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The map label for this gene is pyrP [H]

Identifier: 94985991

GI number: 94985991

Start: 1990148

End: 1991332

Strand: Reverse

Name: pyrP [H]

Synonym: Dgeo_1891

Alternate gene names: 94985991

Gene position: 1991332-1990148 (Counterclockwise)

Preceding gene: 94985995

Following gene: 94985987

Centisome position: 80.71

GC content: 66.24

Gene sequence:

>1185_bases
ATGTTCGGCGCAACTGTGCTGGTACCCATCCTGGTCGGTCTTTCGCCCAGTGTCGCGCTGTTTGCTGCTGGGGTCGCCAC
CCTGATCTTCCACCTGCTCACCGGGGGCCGCGTGCCGATCTTCCTGGGGTCCAGCTTCGCCTTTATTGCGCCGACCGCGC
TGGTGGTCAAAGAATTTGGCCCTGCCGCCGCCGGAGGGGGCTTGATCGCTGCCGGGGCGATGTACCTGCTCTTTAGCGGT
CTGGTGCGGCTGTTTGGCACCGCGCGGCTGCTGCGGGTCTTTCCTCCGGTGGTCACCGGCCCAGTCATCATTGTGATTGG
GCTGGGGCTGTCCAGCGTGGCGGTGAACCAGGCCAAGTCGAACTGGTGGCTGGCCCTCGCCACGCTGGTCGCCGCCGTGG
TCGCCAGCGTGTACGGGCGCGGCCTCTTCCGCATGATCCCGATTCTGGTGGGTGTGGTGGTGGGCGACCTCGTCGCACTC
GCCACCGGGCAGGTGGCTCCGGACGCTCTCGCCGCTATTCGCGCGGCACCCCTCCTCGGTCTTCCCGACTTTCATGCGCC
GGCGTTCGACTGGCGGGCGGTCGCGATCATCGCGCCCGTTGCCATCGTGACCTTTATCGAACATGTCGGAGACGTGATTG
TGAATGGCCGCGTCGTGGGGCAGAACTTCCTGCAAAGCCCTGGCCTGAGCCGCACCCTCTTTGCAGACGGCGTCGCCAAT
ATGACGAGCGCGGCGCTCGGCGGTCCCGCCGCCACCACCTACGCCGAGAATACCGGCGTGCTGGCCCTGACGCGGGTGTA
CGACCCCGCCATTTTGCGCATCGGCGCCCTCTTCGCCATGCTCTTTGGCTGCTCGCCCAAGCTGGCTGCGGTGCTCAAGA
GCCTGCCGCCGGGTGTGCTGGGGGGCGTTTCCATTCTGCTCTTCGGCATGATCGCCTCCGTCGGCATTCGCACCCTGGCC
GAGGCGAAGATCGATTTTGCCCACTCGCGCAACCTGATTGTCGTGAGCGTCATCCTGGTGCTGGGGCTGGGCGGAGCGTC
CTTCCCGATTCACGCGGCGGGCACCACCCTCGAACTGCATGGGATGGCGCTCGCCGCGCTCGTCGGGATCGTGGCAAACC
TACTGCTGCCTGCCCAGAAGGTCGAAGTGGACGGAGCAGGCGAATCGGAACGGGTGTTGCACTGA

Upstream 100 bases:

>100_bases
CTCCGGAGGCCCCATGACCCAGACTGCCAACGCCACCCCGCCCCCCAGTCCCGCCCGCCTGGAACGCCGGCTCGTCCTGG
GTGCTCAGCACGCCATCGCC

Downstream 100 bases:

>100_bases
AGGTCATAAGAAAGTGGGGCCGCTCCACCTCCCCGGAGCGGCCCTTCTGGTGGCGCAAATTGTTGCTCGAGCTAGGCGCT
GGAGTTTGAGCGCCGACCCC

Product: uracil-xanthine permease

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MFGATVLVPILVGLSPSVALFAAGVATLIFHLLTGGRVPIFLGSSFAFIAPTALVVKEFGPAAAGGGLIAAGAMYLLFSG
LVRLFGTARLLRVFPPVVTGPVIIVIGLGLSSVAVNQAKSNWWLALATLVAAVVASVYGRGLFRMIPILVGVVVGDLVAL
ATGQVAPDALAAIRAAPLLGLPDFHAPAFDWRAVAIIAPVAIVTFIEHVGDVIVNGRVVGQNFLQSPGLSRTLFADGVAN
MTSAALGGPAATTYAENTGVLALTRVYDPAILRIGALFAMLFGCSPKLAAVLKSLPPGVLGGVSILLFGMIASVGIRTLA
EAKIDFAHSRNLIVVSVILVLGLGGASFPIHAAGTTLELHGMALAALVGIVANLLLPAQKVEVDGAGESERVLH

Sequences:

>Translated_394_residues
MFGATVLVPILVGLSPSVALFAAGVATLIFHLLTGGRVPIFLGSSFAFIAPTALVVKEFGPAAAGGGLIAAGAMYLLFSG
LVRLFGTARLLRVFPPVVTGPVIIVIGLGLSSVAVNQAKSNWWLALATLVAAVVASVYGRGLFRMIPILVGVVVGDLVAL
ATGQVAPDALAAIRAAPLLGLPDFHAPAFDWRAVAIIAPVAIVTFIEHVGDVIVNGRVVGQNFLQSPGLSRTLFADGVAN
MTSAALGGPAATTYAENTGVLALTRVYDPAILRIGALFAMLFGCSPKLAAVLKSLPPGVLGGVSILLFGMIASVGIRTLA
EAKIDFAHSRNLIVVSVILVLGLGGASFPIHAAGTTLELHGMALAALVGIVANLLLPAQKVEVDGAGESERVLH
>Mature_394_residues
MFGATVLVPILVGLSPSVALFAAGVATLIFHLLTGGRVPIFLGSSFAFIAPTALVVKEFGPAAAGGGLIAAGAMYLLFSG
LVRLFGTARLLRVFPPVVTGPVIIVIGLGLSSVAVNQAKSNWWLALATLVAAVVASVYGRGLFRMIPILVGVVVGDLVAL
ATGQVAPDALAAIRAAPLLGLPDFHAPAFDWRAVAIIAPVAIVTFIEHVGDVIVNGRVVGQNFLQSPGLSRTLFADGVAN
MTSAALGGPAATTYAENTGVLALTRVYDPAILRIGALFAMLFGCSPKLAAVLKSLPPGVLGGVSILLFGMIASVGIRTLA
EAKIDFAHSRNLIVVSVILVLGLGGASFPIHAAGTTLELHGMALAALVGIVANLLLPAQKVEVDGAGESERVLH

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=387, Percent_Identity=26.6149870801034, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI40316845, Length=387, Percent_Identity=26.6149870801034, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI44680143, Length=390, Percent_Identity=25.8974358974359, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI44680145, Length=384, Percent_Identity=25.2604166666667, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1788843, Length=381, Percent_Identity=41.7322834645669, Blast_Score=261, Evalue=4e-71,
Organism=Escherichia coli, GI87081818, Length=398, Percent_Identity=38.9447236180905, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI87082181, Length=425, Percent_Identity=28.4705882352941, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1790087, Length=400, Percent_Identity=24.75, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87082178, Length=313, Percent_Identity=27.7955271565495, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17541904, Length=220, Percent_Identity=25, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71993493, Length=184, Percent_Identity=27.7173913043478, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17558856, Length=379, Percent_Identity=23.4828496042216, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17542260, Length=242, Percent_Identity=25.2066115702479, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17542262, Length=235, Percent_Identity=24.2553191489362, Blast_Score=64, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 40057; Mature: 40057

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFGATVLVPILVGLSPSVALFAAGVATLIFHLLTGGRVPIFLGSSFAFIAPTALVVKEFG
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCC
PAAAGGGLIAAGAMYLLFSGLVRLFGTARLLRVFPPVVTGPVIIVIGLGLSSVAVNQAKS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCEEEEEECCHHHHHHHHHCC
NWWLALATLVAAVVASVYGRGLFRMIPILVGVVVGDLVALATGQVAPDALAAIRAAPLLG
CHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCC
LPDFHAPAFDWRAVAIIAPVAIVTFIEHVGDVIVNGRVVGQNFLQSPGLSRTLFADGVAN
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECHHHHCCCCCCHHHHHCCHHH
MTSAALGGPAATTYAENTGVLALTRVYDPAILRIGALFAMLFGCSPKLAAVLKSLPPGVL
HHHHHCCCCHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHH
GGVSILLFGMIASVGIRTLAEAKIDFAHSRNLIVVSVILVLGLGGASFPIHAAGTTLELH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEECCCEEEHH
GMALAALVGIVANLLLPAQKVEVDGAGESERVLH
HHHHHHHHHHHHHHHCCHHHEEECCCCCCCCCCC
>Mature Secondary Structure
MFGATVLVPILVGLSPSVALFAAGVATLIFHLLTGGRVPIFLGSSFAFIAPTALVVKEFG
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCC
PAAAGGGLIAAGAMYLLFSGLVRLFGTARLLRVFPPVVTGPVIIVIGLGLSSVAVNQAKS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCEEEEEECCHHHHHHHHHCC
NWWLALATLVAAVVASVYGRGLFRMIPILVGVVVGDLVALATGQVAPDALAAIRAAPLLG
CHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCC
LPDFHAPAFDWRAVAIIAPVAIVTFIEHVGDVIVNGRVVGQNFLQSPGLSRTLFADGVAN
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECHHHHCCCCCCHHHHHCCHHH
MTSAALGGPAATTYAENTGVLALTRVYDPAILRIGALFAMLFGCSPKLAAVLKSLPPGVL
HHHHHCCCCHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHH
GGVSILLFGMIASVGIRTLAEAKIDFAHSRNLIVVSVILVLGLGGASFPIHAAGTTLELH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEECCCEEEHH
GMALAALVGIVANLLLPAQKVEVDGAGESERVLH
HHHHHHHHHHHHHHHCCHHHEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8206848 [H]