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The map label for this gene is maeA [H]

Identifier: 94986254

GI number: 94986254

Start: 2270701

End: 2272449

Strand: Reverse

Name: maeA [H]

Synonym: Dgeo_2155

Alternate gene names: 94986254

Gene position: 2272449-2270701 (Counterclockwise)

Preceding gene: 94986255

Following gene: 94986253

Centisome position: 92.11

GC content: 64.84

Gene sequence:

>1749_bases
ATGCCCGAAGCTCCCCGCGTCTCCCGCTACTATGACGTGAAGCGCGACGAGAACGGCCACCGTTACCTCGACGTGAACGT
CACCGGCTTCTCGCTGCTGCATATCCCCCTCCTCAACAAGTCAACCGGATTTACCCGGGAGGAACGCCGCGCGCTGGGGA
TCGAGGGCCTGGTGCCGCCGCACCACAGCACCCTGGAGGAGCAGAAACAGCGCACCTACCTGCGGTACCTTCAGCAGACC
ACAGACCTGGACAAGCATGAGTTTCTGCGCGCGCTTCAGGACCGCAACGAGGTGCTGTTCTATGCCCTGTTTGCAGATCA
CCTCGAGGAGATGCTGCCCATCCTCTACACGCCCACCGTGGGCGAGGCGGTCCGGGTCTTTTCTCACATCTACCGCTATC
CGCGCGGCTTTGCGGTCAGTACTGAGGACATCGACCGAGTGGACGAGCTGCTCGAAAACGTGCCCCTCAATGATGTGCGG
ATGATTGTGGCAACCGATTCCAGCGCGATTCTGGGCATCGGCGACCAAGGCTTTGGGGGCATGGCGATCTCCATCGGCAA
GCTCAGCCTGTACACGGTCGCGGGTGGCGTGGGCCCCGACAAGACGCTGCCGGTTGAGTTGGACGTGGGCACCGATCGCC
AGGACCTGATCGACGACCCGCTTTACCTGGGGGTACATCACCGGCGCCTGACGGGACGCGACTACGACGAGTTTCTCGAC
CGCTTTGTGGAGGCGACGGTCGCCCGCTATCCCAAGGCGATCATTCAGTGGGAGGACTTCGCGCGCGGCACAGCTTTTCG
GGTGCTGGAGCGCTACCGCAAGGTGGTGCCGAGCTTCAATGACGACATTCAGGGCACCGGGGCGATGGCCCTGGCCGGGC
TGATCAGCGCGAGCCGGCTCAAGGGGGAGCGGCTGCAAGACCAGACGTTCGTGGTCGTCGGTGCGGGGGCGGGCGGCATC
GGCGTGGCGCTGGCCATTCGTCAGGGCCTGATGCGTGAGGGGCTGAGTTACGCCGAGGCGAATGCCCGCGTCTTTGTGGT
GGACCGTTACGGCCTGCTGATGCACGGGCAGCCGGGCCTCGAAGAACACCAGCTTTCCTTTGCCCGCTCACCCGAGGATG
TGGCGGGCTGGAGCTGTGAGGGCGAGTGGCCCAGCCTGCACGAGACGGTCGTGCGCAGCGGCGCAACGGCCCTGCTCGGC
CTGACTGGCGTGCCTGGCCTCTTCCGTCAGCCGACTGTCGAGGCGATGCTGGCGCACACCTCCCGACCCATCGTGTTTCC
CCTCTCCAACCCCACCAGCAATGTGGAGGCGCAACCCGCTGACCTGCTGCGCTGGACGAACGGCGCGGCGATCATCGCCA
CCGGCAGCCCCTTCCCCGATATCGAATATGGCGGCCAGATGTACAGCATCGGACAGGGGAACAATGCCTTTATCTTCCCC
GGCTTGGGCTTTGGCGCTGTGATCAGCCGCGCCCGTGAGATCACAGACGGCATGGTGATGGAGGCCGCGCAAACCCTGGC
CGATGAGACGGTGGGGTACGGCAACCGAGTTTATCCGCCCATCAGCGCCATCCGCGAACTCAGCCTCAAGGTGGCCGTCC
GCGTGGCTCGGCAGGCCATCAAGGAAGGGGTATGTGCCGAGCGCCGCATCCGCAACCTCACCGATGATGAGCTAGAGGCT
TTTGTGCGAGGCCGCCAGTGGGTACCCAAGTACCTGCCGCTCCGGAAGGCGGCGGGGGCGCGTGACTGA

Upstream 100 bases:

>100_bases
AGGTGGCAGGCCAGCCGGGACTGAAGATTCTTACATTGCGTAAAAAACCTGCACACGCGCTGGAAGACCTGCCCCCTATC
TGGGCTAGACTCCTCAGGTT

Downstream 100 bases:

>100_bases
AACCTCTGCTCTAGGCAGGCTGGCCACGGCGTACGTCCCCTGGCTAGGCTGAGGCATGGCGCACATCTCCCGCTACTACG
ATGTGAAACGTGACCCTGCC

Product: malate dehydrogenase

Products: NA

Alternate protein names: NAD-ME [H]

Number of amino acids: Translated: 582; Mature: 581

Protein sequence:

>582_residues
MPEAPRVSRYYDVKRDENGHRYLDVNVTGFSLLHIPLLNKSTGFTREERRALGIEGLVPPHHSTLEEQKQRTYLRYLQQT
TDLDKHEFLRALQDRNEVLFYALFADHLEEMLPILYTPTVGEAVRVFSHIYRYPRGFAVSTEDIDRVDELLENVPLNDVR
MIVATDSSAILGIGDQGFGGMAISIGKLSLYTVAGGVGPDKTLPVELDVGTDRQDLIDDPLYLGVHHRRLTGRDYDEFLD
RFVEATVARYPKAIIQWEDFARGTAFRVLERYRKVVPSFNDDIQGTGAMALAGLISASRLKGERLQDQTFVVVGAGAGGI
GVALAIRQGLMREGLSYAEANARVFVVDRYGLLMHGQPGLEEHQLSFARSPEDVAGWSCEGEWPSLHETVVRSGATALLG
LTGVPGLFRQPTVEAMLAHTSRPIVFPLSNPTSNVEAQPADLLRWTNGAAIIATGSPFPDIEYGGQMYSIGQGNNAFIFP
GLGFGAVISRAREITDGMVMEAAQTLADETVGYGNRVYPPISAIRELSLKVAVRVARQAIKEGVCAERRIRNLTDDELEA
FVRGRQWVPKYLPLRKAAGARD

Sequences:

>Translated_582_residues
MPEAPRVSRYYDVKRDENGHRYLDVNVTGFSLLHIPLLNKSTGFTREERRALGIEGLVPPHHSTLEEQKQRTYLRYLQQT
TDLDKHEFLRALQDRNEVLFYALFADHLEEMLPILYTPTVGEAVRVFSHIYRYPRGFAVSTEDIDRVDELLENVPLNDVR
MIVATDSSAILGIGDQGFGGMAISIGKLSLYTVAGGVGPDKTLPVELDVGTDRQDLIDDPLYLGVHHRRLTGRDYDEFLD
RFVEATVARYPKAIIQWEDFARGTAFRVLERYRKVVPSFNDDIQGTGAMALAGLISASRLKGERLQDQTFVVVGAGAGGI
GVALAIRQGLMREGLSYAEANARVFVVDRYGLLMHGQPGLEEHQLSFARSPEDVAGWSCEGEWPSLHETVVRSGATALLG
LTGVPGLFRQPTVEAMLAHTSRPIVFPLSNPTSNVEAQPADLLRWTNGAAIIATGSPFPDIEYGGQMYSIGQGNNAFIFP
GLGFGAVISRAREITDGMVMEAAQTLADETVGYGNRVYPPISAIRELSLKVAVRVARQAIKEGVCAERRIRNLTDDELEA
FVRGRQWVPKYLPLRKAAGARD
>Mature_581_residues
PEAPRVSRYYDVKRDENGHRYLDVNVTGFSLLHIPLLNKSTGFTREERRALGIEGLVPPHHSTLEEQKQRTYLRYLQQTT
DLDKHEFLRALQDRNEVLFYALFADHLEEMLPILYTPTVGEAVRVFSHIYRYPRGFAVSTEDIDRVDELLENVPLNDVRM
IVATDSSAILGIGDQGFGGMAISIGKLSLYTVAGGVGPDKTLPVELDVGTDRQDLIDDPLYLGVHHRRLTGRDYDEFLDR
FVEATVARYPKAIIQWEDFARGTAFRVLERYRKVVPSFNDDIQGTGAMALAGLISASRLKGERLQDQTFVVVGAGAGGIG
VALAIRQGLMREGLSYAEANARVFVVDRYGLLMHGQPGLEEHQLSFARSPEDVAGWSCEGEWPSLHETVVRSGATALLGL
TGVPGLFRQPTVEAMLAHTSRPIVFPLSNPTSNVEAQPADLLRWTNGAAIIATGSPFPDIEYGGQMYSIGQGNNAFIFPG
LGFGAVISRAREITDGMVMEAAQTLADETVGYGNRVYPPISAIRELSLKVAVRVARQAIKEGVCAERRIRNLTDDELEAF
VRGRQWVPKYLPLRKAAGARD

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malic enzymes family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=552, Percent_Identity=39.6739130434783, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI62420882, Length=549, Percent_Identity=38.615664845173, Blast_Score=397, Evalue=1e-110,
Organism=Homo sapiens, GI62420880, Length=549, Percent_Identity=38.615664845173, Blast_Score=397, Evalue=1e-110,
Organism=Homo sapiens, GI239049447, Length=549, Percent_Identity=38.615664845173, Blast_Score=397, Evalue=1e-110,
Organism=Homo sapiens, GI4505145, Length=560, Percent_Identity=36.25, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI270265879, Length=465, Percent_Identity=37.8494623655914, Blast_Score=327, Evalue=2e-89,
Organism=Escherichia coli, GI87081919, Length=562, Percent_Identity=43.4163701067616, Blast_Score=459, Evalue=1e-130,
Organism=Escherichia coli, GI1788806, Length=375, Percent_Identity=25.8666666666667, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17537199, Length=552, Percent_Identity=38.9492753623188, Blast_Score=389, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6322823, Length=572, Percent_Identity=39.6853146853147, Blast_Score=416, Evalue=1e-117,
Organism=Drosophila melanogaster, GI281362674, Length=527, Percent_Identity=39.8481973434535, Blast_Score=397, Evalue=1e-110,
Organism=Drosophila melanogaster, GI281362672, Length=527, Percent_Identity=39.8481973434535, Blast_Score=397, Evalue=1e-110,
Organism=Drosophila melanogaster, GI21356279, Length=527, Percent_Identity=39.8481973434535, Blast_Score=397, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24646388, Length=532, Percent_Identity=38.7218045112782, Blast_Score=381, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24646386, Length=532, Percent_Identity=38.7218045112782, Blast_Score=381, Evalue=1e-106,
Organism=Drosophila melanogaster, GI78707242, Length=540, Percent_Identity=34.2592592592593, Blast_Score=333, Evalue=3e-91,
Organism=Drosophila melanogaster, GI78707238, Length=540, Percent_Identity=34.2592592592593, Blast_Score=333, Evalue=3e-91,
Organism=Drosophila melanogaster, GI78707240, Length=527, Percent_Identity=34.7248576850095, Blast_Score=330, Evalue=2e-90,
Organism=Drosophila melanogaster, GI78707232, Length=510, Percent_Identity=33.921568627451, Blast_Score=313, Evalue=2e-85,
Organism=Drosophila melanogaster, GI281363505, Length=507, Percent_Identity=33.9250493096647, Blast_Score=312, Evalue=5e-85,
Organism=Drosophila melanogaster, GI78707236, Length=507, Percent_Identity=33.9250493096647, Blast_Score=312, Evalue=5e-85,
Organism=Drosophila melanogaster, GI281363503, Length=503, Percent_Identity=33.7972166998012, Blast_Score=308, Evalue=5e-84,
Organism=Drosophila melanogaster, GI19922384, Length=522, Percent_Identity=28.9272030651341, Blast_Score=239, Evalue=3e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR001891
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M [H]

EC number: =1.1.1.38 [H]

Molecular weight: Translated: 64398; Mature: 64267

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEAPRVSRYYDVKRDENGHRYLDVNVTGFSLLHIPLLNKSTGFTREERRALGIEGLVPP
CCCCCCCCHHEECCCCCCCCEEEEEEECCEEEEEEEEECCCCCCCHHHHHHCCCCCCCCC
HHSTLEEQKQRTYLRYLQQTTDLDKHEFLRALQDRNEVLFYALFADHLEEMLPILYTPTV
CCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEHHHHHHHHHHHHEEECCCH
GEAVRVFSHIYRYPRGFAVSTEDIDRVDELLENVPLNDVRMIVATDSSAILGIGDQGFGG
HHHHHHHHHHHHCCCCCEECHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEECCCCCCCC
MAISIGKLSLYTVAGGVGPDKTLPVELDVGTDRQDLIDDPLYLGVHHRRLTGRDYDEFLD
EEEEECCEEEEEEECCCCCCCEEEEEEECCCCHHHHCCCCCEECCCHHCCCCCCHHHHHH
RFVEATVARYPKAIIQWEDFARGTAFRVLERYRKVVPSFNDDIQGTGAMALAGLISASRL
HHHHHHHHHCCHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
KGERLQDQTFVVVGAGAGGIGVALAIRQGLMREGLSYAEANARVFVVDRYGLLMHGQPGL
CCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCHHCCCCEEEEEECCCEEEECCCCC
EEHQLSFARSPEDVAGWSCEGEWPSLHETVVRSGATALLGLTGVPGLFRQPTVEAMLAHT
HHHHHHHCCCCCHHCCCCCCCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHC
SRPIVFPLSNPTSNVEAQPADLLRWTNGAAIIATGSPFPDIEYGGQMYSIGQGNNAFIFP
CCCEEEECCCCCCCCCCCCHHHHEECCCCEEEECCCCCCCCCCCCEEEEECCCCCEEEEC
GLGFGAVISRAREITDGMVMEAAQTLADETVGYGNRVYPPISAIRELSLKVAVRVARQAI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
KEGVCAERRIRNLTDDELEAFVRGRQWVPKYLPLRKAAGARD
HHCHHHHHHHHCCCHHHHHHHHHCCCCCHHHHCHHHHCCCCC
>Mature Secondary Structure 
PEAPRVSRYYDVKRDENGHRYLDVNVTGFSLLHIPLLNKSTGFTREERRALGIEGLVPP
CCCCCCCHHEECCCCCCCCEEEEEEECCEEEEEEEEECCCCCCCHHHHHHCCCCCCCCC
HHSTLEEQKQRTYLRYLQQTTDLDKHEFLRALQDRNEVLFYALFADHLEEMLPILYTPTV
CCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEHHHHHHHHHHHHEEECCCH
GEAVRVFSHIYRYPRGFAVSTEDIDRVDELLENVPLNDVRMIVATDSSAILGIGDQGFGG
HHHHHHHHHHHHCCCCCEECHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEECCCCCCCC
MAISIGKLSLYTVAGGVGPDKTLPVELDVGTDRQDLIDDPLYLGVHHRRLTGRDYDEFLD
EEEEECCEEEEEEECCCCCCCEEEEEEECCCCHHHHCCCCCEECCCHHCCCCCCHHHHHH
RFVEATVARYPKAIIQWEDFARGTAFRVLERYRKVVPSFNDDIQGTGAMALAGLISASRL
HHHHHHHHHCCHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
KGERLQDQTFVVVGAGAGGIGVALAIRQGLMREGLSYAEANARVFVVDRYGLLMHGQPGL
CCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCHHCCCCEEEEEECCCEEEECCCCC
EEHQLSFARSPEDVAGWSCEGEWPSLHETVVRSGATALLGLTGVPGLFRQPTVEAMLAHT
HHHHHHHCCCCCHHCCCCCCCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHC
SRPIVFPLSNPTSNVEAQPADLLRWTNGAAIIATGSPFPDIEYGGQMYSIGQGNNAFIFP
CCCEEEECCCCCCCCCCCCHHHHEECCCCEEEECCCCCCCCCCCCEEEEECCCCCEEEEC
GLGFGAVISRAREITDGMVMEAAQTLADETVGYGNRVYPPISAIRELSLKVAVRVARQAI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
KEGVCAERRIRNLTDDELEAFVRGRQWVPKYLPLRKAAGARD
HHCHHHHHHHHCCCHHHHHHHHHCCCCCHHHHCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA