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The map label for this gene is rsbRA [H]

Identifier: 99079982

GI number: 99079982

Start: 153682

End: 154578

Strand: Reverse

Name: rsbRA [H]

Synonym: TM1040_0141

Alternate gene names: 99079982

Gene position: 154578-153682 (Counterclockwise)

Preceding gene: 99079983

Following gene: 99079981

Centisome position: 4.83

GC content: 52.29

Gene sequence:

>897_bases
ATGTCACAGATTATTTCGTCCACGATTTCCGAAGACACCACTGGAATGAATGATGCATTTGGCTGGTTTGATGTATCGGC
TGAAGATCGCACCCGCGTATCTGCGCTCGAACCTCTCGTGCGCGATAATATTGATGAGATTATCAACGACTTTTATGAAC
GCGCTGGCGGCTTTGATCATTCGGCGTTGAAAATACAGGACAAAAACAGCCTTGAGCTCATAAAAGAAGAGCAAAAAAGG
CACTTCCTTGAGCTTATGGACGCCGGATTGGGCGAAGATTATTTCCAAACGCGAAAGAATGCTGGCATTTTCAACGAGCG
ATTTGGCGTTTCCCCAAGTTTTTACATGGGCGCTTATTCCTATTTTTACGATAGGATTTGTGACATCGTAAAAAGGGAAG
CAAAAAACAAAGATGAAGCGATTGAGATCTTTTTGTCGCTTCACAGGATTGCAGCGTGCCACAAGTCTTTGACAATTGAG
GCCTTTGCCAAGGCTCGGGAACAGACCATTGAGGATCGGGAACGGGAAATCAGCGAACTGCCGGTACCGGTGCTCAAGAT
GCGCGAGGGCCTTCTTCTGGTGCCGGTCGTCGGTACCCTCGACAGCCACCGTGCCAGACTACTGACGTCTCGCATGCTGG
ACGAAATCAGCAAGGTCGGCGCTCGCGCGGTGGTGCTCGACATAACGGGCGTCCCCGCCGTCGACAGCGCTGTTGCAAAC
CACCTGATTCAATCCATGGGCGCTGCCCGCCTGATGGGCGCACATTCCGTCCTGACGGGCATAAGTTCGGATGTCGCTCA
ATCCCTCGTGAAGCTCGGCGTCACCGGTGAAACCCTGAACCCAGCCGGCGACCTTCAGCGTGGGATCGAAACGGCAGAAG
CGCTTTTGGACGGCTAA

Upstream 100 bases:

>100_bases
CCGCATCAAACAACTATTGATTGAATAGCATCCTCAAGAGTCGTTTACTCAAATATAAGGAACACTTCATAATATTGGGG
CAACGATATGAGGTCGCTGT

Downstream 100 bases:

>100_bases
AGATGGCATTGCGTGTCCCGATCCTCAGTCAAGGAGAGTTGCTCATCGCCTCGATCCAGGAGGAGTTGTCAGATAGTGAG
ATCCTTGATCTGCAGGCCCG

Product: anti-sigma-factor antagonist

Products: NA

Alternate protein names: Stressosome protein rsbRA [H]

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MSQIISSTISEDTTGMNDAFGWFDVSAEDRTRVSALEPLVRDNIDEIINDFYERAGGFDHSALKIQDKNSLELIKEEQKR
HFLELMDAGLGEDYFQTRKNAGIFNERFGVSPSFYMGAYSYFYDRICDIVKREAKNKDEAIEIFLSLHRIAACHKSLTIE
AFAKAREQTIEDREREISELPVPVLKMREGLLLVPVVGTLDSHRARLLTSRMLDEISKVGARAVVLDITGVPAVDSAVAN
HLIQSMGAARLMGAHSVLTGISSDVAQSLVKLGVTGETLNPAGDLQRGIETAEALLDG

Sequences:

>Translated_298_residues
MSQIISSTISEDTTGMNDAFGWFDVSAEDRTRVSALEPLVRDNIDEIINDFYERAGGFDHSALKIQDKNSLELIKEEQKR
HFLELMDAGLGEDYFQTRKNAGIFNERFGVSPSFYMGAYSYFYDRICDIVKREAKNKDEAIEIFLSLHRIAACHKSLTIE
AFAKAREQTIEDREREISELPVPVLKMREGLLLVPVVGTLDSHRARLLTSRMLDEISKVGARAVVLDITGVPAVDSAVAN
HLIQSMGAARLMGAHSVLTGISSDVAQSLVKLGVTGETLNPAGDLQRGIETAEALLDG
>Mature_297_residues
SQIISSTISEDTTGMNDAFGWFDVSAEDRTRVSALEPLVRDNIDEIINDFYERAGGFDHSALKIQDKNSLELIKEEQKRH
FLELMDAGLGEDYFQTRKNAGIFNERFGVSPSFYMGAYSYFYDRICDIVKREAKNKDEAIEIFLSLHRIAACHKSLTIEA
FAKAREQTIEDREREISELPVPVLKMREGLLLVPVVGTLDSHRARLLTSRMLDEISKVGARAVVLDITGVPAVDSAVANH
LIQSMGAARLMGAHSVLTGISSDVAQSLVKLGVTGETLNPAGDLQRGIETAEALLDG

Specific function: Negative regulator of sigma-B activity. Non- phosphorylated rsbS binds to rsbT, preventing its association with rsbU. Requires any one of rsbRA, rsbRB, rsbRC or rsbRD to sequester rsbT. When rsbS and the rsbR paralog(s) are phosphorylated, they release rs

COG id: COG1366

COG function: function code T; Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 STAS domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014792
- InterPro:   IPR002645 [H]

Pfam domain/function: PF08678 Rsbr_N; PF01740 STAS [H]

EC number: NA

Molecular weight: Translated: 32921; Mature: 32790

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS50801 STAS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQIISSTISEDTTGMNDAFGWFDVSAEDRTRVSALEPLVRDNIDEIINDFYERAGGFDH
CHHHHHHHHHHCCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCC
SALKIQDKNSLELIKEEQKRHFLELMDAGLGEDYFQTRKNAGIFNERFGVSPSFYMGAYS
CEEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHCCCCCHHHHHHHH
YFYDRICDIVKREAKNKDEAIEIFLSLHRIAACHKSLTIEAFAKAREQTIEDREREISEL
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PVPVLKMREGLLLVPVVGTLDSHRARLLTSRMLDEISKVGARAVVLDITGVPAVDSAVAN
CCHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHH
HLIQSMGAARLMGAHSVLTGISSDVAQSLVKLGVTGETLNPAGDLQRGIETAEALLDG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SQIISSTISEDTTGMNDAFGWFDVSAEDRTRVSALEPLVRDNIDEIINDFYERAGGFDH
HHHHHHHHHHCCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCC
SALKIQDKNSLELIKEEQKRHFLELMDAGLGEDYFQTRKNAGIFNERFGVSPSFYMGAYS
CEEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHCCCCCHHHHHHHH
YFYDRICDIVKREAKNKDEAIEIFLSLHRIAACHKSLTIEAFAKAREQTIEDREREISEL
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PVPVLKMREGLLLVPVVGTLDSHRARLLTSRMLDEISKVGARAVVLDITGVPAVDSAVAN
CCHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHH
HLIQSMGAARLMGAHSVLTGISSDVAQSLVKLGVTGETLNPAGDLQRGIETAEALLDG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8002610; 9384377; 11157946; 10329124 [H]