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The map label for this gene is treY [H]

Identifier: 94984646

GI number: 94984646

Start: 565216

End: 568050

Strand: Reverse

Name: treY [H]

Synonym: Dgeo_0539

Alternate gene names: 94984646

Gene position: 568050-565216 (Counterclockwise)

Preceding gene: 94984647

Following gene: 94984645

Centisome position: 23.02

GC content: 67.13

Gene sequence:

>2835_bases
ATGACGGCATTCGCCTTCCATCTCCCCTCCGCGACCTATCGCCTGCAACTGCACCGTGACTTCGACTTCGCAGCAGCACG
CCGAGTATTGCCGTACCTGAAGCGACTGGGCATCACGGACCTCTACCTCTCCCCGATCTGGGCGAGCACGCCGGGATCCA
CCCACGGGTATGACGTGACCGACCATACCCAGGTGAACCCCGAGTTGGGCGGTGAGGCGGGGCTGCGGCGACTGGCCGCG
CGGGCGGGGGAACTTGGGCTGGGGCTGATTGTGGATTTCGTGCCCAACCATATGGGCATCCAGGACGGGCACAACCCGTA
CTGGGAAGACGTGCTGACGCATGGCCGGGCCAGCCGCTACGCGCACTTTTTCGACATCTCCTGGCAACCGCTCAAGCGTG
CCCTGGAAAACAAGGTGCTGCTCCCGGTGCTGGGCGACCAGTACGGGCGGGTGCTGGAACGGGGCGAACTGCAACTGCGG
CGGGAAGGTGGGCGCTTTTTCCTCACGTACTGGAAAAGGCGGCTGCCCCTCTCGCCGCGCAGCCTCGCACCGCTGCTCGA
AGAGGTGGTGGCGTGTCTCGACCCGCACACCCCCCCAGATGAAGGAGCCGAACTCGCCAGCATCGCGCGGGCGGCGAGCA
ACCTGCCCCGCTCGGTTACGGCGGATCTCAGCGACGCGGATCGCCTGGCGCGCGCCCAGGAATCGGAGGTGATCACCCGC
CGTCTGGGCGCGCTGACAGAAGCTTCTCCCCCCGTCCGTGAGGCCCTGGAGCGCGTGGTGGAGGCCGTCAATGCCGATCC
TGCCCGGCTGGACGCCCTGATCCAGGAGCAGAACTACCGCCTCGCGTCGTGGCGGGTGGCGGCCGAGGAGATCAACTACC
GGCGTTTTTTCGATATCAACGACCTCGCCGCGCTGCGGATGGAAGACCCGCGCGTGTTTGCCTGGGCACATCGCAAGCTG
TTCGAACTCGTCCGTGACGGCGTGGTGAAGGGCGTGCGTCTCGACCACACCGACGGCTTGTTCGACCCTGCTGGGTACTT
CCAGGCTCTGCAACGCGGCGCAGCAGAGGCGCTGGGGCGCGAGTGGCGGGAGGATGAAGCGCTTCCCCTCTACGTGGTTG
CGGAAAAGATTCTGGAACCAGGTGAGCGGTTGCCGGAGGACTGGGCCATCCACGGCACCACTGGGTACGACTTTCTGGCG
CAGTTGAATGGCGTCTTTGTGGAAAGGCAGAGCGAGGAGGAGCTGACCGCCATCTATCGCCGCTTCACCGGGGACCGTGA
CACCTATGGTGAGCACCTCTACCGGGGCAAGCTGTTGATTGAGCGGGTGTCTCTTCCCGGCGAGGTGAACGTGCTGGCCG
AGCACCTAGAACGGATCGCAGAGGCGGATCTGCGCTCGCGCGACTTCACCCTTTCGGCGCTGCGCGAGGTGATCCGCCAG
GTGATCGCGACCTTTCCGGTGTACCGCACCTACGTCCGCGAGGGCGGCTCCCGCGAGCCGGGCGACAACGCCAAGATCGA
ACAGGCGATCCGCGACGCGCGCAGCCACAGCCGCCAGGGACAGCGCGAACTCGACCCTAGCCTCTTCGACTTTCTGGAGG
CGGTCCTCAAGCTCGACGCCCCAGATGAGGCCACCCGCCAACGCTACGCGGGGTTCGCGCTGAAGTTTCAACAGCTCACC
GGCCCGGTGACCGCGAAGGGGGCGGAGGACACGGCCTTCTACCGCTACGCCCGGCTGCTCTCGCTGAATGAGGTGGGCGG
CGACCCCGCCCTCTTTGGCACGCCGCCCCGGAGCTTCCACGCGGATGCCCGGCAACGAGCAGAACGCTGGCCGGGCGCCA
TGCTTGCGGGCAGCACCCACGACACCAAGCGCGGCGAGGACACCCGTGCCCGCATCAGCGTCCTCTCGGAGATGCCCCAG
ACCTGGGCGGCGTACCTCAGCGCTTGGTCCCCTCTGATTCGCGCGCTGGAGCGCCCACTTGACCTGGGTCCGGCGCCCAC
TTCCCTCGATACCTACATCTTCCTCCAGTCGGCGCTGGGCGCTTATCCGCTCGATGGACAGCTGGAGGGGTTCCCAGACC
GCCTGAGCGCCTACATGCTCAAGGCGGCGCGCGAGGCCAAGCTCCGCACCAGCTGGGCTGCCCCCGATCAGGAGTATGAG
GCGGCGCTGGACGGCCTGGTGCGCGGGTTGCTGGCCAACGAACGTTTTGCGGAGAGCCTGCGCGAACTGCATACCCGCAT
CAGTCCCTACGGCGCCCAGAACGGCCTCTCGGCGGCGCTGGTGCGCCTGACCGCCCCCGGTGTTCCCGACACCTACCAAG
GATCGGAAGGCTGGAACCAGAGCCTGGTGGACCCCGACAACCGCCGCCCGGTGAACTACGCCTGGCGCACCCGGACGCTG
GCCCGCATCGAGAAACGCTGGCCCGAGGACAGGCAGAAACTCGCCCGCGAGCTCCTGGCCCGCTACGAGGACGGGGGCGT
GAAACTGCTGGTGACCTGGGTGGCCCTGCGGGCCCGCGCCGCCTTCCCCGACCTGTTCCGGCAGGGCCACTACCACCCCA
TCGAGGCTGGGAAGTACGTCCTCGCCTTTGCCCGCGAGCACGGAGACGAGGTGGCGGTAACCGTCGCGCCGCGCCTGACC
TACACCCTCACCCGCGAGCGGACCCCCTGGGCGCTGGGTGAGACGTGGGGCAACCGGCAGCTCCCCCTTCCGCGACCCGG
GATCTATGAAAACCTGCTTACCGGACAGCGTTTTCGTATCCGCAACGAGAAAATCCCGCTGGCCAAGGTGCTGGAGGAGT
TTCCGCTGGCCCTGCTGGTTAGGCGTCCGGAATAA

Upstream 100 bases:

>100_bases
ATCTCCCGTTCTCGCTCCCCGCACAGGTGCTCCTGCATTCCGAAGGCCGCGAGCATCGCAGGCTGGAGCGCGGCGAGGCG
GTGCTGCTGGGGGCTGGGTC

Downstream 100 bases:

>100_bases
AGGTCAGATTTCCCAACCCGCAGCTTGCAGCTTTTCCCCTGGAACCTTTTGCGCCTCTTGCTCGTATCTCCTGGCGTATG
CAACTGACTGCTACCCGGAC

Product: malto-oligosyltrehalose synthase

Products: NA

Alternate protein names: (1,4)-alpha-D-glucan 1-alpha-D-glucosylmutase [H]

Number of amino acids: Translated: 944; Mature: 943

Protein sequence:

>944_residues
MTAFAFHLPSATYRLQLHRDFDFAAARRVLPYLKRLGITDLYLSPIWASTPGSTHGYDVTDHTQVNPELGGEAGLRRLAA
RAGELGLGLIVDFVPNHMGIQDGHNPYWEDVLTHGRASRYAHFFDISWQPLKRALENKVLLPVLGDQYGRVLERGELQLR
REGGRFFLTYWKRRLPLSPRSLAPLLEEVVACLDPHTPPDEGAELASIARAASNLPRSVTADLSDADRLARAQESEVITR
RLGALTEASPPVREALERVVEAVNADPARLDALIQEQNYRLASWRVAAEEINYRRFFDINDLAALRMEDPRVFAWAHRKL
FELVRDGVVKGVRLDHTDGLFDPAGYFQALQRGAAEALGREWREDEALPLYVVAEKILEPGERLPEDWAIHGTTGYDFLA
QLNGVFVERQSEEELTAIYRRFTGDRDTYGEHLYRGKLLIERVSLPGEVNVLAEHLERIAEADLRSRDFTLSALREVIRQ
VIATFPVYRTYVREGGSREPGDNAKIEQAIRDARSHSRQGQRELDPSLFDFLEAVLKLDAPDEATRQRYAGFALKFQQLT
GPVTAKGAEDTAFYRYARLLSLNEVGGDPALFGTPPRSFHADARQRAERWPGAMLAGSTHDTKRGEDTRARISVLSEMPQ
TWAAYLSAWSPLIRALERPLDLGPAPTSLDTYIFLQSALGAYPLDGQLEGFPDRLSAYMLKAAREAKLRTSWAAPDQEYE
AALDGLVRGLLANERFAESLRELHTRISPYGAQNGLSAALVRLTAPGVPDTYQGSEGWNQSLVDPDNRRPVNYAWRTRTL
ARIEKRWPEDRQKLARELLARYEDGGVKLLVTWVALRARAAFPDLFRQGHYHPIEAGKYVLAFAREHGDEVAVTVAPRLT
YTLTRERTPWALGETWGNRQLPLPRPGIYENLLTGQRFRIRNEKIPLAKVLEEFPLALLVRRPE

Sequences:

>Translated_944_residues
MTAFAFHLPSATYRLQLHRDFDFAAARRVLPYLKRLGITDLYLSPIWASTPGSTHGYDVTDHTQVNPELGGEAGLRRLAA
RAGELGLGLIVDFVPNHMGIQDGHNPYWEDVLTHGRASRYAHFFDISWQPLKRALENKVLLPVLGDQYGRVLERGELQLR
REGGRFFLTYWKRRLPLSPRSLAPLLEEVVACLDPHTPPDEGAELASIARAASNLPRSVTADLSDADRLARAQESEVITR
RLGALTEASPPVREALERVVEAVNADPARLDALIQEQNYRLASWRVAAEEINYRRFFDINDLAALRMEDPRVFAWAHRKL
FELVRDGVVKGVRLDHTDGLFDPAGYFQALQRGAAEALGREWREDEALPLYVVAEKILEPGERLPEDWAIHGTTGYDFLA
QLNGVFVERQSEEELTAIYRRFTGDRDTYGEHLYRGKLLIERVSLPGEVNVLAEHLERIAEADLRSRDFTLSALREVIRQ
VIATFPVYRTYVREGGSREPGDNAKIEQAIRDARSHSRQGQRELDPSLFDFLEAVLKLDAPDEATRQRYAGFALKFQQLT
GPVTAKGAEDTAFYRYARLLSLNEVGGDPALFGTPPRSFHADARQRAERWPGAMLAGSTHDTKRGEDTRARISVLSEMPQ
TWAAYLSAWSPLIRALERPLDLGPAPTSLDTYIFLQSALGAYPLDGQLEGFPDRLSAYMLKAAREAKLRTSWAAPDQEYE
AALDGLVRGLLANERFAESLRELHTRISPYGAQNGLSAALVRLTAPGVPDTYQGSEGWNQSLVDPDNRRPVNYAWRTRTL
ARIEKRWPEDRQKLARELLARYEDGGVKLLVTWVALRARAAFPDLFRQGHYHPIEAGKYVLAFAREHGDEVAVTVAPRLT
YTLTRERTPWALGETWGNRQLPLPRPGIYENLLTGQRFRIRNEKIPLAKVLEEFPLALLVRRPE
>Mature_943_residues
TAFAFHLPSATYRLQLHRDFDFAAARRVLPYLKRLGITDLYLSPIWASTPGSTHGYDVTDHTQVNPELGGEAGLRRLAAR
AGELGLGLIVDFVPNHMGIQDGHNPYWEDVLTHGRASRYAHFFDISWQPLKRALENKVLLPVLGDQYGRVLERGELQLRR
EGGRFFLTYWKRRLPLSPRSLAPLLEEVVACLDPHTPPDEGAELASIARAASNLPRSVTADLSDADRLARAQESEVITRR
LGALTEASPPVREALERVVEAVNADPARLDALIQEQNYRLASWRVAAEEINYRRFFDINDLAALRMEDPRVFAWAHRKLF
ELVRDGVVKGVRLDHTDGLFDPAGYFQALQRGAAEALGREWREDEALPLYVVAEKILEPGERLPEDWAIHGTTGYDFLAQ
LNGVFVERQSEEELTAIYRRFTGDRDTYGEHLYRGKLLIERVSLPGEVNVLAEHLERIAEADLRSRDFTLSALREVIRQV
IATFPVYRTYVREGGSREPGDNAKIEQAIRDARSHSRQGQRELDPSLFDFLEAVLKLDAPDEATRQRYAGFALKFQQLTG
PVTAKGAEDTAFYRYARLLSLNEVGGDPALFGTPPRSFHADARQRAERWPGAMLAGSTHDTKRGEDTRARISVLSEMPQT
WAAYLSAWSPLIRALERPLDLGPAPTSLDTYIFLQSALGAYPLDGQLEGFPDRLSAYMLKAAREAKLRTSWAAPDQEYEA
ALDGLVRGLLANERFAESLRELHTRISPYGAQNGLSAALVRLTAPGVPDTYQGSEGWNQSLVDPDNRRPVNYAWRTRTLA
RIEKRWPEDRQKLARELLARYEDGGVKLLVTWVALRARAAFPDLFRQGHYHPIEAGKYVLAFAREHGDEVAVTVAPRLTY
TLTRERTPWALGETWGNRQLPLPRPGIYENLLTGQRFRIRNEKIPLAKVLEEFPLALLVRRPE

Specific function: Catalyzes the conversion of maltooligosaccharide into the non-reducing saccharide, maltooligosyl trehalose (alpha- maltooligosyl alpha-D-glucoside) by intramolecular transglycosylation [H]

COG id: COG3280

COG function: function code G; Maltooligosyl trehalose synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 13 family [H]

Homologues:

Organism=Escherichia coli, GI1786604, Length=83, Percent_Identity=42.1686746987952, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006047
- InterPro:   IPR017853
- InterPro:   IPR013781
- InterPro:   IPR013797
- InterPro:   IPR012767 [H]

Pfam domain/function: PF00128 Alpha-amylase [H]

EC number: =5.4.99.15 [H]

Molecular weight: Translated: 106639; Mature: 106508

Theoretical pI: Translated: 6.82; Mature: 6.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAFAFHLPSATYRLQLHRDFDFAAARRVLPYLKRLGITDLYLSPIWASTPGSTHGYDVT
CCEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCCC
DHTQVNPELGGEAGLRRLAARAGELGLGLIVDFVPNHMGIQDGHNPYWEDVLTHGRASRY
CCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCHHCC
AHFFDISWQPLKRALENKVLLPVLGDQYGRVLERGELQLRREGGRFFLTYWKRRLPLSPR
EEEECCCHHHHHHHHHCCEEEEHHCHHHHHHHHHCCHHEECCCCCEEEEHHHHHCCCCHH
SLAPLLEEVVACLDPHTPPDEGAELASIARAASNLPRSVTADLSDADRLARAQESEVITR
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
RLGALTEASPPVREALERVVEAVNADPARLDALIQEQNYRLASWRVAAEEINYRRFFDIN
HHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEHHHHHHHHHCCCCEEECCC
DLAALRMEDPRVFAWAHRKLFELVRDGVVKGVRLDHTDGLFDPAGYFQALQRGAAEALGR
HHHHHEECCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHHHHHHHH
EWREDEALPLYVVAEKILEPGERLPEDWAIHGTTGYDFLAQLNGVFVERQSEEELTAIYR
HHCCCCCCCHHHHHHHHHCCHHCCCCCCEECCCCHHHHHHHHCCCEEECCCHHHHHHHHH
RFTGDRDTYGEHLYRGKLLIERVSLPGEVNVLAEHLERIAEADLRSRDFTLSALREVIRQ
HHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
VIATFPVYRTYVREGGSREPGDNAKIEQAIRDARSHSRQGQRELDPSLFDFLEAVLKLDA
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHCCC
PDEATRQRYAGFALKFQQLTGPVTAKGAEDTAFYRYARLLSLNEVGGDPALFGTPPRSFH
CCHHHHHHHHHHHEEHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
ADARQRAERWPGAMLAGSTHDTKRGEDTRARISVLSEMPQTWAAYLSAWSPLIRALERPL
HHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DLGPAPTSLDTYIFLQSALGAYPLDGQLEGFPDRLSAYMLKAAREAKLRTSWAAPDQEYE
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
AALDGLVRGLLANERFAESLRELHTRISPYGAQNGLSAALVRLTAPGVPDTYQGSEGWNQ
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCC
SLVDPDNRRPVNYAWRTRTLARIEKRWPEDRQKLARELLARYEDGGVKLLVTWVALRARA
CCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
AFPDLFRQGHYHPIEAGKYVLAFAREHGDEVAVTVAPRLTYTLTRERTPWALGETWGNRQ
CCHHHHHCCCCCCCCCCHHHHHHHHHCCCEEEEEEECCEEEEEECCCCCCCCCCCCCCCC
LPLPRPGIYENLLTGQRFRIRNEKIPLAKVLEEFPLALLVRRPE
CCCCCCCHHHHHHCCCCEEECCCCCCHHHHHHHCCHHHEEECCC
>Mature Secondary Structure 
TAFAFHLPSATYRLQLHRDFDFAAARRVLPYLKRLGITDLYLSPIWASTPGSTHGYDVT
CEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCCC
DHTQVNPELGGEAGLRRLAARAGELGLGLIVDFVPNHMGIQDGHNPYWEDVLTHGRASRY
CCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCHHCC
AHFFDISWQPLKRALENKVLLPVLGDQYGRVLERGELQLRREGGRFFLTYWKRRLPLSPR
EEEECCCHHHHHHHHHCCEEEEHHCHHHHHHHHHCCHHEECCCCCEEEEHHHHHCCCCHH
SLAPLLEEVVACLDPHTPPDEGAELASIARAASNLPRSVTADLSDADRLARAQESEVITR
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
RLGALTEASPPVREALERVVEAVNADPARLDALIQEQNYRLASWRVAAEEINYRRFFDIN
HHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEHHHHHHHHHCCCCEEECCC
DLAALRMEDPRVFAWAHRKLFELVRDGVVKGVRLDHTDGLFDPAGYFQALQRGAAEALGR
HHHHHEECCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHHHHHHHH
EWREDEALPLYVVAEKILEPGERLPEDWAIHGTTGYDFLAQLNGVFVERQSEEELTAIYR
HHCCCCCCCHHHHHHHHHCCHHCCCCCCEECCCCHHHHHHHHCCCEEECCCHHHHHHHHH
RFTGDRDTYGEHLYRGKLLIERVSLPGEVNVLAEHLERIAEADLRSRDFTLSALREVIRQ
HHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
VIATFPVYRTYVREGGSREPGDNAKIEQAIRDARSHSRQGQRELDPSLFDFLEAVLKLDA
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHCCC
PDEATRQRYAGFALKFQQLTGPVTAKGAEDTAFYRYARLLSLNEVGGDPALFGTPPRSFH
CCHHHHHHHHHHHEEHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
ADARQRAERWPGAMLAGSTHDTKRGEDTRARISVLSEMPQTWAAYLSAWSPLIRALERPL
HHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DLGPAPTSLDTYIFLQSALGAYPLDGQLEGFPDRLSAYMLKAAREAKLRTSWAAPDQEYE
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
AALDGLVRGLLANERFAESLRELHTRISPYGAQNGLSAALVRLTAPGVPDTYQGSEGWNQ
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCC
SLVDPDNRRPVNYAWRTRTLARIEKRWPEDRQKLARELLARYEDGGVKLLVTWVALRARA
CCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
AFPDLFRQGHYHPIEAGKYVLAFAREHGDEVAVTVAPRLTYTLTRERTPWALGETWGNRQ
CCHHHHHCCCCCCCCCCHHHHHHHHHCCCEEEEEEECCEEEEEECCCCCCCCCCCCCCCC
LPLPRPGIYENLLTGQRFRIRNEKIPLAKVLEEFPLALLVRRPE
CCCCCCCHHHHHHCCCCEEECCCCCCHHHHHHHCCHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8605217; 8611744 [H]