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The map label for this gene is pip [H]

Identifier: 94984301

GI number: 94984301

Start: 180096

End: 181013

Strand: Reverse

Name: pip [H]

Synonym: Dgeo_0193

Alternate gene names: 94984301

Gene position: 181013-180096 (Counterclockwise)

Preceding gene: 94984308

Following gene: 94984300

Centisome position: 7.34

GC content: 67.32

Gene sequence:

>918_bases
ATGAGCACCCCCGACGAGTCCAACTTCGAGCGCCTGAACGGCGCGGACCTGTACTTCGAGGTGACCGGCCCGCAGGACAC
TCCGGGGGCCGAGCCGCCCATTGTGTTTCTACACGGTGGCCCCGGCTACAACAGCTACTCGTTCCGCGAACTGTTTGGAG
ACCGCCTGCAGGGCCGCCGGGTGGTGTACCTCGACCAGCGCGGTTCGGGACGCAGCGGTCCCCTACAGGACACCGAACAG
GGGGGTGAGACGTTGGACCTCGATACGCTGGTCGCTGACGTGGAGGCGCTGCGCGAGCACCTGGGCGCCGAACAGATCGT
GCCGCTGGGTCACGGTTTCGGGGCGCTCGTGGCCCTGGAGTATGCCCGGCGGCACCCCACGCGCACGGCGCGCGTGATTG
TCGTCAACCCCTGGGTACATTTCCCCGAACTCGCCCTGACGCTGCTGCGCGAGGCCGCAGCCCTACGCGGGGTGCCGCTC
GATGACCCCGCCCAGGCTGTGCGCGCCCGCACGCCGGAAGGCCAGTATCCCGCAGTGGGCGAGGCACGGGTAGAGGCGGC
CTTTGCCCTGCTCAACGCCCGCGACCTGCTCAACACGCTGCAATTTCGTGACAACGCCAGCCGCATGCGCCTGGAATTTA
TTGATGCAGAAGGACAGCTCAGCGGCGGCGGCGAGGTGCAGGAGGCGCTGGTCAATCAGGGCCTCTGGGAATTCGAGTAT
CCGCCCTTTTTGCAGGAGCTGCGCCGCCCCCTCTTTGTGATTGCCGGCGTCCACGACCGCACCAGTTACCCCGAACAGGT
CGAGTGGTTGGTTGATCTCGGCGGCGCGGACGTGACGGTGCTCGACGCGGGCCACTACCCCTGGCTCGACGATGAGGACG
CCTTTGCGGAGGCGCTGGAGGAGGCCTTGACGCGTTAG

Upstream 100 bases:

>100_bases
TCGGTGGTACGGGGGTCATGGGAGCAGGGTAGCGAAGGCGCCCAACGTTGCCCGTGAGCCTGGCCAGCCTTGAAGCAGCG
GAGCCCCCTAGAATGCCCGC

Downstream 100 bases:

>100_bases
GGTAGGAGAAGCGCTAGGGTGACCTCTGCCCCGCCTCTCCCTTCTCTCACAGACGTGCCGCTATACTCGGTTCACCCTAT
GAAAGGTGTGATCCTCGCTG

Product: alpha/beta hydrolase fold

Products: NA

Alternate protein names: PIP; Prolyl aminopeptidase; PAP [H]

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MSTPDESNFERLNGADLYFEVTGPQDTPGAEPPIVFLHGGPGYNSYSFRELFGDRLQGRRVVYLDQRGSGRSGPLQDTEQ
GGETLDLDTLVADVEALREHLGAEQIVPLGHGFGALVALEYARRHPTRTARVIVVNPWVHFPELALTLLREAAALRGVPL
DDPAQAVRARTPEGQYPAVGEARVEAAFALLNARDLLNTLQFRDNASRMRLEFIDAEGQLSGGGEVQEALVNQGLWEFEY
PPFLQELRRPLFVIAGVHDRTSYPEQVEWLVDLGGADVTVLDAGHYPWLDDEDAFAEALEEALTR

Sequences:

>Translated_305_residues
MSTPDESNFERLNGADLYFEVTGPQDTPGAEPPIVFLHGGPGYNSYSFRELFGDRLQGRRVVYLDQRGSGRSGPLQDTEQ
GGETLDLDTLVADVEALREHLGAEQIVPLGHGFGALVALEYARRHPTRTARVIVVNPWVHFPELALTLLREAAALRGVPL
DDPAQAVRARTPEGQYPAVGEARVEAAFALLNARDLLNTLQFRDNASRMRLEFIDAEGQLSGGGEVQEALVNQGLWEFEY
PPFLQELRRPLFVIAGVHDRTSYPEQVEWLVDLGGADVTVLDAGHYPWLDDEDAFAEALEEALTR
>Mature_304_residues
STPDESNFERLNGADLYFEVTGPQDTPGAEPPIVFLHGGPGYNSYSFRELFGDRLQGRRVVYLDQRGSGRSGPLQDTEQG
GETLDLDTLVADVEALREHLGAEQIVPLGHGFGALVALEYARRHPTRTARVIVVNPWVHFPELALTLLREAAALRGVPLD
DPAQAVRARTPEGQYPAVGEARVEAAFALLNARDLLNTLQFRDNASRMRLEFIDAEGQLSGGGEVQEALVNQGLWEFEYP
PFLQELRRPLFVIAGVHDRTSYPEQVEWLVDLGGADVTVLDAGHYPWLDDEDAFAEALEEALTR

Specific function: Specifically catalyzes the removal of N-terminal proline residues from peptides [H]

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S33 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR005944
- InterPro:   IPR002410 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.4.11.5 [H]

Molecular weight: Translated: 33716; Mature: 33585

Theoretical pI: Translated: 4.27; Mature: 4.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPDESNFERLNGADLYFEVTGPQDTPGAEPPIVFLHGGPGYNSYSFRELFGDRLQGRR
CCCCCCCCHHHCCCCEEEEEEECCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCE
VVYLDQRGSGRSGPLQDTEQGGETLDLDTLVADVEALREHLGAEQIVPLGHGFGALVALE
EEEEECCCCCCCCCCCCHHCCCCEECHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHH
YARRHPTRTARVIVVNPWVHFPELALTLLREAAALRGVPLDDPAQAVRARTPEGQYPAVG
HHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCC
EARVEAAFALLNARDLLNTLQFRDNASRMRLEFIDAEGQLSGGGEVQEALVNQGLWEFEY
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCC
PPFLQELRRPLFVIAGVHDRTSYPEQVEWLVDLGGADVTVLDAGHYPWLDDEDAFAEALE
CHHHHHHCCCEEEEECCCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHH
EALTR
HHHCC
>Mature Secondary Structure 
STPDESNFERLNGADLYFEVTGPQDTPGAEPPIVFLHGGPGYNSYSFRELFGDRLQGRR
CCCCCCCHHHCCCCEEEEEEECCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCE
VVYLDQRGSGRSGPLQDTEQGGETLDLDTLVADVEALREHLGAEQIVPLGHGFGALVALE
EEEEECCCCCCCCCCCCHHCCCCEECHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHH
YARRHPTRTARVIVVNPWVHFPELALTLLREAAALRGVPLDDPAQAVRARTPEGQYPAVG
HHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCC
EARVEAAFALLNARDLLNTLQFRDNASRMRLEFIDAEGQLSGGGEVQEALVNQGLWEFEY
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCC
PPFLQELRRPLFVIAGVHDRTSYPEQVEWLVDLGGADVTVLDAGHYPWLDDEDAFAEALE
CHHHHHHCCCEEEEECCCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHH
EALTR
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9348090; 11011150; 10467172 [H]