Click here to switch to the map view.

The map label for this gene is cytR [H]

Identifier: 94986342

GI number: 94986342

Start: 2366707

End: 2367726

Strand: Reverse

Name: cytR [H]

Synonym: Dgeo_2243

Alternate gene names: 94986342

Gene position: 2367726-2366707 (Counterclockwise)

Preceding gene: 94986344

Following gene: 94986341

Centisome position: 95.97

GC content: 71.67

Gene sequence:

>1020_bases
ATGTCCCCTGCCAAGCTGCCGGTGCGCCGCGTAACCCTGCGGGACGTGGCGGCCCGGCTGGGTGTGTCCCCGGCCACCGT
CAGCAACGCCTACAACCGGCCTGATCAGCTCTCGCCCGAACTGCGCGAGCGGGTGCTGAGGGCGGCCCACGAACTGGGTT
ACAGCGGGCCTAATCCGCTGGCGCGCAGCCTGCGGCGAGGCCGCACCGGCGTGATCGGCGTGGTGTACGACAGTTCGCTG
CACTCCGCCTTTGCCGATCCCGCCGCCAGCCTCTTTCTGGGCGGGGTGGCCCGCGCCGTGCAGGACGAGGGCCTAAACCT
GCTGTTGCTGGCGGCTGTCCGGGGAGCGGCTCCTGCGGTGGAGAGCGCCAGTGTGGACGGCCTGATTCTGTATGCCACCA
CCGCCGCCAGCCCCGCTCTGGCCGCTGCTCGTACCCGTGCTCTTCCCGCCGTGCTGGTGGATCAGGCTCCCCAGCCGGGC
TTTCCGCTGATCGGGATCGAGGACGAGCGGGGCGCCGAGGCGGCGGCCCGGCATCTGCTGGAATGGGGCCACCGCGAGAT
CGGGGTGCTGGCGCTGCCCTTCGGCCCGAACGCGGCCCCGAATGTTCATCTTCGTGCCCGCCTGCACGGGTACCGCCGCG
CCCTCAGGGGTTCGGCGGGCCAGCTCTATATCGGCGCCTCCCCCGACAACTCCCCCGAATCGGGCGAGCGGCTCACCCGT
GAGCTGCTCGCCGCGCAACCCCAGGTCACGGCCCTGCTGTGCATGAGTGACGTGCTGGCCCAGGGAGCGCTGCGAGCGGC
CGCAGGAGCGGGCCTGCGGGTTCCCGGCGACCTGAGCGTGGTGGGCTATGACGATATCCCCAGCAGTACTGCCCTCAACC
TCACCACGGTGCATCAGCCCACCGCCGAGAAGGGCCTGGAGGCGGGGCGTGCCATGCTGGCCCTGCTGCGCGGTGAGACG
CCCCCGAGCGTGACGCTGCCGACCCGCTTGGTGGTGCGAGGGAGCAGCGGCGCCCCCTAA

Upstream 100 bases:

>100_bases
AGAGGGACAGGTCAGTCATGGGTCCTCCGAAAAGGGCAGGTCAAGGCAGAAACGAGGCTAAATCGATTTAGATCGCATCT
CCATACGCTAGCATCCGGCT

Downstream 100 bases:

>100_bases
AGGAATCCTTTGGCGCCCCGCGGCCGTTCCATCGCTTACCCTGTCTTTCATGAAGCTGATGGTGGTGGGAGGGGCTGGCT
ACATCGGGTCGCATACCGTG

Product: LacI family transcription regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MSPAKLPVRRVTLRDVAARLGVSPATVSNAYNRPDQLSPELRERVLRAAHELGYSGPNPLARSLRRGRTGVIGVVYDSSL
HSAFADPAASLFLGGVARAVQDEGLNLLLLAAVRGAAPAVESASVDGLILYATTAASPALAAARTRALPAVLVDQAPQPG
FPLIGIEDERGAEAAARHLLEWGHREIGVLALPFGPNAAPNVHLRARLHGYRRALRGSAGQLYIGASPDNSPESGERLTR
ELLAAQPQVTALLCMSDVLAQGALRAAAGAGLRVPGDLSVVGYDDIPSSTALNLTTVHQPTAEKGLEAGRAMLALLRGET
PPSVTLPTRLVVRGSSGAP

Sequences:

>Translated_339_residues
MSPAKLPVRRVTLRDVAARLGVSPATVSNAYNRPDQLSPELRERVLRAAHELGYSGPNPLARSLRRGRTGVIGVVYDSSL
HSAFADPAASLFLGGVARAVQDEGLNLLLLAAVRGAAPAVESASVDGLILYATTAASPALAAARTRALPAVLVDQAPQPG
FPLIGIEDERGAEAAARHLLEWGHREIGVLALPFGPNAAPNVHLRARLHGYRRALRGSAGQLYIGASPDNSPESGERLTR
ELLAAQPQVTALLCMSDVLAQGALRAAAGAGLRVPGDLSVVGYDDIPSSTALNLTTVHQPTAEKGLEAGRAMLALLRGET
PPSVTLPTRLVVRGSSGAP
>Mature_338_residues
SPAKLPVRRVTLRDVAARLGVSPATVSNAYNRPDQLSPELRERVLRAAHELGYSGPNPLARSLRRGRTGVIGVVYDSSLH
SAFADPAASLFLGGVARAVQDEGLNLLLLAAVRGAAPAVESASVDGLILYATTAASPALAAARTRALPAVLVDQAPQPGF
PLIGIEDERGAEAAARHLLEWGHREIGVLALPFGPNAAPNVHLRARLHGYRRALRGSAGQLYIGASPDNSPESGERLTRE
LLAAQPQVTALLCMSDVLAQGALRAAAGAGLRVPGDLSVVGYDDIPSSTALNLTTVHQPTAEKGLEAGRAMLALLRGETP
PSVTLPTRLVVRGSSGAP

Specific function: This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=341, Percent_Identity=32.258064516129, Blast_Score=141, Evalue=5e-35,
Organism=Escherichia coli, GI1787948, Length=340, Percent_Identity=32.9411764705882, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1790194, Length=306, Percent_Identity=31.6993464052288, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1786540, Length=340, Percent_Identity=32.6470588235294, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI1787580, Length=338, Percent_Identity=25.1479289940828, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1789202, Length=307, Percent_Identity=31.2703583061889, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1788474, Length=309, Percent_Identity=30.7443365695793, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI48994940, Length=332, Percent_Identity=28.3132530120482, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1789456, Length=336, Percent_Identity=26.1904761904762, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790689, Length=329, Percent_Identity=24.6200607902736, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 35210; Mature: 35078

Theoretical pI: Translated: 9.92; Mature: 9.92

Prosite motif: PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPAKLPVRRVTLRDVAARLGVSPATVSNAYNRPDQLSPELRERVLRAAHELGYSGPNPL
CCCCCCCHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHH
ARSLRRGRTGVIGVVYDSSLHSAFADPAASLFLGGVARAVQDEGLNLLLLAAVRGAAPAV
HHHHHCCCCCEEEEEECCHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEHHHCCCCCC
ESASVDGLILYATTAASPALAAARTRALPAVLVDQAPQPGFPLIGIEDERGAEAAARHLL
CCCCCCEEEEEEECCCCHHHHHHHHHCCHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHH
EWGHREIGVLALPFGPNAAPNVHLRARLHGYRRALRGSAGQLYIGASPDNSPESGERLTR
HCCCCCCCEEEECCCCCCCCCCEEHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHH
ELLAAQPQVTALLCMSDVLAQGALRAAAGAGLRVPGDLSVVGYDDIPSSTALNLTTVHQP
HHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCEEEEEECCCC
TAEKGLEAGRAMLALLRGETPPSVTLPTRLVVRGSSGAP
CHHHHHHHHHHHHHHHHCCCCCCEECCEEEEEECCCCCC
>Mature Secondary Structure 
SPAKLPVRRVTLRDVAARLGVSPATVSNAYNRPDQLSPELRERVLRAAHELGYSGPNPL
CCCCCCHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHH
ARSLRRGRTGVIGVVYDSSLHSAFADPAASLFLGGVARAVQDEGLNLLLLAAVRGAAPAV
HHHHHCCCCCEEEEEECCHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEHHHCCCCCC
ESASVDGLILYATTAASPALAAARTRALPAVLVDQAPQPGFPLIGIEDERGAEAAARHLL
CCCCCCEEEEEEECCCCHHHHHHHHHCCHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHH
EWGHREIGVLALPFGPNAAPNVHLRARLHGYRRALRGSAGQLYIGASPDNSPESGERLTR
HCCCCCCCEEEECCCCCCCCCCEEHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHH
ELLAAQPQVTALLCMSDVLAQGALRAAAGAGLRVPGDLSVVGYDDIPSSTALNLTTVHQP
HHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCEEEEEECCCC
TAEKGLEAGRAMLALLRGETPPSVTLPTRLVVRGSSGAP
CHHHHHHHHHHHHHHHHCCCCCCEECCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]