKELDTSM
CEEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
ALCGEKHVTDLGRHNLLVPEDFTGRWA
HHHCCHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PVITNIEDLKRIYARRVPKMFYDYAESGSWTEQTFRENSTDFDQIRLRQRVAVDMAGRS
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHCCCH
TASQMIGQDVAMPVALAPVGLTGMQCADGEIKAARAAEAFGVPFTLSTMSINSIEEVSEA
HHHHHHHHHHCCCHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHH
TSKPFWFQLYTMKDDDYIRRLIARAKDANCSALVITLDLQILGQRHKDLKNGLSAPPKLT
HCCCEEEEEEEECCHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHHHHHHHCCCCCCCCCC
PKTIANLMTKWAWGIEMLGAKRRNFGNIVGHVEGVSDASSLGSWTAEQFDPSLDWGKIEK
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHCCCCHHHCCCCCCHHHHHH
LKEMWGGKVILKGILDEEDAKMAAKVGADAITVSNHGGRQLDGALSSIRMLPRIMDAVGD
HHHHHCCCEEEHHHCCCHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCC
QVEVHLDSGIRSGQDVLKALALGATGTMIGRAFVYGLGAMGQKGVTRALEVIHKELDTSM
CEEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
ALCGEKHVTDLGRHNLLVPEDFTGRWA
HHHCCHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA