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The map label for this gene is pbpD [H]

Identifier: 94985995

GI number: 94985995

Start: 1992948

End: 1995407

Strand: Reverse

Name: pbpD [H]

Synonym: Dgeo_1895

Alternate gene names: 94985995

Gene position: 1995407-1992948 (Counterclockwise)

Preceding gene: 94985998

Following gene: 94985991

Centisome position: 80.88

GC content: 67.15

Gene sequence:

>2460_bases
ATGCGGTTTTTCACTGGCCTGGGTGTCCTCCTGTTGCTGGGAGCGGCGGGTGCGGGCGGCCTGTGGTGGATGTGGGGGCG
CGATCTCCCCAGCGTACAGGATCTCGACGTGCTGGAACTCAGCGGCAAGACCCGCGTGTATGACCGAAACAACGTCTTGG
TGGGGACGCTCACGCCCAGCCTGGGCAGCGGCCAGAGCGTGAACCGCGACCTGCTGAAGCTGAACCAGATCAGCCCCTGG
CTCCAAAAGGCCATTGTGACCAGTGAGGATCGCCGTTTCTACGAGCACCACGGCGTCGACTACATCGGCATCGCGCGCGG
CCTCCTCAAGGGCCTGCTGAAAAATGACCTGGAGGGCGGCTCCTCCATCACGCAGCAGGTGGTGAAAAATACCTTGCTCG
CCGACCTCCACAGCGCCCGCACGCCCGAGCGCAAATTCAAGGAAGCCTTGCTGGCCTACCAGTTGGAGCGCAATTTTAAC
AAGGACCAGATCCTGAACGCCTACCTGAACGTCGTCTACTGGGGTGACGGGGGCCGCAACGACATCATCGGCGCGGGGAC
AGCGGCGCAGGCGTACTTCCGCAAACCCGCCTCCGACCTGAACCTGGCCGAGAGCGTGTATCTCACCATCCTGGTGCCCG
CGCCCAACAGCCGCTACAAGGACTTCAAGGCGTACCGCCCCTTGATGAAGGATCTGCTGAACCGCATGGTAGAGGACGGC
CGCATCACCCAGGCCGAGGCTGAGGCCGCGTGGAAAACGCCCATCTATCCGGCGGGCTGGCGGATCGGCTGGAACAGTGA
CGGCACCGTGCGCAGCGCCGTGCTGGAAAACCCCGGACGTCTCCAGCAGAATATGCCGCCTCCCCCCACGCAGACGGCCT
TTCACTACCTCCAAGCGGTCGAGCGCGAGCTGATTCCCAAGATCGGGCGCAAGGCCCTCTTTGCGGGGGGCAAGGTGTAC
ACGGCGCTTGACCTTCAGGCGCAACAGGCGGCGGAGCGGGCCAGTCGGAACGCCCAGCTGCCCGACGGCGCAACGCTGGG
CTTGGCGCTCGTCAGCCCGAAAAACGGTGAGGTGCTGGCGCTGGTGGGGCAGAAGTTGACGGGTGGGCGGCCCTCCGATT
GGGACAACGCGACCCAGGCGCGGCGGCAGGTTGGAAGTTCGATCAAGCCGCTGCTCTACACCCTGGCGCTCGAAAAGGGC
TGGAAGCAGAGTGACACCGTGCTGGATGCGCCCCTTACGGGTGACTACCAGCCGCAGAACTACAATGGGCGCTGGACGGG
CCGCTACGTCACCCTGCGCTATGCCCTTGACCACAGCCTGAACCTCCCCACCGTTCGCATCGCGCAGGAGATCGGGCTTC
CAGCCTTCGAGGACAAGCTGCGTGCGCTGGGCCTCACGCCGCCGCCCGACGCAGGGCTTTCGCTGAGCATCGGCACACTG
GAGGCGAGTCCCCTGCAGATGGCCGCTGCCTACGCCCCCTTTGCCAATGGCGGGATCTACTACGCCCCCACCCTGGTTCG
CCGCGTGGAGGACGAACGCGGACAGACCATCTACACCCGGCCCGCGCCGCAGGGTAAGCGGGTGTGGGACGTGCGGACGG
CCTGGCTGGGGCTGGACATGATCCGCGGCGTGGTGAATGACCTGACCGCGGAGCAGGGCGGCCTGGCCACCCGCGCGCAG
ATCCCCGGCTGGGATGTGGGCGGCAAGACCGGCACCACCAACGACGTGAAAGACCTGTGGTTCGTAGGGGTGACGCCCAA
CGTCGCGGGTGCGGTGTGGGTTGGCAAGCAGGCGGGCGGCCCACTGCCGGGCTGGGCCTACAGCGGCGAAATCCCCACGC
CGGTCTGGCAGCAGGCGGTGGCGGGGGCGCTGGCGGGGCAGCCCCATCAGACCTTTCGTGAGCCGAGCGGCATCACCTAC
CGGGTGGTGCGCCGGGTGGAAATGGCCTTCCGTGAGGAGGAGGCCGACCAGGAGCAGATGGCGCACGACGGCAGCGGCGA
CAACCGCAGCGGAGGCTTCTTCAGCCGCCGCAGCTCCACACCTGCGCCCGCACCTGAACCCGAAGCCCAACCCAGCCCTG
TGACCGGAGCGCCCACGCCGGGAGACGGCGATCAGGCAGCGCCTACGATGCCAGAAACGACCGACCAGCAGGCAGCGCTG
GAGCCTGCGCCTGCAGAGTCCGCCTCGAATGAACCCCTCCAGAACACGTCTCCCCAGAACTCCTCCGGTCTCTCCGAGGC
GGGCAGTGGCTCCCAGGACGGCACGGGCGACCTCTTGACGCCTGCGCCTCCGGAAGACCTACCGACCGAACCAGTGCCGG
GCGTGTCGCCCAGCGAACTGCAACCTGTCCCTCAGACGCCCGACGAGGGCAACGGGTATGACAACCTGCCCCCCGACGGC
GCCTGGCAGAGTGGCGGCGACCCGAACAGCGGGGGTGTCGGCGCGCCCCCTACGTTCTAG

Upstream 100 bases:

>100_bases
CGACACCGGGCGTGGTGACCCGTACCCTGAAGGGCAAGATGCCGAGTCACCGTGACCTTTCCCCCCAGCCGCGGCGTGTT
GGACCGCTAAAGTGAACGTC

Downstream 100 bases:

>100_bases
CCGTCCAGCGGCAAGAGGGTCAGGGTGCCCCTGTCGGCGGGGCCGTCGATGGTGAGCACTTCTAGGCGGCAGGGGAGATC
TTCCCGGCCATGCTCGCGGC

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP 4 [H]

Number of amino acids: Translated: 819; Mature: 819

Protein sequence:

>819_residues
MRFFTGLGVLLLLGAAGAGGLWWMWGRDLPSVQDLDVLELSGKTRVYDRNNVLVGTLTPSLGSGQSVNRDLLKLNQISPW
LQKAIVTSEDRRFYEHHGVDYIGIARGLLKGLLKNDLEGGSSITQQVVKNTLLADLHSARTPERKFKEALLAYQLERNFN
KDQILNAYLNVVYWGDGGRNDIIGAGTAAQAYFRKPASDLNLAESVYLTILVPAPNSRYKDFKAYRPLMKDLLNRMVEDG
RITQAEAEAAWKTPIYPAGWRIGWNSDGTVRSAVLENPGRLQQNMPPPPTQTAFHYLQAVERELIPKIGRKALFAGGKVY
TALDLQAQQAAERASRNAQLPDGATLGLALVSPKNGEVLALVGQKLTGGRPSDWDNATQARRQVGSSIKPLLYTLALEKG
WKQSDTVLDAPLTGDYQPQNYNGRWTGRYVTLRYALDHSLNLPTVRIAQEIGLPAFEDKLRALGLTPPPDAGLSLSIGTL
EASPLQMAAAYAPFANGGIYYAPTLVRRVEDERGQTIYTRPAPQGKRVWDVRTAWLGLDMIRGVVNDLTAEQGGLATRAQ
IPGWDVGGKTGTTNDVKDLWFVGVTPNVAGAVWVGKQAGGPLPGWAYSGEIPTPVWQQAVAGALAGQPHQTFREPSGITY
RVVRRVEMAFREEEADQEQMAHDGSGDNRSGGFFSRRSSTPAPAPEPEAQPSPVTGAPTPGDGDQAAPTMPETTDQQAAL
EPAPAESASNEPLQNTSPQNSSGLSEAGSGSQDGTGDLLTPAPPEDLPTEPVPGVSPSELQPVPQTPDEGNGYDNLPPDG
AWQSGGDPNSGGVGAPPTF

Sequences:

>Translated_819_residues
MRFFTGLGVLLLLGAAGAGGLWWMWGRDLPSVQDLDVLELSGKTRVYDRNNVLVGTLTPSLGSGQSVNRDLLKLNQISPW
LQKAIVTSEDRRFYEHHGVDYIGIARGLLKGLLKNDLEGGSSITQQVVKNTLLADLHSARTPERKFKEALLAYQLERNFN
KDQILNAYLNVVYWGDGGRNDIIGAGTAAQAYFRKPASDLNLAESVYLTILVPAPNSRYKDFKAYRPLMKDLLNRMVEDG
RITQAEAEAAWKTPIYPAGWRIGWNSDGTVRSAVLENPGRLQQNMPPPPTQTAFHYLQAVERELIPKIGRKALFAGGKVY
TALDLQAQQAAERASRNAQLPDGATLGLALVSPKNGEVLALVGQKLTGGRPSDWDNATQARRQVGSSIKPLLYTLALEKG
WKQSDTVLDAPLTGDYQPQNYNGRWTGRYVTLRYALDHSLNLPTVRIAQEIGLPAFEDKLRALGLTPPPDAGLSLSIGTL
EASPLQMAAAYAPFANGGIYYAPTLVRRVEDERGQTIYTRPAPQGKRVWDVRTAWLGLDMIRGVVNDLTAEQGGLATRAQ
IPGWDVGGKTGTTNDVKDLWFVGVTPNVAGAVWVGKQAGGPLPGWAYSGEIPTPVWQQAVAGALAGQPHQTFREPSGITY
RVVRRVEMAFREEEADQEQMAHDGSGDNRSGGFFSRRSSTPAPAPEPEAQPSPVTGAPTPGDGDQAAPTMPETTDQQAAL
EPAPAESASNEPLQNTSPQNSSGLSEAGSGSQDGTGDLLTPAPPEDLPTEPVPGVSPSELQPVPQTPDEGNGYDNLPPDG
AWQSGGDPNSGGVGAPPTF
>Mature_819_residues
MRFFTGLGVLLLLGAAGAGGLWWMWGRDLPSVQDLDVLELSGKTRVYDRNNVLVGTLTPSLGSGQSVNRDLLKLNQISPW
LQKAIVTSEDRRFYEHHGVDYIGIARGLLKGLLKNDLEGGSSITQQVVKNTLLADLHSARTPERKFKEALLAYQLERNFN
KDQILNAYLNVVYWGDGGRNDIIGAGTAAQAYFRKPASDLNLAESVYLTILVPAPNSRYKDFKAYRPLMKDLLNRMVEDG
RITQAEAEAAWKTPIYPAGWRIGWNSDGTVRSAVLENPGRLQQNMPPPPTQTAFHYLQAVERELIPKIGRKALFAGGKVY
TALDLQAQQAAERASRNAQLPDGATLGLALVSPKNGEVLALVGQKLTGGRPSDWDNATQARRQVGSSIKPLLYTLALEKG
WKQSDTVLDAPLTGDYQPQNYNGRWTGRYVTLRYALDHSLNLPTVRIAQEIGLPAFEDKLRALGLTPPPDAGLSLSIGTL
EASPLQMAAAYAPFANGGIYYAPTLVRRVEDERGQTIYTRPAPQGKRVWDVRTAWLGLDMIRGVVNDLTAEQGGLATRAQ
IPGWDVGGKTGTTNDVKDLWFVGVTPNVAGAVWVGKQAGGPLPGWAYSGEIPTPVWQQAVAGALAGQPHQTFREPSGITY
RVVRRVEMAFREEEADQEQMAHDGSGDNRSGGFFSRRSSTPAPAPEPEAQPSPVTGAPTPGDGDQAAPTMPETTDQQAAL
EPAPAESASNEPLQNTSPQNSSGLSEAGSGSQDGTGDLLTPAPPEDLPTEPVPGVSPSELQPVPQTPDEGNGYDNLPPDG
AWQSGGDPNSGGVGAPPTF

Specific function: Cell Wall Formation. Synthesis Of Cross-Linked Peptidoglycan From The Lipid Intermediates. The Enzyme Has A Penicillin-Insensitive Transglycosylase N-Terminal Domain (Formation Of Linear Glycan Strands) And A Penicillin-Sensitive Transpeptidase C-Terminal

COG id: COG0744

COG function: function code M; Membrane carboxypeptidase (penicillin-binding protein)

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786343, Length=570, Percent_Identity=30.7017543859649, Blast_Score=194, Evalue=3e-50,
Organism=Escherichia coli, GI87082258, Length=345, Percent_Identity=31.8840579710145, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1788867, Length=626, Percent_Identity=26.3578274760383, Blast_Score=127, Evalue=3e-30,
Organism=Escherichia coli, GI1789601, Length=154, Percent_Identity=38.3116883116883, Blast_Score=96, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.1.129; 3.4.-.- [C]

Molecular weight: Translated: 88132; Mature: 88132

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFFTGLGVLLLLGAAGAGGLWWMWGRDLPSVQDLDVLELSGKTRVYDRNNVLVGTLTPS
CCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCEEEECCCEEEEECCCEEEEEECCC
LGSGQSVNRDLLKLNQISPWLQKAIVTSEDRRFYEHHGVDYIGIARGLLKGLLKNDLEGG
CCCCCCCCHHHHHHHHCCHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCC
SSITQQVVKNTLLADLHSARTPERKFKEALLAYQLERNFNKDQILNAYLNVVYWGDGGRN
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHEEEEEECCCCCC
DIIGAGTAAQAYFRKPASDLNLAESVYLTILVPAPNSRYKDFKAYRPLMKDLLNRMVEDG
CEEECCHHHHHHHHCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCC
RITQAEAEAAWKTPIYPAGWRIGWNSDGTVRSAVLENPGRLQQNMPPPPTQTAFHYLQAV
CCCHHHHHHHHCCCCCCCCEEECCCCCCCHHHHHHCCCCHHHCCCCCCCHHHHHHHHHHH
ERELIPKIGRKALFAGGKVYTALDLQAQQAAERASRNAQLPDGATLGLALVSPKNGEVLA
HHHHHHHHCCHHHHCCCEEEEEECHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCEEE
LVGQKLTGGRPSDWDNATQARRQVGSSIKPLLYTLALEKGWKQSDTVLDAPLTGDYQPQN
EECCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCC
YNGRWTGRYVTLRYALDHSLNLPTVRIAQEIGLPAFEDKLRALGLTPPPDAGLSLSIGTL
CCCEEEEEEEEEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCEEEEECC
EASPLQMAAAYAPFANGGIYYAPTLVRRVEDERGQTIYTRPAPQGKRVWDVRTAWLGLDM
CCCHHHHHHHHCCCCCCCEEEHHHHHHHHHHHCCCEEEECCCCCCCEEEEHHHHHHHHHH
IRGVVNDLTAEQGGLATRAQIPGWDVGGKTGTTNDVKDLWFVGVTPNVAGAVWVGKQAGG
HHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCEEEECCCCCC
PLPGWAYSGEIPTPVWQQAVAGALAGQPHQTFREPSGITYRVVRRVEMAFREEEADQEQM
CCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AHDGSGDNRSGGFFSRRSSTPAPAPEPEAQPSPVTGAPTPGDGDQAAPTMPETTDQQAAL
HCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCC
EPAPAESASNEPLQNTSPQNSSGLSEAGSGSQDGTGDLLTPAPPEDLPTEPVPGVSPSEL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHC
QPVPQTPDEGNGYDNLPPDGAWQSGGDPNSGGVGAPPTF
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRFFTGLGVLLLLGAAGAGGLWWMWGRDLPSVQDLDVLELSGKTRVYDRNNVLVGTLTPS
CCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCEEEECCCEEEEECCCEEEEEECCC
LGSGQSVNRDLLKLNQISPWLQKAIVTSEDRRFYEHHGVDYIGIARGLLKGLLKNDLEGG
CCCCCCCCHHHHHHHHCCHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCC
SSITQQVVKNTLLADLHSARTPERKFKEALLAYQLERNFNKDQILNAYLNVVYWGDGGRN
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHEEEEEECCCCCC
DIIGAGTAAQAYFRKPASDLNLAESVYLTILVPAPNSRYKDFKAYRPLMKDLLNRMVEDG
CEEECCHHHHHHHHCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCC
RITQAEAEAAWKTPIYPAGWRIGWNSDGTVRSAVLENPGRLQQNMPPPPTQTAFHYLQAV
CCCHHHHHHHHCCCCCCCCEEECCCCCCCHHHHHHCCCCHHHCCCCCCCHHHHHHHHHHH
ERELIPKIGRKALFAGGKVYTALDLQAQQAAERASRNAQLPDGATLGLALVSPKNGEVLA
HHHHHHHHCCHHHHCCCEEEEEECHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCEEE
LVGQKLTGGRPSDWDNATQARRQVGSSIKPLLYTLALEKGWKQSDTVLDAPLTGDYQPQN
EECCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCC
YNGRWTGRYVTLRYALDHSLNLPTVRIAQEIGLPAFEDKLRALGLTPPPDAGLSLSIGTL
CCCEEEEEEEEEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCEEEEECC
EASPLQMAAAYAPFANGGIYYAPTLVRRVEDERGQTIYTRPAPQGKRVWDVRTAWLGLDM
CCCHHHHHHHHCCCCCCCEEEHHHHHHHHHHHCCCEEEECCCCCCCEEEEHHHHHHHHHH
IRGVVNDLTAEQGGLATRAQIPGWDVGGKTGTTNDVKDLWFVGVTPNVAGAVWVGKQAGG
HHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCEEEECCCCCC
PLPGWAYSGEIPTPVWQQAVAGALAGQPHQTFREPSGITYRVVRRVEMAFREEEADQEQM
CCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AHDGSGDNRSGGFFSRRSSTPAPAPEPEAQPSPVTGAPTPGDGDQAAPTMPETTDQQAAL
HCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCC
EPAPAESASNEPLQNTSPQNSSGLSEAGSGSQDGTGDLLTPAPPEDLPTEPVPGVSPSEL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHC
QPVPQTPDEGNGYDNLPPDGAWQSGGDPNSGGVGAPPTF
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferases; Acyltransferases; Aminoacyltransferases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7961491; 9274030; 9384377 [H]