Click here to switch to the map view.

The map label for this gene is aqpZ2 [H]

Identifier: 94984623

GI number: 94984623

Start: 543938

End: 544717

Strand: Reverse

Name: aqpZ2 [H]

Synonym: Dgeo_0516

Alternate gene names: 94984623

Gene position: 544717-543938 (Counterclockwise)

Preceding gene: 94984624

Following gene: 94984622

Centisome position: 22.08

GC content: 67.82

Gene sequence:

>780_bases
GTGCGCCGTGGCATCATAGACGACGTGCAGGCCAGCCAGAGAGAGCCCTCTTTGCAAGAGAAGGCCCAAGCCGCCTCGGA
CGAAAGCTGGTTGGATTTCCACCCCATGCGCGCGCTGGTCGCGGAGGCGCTCGGGACGTTTCTGCTGACCTTTGCCAGCG
TGGGTGCGCTGCTGCTCGCGCAACTGGGCTTCCTGCCTGAGCTGGCCGCAGCGGCCCTCACCCCCGGGCTGGTGGTGCTC
GCGATGATCTACGCCCTCAGCGACGTGTCGGGCGCCCATATCAATCCCGCCGTAACGCTGGCGTTCGCCCTGCGCGGCGC
CTTTTCCTGGAAACTGGTGCTGCCGTATTGGGCGGTGCAATTTGCGGCGGCGGGGGCGGCGGGCCTGCTGCTCGGCGCCT
TCACCCACATTCCGCCTGCGACAGAACGCGTCCCGGTGGGCGGCGCCTTTCTGTTGGACGCGGGCGCCACGGCGGTGCTG
CTGGTGGTGATCCTCGCCACCGCACACCGAAACGCCCAATTCAAACCCGTGGCGGGTCTAGCGGTGGGCGCCACGGTCGG
CCTCGACCACTTTCTGACCAATAGTGTCTCCGCGGTGGCCATGAATCCCGCCAAAACGTTCGGCCCGGCGCTGGTCGCAG
GCCGGCTGACGCAAGCCTGGCCGCACCTGTTGGGGCCGGTGCTGGGCGCTCTGGTCGCGGTGCTGGTGATCTGGGCGACA
CGTGGGCCACTCAACTCCGATGAGCGCGAGGCGGCACAAGGCCATGACGGTCAAGGTTGA

Upstream 100 bases:

>100_bases
TCCTGATCGACCCACAAGGGTTACCGGAGGCGGCAGCCGCCTTCCTGCACGGAGCCTGACTCCGGCTCACCGGTTCGCTG
TCCGCTCCAGACTGCCCGGG

Downstream 100 bases:

>100_bases
ATGGAGGTCGAATGGAGGCTACCCCGGTGGCCTTCTCTTCATCTCCCATGCATAGTAAGGGGGTAAAACGGGTCCGCTGG
GCCTTGCCGAGGTGACTCTT

Product: major intrinsic protein

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MRRGIIDDVQASQREPSLQEKAQAASDESWLDFHPMRALVAEALGTFLLTFASVGALLLAQLGFLPELAAAALTPGLVVL
AMIYALSDVSGAHINPAVTLAFALRGAFSWKLVLPYWAVQFAAAGAAGLLLGAFTHIPPATERVPVGGAFLLDAGATAVL
LVVILATAHRNAQFKPVAGLAVGATVGLDHFLTNSVSAVAMNPAKTFGPALVAGRLTQAWPHLLGPVLGALVAVLVIWAT
RGPLNSDEREAAQGHDGQG

Sequences:

>Translated_259_residues
MRRGIIDDVQASQREPSLQEKAQAASDESWLDFHPMRALVAEALGTFLLTFASVGALLLAQLGFLPELAAAALTPGLVVL
AMIYALSDVSGAHINPAVTLAFALRGAFSWKLVLPYWAVQFAAAGAAGLLLGAFTHIPPATERVPVGGAFLLDAGATAVL
LVVILATAHRNAQFKPVAGLAVGATVGLDHFLTNSVSAVAMNPAKTFGPALVAGRLTQAWPHLLGPVLGALVAVLVIWAT
RGPLNSDEREAAQGHDGQG
>Mature_259_residues
MRRGIIDDVQASQREPSLQEKAQAASDESWLDFHPMRALVAEALGTFLLTFASVGALLLAQLGFLPELAAAALTPGLVVL
AMIYALSDVSGAHINPAVTLAFALRGAFSWKLVLPYWAVQFAAAGAAGLLLGAFTHIPPATERVPVGGAFLLDAGATAVL
LVVILATAHRNAQFKPVAGLAVGATVGLDHFLTNSVSAVAMNPAKTFGPALVAGRLTQAWPHLLGPVLGALVAVLVIWAT
RGPLNSDEREAAQGHDGQG

Specific function: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI6912506, Length=207, Percent_Identity=33.8164251207729, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI86792455, Length=209, Percent_Identity=33.9712918660287, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI37694062, Length=230, Percent_Identity=29.5652173913043, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI4502179, Length=219, Percent_Identity=32.4200913242009, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI4502183, Length=233, Percent_Identity=31.7596566523605, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI45446752, Length=224, Percent_Identity=30.3571428571429, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI4502181, Length=214, Percent_Identity=27.5700934579439, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI4755125, Length=214, Percent_Identity=27.5700934579439, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24652747, Length=213, Percent_Identity=34.7417840375587, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI45551084, Length=213, Percent_Identity=34.7417840375587, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 26758; Mature: 26758

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRGIIDDVQASQREPSLQEKAQAASDESWLDFHPMRALVAEALGTFLLTFASVGALLLA
CCCCCCCHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLGFLPELAAAALTPGLVVLAMIYALSDVSGAHINPAVTLAFALRGAFSWKLVLPYWAVQ
HHCCHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCEEHHHHHHHHH
FAAAGAAGLLLGAFTHIPPATERVPVGGAFLLDAGATAVLLVVILATAHRNAQFKPVAGL
HHHCCHHHHHHHHHHCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCCCHHH
AVGATVGLDHFLTNSVSAVAMNPAKTFGPALVAGRLTQAWPHLLGPVLGALVAVLVIWAT
HHHHHHHHHHHHHCCHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RGPLNSDEREAAQGHDGQG
CCCCCCCHHHHHCCCCCCC
>Mature Secondary Structure
MRRGIIDDVQASQREPSLQEKAQAASDESWLDFHPMRALVAEALGTFLLTFASVGALLLA
CCCCCCCHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLGFLPELAAAALTPGLVVLAMIYALSDVSGAHINPAVTLAFALRGAFSWKLVLPYWAVQ
HHCCHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCEEHHHHHHHHH
FAAAGAAGLLLGAFTHIPPATERVPVGGAFLLDAGATAVLLVVILATAHRNAQFKPVAGL
HHHCCHHHHHHHHHHCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCCCHHH
AVGATVGLDHFLTNSVSAVAMNPAKTFGPALVAGRLTQAWPHLLGPVLGALVAVLVIWAT
HHHHHHHHHHHHHCCHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RGPLNSDEREAAQGHDGQG
CCCCCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]