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The map label for this gene is aceE [H]

Identifier: 94985987

GI number: 94985987

Start: 1983610

End: 1986318

Strand: Reverse

Name: aceE [H]

Synonym: Dgeo_1887

Alternate gene names: 94985987

Gene position: 1986318-1983610 (Counterclockwise)

Preceding gene: 94985991

Following gene: 94985986

Centisome position: 80.51

GC content: 64.93

Gene sequence:

>2709_bases
GTGCCACCGCGCGCCGCCCTGTCCCCACAGGAGCGTGAACAGCTCAATTCTGTGGAAACGCAGGAGTGGCTCGACTCGCT
CGCCTACGTTCTGGCAGACGCAGGCGACGACCGCGCCGCGCAGCTGTTGGAAGAGCTGGACCACTACGCCTACTTCCACG
GCGCCCCCATCCTCTTTAAGCAGAACACGCCCTACATCAACACGATCGACGTAGAGGCGCAGCCCGAGTATCCCGGCAAC
CTGGAGCTGGAGCGCAAGATTCGCAACGCGGTGCGCTGGAACGCCGTCGTGATGGTGCTGCGGGCCAACAAGCGGGCCGA
AGGCATCGGCGGGCACCTCGCGACCTACGCGAGCAGTGCGGAGCTGTACGAGGTGGGCTTTAACCACTTTTTCCGGGGGC
ACGGCGCGGGGGTGAACCGCGACCTCATCTTCTTCCAGGGTCACGCCAGTCCCGGCATCTATGCCCGCTCCTTCCTGGAG
GGCCGCATCAGCGAGGCGCAGATGAACAACTTCCGCCGGGAACTCAGCCCCGATGGTCCCGGCCTATCGAGTTACCCGCA
TCCCTGGCTGATGCCGCACTACTGGGAGTTTCCGACCGTCAGCATGGGTCTCGGGCCCATCCAGGCGATCTACCAGGCGC
GGTACATCCGGTACCTCGAAAACCGCGGTCTCAAGGCGAAGGGCAACGCGAAGGTCTGGGCCTTTTTGGGGGACGGCGAG
ATGGACGAGCCGCAGTCGGTGGGTGCGCTGCGCTTTGCCGCCTACGAGAACCTGGACAATCTCGTCTTTGTGCTCAACGC
GAACCTGCAGCGCCTCGACGGCCCGGTGCGCGCCAACTCCAAGGTGATCCAGGAGTTCGAGGCCCTGTTCCGCGGGGCGG
GCTGGAACGTGATCAAGGTCGTGTGGGACTCCAAGTGGGACGAGCTGCTCGCCAAGGACTACAACGGCGCGATCGTCAAG
CGCTTCGAGGCGCTCGTGGACGGCGAGTCGCAGCGCTACGCGGCCTTTGGTGGCAAGGAGCTGCGCGAGAAGTTCTTCAA
CACGCCCGAACTTCAGCAGCTGATCGAAGGCTGGAGCGACGCCGACCTTGAACTGCTCAACCGTGGCGGTCACGATGTCA
AGAAGGTCTTTGCTGCCTACGACGCCGCCGTCAAGCACCGGGGCCAGCCCACCGTCATCATCGCCCGCACCGTGAAGGGC
TACGGCCTGGGCGAGACAGCGCAGGCGCGCAACGTGGCCCACCAGGTCAAGAAGCTGGACTTCCACGCGCTGAAGAACCT
GCGCGACCTGCTTGAGCTGCCGCTGACTGACGAGCAGGTCGAACACCTGGAGTACTACAACCCCGGCCCCGACAGCCCCG
AGATTCGGTACATGCTCGAGCGCCGCGCGGCGCTGGGCGGCTTCGTGCCCGAGCGCCGGGTGGATTACCCGCGCCCCAGC
GTCCCCACCGGCGAGTTCTACGAGGAATTTGCCGCCGGCAGCAAGGGCCGCGCCGTCAGCACCACGATGGCCGCCGTGCA
GATCTTGAGCAAGCTGCTGCGCGACCCCGAGGTCGGCAAGTACATCGTGCCGATTGTGCCCGATGAGGCGCGCACCTTTG
GGATGGACGCCCTGGTGCCACGCATCGGCATCTACTCGCCGCGTGGCCAGACCTACACCCCAGTCGACTCCGGCAGCCTG
ATGGTCTACAAGGAGAGCACCGACGGCCAGATGCTGGAAGAGGGCATCACCGAAGACGGGGCGATGTCGTCCTGGATTGC
GGCCGCAACCGCCTACGCCAACCACGGCGTTCCGACCATCCCCTTCTACGTCTTCTACTCGATGTTTGGCATGCAGCGCA
TCGGCGACCTGGTGTGGGCTGCGGCCGACCAGCGTGCGCGCGGCTTCCTTTTCGGCGCGACGGCGGGCCGCACCACGCTG
GCGGGTGAGGGATTGCAGCACCAGGACGGCAACAGCCTGCTGCAGGCCTATGTGGTGCCCACCCTCAAGGTGTATGACCC
AGCCTTTGCCTACGAACTCGCGGTGATTGTCGAACACGGCATCCAGCGGATGTACGTGGACAACATCGACGAGTTTTATT
ACGTCACCATCGACAACGAGAACGAGGTGCAGCCGCCCATGCCGGAGGACGGCCGCAGCCACGACGAGATTCGCCAGGGC
ATCATCCGGGGACTGTACCGCTTTCAGCAGAGCGGCAACAAAAAGGCCAAGCTGCGCGCTCAGCTTCTCGCCAGCGGCCC
CGCGATGGGCGCAGCGCTCGAAGCGGTGCAGAAGCTGGAAGCCTACGGCGTGGCCGCCGACGTGTGGAGCGTGACGAGTT
ACAAGGAACTCCACCAGGACGCCCTGCTGACCCAGCGTTACAACATGCTGCACCCCACCGCAGAACCGCGCGTCTCCTAC
GTGGCCTCTCAGCTCAGCCAGGAGAACGCTCCCGGCGTGCTGGTTTCAGTGAGTGATTACGTGAAACTGGGCGCCGACGG
CCTGAACGGACACCTCGATCGCAAGCTCTGGGTGCTGGGCACCGACGGCTTTGGCCGCTCGGAAGACCGCTCCGAACTGC
GTGACTTCTTCGAGGTGGACGCCCGCTACGTGACCCTCGCCACCCTCTACGCCCTCCAGCGCGAAGGCAAGCTCAAGGGA
GACGTGGTGGCGCGGGCCATTTCCGAGCTTGGCATCGACCCGGAACGCGAGGCGCCAGTTTTGCGTTAA

Upstream 100 bases:

>100_bases
GCTCCAGCTTGTCACACTCACCACACAGGATGGTTAATCGCCTCATTTTGGCTGTTGGAAGCAGTCAATGGGGAGGCTTA
CACTATAGGGTATGACGAAC

Downstream 100 bases:

>100_bases
CCCGTCAGCCATCAGCTTGTAGTGACCAGCCCTCTATGCTGAAGGCCGATCGCTGCCGGCTGATGGCCCTCTCAATCAAG
GAGCGTGACTGCCCATGGCA

Product: pyruvate dehydrogenase subunit E1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 902; Mature: 901

Protein sequence:

>902_residues
MPPRAALSPQEREQLNSVETQEWLDSLAYVLADAGDDRAAQLLEELDHYAYFHGAPILFKQNTPYINTIDVEAQPEYPGN
LELERKIRNAVRWNAVVMVLRANKRAEGIGGHLATYASSAELYEVGFNHFFRGHGAGVNRDLIFFQGHASPGIYARSFLE
GRISEAQMNNFRRELSPDGPGLSSYPHPWLMPHYWEFPTVSMGLGPIQAIYQARYIRYLENRGLKAKGNAKVWAFLGDGE
MDEPQSVGALRFAAYENLDNLVFVLNANLQRLDGPVRANSKVIQEFEALFRGAGWNVIKVVWDSKWDELLAKDYNGAIVK
RFEALVDGESQRYAAFGGKELREKFFNTPELQQLIEGWSDADLELLNRGGHDVKKVFAAYDAAVKHRGQPTVIIARTVKG
YGLGETAQARNVAHQVKKLDFHALKNLRDLLELPLTDEQVEHLEYYNPGPDSPEIRYMLERRAALGGFVPERRVDYPRPS
VPTGEFYEEFAAGSKGRAVSTTMAAVQILSKLLRDPEVGKYIVPIVPDEARTFGMDALVPRIGIYSPRGQTYTPVDSGSL
MVYKESTDGQMLEEGITEDGAMSSWIAAATAYANHGVPTIPFYVFYSMFGMQRIGDLVWAAADQRARGFLFGATAGRTTL
AGEGLQHQDGNSLLQAYVVPTLKVYDPAFAYELAVIVEHGIQRMYVDNIDEFYYVTIDNENEVQPPMPEDGRSHDEIRQG
IIRGLYRFQQSGNKKAKLRAQLLASGPAMGAALEAVQKLEAYGVAADVWSVTSYKELHQDALLTQRYNMLHPTAEPRVSY
VASQLSQENAPGVLVSVSDYVKLGADGLNGHLDRKLWVLGTDGFGRSEDRSELRDFFEVDARYVTLATLYALQREGKLKG
DVVARAISELGIDPEREAPVLR

Sequences:

>Translated_902_residues
MPPRAALSPQEREQLNSVETQEWLDSLAYVLADAGDDRAAQLLEELDHYAYFHGAPILFKQNTPYINTIDVEAQPEYPGN
LELERKIRNAVRWNAVVMVLRANKRAEGIGGHLATYASSAELYEVGFNHFFRGHGAGVNRDLIFFQGHASPGIYARSFLE
GRISEAQMNNFRRELSPDGPGLSSYPHPWLMPHYWEFPTVSMGLGPIQAIYQARYIRYLENRGLKAKGNAKVWAFLGDGE
MDEPQSVGALRFAAYENLDNLVFVLNANLQRLDGPVRANSKVIQEFEALFRGAGWNVIKVVWDSKWDELLAKDYNGAIVK
RFEALVDGESQRYAAFGGKELREKFFNTPELQQLIEGWSDADLELLNRGGHDVKKVFAAYDAAVKHRGQPTVIIARTVKG
YGLGETAQARNVAHQVKKLDFHALKNLRDLLELPLTDEQVEHLEYYNPGPDSPEIRYMLERRAALGGFVPERRVDYPRPS
VPTGEFYEEFAAGSKGRAVSTTMAAVQILSKLLRDPEVGKYIVPIVPDEARTFGMDALVPRIGIYSPRGQTYTPVDSGSL
MVYKESTDGQMLEEGITEDGAMSSWIAAATAYANHGVPTIPFYVFYSMFGMQRIGDLVWAAADQRARGFLFGATAGRTTL
AGEGLQHQDGNSLLQAYVVPTLKVYDPAFAYELAVIVEHGIQRMYVDNIDEFYYVTIDNENEVQPPMPEDGRSHDEIRQG
IIRGLYRFQQSGNKKAKLRAQLLASGPAMGAALEAVQKLEAYGVAADVWSVTSYKELHQDALLTQRYNMLHPTAEPRVSY
VASQLSQENAPGVLVSVSDYVKLGADGLNGHLDRKLWVLGTDGFGRSEDRSELRDFFEVDARYVTLATLYALQREGKLKG
DVVARAISELGIDPEREAPVLR
>Mature_901_residues
PPRAALSPQEREQLNSVETQEWLDSLAYVLADAGDDRAAQLLEELDHYAYFHGAPILFKQNTPYINTIDVEAQPEYPGNL
ELERKIRNAVRWNAVVMVLRANKRAEGIGGHLATYASSAELYEVGFNHFFRGHGAGVNRDLIFFQGHASPGIYARSFLEG
RISEAQMNNFRRELSPDGPGLSSYPHPWLMPHYWEFPTVSMGLGPIQAIYQARYIRYLENRGLKAKGNAKVWAFLGDGEM
DEPQSVGALRFAAYENLDNLVFVLNANLQRLDGPVRANSKVIQEFEALFRGAGWNVIKVVWDSKWDELLAKDYNGAIVKR
FEALVDGESQRYAAFGGKELREKFFNTPELQQLIEGWSDADLELLNRGGHDVKKVFAAYDAAVKHRGQPTVIIARTVKGY
GLGETAQARNVAHQVKKLDFHALKNLRDLLELPLTDEQVEHLEYYNPGPDSPEIRYMLERRAALGGFVPERRVDYPRPSV
PTGEFYEEFAAGSKGRAVSTTMAAVQILSKLLRDPEVGKYIVPIVPDEARTFGMDALVPRIGIYSPRGQTYTPVDSGSLM
VYKESTDGQMLEEGITEDGAMSSWIAAATAYANHGVPTIPFYVFYSMFGMQRIGDLVWAAADQRARGFLFGATAGRTTLA
GEGLQHQDGNSLLQAYVVPTLKVYDPAFAYELAVIVEHGIQRMYVDNIDEFYYVTIDNENEVQPPMPEDGRSHDEIRQGI
IRGLYRFQQSGNKKAKLRAQLLASGPAMGAALEAVQKLEAYGVAADVWSVTSYKELHQDALLTQRYNMLHPTAEPRVSYV
ASQLSQENAPGVLVSVSDYVKLGADGLNGHLDRKLWVLGTDGFGRSEDRSELRDFFEVDARYVTLATLYALQREGKLKGD
VVARAISELGIDPEREAPVLR

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG2609

COG function: function code C; Pyruvate dehydrogenase complex, dehydrogenase (E1) component

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786304, Length=897, Percent_Identity=48.6064659977703, Blast_Score=856, Evalue=0.0,

Paralogues:

None

Copy number: 1140 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 400 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004660
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 100727; Mature: 100596

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPRAALSPQEREQLNSVETQEWLDSLAYVLADAGDDRAAQLLEELDHYAYFHGAPILFK
CCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEECCCEEEEE
QNTPYINTIDVEAQPEYPGNLELERKIRNAVRWNAVVMVLRANKRAEGIGGHLATYASSA
CCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHEEEEEEEECCCCCCCCCCHHHHHHCCC
ELYEVGFNHFFRGHGAGVNRDLIFFQGHASPGIYARSFLEGRISEAQMNNFRRELSPDGP
HHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GLSSYPHPWLMPHYWEFPTVSMGLGPIQAIYQARYIRYLENRGLKAKGNAKVWAFLGDGE
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCC
MDEPQSVGALRFAAYENLDNLVFVLNANLQRLDGPVRANSKVIQEFEALFRGAGWNVIKV
CCCCHHCCHHHHHHHHCCCCEEEEEECCHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEEE
VWDSKWDELLAKDYNGAIVKRFEALVDGESQRYAAFGGKELREKFFNTPELQQLIEGWSD
EECCCHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHCCCHHHHHHHCCCHHHHHHHCCCCC
ADLELLNRGGHDVKKVFAAYDAAVKHRGQPTVIIARTVKGYGLGETAQARNVAHQVKKLD
CCHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHH
FHALKNLRDLLELPLTDEQVEHLEYYNPGPDSPEIRYMLERRAALGGFVPERRVDYPRPS
HHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCC
VPTGEFYEEFAAGSKGRAVSTTMAAVQILSKLLRDPEVGKYIVPIVPDEARTFGMDALVP
CCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHCHHHHHH
RIGIYSPRGQTYTPVDSGSLMVYKESTDGQMLEEGITEDGAMSSWIAAATAYANHGVPTI
HHCCCCCCCCEECCCCCCCEEEEEECCCCHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCH
PFYVFYSMFGMQRIGDLVWAAADQRARGFLFGATAGRTTLAGEGLQHQDGNSLLQAYVVP
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEECCCCCCCCCCHHHHHHHHCC
TLKVYDPAFAYELAVIVEHGIQRMYVDNIDEFYYVTIDNENEVQPPMPEDGRSHDEIRQG
CCEECCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHH
IIRGLYRFQQSGNKKAKLRAQLLASGPAMGAALEAVQKLEAYGVAADVWSVTSYKELHQD
HHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
ALLTQRYNMLHPTAEPRVSYVASQLSQENAPGVLVSVSDYVKLGADGLNGHLDRKLWVLG
HHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEEEHHHHHHCCCCCCCCCCCEEEEEE
TDGFGRSEDRSELRDFFEVDARYVTLATLYALQREGKLKGDVVARAISELGIDPEREAPV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCC
LR
CC
>Mature Secondary Structure 
PPRAALSPQEREQLNSVETQEWLDSLAYVLADAGDDRAAQLLEELDHYAYFHGAPILFK
CCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEECCCEEEEE
QNTPYINTIDVEAQPEYPGNLELERKIRNAVRWNAVVMVLRANKRAEGIGGHLATYASSA
CCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHEEEEEEEECCCCCCCCCCHHHHHHCCC
ELYEVGFNHFFRGHGAGVNRDLIFFQGHASPGIYARSFLEGRISEAQMNNFRRELSPDGP
HHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
GLSSYPHPWLMPHYWEFPTVSMGLGPIQAIYQARYIRYLENRGLKAKGNAKVWAFLGDGE
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCC
MDEPQSVGALRFAAYENLDNLVFVLNANLQRLDGPVRANSKVIQEFEALFRGAGWNVIKV
CCCCHHCCHHHHHHHHCCCCEEEEEECCHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEEE
VWDSKWDELLAKDYNGAIVKRFEALVDGESQRYAAFGGKELREKFFNTPELQQLIEGWSD
EECCCHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHCCCHHHHHHHCCCHHHHHHHCCCCC
ADLELLNRGGHDVKKVFAAYDAAVKHRGQPTVIIARTVKGYGLGETAQARNVAHQVKKLD
CCHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHH
FHALKNLRDLLELPLTDEQVEHLEYYNPGPDSPEIRYMLERRAALGGFVPERRVDYPRPS
HHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCC
VPTGEFYEEFAAGSKGRAVSTTMAAVQILSKLLRDPEVGKYIVPIVPDEARTFGMDALVP
CCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHCHHHHHH
RIGIYSPRGQTYTPVDSGSLMVYKESTDGQMLEEGITEDGAMSSWIAAATAYANHGVPTI
HHCCCCCCCCEECCCCCCCEEEEEECCCCHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCH
PFYVFYSMFGMQRIGDLVWAAADQRARGFLFGATAGRTTLAGEGLQHQDGNSLLQAYVVP
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEECCCCCCCCCCHHHHHHHHCC
TLKVYDPAFAYELAVIVEHGIQRMYVDNIDEFYYVTIDNENEVQPPMPEDGRSHDEIRQG
CCEECCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHH
IIRGLYRFQQSGNKKAKLRAQLLASGPAMGAALEAVQKLEAYGVAADVWSVTSYKELHQD
HHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
ALLTQRYNMLHPTAEPRVSYVASQLSQENAPGVLVSVSDYVKLGADGLNGHLDRKLWVLG
HHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEEEHHHHHHCCCCCCCCCCCEEEEEE
TDGFGRSEDRSELRDFFEVDARYVTLATLYALQREGKLKGDVVARAISELGIDPEREAPV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCC
LR
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9171401; 10984043 [H]