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The map label for this gene is yciC [H]

Identifier: 94984643

GI number: 94984643

Start: 561416

End: 562474

Strand: Reverse

Name: yciC [H]

Synonym: Dgeo_0536

Alternate gene names: 94984643

Gene position: 562474-561416 (Counterclockwise)

Preceding gene: 94984645

Following gene: 94984642

Centisome position: 22.8

GC content: 62.89

Gene sequence:

>1059_bases
ATGCCTATGCCTGCTCCCCCATCGACCCGTTCTGTCCCCATCACCGTGCTGTGTGGCTTTCTGGGGGCGGGCAAAACTAC
GCTACTGAACCACCTGCTGACCCAGACGGAGCACCTGAAGGTCGCCGTGATTGTGAACGAGTTTGGCGCCGTGAATGTAG
ACGCCTCCTTGGTCGTCAAGACCGATGAGCAGACCATCGAATTGAGCAACGGCTGTATCTGCTGCACGTTGCGCGGTGAC
CTGCTGTACGCGGTCGACGAGCTGCTGCAGCGCGACATCGACGCCATCCTGATCGAGTCCACGGGCATCGGGGAGCCGCT
TCCTATCGCCCAGAGCTTTTGCCTCACACCCGAGACCCTGGGGCTGGTCCCTGAGGCAGGACAGCCCGAGTTGCCTGATC
TGCTGGGCCGCGTCCATGTGGACGCAATGGTAACCGTGGTGGACAGTGCGCAGTTTTTCACGCTCTGGAACCGCACCGAC
GAGATCCCAGGTGACGACTTCGGACGCGGCTTCGGAGAGCTGTTGGCCGAACAGATCGAATTTGCCGACCTCGTCGTCCT
GAACAAACTCGACCTCGCCACTCCAGAAGACGTGCAGTCGCTGCGCGAACTCGTGCACATTACCAACCCGCGTGCCCGCG
TGCTGGAAGCCACCCACGGTCAAGTCGAGGCGGATCAGGTGCTCAACGTGGGGCTTTTCAATCTGGACGCCGCCTCGCAG
CTCGACGCCTGGATGGCAGAGCTGGGCAAGGCGCATACCCCCGAATCGGAAACCTACGGCCTGGGCACACACATCTACCG
CGCCGAGCGGCCCTTCGACCCTGGCCGTCTGCACGCCGTACTCACGGCTGGGCTGCCCCAGAGCGTCATCCGTTCGAAGG
GATGGATTCACCTTGGGGACGGTGTGGCGACGCTCTGGAACCATACCGGCCGGCAGCTCACGCTGGAGCAGGCGGGCACC
TGGCACCACCCCGAGGATGCCTGCAGCGAAGTTGTGTTTATCGGCCGCGATCTTGACGGCCCCGCCCTCAACCAACTGCT
GGACAGTGCACTGGCCTAA

Upstream 100 bases:

>100_bases
CCGGTCGCTGGAGCTGGCCGAGTGCAGGCGCAGCCCCCTCGCCAGGACCAAGCCCCGCAGAACCTTGTGTTATTTCTGAT
AATGGATTATCGTTATCGGC

Downstream 100 bases:

>100_bases
CCGGTGCCCTGGCCGCCAACGTACGCCAGCAGCCCCCACGGGACACTTCACCTGTTTTGGAGATGATAAGGATAAATCAG
TATGAGCCATCAATGCTACT

Product: cobalamin synthesis protein, P47K

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MPMPAPPSTRSVPITVLCGFLGAGKTTLLNHLLTQTEHLKVAVIVNEFGAVNVDASLVVKTDEQTIELSNGCICCTLRGD
LLYAVDELLQRDIDAILIESTGIGEPLPIAQSFCLTPETLGLVPEAGQPELPDLLGRVHVDAMVTVVDSAQFFTLWNRTD
EIPGDDFGRGFGELLAEQIEFADLVVLNKLDLATPEDVQSLRELVHITNPRARVLEATHGQVEADQVLNVGLFNLDAASQ
LDAWMAELGKAHTPESETYGLGTHIYRAERPFDPGRLHAVLTAGLPQSVIRSKGWIHLGDGVATLWNHTGRQLTLEQAGT
WHHPEDACSEVVFIGRDLDGPALNQLLDSALA

Sequences:

>Translated_352_residues
MPMPAPPSTRSVPITVLCGFLGAGKTTLLNHLLTQTEHLKVAVIVNEFGAVNVDASLVVKTDEQTIELSNGCICCTLRGD
LLYAVDELLQRDIDAILIESTGIGEPLPIAQSFCLTPETLGLVPEAGQPELPDLLGRVHVDAMVTVVDSAQFFTLWNRTD
EIPGDDFGRGFGELLAEQIEFADLVVLNKLDLATPEDVQSLRELVHITNPRARVLEATHGQVEADQVLNVGLFNLDAASQ
LDAWMAELGKAHTPESETYGLGTHIYRAERPFDPGRLHAVLTAGLPQSVIRSKGWIHLGDGVATLWNHTGRQLTLEQAGT
WHHPEDACSEVVFIGRDLDGPALNQLLDSALA
>Mature_351_residues
PMPAPPSTRSVPITVLCGFLGAGKTTLLNHLLTQTEHLKVAVIVNEFGAVNVDASLVVKTDEQTIELSNGCICCTLRGDL
LYAVDELLQRDIDAILIESTGIGEPLPIAQSFCLTPETLGLVPEAGQPELPDLLGRVHVDAMVTVVDSAQFFTLWNRTDE
IPGDDFGRGFGELLAEQIEFADLVVLNKLDLATPEDVQSLRELVHITNPRARVLEATHGQVEADQVLNVGLFNLDAASQL
DAWMAELGKAHTPESETYGLGTHIYRAERPFDPGRLHAVLTAGLPQSVIRSKGWIHLGDGVATLWNHTGRQLTLEQAGTW
HHPEDACSEVVFIGRDLDGPALNQLLDSALA

Specific function: May bind GTP. Might act as metal chaperone (Potential). Contributes to optimal growth under starvation for zinc [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI126722884, Length=366, Percent_Identity=28.1420765027322, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI148727351, Length=366, Percent_Identity=28.1420765027322, Blast_Score=128, Evalue=8e-30,
Organism=Homo sapiens, GI33469141, Length=366, Percent_Identity=27.8688524590164, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI146231952, Length=363, Percent_Identity=29.2011019283747, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI223941779, Length=221, Percent_Identity=33.4841628959276, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI223941776, Length=374, Percent_Identity=27.2727272727273, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI119120938, Length=160, Percent_Identity=35, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI87082430, Length=341, Percent_Identity=29.3255131964809, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI1788499, Length=212, Percent_Identity=27.8301886792453, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324356, Length=242, Percent_Identity=28.099173553719, Blast_Score=100, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 38118; Mature: 37987

Theoretical pI: Translated: 4.32; Mature: 4.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPMPAPPSTRSVPITVLCGFLGAGKTTLLNHLLTQTEHLKVAVIVNEFGAVNVDASLVVK
CCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCEEEEE
TDEQTIELSNGCICCTLRGDLLYAVDELLQRDIDAILIESTGIGEPLPIAQSFCLTPETL
CCCCEEEECCCEEEEEECCCHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHCCCHHHH
GLVPEAGQPELPDLLGRVHVDAMVTVVDSAQFFTLWNRTDEIPGDDFGRGFGELLAEQIE
CCCCCCCCCCHHHHHHHHHHHHEEEEECCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHH
FADLVVLNKLDLATPEDVQSLRELVHITNPRARVLEATHGQVEADQVLNVGLFNLDAASQ
HHHEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHCCCEECCCCHHH
LDAWMAELGKAHTPESETYGLGTHIYRAERPFDPGRLHAVLTAGLPQSVIRSKGWIHLGD
HHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCCEEEEEECCCCHHHHHCCCCEEECC
GVATLWNHTGRQLTLEQAGTWHHPEDACSEVVFIGRDLDGPALNQLLDSALA
CHHHHHCCCCCEEEEECCCCCCCCHHHHCCEEEEECCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
PMPAPPSTRSVPITVLCGFLGAGKTTLLNHLLTQTEHLKVAVIVNEFGAVNVDASLVVK
CCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCEEEEE
TDEQTIELSNGCICCTLRGDLLYAVDELLQRDIDAILIESTGIGEPLPIAQSFCLTPETL
CCCCEEEECCCEEEEEECCCHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHCCCHHHH
GLVPEAGQPELPDLLGRVHVDAMVTVVDSAQFFTLWNRTDEIPGDDFGRGFGELLAEQIE
CCCCCCCCCCHHHHHHHHHHHHEEEEECCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHH
FADLVVLNKLDLATPEDVQSLRELVHITNPRARVLEATHGQVEADQVLNVGLFNLDAASQ
HHHEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHCCCEECCCCHHH
LDAWMAELGKAHTPESETYGLGTHIYRAERPFDPGRLHAVLTAGLPQSVIRSKGWIHLGD
HHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCCEEEEEECCCCHHHHHCCCCEEECC
GVATLWNHTGRQLTLEQAGTWHHPEDACSEVVFIGRDLDGPALNQLLDSALA
CHHHHHCCCCCEEEEECCCCCCCCHHHHCCEEEEECCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 9811636 [H]